Works by Young, Alexandra L

Results: 62
    1

    Distinct spatiotemporal atrophy patterns in corticobasal syndrome are associated with different underlying pathologies.

    Published in:
    Brain Communications, 2025, v. 7, n. 2, p. 1, doi. 10.1093/braincomms/fcaf066
    By:
    • Scotton, William J;
    • Shand, Cameron;
    • Todd, Emily G;
    • Bocchetta, Martina;
    • Kobylecki, Christopher;
    • Cash, David M;
    • VandeVrede, Lawren;
    • Heuer, Hilary W;
    • Quaegebeur, Annelies;
    • Young, Alexandra L;
    • Oxtoby, Neil;
    • Alexander, Daniel;
    • Rowe, James B;
    • Morris, Huw R;
    • Consortium, for the PROSPECT;
    • Boxer, Adam L;
    • Consortium, for the 4RTNI;
    • Rohrer, Jonathan D;
    • Wijeratne, Peter A
    Publication type:
    Article
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    Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology.

    Published in:
    Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49402-x
    By:
    • Mastenbroek, Sophie E.;
    • Vogel, Jacob W.;
    • Collij, Lyduine E.;
    • Serrano, Geidy E.;
    • Tremblay, Cécilia;
    • Young, Alexandra L.;
    • Arce, Richard A.;
    • Shill, Holly A.;
    • Driver-Dunckley, Erika D.;
    • Mehta, Shyamal H.;
    • Belden, Christine M.;
    • Atri, Alireza;
    • Choudhury, Parichita;
    • Barkhof, Frederik;
    • Adler, Charles H.;
    • Ossenkoppele, Rik;
    • Beach, Thomas G.;
    • Hansson, Oskar
    Publication type:
    Article
    8

    DATA-DRIVEN DISEASE PROGRESSION PATTERNS OF BRAIN MORPHOLOGY IN SCHIZOPHRENIA: MORE PROGRESSED STAGES IN TREATMENT-RESISTANCE.

    Published in:
    International Journal of Neuropsychopharmacology, 2025, v. 28, p. i222, doi. 10.1093/ijnp/pyae059.389
    By:
    • Daichi Sone;
    • Young, Alexandra L.;
    • Shunichiro Shinagawa;
    • Sakiko Tsugawa;
    • Yusuke Iwata;
    • Ryosuke Tarumi;
    • Kamiyu Ogyu;
    • Shiori Honda;
    • Ryo Ochi;
    • Karin Matsushita;
    • Fumihiko Ueno;
    • Nobuaki Hondo;
    • Akihiro Koreki;
    • Edgardo Torres-Carmona;
    • Wanna Mar;
    • Nathan Chan;
    • Teruki Koizumi;
    • Hideo Kato;
    • Keisuke Kusudo;
    • Vincenzo De Luca
    Publication type:
    Article
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    Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference.

    Published in:
    Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05892-0
    By:
    • Young, Alexandra L;
    • Marinescu, Razvan V;
    • Oxtoby, Neil P;
    • Bocchetta, Martina;
    • Yong, Keir;
    • Firth, Nicholas C;
    • Cash, David M;
    • Thomas, David L;
    • Dick, Katrina M;
    • Cardoso, Jorge;
    • van Swieten, John;
    • Borroni, Barbara;
    • Galimberti, Daniela;
    • Masellis, Mario;
    • Tartaglia, Maria Carmela;
    • Rowe, James B;
    • Graff, Caroline;
    • Tagliavini, Fabrizio;
    • Frisoni, Giovanni B;
    • Laforce, Robert
    Publication type:
    Article
    11

    Progression of regional grey matter atrophy in multiple sclerosis.

    Published in:
    2018
    By:
    • Eshaghi, Arman;
    • Marinescu, Razvan V.;
    • Young, Alexandra L.;
    • Firth, Nicholas C.;
    • Prados, Ferran;
    • Cardoso, M. Jorge;
    • Tur, Carmen;
    • De Angelis, Floriana;
    • Cawley, Niamh;
    • Brownlee, Wallace J.;
    • De Stefano, Nicola;
    • Stromillo, M. Laura;
    • Battaglini, Marco;
    • Ruggieri, Serena;
    • Gasperini, Claudio;
    • Filippi, Massimo;
    • Rocca, Maria A.;
    • Rovira, Alex;
    • Sastre-Garriga, Jaume;
    • Geurts, Jeroen J. G.
    Publication type:
    journal article
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    Evolution of white matter damage in amyotrophic lateral sclerosis.

    Published in:
    Annals of Clinical & Translational Neurology, 2020, v. 7, n. 5, p. 722, doi. 10.1002/acn3.51035
    By:
    • Gabel, Matt C.;
    • Broad, Rebecca J.;
    • Young, Alexandra L.;
    • Abrahams, Sharon;
    • Bastin, Mark E.;
    • Menke, Ricarda A. L.;
    • Al‐Chalabi, Ammar;
    • Goldstein, Laura H.;
    • Tsermentseli, Stella;
    • Alexander, Daniel C.;
    • Turner, Martin R.;
    • Leigh, P. Nigel;
    • Cercignani, Mara
    Publication type:
    Article
    17

    An image‐based model of brain volume biomarker changes in Huntington's disease.

    Published in:
    Annals of Clinical & Translational Neurology, 2018, v. 5, n. 5, p. 570, doi. 10.1002/acn3.558
    By:
    • Wijeratne, Peter A.;
    • Young, Alexandra L.;
    • Oxtoby, Neil P.;
    • Marinescu, Razvan V.;
    • Firth, Nicholas C.;
    • Johnson, Eileanoir B.;
    • Mohan, Amrita;
    • Sampaio, Cristina;
    • Scahill, Rachael I.;
    • Tabrizi, Sarah J.;
    • Alexander, Daniel C.
    Publication type:
    Article
    18
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    Individual variation in proteomic cascades along the Alzheimer's disease spectrum.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S2, p. 1, doi. 10.1002/alz.091914
    By:
    • Vogel, Jacob W.;
    • Vilkaite, Gabriele;
    • Binette, Alexa Pichet;
    • Hristovska, Ines;
    • Xiao, Yu;
    • Mastenbroek, Sophie E.;
    • Rittmo, Jonathan;
    • Janelidze, Shorena;
    • Palmqvist, Sebastian;
    • Salvadó, Gemma;
    • Smith, Ruben;
    • Stomrud, Erik;
    • Strandberg, Olof;
    • Young, Alexandra L.;
    • Ossenkoppele, Rik;
    • Mattsson‐Carlgren, Niklas;
    • Hansson, Oskar
    Publication type:
    Article
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    Biomarker pathway heterogeneity of amyloid‐positive individuals.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 12, p. 8503, doi. 10.1002/alz.14287
    By:
    • Prosser, Lloyd;
    • Sudre, Carole H.;
    • Oxtoby, Neil P.;
    • Young, Alexandra L.;
    • Malone, Ian B.;
    • Manning, Emily N.;
    • Pemberton, Hugh;
    • Walsh, Phoebe;
    • Barkhof, Frederik;
    • Biessels, Geert Jan;
    • Cash, David M.;
    • Barnes, Josephine
    Publication type:
    Article
    22

    What time window do AD trajectories depart from normal? Estimating age‐related trajectories to chart preclinical phase of Alzheimer's disease and select trial‐ready cohorts.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078143
    By:
    • Cash, David M;
    • Verdi, Serena;
    • Shand, Cameron;
    • Coath, William;
    • Keuss, Sarah E;
    • O'Connor, Antoinette;
    • Bollack, Ariane;
    • Veale, Thomas;
    • Biondo, Francesca;
    • Young, Alexandra L.;
    • Fox, Nick C;
    • Schott, Jonathan M;
    • Oxtoby, Neil P;
    • Cole, James H
    Publication type:
    Article
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    Empirical pathological staging and subtyping of TDP‐43 proteinopathies.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.063390
    By:
    • Young, Alexandra L.;
    • Vogel, Jacob W;
    • Robinson, John;
    • McMillan, Corey T;
    • Ossenkoppele, Rik;
    • Wolk, David A.;
    • Irwin, David J.;
    • Elman, Lauren;
    • Grossman, Murray;
    • Lee, Virginia M‐Y;
    • Lee, Eddie B;
    • Trojanowski, John Q;
    • Hansson, Oskar
    Publication type:
    Article
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    Spatiotemporal imaging phenotypes of tau pathology in Alzheimer's disease: Neuroimaging: Understanding tau progression.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045612
    By:
    • Vogel, Jacob W.;
    • Young, Alexandra L.;
    • Oxtoby, Neil P.;
    • Smith, Ruben;
    • Ossenkoppele, Rik;
    • Aksman, Leon M.;
    • Strandberg, Olof;
    • La Joie, Renaud;
    • Grothe, Michel;
    • Medina, Yasser Iturria;
    • Rabinovici, Gil D.;
    • Alexander, Daniel C.;
    • Evans, Alan C.;
    • Hansson, Oskar
    Publication type:
    Article
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    Subtype and stage inference identifies distinct atrophy patterns in genetic frontotemporal dementia that MAP onto specific MAPT mutations: Imaging and non‐AD neurodegeneration.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.042996
    By:
    • Young, Alexandra L.;
    • Bocchetta, Martina;
    • Cash, David M;
    • Convery, Rhian S;
    • Moore, Katrina M;
    • Neason, Mollie R;
    • Thomas, David L;
    • van Swieten, John C.;
    • Borroni, Barbara;
    • Sanchez‐Valle, Raquel;
    • Moreno, Fermin;
    • Laforce, Robert;
    • Graff, Caroline;
    • Synofzik, Matthis;
    • Galimberti, Daniela;
    • Rowe, James B;
    • Masellis, Mario;
    • Tartaglia, Carmela;
    • Finger, Elizabeth;
    • Vandenberghe, Rik
    Publication type:
    Article
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    Accounting for systematic spatiotemporal variation improves connectome‐based models of tau spreading in human Alzheimer's disease: Person‐centered prediction of tau spreading in Alzheimer's disease and related disorders.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.040586
    By:
    • Vogel, Jacob W.;
    • Young, Alexandra L.;
    • Oxtoby, Neil P.;
    • Smith, Ruben;
    • Ossenkoppele, Rik;
    • Aksman, Leon M;
    • Strandberg, Olof;
    • La Joie, Renaud;
    • Grothe, Michel J.;
    • Rabinovici, Gil D.;
    • Alexander, Daniel C.;
    • Evans, Alan C.;
    • Hansson, Oskar
    Publication type:
    Article
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    MULTIPLE DISTINCT ATROPHY PATTERNS FOUND IN GENETIC FRONTOTEMPORAL DEMENTIA USING SUBTYPE AND STAGE INFERENCE (SUSTAIN).

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P453, doi. 10.1016/j.jalz.2017.06.459
    By:
    • Young, Alexandra L.;
    • Marinescu, Razvan Valentin;
    • Oxtoby, Neil P.;
    • Bocchetta, Martina;
    • Cash, David M.;
    • Thomas, David L.;
    • Dick, Katrina M.;
    • Cardoso, M. Jorge;
    • Ourselin, Sebastien;
    • van Swieten, John C.;
    • Borroni, Barbara;
    • Galimberti, Daniela;
    • Masellis, Mario;
    • Tartaglia, Maria Carmela;
    • Rowe, James B.;
    • Graff, Caroline;
    • Tagliavini, Fabrizio;
    • Frisoni, Giovanni B.;
    • Jr.Laforce, Robert;
    • Finger, Elizabeth
    Publication type:
    Article
    45

    MULTIPLE DISTINCT ATROPHY PATTERNS FOUND IN GENETIC FRONTOTEMPORAL DEMENTIA USING SUBTYPE AND STAGE INFERENCE (SUSTAIN).

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P65, doi. 10.1016/j.jalz.2017.06.2352
    By:
    • Young, Alexandra L.;
    • Marinescu, Razvan Valentin;
    • Oxtoby, Neil P.;
    • Bocchetta, Martina;
    • Cash, David M.;
    • Thomas, David L.;
    • Dick, Katrina M.;
    • Cardoso, M. Jorge;
    • Ourselin, Sebastien;
    • van Swieten, John C.;
    • Borroni, Barbara;
    • Galimberti, Daniela;
    • Masellis, Mario;
    • Tartaglia, Maria Carmela;
    • Rowe, James B.;
    • Graff, Caroline;
    • Tagliavini, Fabrizio;
    • Frisoni, Giovanni B.;
    • Jr.Laforce, Robert;
    • Finger, Elizabeth
    Publication type:
    Article
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    ANALYSIS OF THE HETEROGENEITY OF POSTERIOR CORTICAL ATROPHY: DATA-DRIVEN MODEL PREDICTS DISTINCT ATROPHY PATTERNS FOR THREE DIFFERENT COGNITIVE SUBGROUPS.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P106, doi. 10.1016/j.jalz.2017.06.2415
    By:
    • Marinescu, Razvan Valentin;
    • Primativo, Silvia;
    • Young, Alexandra L.;
    • Oxtoby, Neil P.;
    • Firth, Nicholas C.;
    • Eshaghi, Arman;
    • Garbarino, Sara;
    • Cardoso, Jorge M.;
    • Yong, Keir;
    • Fox, Nick C.;
    • Lehmann, Manja;
    • Shakespeare, Timothy J.;
    • Crutch, Sebastian J.;
    • Alexander, Daniel C.
    Publication type:
    Article
    48

    ANALYSIS OF THE HETEROGENEITY OF POSTERIOR CORTICAL ATROPHY: DATA-DRIVEN MODEL PREDICTS DISTINCT ATROPHY PATTERNS FOR THREE DIFFERENT COGNITIVE SUBGROUPS.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1379, doi. 10.1016/j.jalz.2017.06.2126
    By:
    • Marinescu, Razvan Valentin;
    • Primativo, Silvia;
    • Young, Alexandra L.;
    • Oxtoby, Neil P.;
    • Firth, Nicholas C.;
    • Eshaghi, Arman;
    • Garbarino, Sara;
    • Cardoso, Jorge M.;
    • Yong, Keir;
    • Fox, Nick C.;
    • Lehmann, Manja;
    • Shakespeare, Timothy J.;
    • Crutch, Sebastian J.;
    • Alexander, Daniel C.
    Publication type:
    Article
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    A DATA-DRIVEN COMPARISON OF THE PROGRESSION OF BRAIN ATROPHY IN POSTERIOR CORTICAL ATROPHY AND ALZHEIMER'S DISEASE.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P401, doi. 10.1016/j.jalz.2016.06.756
    By:
    • Marinescu, Razvan Valentin;
    • Young, Alexandra L.;
    • Oxtoby, Neil P.;
    • Firth, Nicholas C.;
    • Lorenzi, Marco;
    • Eshaghi, Arman;
    • Wottschel, Viktor;
    • Cardoso, M. Jorge;
    • Modat, Marc;
    • Yong, Keir;
    • Primativo, Silvia;
    • Fox, Nick C.;
    • Lehmann, Manja;
    • Shakespeare, Timothy J.;
    • Crutch, Sebastian J.;
    • Alexander, Daniel C.
    Publication type:
    Article