Works by Zamyatina, Alla

Results: 25

Structural insight into TLR4/MD-2 activation by synthetic LPS mimetics with distinct binding modes.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59550-3

By:

Fu, Yaoyao;
Kim, Hyojin;
Lee, Dong Sun;
Han, Ah-reum;
Heine, Holger;
Zamyatina, Alla;
Kim, Ho Min

Publication type:

Article

Lipid A Mimetics Based on Unnatural Disaccharide Scaffold as Potent TLR4 Agonists for Prospective Immunotherapeutics and Adjuvants.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 35, p. 1, doi. 10.1002/chem.202200547

By:

Strobl, Sebastian;
Hofbauer, Karin;
Heine, Holger;
Zamyatina, Alla

Publication type:

Article

Nonreducing Sugar Scaffold Enables the Development of Immunomodulatory TLR4‐specific LPS Mimetics with Picomolar Potency.

Published in:

Angewandte Chemie International Edition, 2024, v. 63, n. 39, p. 1, doi. 10.1002/anie.202408421

By:

Strobl, Sebastian;
Zucchetta, Daniele;
Vašíček, Tomáš;
Monti, Alessandro;
Ruda, Alessandro;
Widmalm, Göran;
Heine, Holger;
Zamyatina, Alla

Publication type:

Article

Exploring Species-Specificity in TLR4/MD-2 Inhibition with Amphiphilic Lipid A Mimicking Glycolipids.

Published in:

Molecules, 2023, v. 28, n. 16, p. 5948, doi. 10.3390/molecules28165948

By:

Borio, Alessio;
Holgado, Aurora;
Passegger, Christina;
Strobl, Herbert;
Beyaert, Rudi;
Heine, Holger;
Zamyatina, Alla

Publication type:

Article

ADP‐heptose is a newly identified pathogen‐associated molecular pattern of Shigella flexneri.

Published in:

EMBO Reports, 2018, v. 19, n. 12, p. N.PAG, doi. 10.15252/embr.201846943

By:

García‐Weber, Diego;
Dangeard, Anne‐Sophie;
Cornil, Johan;
Thai, Linda;
Rytter, Héloïse;
Zamyatina, Alla;
Mulard, Laurence A;
Arrieumerlou, Cécile

Publication type:

Article

Versatile approach towards fully desymmetrized trehalose with a novel set of orthogonal protecting groups.

Published in:

Frontiers in Chemistry, 2024, p. 1, doi. 10.3389/fchem.2023.1332837

By:

Vasi'cek, Tomas;
Arensmeyer, Benjamin;
Monti, Alessandro;
Zamyatina, Alla;
Afonso, Carlos;
Lopes, Susana M. M.

Publication type:

Article

Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways.

Published in:

Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.585146

By:

Zamyatina, Alla;
Heine, Holger

Publication type:

Article

Disaccharide‐Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide‐Induced Inflammation.

Published in:

ChemMedChem, 2018, v. 13, n. 21, p. 2317, doi. 10.1002/cmdc.201800505

By:

Borio, Alessio;
Holgado, Aurora;
Garate, Jose Antonio;
Beyaert, Rudi;
Heine, Holger;
Zamyatina, Alla

Publication type:

Article

Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold.

Published in:

Innate Immunity, 2015, v. 21, n. 5, p. 490, doi. 10.1177/1753425914550426

By:

Garate, Jose Antonio;
Stöckl, Johannes;
del Carmen Fernández-Alonso, María;
Artner, Daniel;
Haegman, Mira;
Oostenbrink, Chris;
Jiménez-Barbero, Jesús;
Beyaert, Rudi;
Heine, Holger;
Kosma, Paul;
Zamyatina, Alla

Publication type:

Article

Investigation on the agonistic and antagonistic biological activities of synthetic Chlamydia lipid A and its use in in vitro enzymatic assays.

Published in:

Innate Immunity, 2007, v. 13, n. 2, p. 126, doi. 10.1177/0968051907079122

By:

Heine, Holger;
Gronow, Sabine;
Zamyatina, Alla;
Kosma, Paul;
Brade, Helmut

Publication type:

Article

Characterization of the physiological substrate for lipopolysaccharide heptosyltransferases I and II.

Published in:

Innate Immunity, 2001, v. 7, n. 4, p. 263, doi. 10.1177/09680519010070040701

By:

Gronow, Sabine;
Oertelt, Clemens;
Ervelä, Elise;
Zamyatina, Alla;
Kosma, Paul;
Skurnik, Mikael;
Holst, Otto

Publication type:

Article

Synthesis of inner core antigens related to Chlamydia, Pseudomonas and Acinetobacter LPS.

Published in:

Innate Immunity, 1999, v. 5, n. 3, p. 157, doi. 10.1177/09680519990050031001

By:

Kosma, Paul;
Reiter, Andreas;
Zamyatina, Alla;
Wimmer, Norbert;
Glück, Alexander;
Brade, Helmut

Publication type:

Article

Synthesis of lipid A and inner-core lipopolysaccharide (LPS) ligands containing 4-amino-4-deoxy-L-arabinose units.

Published in:

Pure & Applied Chemistry, 2012, v. 84, n. 1, p. 11

By:

Zamyatina, Alla;
Hollaus, Ralph;
Blaukopf, Markus;
Kosma, Paul

Publication type:

Article

Nonreducing Sugar Scaffold Enables the Development of Immunomodulatory TLR4‐specific LPS Mimetics with Picomolar Potency.

Published in:

Angewandte Chemie, 2024, v. 136, n. 39, p. 1, doi. 10.1002/ange.202408421

By:

Strobl, Sebastian;
Zucchetta, Daniele;
Vašíček, Tomáš;
Monti, Alessandro;
Ruda, Alessandro;
Widmalm, Göran;
Heine, Holger;
Zamyatina, Alla

Publication type:

Article

Chemical Synthesis of Burkholderia Lipid A Modified with Glycosyl Phosphodiester-Linked 4-Amino-4-deoxy-β-L-arabinose and Its Immunomodulatory Potential.

Published in:

Chemistry - A European Journal, 2015, v. 21, n. 10, p. 4102, doi. 10.1002/chem.201406058

By:

Hollaus, Ralph;
Ittig, Simon;
Hofinger, Andreas;
Haegman, Mira;
Beyaert, Rudi;
Kosma, Paul;
Zamyatina, Alla

Publication type:

Article

Chemistry of Lipid A: At the Heart of Innate Immunity.

Published in:

Chemistry - A European Journal, 2015, v. 21, n. 2, p. 500, doi. 10.1002/chem.201403923

By:

Molinaro, Antonio;
Holst, Otto;
Di Lorenzo, Flaviana;
Callaghan, Maire;
Nurisso, Alessandra;
D'Errico, Gerardino;
Zamyatina, Alla;
Peri, Francesco;
Berisio, Rita;
Jerala, Roman;
Jiménez‐Barbero, Jesús;
Silipo, Alba;
Martín‐Santamaría, Sonsoles

Publication type:

Article

Cover Picture: Chemistry of Lipid A: At the Heart of Innate Immunity (Chem. Eur. J. 2/2015).

Published in:

Chemistry - A European Journal, 2015, v. 21, n. 2, p. 473, doi. 10.1002/chem.201590000

By:

Molinaro, Antonio;
Holst, Otto;
Di Lorenzo, Flaviana;
Callaghan, Maire;
Nurisso, Alessandra;
D'Errico, Gerardino;
Zamyatina, Alla;
Peri, Francesco;
Berisio, Rita;
Jerala, Roman;
Jiménez‐Barbero, Jesús;
Silipo, Alba;
Martín‐Santamaría, Sonsoles

Publication type:

Article

Chemistry of Lipid A: At the Heart of Innate Immunity.

Published in:

2015

By:

Molinaro, Antonio;
Holst, Otto;
Di Lorenzo, Flaviana;
Callaghan, Maire;
Nurisso, Alessandra;
D'Errico, Gerardino;
Zamyatina, Alla;
Peri, Francesco;
Berisio, Rita;
Jerala, Roman;
Jiménez‐Barbero, Jesús;
Silipo, Alba;
Martín‐Santamaría, Sonsoles

Publication type:

Other

Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation.

Published in:

Pharmaceutics, 2021, v. 13, n. 4, p. 501, doi. 10.3390/pharmaceutics13040501

By:

Schijns, Virgil;
Majhen, Dragomira;
van der Ley, Peter;
Thakur, Aneesh;
Summerfield, Artur;
Berisio, Rita;
Nativi, Cristina;
Fernández-Tejada, Alberto;
Alvarez-Dominguez, Carmen;
Gizurarson, Sveinbjörn;
Zamyatina, Alla;
Molinaro, Antonio;
Rosano, Camillo;
Jakopin, Žiga;
Gursel, Ihsan;
McClean, Siobhán;
Moon, James J.

Publication type:

Article

Therapeutic Targeting of TLR4 for Inflammation, Infection, and Cancer: A Perspective for Disaccharide Lipid A Mimetics.

Published in:

Pharmaceuticals (14248247), 2023, v. 16, n. 1, p. 23, doi. 10.3390/ph16010023

By:

Heine, Holger;
Zamyatina, Alla

Publication type:

Article

Efficient Chemical Synthesis of the Two Anomers of ADP- L- glycero- and D- glycero- D- manno-Heptopyranose Allows the Determination of the Substrate Specificities of Bacterial Heptosyltransferases.

Published in:

Angewandte Chemie International Edition, 2000, v. 39, n. 22, p. 4150, doi. 10.1002/1521-3773(20001117)39:22<4150::AID-ANIE4150>3.0.CO;2-A

By:

Zamyatina, Alla;
Gronow, Sabine;
Oertelt, Clemens;
Puchberger, Michael;
Brade, Helmut;
Kosma, Paul

Publication type:

Article

Substrate flexibility of Mycoplasma fermentans mf1 phosphorylcholine transferase.

Published in:

Glycoconjugate Journal, 2025, v. 42, n. 2, p. 87, doi. 10.1007/s10719-025-10181-2

By:

Nuschy, Lena;
Sarkar, Biswajit;
Zamyatina, Alla;
Wilson, Iain B. H.

Publication type:

Article

Shortening the Lipid A Acyl Chains of Bordetella pertussis Enables Depletion of Lipopolysaccharide Endotoxic Activity.

Published in:

Vaccines, 2020, v. 8, n. 4, p. 594, doi. 10.3390/vaccines8040594

By:

Arenas, Jesús;
Pupo, Elder;
Phielix, Coen;
David, Dionne;
Zariri, Afshin;
Zamyatina, Alla;
Tommassen, Jan;
van der Ley, Peter

Publication type:

Article

Tailored Modulation of Cellular Pro-inflammatory Responses With Disaccharide Lipid A Mimetics.

Published in:

Frontiers in Immunology, 2021, v. 11, p. N.PAG, doi. 10.3389/fimmu.2021.631797

By:

Heine, Holger;
Adanitsch, Florian;
Peternelj, Tina Tinkara;
Haegman, Mira;
Kasper, Christoph;
Ittig, Simon;
Beyaert, Rudi;
Jerala, Roman;
Zamyatina, Alla

Publication type:

Article

Corrigendum: Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways.

Published in:

2021

By:

Zamyatina, Alla;
Heine, Holger

Publication type:

Correction Notice