Works by Yukio Matsuba

Results: 23

Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression.

Published in:

Journal of Neuroscience, 2016, v. 36, n. 38, p. 9933, doi. 10.1523/JNEUROSCI.1907-16.2016

By:

Takashi Saito;
Yukio Matsuba;
Naomi Yamazaki;
Shoko Hashimoto;
Saido, Takaomi C.

Publication type:

Article

Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab.

Published in:

Life Science Alliance, 2024, v. 7, n. 12, p. 1, doi. 10.26508/lsa.202402650

By:

Nobuhisa Iwata;
Satoshi Tsubuki;
Misaki Sekiguchi;
Kaori Watanabe-Iwata;
Yukio Matsuba;
Naoko Kamano;
Ryo Fujioka;
Risa Takamura;
Naoto Watamura;
Naomasa Kakiya;
Naomi Mihira;
Takahiro Morito;
Keiro Shirotani;
Mann, David M. A.;
Robinson, Andrew C.;
Shoko Hashimoto;
Hiroki Sasaguri;
Takashi Saito;
Makoto Higuchi;
Saido, Takaomi C.

Publication type:

Article

Neuronal glutathione depletion elevates the Aβ42/Aβ40 ratio and tau aggregation in Alzheimer's disease mice.

Published in:

FEBS Letters, 2024, v. 598, n. 13, p. 1576, doi. 10.1002/1873-3468.14895

By:

Hashim, Khairun Nisa Binti;
Matsuba, Yukio;
Takahashi, Mika;
Kamano, Naoko;
Tooyama, Ikuo;
Saido, Takaomi C.;
Hashimoto, Shoko

Publication type:

Article

Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-27653-w

By:

Hashimoto, Shoko;
Matsuba, Yukio;
Takahashi, Mika;
Kamano, Naoko;
Watamura, Naoto;
Sasaguri, Hiroki;
Takado, Yuhei;
Yoshihara, Yoshihiro;
Saito, Takashi;
Saido, Takaomi C.

Publication type:

Article

The Role of Neprilysin and Insulin-Degrading Enzyme in the Etiology of Sporadic Alzheimer's Disease.

Published in:

Journal of Neuroscience, 2025, v. 45, n. 23, p. 1, doi. 10.1523/JNEUROSCI.2152-24.2025

By:

Takahiro Morito;
Shoko Hashimoto;
Risa Takamura;
Naoto Watamura;
Naomasa Kakiya;
Ryo Fujioka;
Naomi Mihara;
Misaki Sekiguchi;
Kaori Watanabe-Iwata;
Naoko Kamano;
Mohan Qi;
Yukio Matsuba;
Satoshi Tsubuki;
Takashi Saito;
Nobuhisa Iwata;
Hiroki Sasaguri;
Saido, Takaomi C.

Publication type:

Article

Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease.

Published in:

Annals of Neurology, 2005, v. 57, n. 6, p. 832

By:

Masahiro Maruyama;
Makoto Higuchi;
Yoshie Takaki;
Yukio Matsuba;
Haruko Tanji;
Miyako Nemoto;
Naoki Tomita;
Toshifumi Matsui;
Nobuhisa Iwata;
Hiroaki Mizukami;
Shin‐Ichi Muramatsu;
Keiya Ozawa;
Takaomi C. Saido;
Hiroyuki Arai;
Hidetada Sasaki

Publication type:

Article

Single App knock-in mouse models of Alzheimer's disease.

Published in:

Nature Neuroscience, 2014, v. 17, n. 5, p. 661, doi. 10.1038/nn.3697

By:

Saito, Takashi;
Matsuba, Yukio;
Mihira, Naomi;
Takano, Jiro;
Nilsson, Per;
Itohara, Shigeyoshi;
Iwata, Nobuhisa;
Saido, Takaomi C

Publication type:

Article

Potent amyloidogenicity and pathogenicity of A?43.

Published in:

Nature Neuroscience, 2011, v. 14, n. 8, p. 1023, doi. 10.1038/nn.2858

By:

Saito, Takashi;
Suemoto, Takahiro;
Brouwers, Nathalie;
Sleegers, Kristel;
Funamoto, Satoru;
Mihira, Naomi;
Matsuba, Yukio;
Yamada, Kazuyuki;
Nilsson, Per;
Takano, Jiro;
Nishimura, Masaki;
Iwata, Nobuhisa;
Van Broeckhoven, Christine;
Ihara, Yasuo;
Saido, Takaomi C.

Publication type:

Article

Tau-binding protein PRMT8 facilitates vacuole degeneration in the brain.

Published in:

Journal of Biochemistry, 2022, v. 172, n. 4, p. 233, doi. 10.1093/jb/mvac058

By:

Ishii, Ayano;
Matsuba, Yukio;
Mihira, Naomi;
Kamano, Naoko;
Saito, Takashi;
Muramatsu, Shin-ichi;
Yokosuka, Makoto;
Saido, Takaomi C;
Hashimoto, Shoko

Publication type:

Article

Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID.

Published in:

Nature Communications, 2018, v. 9, p. 1, doi. 10.1038/s41467-018-05262-w

By:

Hiroki Sasaguri;
Kenichi Nagata;
Misaki Sekiguchi;
Ryo Fujioka;
Yukio Matsuba;
Shoko Hashimoto;
Kaori Sato;
Kurup, Deepika;
Takanori Yokota;
Saido, Takaomi C.

Publication type:

Article

Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s diseaselike pathology.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04238-0

By:

Kenichi Nagata;
Mika Takahashi;
Yukio Matsuba;
Fumi Okuyama-Uchimura;
Kaori Sato;
Shoko Hashimoto;
Takashi Saito;
Saido, Takaomi C.

Publication type:

Article

Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology.

Published in:

FASEB Journal, 2012, v. 26, n. 3, p. 1204, doi. 10.1096/fj.11-187740

By:

Higuchi, Makoto;
Iwata, Nobuhisa;
Matsuba, Yukio;
Takano, Jiro;
Suemoto, Takahiro;
Maeda, Jun;
Ji, Bin;
Ono, Maiko;
Staufenbiel, Matthias;
Suhara, Tetsuya;
Saido, Takaomi C.

Publication type:

Article

<sup>19</sup>F and<sup>1</sup>H MRI detection of amyloidßplaques in vivo.

Published in:

Nature Neuroscience, 2005, v. 8, n. 4, p. 527, doi. 10.1038/nn1422

By:

Higuchi, Makoto;
Iwata, Nobuhisa;
Matsuba, Yukio;
Sato, Kumi;
Sasamoto, Kazumi;
Saido, Takaomi C

Publication type:

Article

P2‐076: GENERATION OF AD ANIMAL MODELS USING A NOVEL RNA‐GUIDED GENE EDITING TECHNOLOGY.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P601, doi. 10.1016/j.jalz.2019.06.2483

By:

Sasaguri, Hiroki;
Sekiguchi, Misaki;
Fujioka, Ryo;
Matsuba, Yukio;
Nagata, Kenichi;
Saido, Takaomi C.

Publication type:

Article

P4‐224: ATTENUATION OF Aβ PATHOLOGY BY GENOME EDITING: TOWARDS APPLICATION OF ANTISENSE THERAPIES TO TREATMENT OF ALZHEIMER'S DISEASE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1528, doi. 10.1016/j.jalz.2018.07.045

By:

Sasaguri, Hiroki;
Nagata, Kenichi;
Takahashi, Mika;
Matsuba, Yukio;
Saido, Takaomi C.

Publication type:

Article

NEPRILYSIN IS THE MAJOR ENZYME TO DEGRADE EXTRACELLULAR Aβ IN NOVEL AD ANIMAL MODELS.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P310, doi. 10.1016/j.jalz.2017.06.243

By:

Sasaguri, Hiroki;
Sekiguchi, Misaki;
Matsuba, Yukio;
Saito, Takashi;
Saido, Takaomi C.

Publication type:

Article

APP knock-in mouse: A novel and more relevant model mouse for Alzheimer's disease

Published in:

2012

By:

Saito, Takashi;
Matsuba, Yukio;
Mihira, Naomi;
Iwata, Nobuhisa;
Takano, Jiro;
Nilsson, Per;
Saido, Takaomi

Publication type:

Abstract

Aβ43 is potently amyloidogenic in vivo

Published in:

2010

By:

Saito, Takashi;
Suemoto, Takahiro;
Mihira, Naomi;
Matsuba, Yukio;
Takano, Jiro;
Nilsson, Per;
Nishimura, Masaki;
Iwata, Nobuhisa;
Saido, Takaomi C.

Publication type:

Abstract

The biological effects of R278I-Presenilin-1 familial mutation on γ-secretase activity and amyloid pathology

Published in:

2009

By:

Saito, Takashi;
Suemoto, Takahiro;
Mihira, Naomi;
Matsuba, Yukio;
Takano, Jiro;
Nishimura, Masaki;
Iwata, Nobuhisa;
Saido, Takaomi C.

Publication type:

Abstract

P1-113: Accecelerated Aβ plaque formation by low level expression of presenilin-1 with R278I mutation in knock-in mouse

Published in:

2008

By:

Suemoto, Takahiro;
Saito, Takashi;
Takano, Jiro;
Matsuba, Yukio;
Yamazaki, Naomi;
Nishimura, Masaki;
Iwata, Nobuhisa;
Saido, Takaomi C.

Publication type:

Abstract

Tau Accumulation Induces Microglial State Alterations in Alzheimer's Disease Model Mice.

Published in:

eNeuro, 2024, v. 11, n. 12, p. 1, doi. 10.1523/ENEURO.0260-24.2024

By:

Kenichi Nagata;
Shoko Hashimoto;
Daisuke Joho;
Ryo Fujioka;
Yukio Matsuba;
Misaki Sekiguchi;
Naomi Mihira;
Daisuke Motooka;
Yu-Chen Liu;
Daisuke Okuzaki;
Masataka Kikuchi;
Shigeo Murayama;
Saido, Takaomi C.;
Hiroshi Kiyama;
Hiroki Sasaguri

Publication type:

Article

Author Correction: Tau binding protein CAPON induces tau aggregation and neurodegeneration.

Published in:

2019

By:

Hashimoto, Shoko;
Matsuba, Yukio;
Kamano, Naoko;
Mihira, Naomi;
Sahara, Naruhiko;
Takano, Jiro;
Muramatsu, Shin-ichi;
Saido, Takaomi C.;
Saito, Takashi

Publication type:

Correction Notice

Tau binding protein CAPON induces tau aggregation and neurodegeneration.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-10990-8

By:

Hashimoto, Shoko;
Matsuba, Yukio;
Kamano, Naoko;
Mihira, Naomi;
Sahara, Naruhiko;
Takano, Jiro;
Muramatsu, Shin-ichi;
Saido, Takaomi C.;
Saito, Takashi

Publication type:

Article