Works matching AU Young, Samuel N.

Results: 24

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27032-x

By:

Meng, Yanxiang;
Davies, Katherine A.;
Fitzgibbon, Cheree;
Young, Samuel N.;
Garnish, Sarah E.;
Horne, Christopher R.;
Luo, Cindy;
Garnier, Jean-Marc;
Liang, Lung-Yu;
Cowan, Angus D.;
Samson, Andre L.;
Lessene, Guillaume;
Sandow, Jarrod J.;
Czabotar, Peter E.;
Murphy, James M.

Publication type:

Article

Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23474-5

By:

Garcia, Laura Ramos;
Tenev, Tencho;
Newman, Richard;
Haich, Rachel O.;
Liccardi, Gianmaria;
John, Sidonie Wicky;
Annibaldi, Alessandro;
Yu, Lu;
Pardo, Mercedes;
Young, Samuel N.;
Fitzgibbon, Cheree;
Fernando, Winnie;
Guppy, Naomi;
Kim, Hyojin;
Liang, Lung-Yu;
Lucet, Isabelle S.;
Kueh, Andrew;
Roxanis, Ioannis;
Gazinska, Patrycja;
Sims, Martin

Publication type:

Article

Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis.

Published in:

EMBO Journal, 2021, v. 40, n. 23, p. 1, doi. 10.15252/embj.2019103718

By:

Liu, Zikou;
Dagley, Laura F;
Shield‐Artin, Kristy;
Young, Samuel N;
Bankovacki, Aleksandra;
Wang, Xiangyi;
Tang, Michelle;
Howitt, Jason;
Stafford, Che A;
Nachbur, Ueli;
Fitzgibbon, Cheree;
Garnish, Sarah E;
Webb, Andrew I;
Komander, David;
Murphy, James M;
Hildebrand, Joanne M;
Silke, John

Publication type:

Article

Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia.

Published in:

Growth Factors, 2014, v. 32, n. 1, p. 18, doi. 10.3109/08977194.2013.874347

By:

Varghese, Leila N.;
Zhang, Jian-Guo;
Young, Samuel N.;
Willson, Tracy A.;
Alexander, Warren S.;
Nicola, Nicos A.;
Babon, Jeffrey J.;
Murphy, James M.

Publication type:

Article

Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42255-w

By:

Meng, Yanxiang;
Garnish, Sarah E.;
Davies, Katherine A.;
Black, Katrina A.;
Leis, Andrew P.;
Horne, Christopher R.;
Hildebrand, Joanne M.;
Hoblos, Hanadi;
Fitzgibbon, Cheree;
Young, Samuel N.;
Dite, Toby;
Dagley, Laura F.;
Venkat, Aarya;
Kannan, Natarajan;
Koide, Akiko;
Koide, Shohei;
Glukhova, Alisa;
Czabotar, Peter E.;
Murphy, James M.

Publication type:

Article

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41724-6

By:

Garnish, Sarah E.;
Martin, Katherine R.;
Kauppi, Maria;
Jackson, Victoria E.;
Ambrose, Rebecca;
Eng, Vik Ven;
Chiou, Shene;
Meng, Yanxiang;
Frank, Daniel;
Tovey Crutchfield, Emma C.;
Patel, Komal M.;
Jacobsen, Annette V.;
Atkin-Smith, Georgia K.;
Di Rago, Ladina;
Doerflinger, Marcel;
Horne, Christopher R.;
Hall, Cathrine;
Young, Samuel N.;
Cook, Matthew;
Athanasopoulos, Vicki

Publication type:

Article

An immunohistochemical atlas of necroptotic pathway expression.

Published in:

EMBO Molecular Medicine, 2024, v. 16, n. 7, p. 1717, doi. 10.1038/s44321-024-00074-6

By:

Chiou, Shene;
Al-Ani, Aysha H;
Pan, Yi;
Patel, Komal M;
Kong, Isabella Y;
Whitehead, Lachlan W;
Light, Amanda;
Young, Samuel N;
Barrios, Marilou;
Sargeant, Callum;
Rajasekhar, Pradeep;
Zhu, Leah;
Hempel, Anne;
Lin, Ann;
Rickard, James A;
Hall, Cathrine;
Gangatirkar, Pradnya;
Yip, Raymond KH;
Cawthorne, Wayne;
Jacobsen, Annette V

Publication type:

Article

Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06118-4

By:

Liang, Lung-Yu;
Geoghegan, Niall D.;
Mlodzianoski, Michael;
Leis, Andrew;
Whitehead, Lachlan W.;
Surudoi, Minglyanna G.;
Young, Samuel N.;
Janes, Peter;
Shepherd, Doulin;
Ghosal, Debnath;
Rogers, Kelly L.;
Murphy, James M.;
Lucet, Isabelle S.

Publication type:

Article

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04714-7

By:

Petrie, Emma J.;
Sandow, Jarrod J.;
Jacobsen, Annette V.;
Smith, Brian J.;
Griffin, Michael D. W.;
Lucet, Isabelle S.;
Weiwen Dai;
Young, Samuel N.;
Tanzer, Maria C.;
Wardak, Ahmad;
Lung-Yu Liang;
Cowan, Angus D.;
Hildebrand, Joanne M.;
Kersten, Wilhelmus J. A.;
Lessene, Guillaume;
Silke, John;
Czabotar, Peter E.;
Webb, Andrew I.;
Murphy, James M.

Publication type:

Article

Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation.

Published in:

Biochemical Journal, 2024, v. 481, n. 17, p. 1125, doi. 10.1042/BCJ20240255

By:

Garnish, Sarah E.;
Horne, Christopher R.;
Yanxiang Meng;
Young, Samuel N.;
Jacobsen, Annette V.;
Hildebrand, Joanne M.;
Murphy, James M.

Publication type:

Article

SMCHD1’s ubiquitin-like domain is required for N-terminal dimerization and chromatin localization.

Published in:

Biochemical Journal, 2021, v. 478, n. 13, p. 2555, doi. 10.1042/BCJ20210278

By:

Gurzau, Alexandra D.;
Horne, Christopher R.;
Mok, Yee-Foong;
Iminitoff, Megan;
Willson, Tracy A.;
Young, Samuel N.;
Blewitt, Marnie E.;
Murphy, James M.

Publication type:

Article

The epigenetic regulator Smchd1 contains a functional GHKL-type ATPase domain.

Published in:

Biochemical Journal, 2016, v. 473, n. 12, p. 1733, doi. 10.1042/BCJ20160189

By:

Kelan Chen;
Dobson, Renwick C. J.;
Lucet, Isabelle S.;
Young, Samuel N.;
Pearce, F. Grant;
Blewitt, Marnie E.;
Murphy, James M.

Publication type:

Article

Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop.

Published in:

Biochemical Journal, 2015, v. 471, n. 2, p. 255, doi. 10.1042/BJ20150678

By:

Tanzer, Maria C.;
Tripaydonis, Anne;
Webb, Andrew I.;
Young, Samuel N.;
Varghese, Leila N.;
Hall, Cathrine;
Alexander, Warren S.;
Hildebrand, Joanne M.;
Silke, John;
Murphy, James M.

Publication type:

Article

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.

Published in:

Biochemical Journal, 2014, v. 458, n. 2, p. 395, doi. 10.1042/BJ20131516

By:

VARGHESE, Leila N.;
UNGUREANU, Daniela;
LIAU, Nicholas P. D.;
YOUNG, Samuel N.;
LAKTYUSHIN, Artem;
HAMMAREN, Henrik;
LUCET, Isabelle S.;
NICOLA, Nicos A.;
SILVENNOINEN, Olli;
BABON, Jeffrey J.;
MURPHY, James M.

Publication type:

Article

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL.

Published in:

Biochemical Journal, 2014, v. 457, n. 3, p. 369, doi. 10.1042/BJ20131270

By:

MURPHY, James M.;
LUCET, Isabelle S.;
HILDEBRAND, Joanne M.;
TANZER, Maria C.;
YOUNG, Samuel N.;
SHARMA, Pooja;
LESSENE, Guillaume;
ALEXANDER, Warren S.;
BABON, Jeffrey J.;
SILKE, John;
CZABOTAR, Peter E.

Publication type:

Article

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.

Published in:

Biochemical Journal, 2014, v. 457, n. 2, p. 323, doi. 10.1042/BJ20131174

By:

MURPHY, James M.;
Qingwei ZHANG;
YOUNG, Samuel N.;
REESE, Michael L.;
BAILEY, Fiona P.;
EYERS, Patrick A.;
UNGUREANU, Daniela;
HAMMAREN, Henrik;
SILVENNOINEN, Olli;
VARGHESE, Leila N.;
CHEN, Kelan;
TRIPAYDONIS, Anne;
JURA, Natalia;
FUKUDA, Koichi;
QIN, Jun;
NIMCHUK, Zachary;
MUDGETT, Mary Beth;
ELOWE, Sabine;
GEE, Christine L.;
Ling LIU

Publication type:

Article

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22400-z

By:

Garnish, Sarah E.;
Meng, Yanxiang;
Koide, Akiko;
Sandow, Jarrod J.;
Denbaum, Eric;
Jacobsen, Annette V.;
Yeung, Wayland;
Samson, Andre L.;
Horne, Christopher R.;
Fitzgibbon, Cheree;
Young, Samuel N.;
Smith, Phoebe P. C.;
Webb, Andrew I.;
Petrie, Emma J.;
Hildebrand, Joanne M.;
Kannan, Natarajan;
Czabotar, Peter E.;
Koide, Shohei;
Murphy, James M.

Publication type:

Article

Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-21191-7

By:

Oliver, Michael R.;
Horne, Christopher R.;
Shrestha, Safal;
Keown, Jeremy R.;
Liang, Lung-Yu;
Young, Samuel N.;
Sandow, Jarrod J.;
Webb, Andrew I.;
Goldstone, David C.;
Lucet, Isabelle S.;
Kannan, Natarajan;
Metcalf, Peter;
Murphy, James M.

Publication type:

Article

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16887-1

By:

Samson, Andre L.;
Zhang, Ying;
Geoghegan, Niall D.;
Gavin, Xavier J.;
Davies, Katherine A.;
Mlodzianoski, Michael J.;
Whitehead, Lachlan W.;
Frank, Daniel;
Garnish, Sarah E.;
Fitzgibbon, Cheree;
Hempel, Anne;
Young, Samuel N.;
Jacobsen, Annette V.;
Cawthorne, Wayne;
Petrie, Emma J.;
Faux, Maree C.;
Shield-Artin, Kristy;
Lalaoui, Najoua;
Hildebrand, Joanne M.;
Silke, John

Publication type:

Article

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16823-3

By:

Davies, Katherine A.;
Fitzgibbon, Cheree;
Young, Samuel N.;
Garnish, Sarah E.;
Yeung, Wayland;
Coursier, Diane;
Birkinshaw, Richard W.;
Sandow, Jarrod J.;
Lehmann, Wil I. L.;
Liang, Lung-Yu;
Lucet, Isabelle S.;
Chalmers, James D.;
Patrick, Wayne M.;
Kannan, Natarajan;
Petrie, Emma J.;
Czabotar, Peter E.;
Murphy, James M.

Publication type:

Article

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16819-z

By:

Hildebrand, Joanne M.;
Kauppi, Maria;
Majewski, Ian J.;
Liu, Zikou;
Cox, Allison J.;
Miyake, Sanae;
Petrie, Emma J.;
Silk, Michael A.;
Li, Zhixiu;
Tanzer, Maria C.;
Brumatti, Gabriela;
Young, Samuel N.;
Hall, Cathrine;
Garnish, Sarah E.;
Corbin, Jason;
Stutz, Michael D.;
Di Rago, Ladina;
Gangatirkar, Pradnya;
Josefsson, Emma C.;
Rigbye, Kristin

Publication type:

Article

Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid–binding residues.

Published in:

Science Signaling, 2020, v. 13, n. 636, p. 1, doi. 10.1126/scisignal.aaz5599

By:

Chen, Kelan;
Birkinshaw, Richard W.;
Gurzau, Alexandra D.;
Wanigasuriya, Iromi;
Wang, Ruoyun;
Iminitoff, Megan;
Sandow, Jarrod J.;
Young, Samuel N.;
Hennessy, Patrick J.;
Willson, Tracy A.;
Heckmann, Denise A.;
Webb, Andrew I.;
Blewitt, Marnie E.;
Czabotar, Peter E.;
Murphy, James M.

Publication type:

Article

Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling.

Published in:

Cell Death & Disease, 2022, v. 13, n. 6, p. 1, doi. 10.1038/s41419-022-05009-y

By:

Meng, Yanxiang;
Horne, Christopher R.;
Samson, Andre L.;
Dagley, Laura F.;
Young, Samuel N.;
Sandow, Jarrod J.;
Czabotar, Peter E.;
Murphy, James M.

Publication type:

Article

A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes.

Published in:

Cell Death & Disease, 2021, v. 12, n. 4, p. 1, doi. 10.1038/s41419-021-03636-5

By:

Hildebrand, Joanne M.;
Lo, Bernice;
Tomei, Sara;
Mattei, Valentina;
Young, Samuel N.;
Fitzgibbon, Cheree;
Murphy, James M.;
Fadda, Abeer

Publication type:

Article