Works by Younghwa Na

Results: 20

Drug-Like Small Molecule HSP27 Functional Inhibitor Sensitizes Lung Cancer Cells to Gefitinib or Cisplatin by Inducing Altered Cross-Linked Hsp27 Dimers.

Published in:

Pharmaceutics, 2021, v. 13, n. 5, p. 630, doi. 10.3390/pharmaceutics13050630

By:

Yoo, Hawon;
Choi, Seul-Ki;
Lee, Jaeok;
Park, So Hyeon;
Park, You Na;
Hwang, Soo-Yeon;
Shin, Jae-Ho;
Na, Younghwa;
Kwon, Youngjoo;
Lee, Hwa Jeong;
Lee, Yun-Sil;
Grossi, Francesco

Publication type:

Article

Dual Inhibition of P-gp and BCRP Improves Oral Topotecan Bioavailability in Rodents.

Published in:

Pharmaceutics, 2021, v. 13, n. 4, p. 559, doi. 10.3390/pharmaceutics13040559

By:

Lee, Jaeok;
Kang, Jiyeon;
Kwon, Na-Yun;
Sivaraman, Aneesh;
Naik, Ravi;
Jin, So-Young;
Oh, A. Reum;
Shin, Jae-Ho;
Na, Younghwa;
Lee, Kyeong;
Lee, Hwa-Jeong;
Lee, Yonghyun

Publication type:

Article

The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosis.

Published in:

Journal of Biomedical Science, 2023, v. 30, n. 1, p. 1, doi. 10.1186/s12929-023-00896-5

By:

Jeon, Seulgi;
Jin, Hee;
Kim, Jin-Mo;
Hur, Youmin;
Song, Eun Joo;
Lee, Yoon-Jin;
Na, Younghwa;
Cho, Jaeho;
Lee, Yun-Sil

Publication type:

Article

Calpain 2 Isoform‐Specific Cleavage of Filamin A Enhances HIF1α Nuclear Translocation, Promoting Metastasis in Triple‐Negative Breast Cancer.

Published in:

MedComm, 2025, v. 6, n. 4, p. 1, doi. 10.1002/mco2.70147

By:

Jeon, Kyung‐Hwa;
Park, Seojeong;
Pak, Eun Seon;
Kim, Jeong‐Ahn;
Liu, Yi;
Hwang, Soo‐Yeon;
Na, Younghwa;
Kwon, Youngjoo

Publication type:

Article

Synthesis and biological assessment of chalcone and pyrazoline derivatives as novel inhibitor for ELF3-MED23 interaction.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.97051

By:

Soo-Yeon Hwang;
Kyung-Hwa Jeon;
Hwa-Jong Lee;
Inhye Moon;
Sehyun Jung;
Seul-Ah Kim;
Hyunji Jo;
Seojeong Park;
Misun Ahn;
Soo-Yeon Kwak;
Younghwa Na;
Youngjoo Kwon

Publication type:

Article

Activation of the HSP27-AKT axis contributes to gefitinib resistance in non-small cell lung cancer cells independent of EGFR mutations.

Published in:

Cellular Oncology (2211-3428), 2022, v. 45, n. 5, p. 913, doi. 10.1007/s13402-022-00696-3

By:

Choi, Seul-Ki;
Kim, Minsuh;
Lee, Haeseung;
Kwon, Youngjoo;
Cha, Hyuk-Jin;
Jang, Se Jin;
Na, Younghwa;
Lee, Yun-Sil

Publication type:

Article

Specific Roles of HSP27 S15 Phosphorylation Augmenting the Nuclear Function of HER2 to Promote Trastuzumab Resistance.

Published in:

Cancers, 2020, v. 12, n. 6, p. 1540, doi. 10.3390/cancers12061540

By:

Hwang, Soo-Yeon;
Choi, Seul-Ki;
Seo, Seung Hee;
Jo, Hyunji;
Shin, Jae-Ho;
Na, Younghwa;
Lee, Yun-Sil;
Kwon, Youngjoo

Publication type:

Article

Pharmacological Activation of AMP-activated Protein Kinase Ameliorates Liver Fibrosis in a Metabolic Dysfunction-Associated Steatohepatitis Mouse Model.

Published in:

International Journal of Biological Sciences, 2025, v. 21, n. 7, p. 2957, doi. 10.7150/ijbs.108731

By:

Seojeong Kim;
Jae-Ho Shin;
Minjung Seo;
Eun Seon Pak;
Kyung-Hwa Jeon;
Inhye Moon;
Jisoo Kang;
Wonhyo Seo;
Younghwa Na;
Youngjoo Kwon

Publication type:

Article

Novel TGF‐β1 inhibitor antagonizes TGF‐β1‐induced epithelial‐mesenchymal transition in human A549 lung cancer cells.

Published in:

Journal of Cellular Biochemistry, 2019, v. 120, n. 1, p. 977, doi. 10.1002/jcb.27460

By:

Jeong, Ji‐Hoon;
Jang, Hae Jin;
Kwak, Sungmin;
Sung, Gi‐Jun;
Park, Seung‐Ho;
Song, Ji‐Hye;
Kim, Hyunhee;
Na, Younghwa;
Choi, Kyung‐Chul

Publication type:

Article

A New TGF-β1 Inhibitor, CTI-82, Antagonizes Epithelial–Mesenchymal Transition through Inhibition of Phospho-SMAD2/3 and Phospho-ERK.

Published in:

Biology (2079-7737), 2020, v. 9, n. 7, p. 143, doi. 10.3390/biology9070143

By:

Jeong, Ji-Hoon;
Kim, Hyunhee;
Park, Seung-Ho;
Park, Hayeon;
Jeong, Minseok;
Kwak, Sungmin;
Sung, Gi-Jun;
Song, Ji-Hye;
Na, Younghwa;
Choi, Kyung-Chul

Publication type:

Article

Targeting the HER2-ELF3-KRAS axis: a novel therapeutic strategy for KRASG13D colorectal cancer.

Published in:

Molecular Cancer, 2025, v. 24, n. 1, p. 1, doi. 10.1186/s12943-025-02343-5

By:

Hwang, Soo-Yeon;
Seo, Yoojeong;
Park, Seojeong;
Kim, Seul-Ah;
Moon, Inhye;
Liu, Yi;
Kim, Seojeong;
Pak, Eun Seon;
Jung, Sehyun;
Kim, Hyeyoon;
Jeon, Kyung-Hwa;
Seo, Seung Hee;
Sung, Inyoung;
Lee, Heetak;
Park, So-Yeon;
Na, Younghwa;
Kim, Tae Il;
Kwon, Youngjoo

Publication type:

Article

Drug like HSP27 cross linkers with chromenone structure ameliorates pulmonary fibrosis.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1203033

By:

Young Jo Yoo;
Seulgi Jeon;
Hee Jin;
Hee Yeon Won;
Mi Gyeong Jeong;
Yeseul Cho;
Eun Sook Hwang;
Younghwa Na;
Jaeho Cho;
Yun-Sil Lee

Publication type:

Article

Intestinal P‐glycoprotein inhibitors, benzoxanthone analogues.

Published in:

Journal of Pharmacy & Pharmacology, 2018, v. 70, n. 2, p. 234, doi. 10.1111/jphp.12832

By:

Chae, Song Wha;
Lee, Jaeok;
Park, Jung Hyun;
Kwon, Youngjoo;
Na, Younghwa;
Lee, Hwa Jeong

Publication type:

Article

Recent cancer drug development with xanthone structures.

Published in:

Journal of Pharmacy & Pharmacology, 2009, v. 61, n. 6, p. 707, doi. 10.1211/jpp.61.06.0002

By:

Younghwa Na

Publication type:

Article

Synergistic effect of melatonin and ghrelin in preventing cisplatin-induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27Kip1 promoter in primordial follicles.

Published in:

Journal of Pineal Research, 2017, v. 63, n. 3, p. n/a, doi. 10.1111/jpi.12432

By:

Jang, Hoon;
Na, Younghwa;
Hong, Kwonho;
Lee, Sangho;
Moon, Sohyeon;
Cho, Minha;
Park, Miseon;
Lee, Ok‐Hee;
Chang, Eun Mi;
Lee, Dong Ryul;
Ko, Jung Jae;
Lee, Woo Sik;
Choi, Youngsok

Publication type:

Article

Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple‐negative breast cancer cells.

Published in:

Cancer Science, 2024, v. 115, n. 6, p. 2036, doi. 10.1111/cas.16174

By:

Choi, Eun;
Jeon, Kyung‐Hwa;
Lee, Hanhee;
Mun, Gil‐Im;
Kim, Jeong‐Ahn;
Shin, Jae‐Ho;
Kwon, Youngjoo;
Na, Younghwa;
Lee, Yun‐Sil

Publication type:

Article

High density peptide microarrays. In situ synthesis and applications.

Published in:

Molecular Diversity, 2004, v. 8, n. 3, p. 177, doi. 10.1023/B:MODI.0000036233.58271.25

By:

Gao, Xiaolian;
Pellois, Jean;
Na, Younghwa;
Kim, Younkee;
Gulari, Erdogan;
Zhou, Xiaochuan

Publication type:

Article

Selective PCAF inhibitor ameliorates cognitive and behavioral deficits by suppressing NF-κB-mediated neuroinflammation induced by Aβ in a model of Alzheimer's disease.

Published in:

International Journal of Molecular Medicine, 2015, v. 35, n. 4, p. 1109, doi. 10.3892/ijmm.2015.2099

By:

SOO-YEON PARK;
MI-JEONG KIM;
YOUNG JUN KIM;
YOO-HYUN LEE;
DONGHYUK BAE;
SUNOH KIM;
YOUNGHWA NA;
HO-GEUN YOON

Publication type:

Article

Conversion of Medium-Sized Lactams to α-Vinyl or α-Acetylenyl Azacycles via N,O-Acetal TMS Ethers.

Published in:

Molecules, 2018, v. 23, n. 11, p. 3023, doi. 10.3390/molecules23113023

By:

Kim, Minjun;
Jang, Jaebong;
Choi, Goyoung;
Chung, Sungkyun;
Lim, Changjin;
Hur, Joonseong;
Kim, Hyun Su;
Na, Younghwa;
Son, Woo Sung;
Suh, Young-Ger;
Jung, Jong-Wha;
Kim, Seok-Ho

Publication type:

Article

Asymmetric Synthesis of (-)-6-Desmethyl-Fluvirucinine A1 via Conformationally-Controlled Diastereoselective Lactam-Ring Expansions.

Published in:

Molecules, 2018, v. 23, n. 9, p. 2351, doi. 10.3390/molecules23092351

By:

Hyunyoung Moon;
Hojong Yoon;
Changjin Lim;
Jaebong Jang;
Jong-Jae Yi;
Jae Kyun Lee;
Jeeyeon Lee;
Younghwa Na;
Woo Sung Son;
Seok-Ho Kim;
Young-Ger Suh

Publication type:

Article

Works by Younghwa Na

Drug-Like Small Molecule HSP27 Functional Inhibitor Sensitizes Lung Cancer Cells to Gefitinib or Cisplatin by Inducing Altered Cross-Linked Hsp27 Dimers.

Dual Inhibition of P-gp and BCRP Improves Oral Topotecan Bioavailability in Rodents.

The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosis.

Calpain 2 Isoform‐Specific Cleavage of Filamin A Enhances HIF1α Nuclear Translocation, Promoting Metastasis in Triple‐Negative Breast Cancer.

Synthesis and biological assessment of chalcone and pyrazoline derivatives as novel inhibitor for ELF3-MED23 interaction.

Activation of the HSP27-AKT axis contributes to gefitinib resistance in non-small cell lung cancer cells independent of EGFR mutations.

Specific Roles of HSP27 S15 Phosphorylation Augmenting the Nuclear Function of HER2 to Promote Trastuzumab Resistance.

Pharmacological Activation of AMP-activated Protein Kinase Ameliorates Liver Fibrosis in a Metabolic Dysfunction-Associated Steatohepatitis Mouse Model.

Novel TGF‐β1 inhibitor antagonizes TGF‐β1‐induced epithelial‐mesenchymal transition in human A549 lung cancer cells.

A New TGF-β1 Inhibitor, CTI-82, Antagonizes Epithelial–Mesenchymal Transition through Inhibition of Phospho-SMAD2/3 and Phospho-ERK.

Targeting the HER2-ELF3-KRAS axis: a novel therapeutic strategy for KRAS<sup>G13D</sup> colorectal cancer.

Drug like HSP27 cross linkers with chromenone structure ameliorates pulmonary fibrosis.

Intestinal P‐glycoprotein inhibitors, benzoxanthone analogues.

Recent cancer drug development with xanthone structures.

Synergistic effect of melatonin and ghrelin in preventing cisplatin-induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27<sup>Kip1</sup> promoter in primordial follicles.

Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple‐negative breast cancer cells.

High density peptide microarrays. In situ synthesis and applications.

Selective PCAF inhibitor ameliorates cognitive and behavioral deficits by suppressing NF-κB-mediated neuroinflammation induced by Aβ in a model of Alzheimer's disease.

Conversion of Medium-Sized Lactams to α-Vinyl or α-Acetylenyl Azacycles via N,O-Acetal TMS Ethers.

Asymmetric Synthesis of (-)-6-Desmethyl-Fluvirucinine A<sub>1</sub> via Conformationally-Controlled Diastereoselective Lactam-Ring Expansions.