Works by Yoshiaki Ohtsu

Results: 23

An Open‐Label, Single‐Dose, Human Mass Balance Study of Amenamevir in Healthy Male Adults.

Published in:

Clinical Pharmacology in Drug Development, 2019, v. 8, n. 5, p. 595, doi. 10.1002/cpdd.630

By:

Kato, Kota;
den Adel, Martin;
Groenendaal‐van de Meent, Dorien;
Ohtsu, Yoshiaki;
Takada, Akitsugu;
Katashima, Masataka

Publication type:

Article

Pharmacokinetics and Safety of Amenamevir in Healthy Subjects: Analysis of Four Randomized Phase 1 Studies.

Published in:

2017

By:

Kusawake, Tomohiro;
Keirns, James;
Kowalski, Donna;
den Adel, Martin;
Groenendaal-van de Meent, Dorien;
Takada, Akitsugu;
Ohtsu, Yoshiaki;
Katashima, Masataka;
Keirns, James J

Publication type:

journal article

Pharmacokinetic Evaluation of the Interactions of Amenamevir (ASP2151) with Ketoconazole, Rifampicin, Midazolam, and Warfarin in Healthy Adults.

Published in:

2017

By:

Kusawake, Tomohiro;
den Adel, Martin;
Groenendaal-van de Meent, Dorien;
Garcia-Hernandez, Alberto;
Takada, Akitsugu;
Kato, Kota;
Ohtsu, Yoshiaki;
Katashima, Masataka

Publication type:

journal article

Intersubject and Intrasubject Variability of Potential Plasma and Urine Metabolite and Protein Biomarkers in Healthy Human Volunteers.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 2, p. 397, doi. 10.1002/cpt.1606

By:

Duisters, Kevin;
Ogino, Shinji;
Andou, Tomohiro;
Ito, Kazumi;
Akabane, Takafumi;
Harms, Amy;
Moerland, Matthijs;
Hashimoto, Yuka;
Ando, Ayumi;
Ohtsu, Yoshiaki;
Wada, Naoya;
Yukinaga, Hideo;
Meulman, Jacqueline;
Kobayashi, Hiroyuki;
Kobayashi, Nobuhiro;
Suzumura, Kenichi;
Hankemeier, Thomas

Publication type:

Article

Sweet Taste-Sensing Receptors Expressed in Pancreatic ß-Cells: Sweet Molecules Act as Biased Agonists.

Published in:

Endocrinology & Metabolism, 2014, v. 29, n. 1, p. 12, doi. 10.3803/EnM.2014.29.1.12

By:

Itaru Kojima;
Yuko Nakagawa;
Yoshiaki Ohtsu;
Anya Medina;
Masahiro Nagasawa

Publication type:

Article

Return of the glucoreceptor: Glucose activates the glucose-sensing receptor T1R3 and facilitates metabolism in pancreatic β-cells.

Published in:

Journal of Diabetes Investigation, 2015, v. 6, n. 3, p. 256, doi. 10.1111/jdi.12304

By:

Kojima, Itaru;
Nakagawa, Yuko;
Ohtsu, Yoshiaki;
Hamano, Kunihisa;
Medina, Johan;
Nagasawa, Masahiro

Publication type:

Article

Two cases of cytochrome P450 oxidoreductase deficiency with severe scoliosis and surgery requirement.

Published in:

Congenital Anomalies, 2021, v. 61, n. 5, p. 202, doi. 10.1111/cga.12434

By:

Onuki, Takanori;
Ohtsu, Yoshiaki;
Hiroshima, Shota;
Sawano, Kentaro;
Nagasaki, Keisuke

Publication type:

Article

Retrospective study of the renal function using estimated glomerular filtration rate and congenital anomalies of the kidney‐urinary tract in pediatric Turner syndrome.

Published in:

Congenital Anomalies, 2020, v. 60, n. 6, p. 175, doi. 10.1111/cga.12384

By:

Izumita, Yukie;
Nishigaki, Satsuki;
Satoh, Mari;
Takubo, Noriyuki;
Numakura, Chikahiko;
Takahashi, Ikuko;
Soneda, Shun;
Abe, Yoshifusa;
Kamasaki, Hotaka;
Ohtsu, Yoshiaki;
Igaki, Junko;
Hasegawa, Yukihiro;
Nagasaki, Keisuke

Publication type:

Article

Stability: Recommendation for Best Practices and Harmonization from the Global Bioanalysis Consortium Harmonization Team.

Published in:

AAPS Journal, 2014, v. 16, n. 3, p. 392, doi. 10.1208/s12248-014-9573-z

By:

van de Merbel, Nico;
Savoie, Natasha;
Yadav, Manish;
Ohtsu, Yoshiaki;
White, Joleen;
Riccio, Maria;
Dong, Kelly;
de Vries, Ronald;
Diancin, Julie

Publication type:

Article

Absorption, distribution, metabolism and excretion of novel phosphodiesterase type 4 inhibitor ASP3258 in rats.

Published in:

Biopharmaceutics & Drug Disposition, 2015, v. 36, n. 1, p. 34, doi. 10.1002/bdd.1921

By:

Ohtsu, Yoshiaki;
Sonoda, Takuya;
Susaki, Yoko;
Tohda, Toshifumi;
Fukunaga, Yasuhisa;
Iwatsubo, Takafumi;
Noguchi, Kiyoshi

Publication type:

Article

Clinical Pharmacokinetic Studies of Enzalutamide.

Published in:

2015

By:

Gibbons, Jacqueline;
Ouatas, Taoufik;
Krauwinkel, Walter;
Ohtsu, Yoshiaki;
Walt, Jan-Stefan;
Beddo, Vanessa;
Vries, Michiel;
Mordenti, Joyce;
Gibbons, Jacqueline A;
van der Walt, Jan-Stefan;
de Vries, Michiel

Publication type:

journal article

Pharmacokinetic Drug Interaction Studies with Enzalutamide.

Published in:

2015

By:

Gibbons, Jacqueline;
Vries, Michiel;
Krauwinkel, Walter;
Ohtsu, Yoshiaki;
Noukens, Jan;
Walt, Jan-Stefan;
Mol, Roelof;
Mordenti, Joyce;
Ouatas, Taoufik;
Gibbons, Jacqueline A;
de Vries, Michiel;
van der Walt, Jan-Stefan

Publication type:

journal article

Language delay and developmental catch-up would be a clinical feature of pseudohypoparathyroidism type 1A during childhood.

Published in:

Endocrine Journal, 2019, v. 66, n. 3, p. 215, doi. 10.1507/endocrj.EJ18-0326

By:

Yuichi Miyakawa;
Kei Takasawa;
Yohei Matsubara;
Kenji Ihara;
Yoshiaki Ohtsu;
Hotaka Kamasaki;
Kazuteru Kitsuda;
Hironori Kobayashi;
Mari Satoh;
Sinichiro Sano;
Sumito Dateki;
Hiroshi Mochizuki;
Ichiro Yokota;
Yukihiro Hasegawa;
Kenichi Kashimada

Publication type:

Article

Sucralose, an activator of the glucose-sensing receptor, increases ATP by calcium-dependent and -independent mechanisms.

Published in:

Endocrine Journal, 2016, v. 63, n. 8, p. 715, doi. 10.1507/endocrj.ej16-0217

By:

Longfei Li;
Yoshiaki Ohtsu;
Yuko Nakagawa;
Katsuyoshi Masuda;
Itaru Kojima

Publication type:

Article

A novel mutation in HESX1 causes combined pituitary hormone deficiency without septo optic dysplasia phenotypes.

Published in:

Endocrine Journal, 2016, v. 63, n. 4, p. 405, doi. 10.1507/endocrj.ej15-0409

By:

Masaki Takagi;
Mai Takahashi;
Yoshiaki Ohtsu;
Takeshi Sato;
Satoshi Narumi;
Hirokazu Arakawa;
Tomonobu Hasegawa

Publication type:

Article

Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor T1R3.

Published in:

Endocrine Journal, 2014, v. 61, n. 2, p. 119, doi. 10.1507/endocrj.ej13-0431

By:

Yuko Nakagawa;
Yoshiaki Ohtsu;
Masahiro Nagasawa;
Hiroshi Shibata;
Itaru Kojima

Publication type:

Article

Therapeutic Potential of ASP3258, a Selective Phosphodiesterase 4 Inhibitor, on Chronic Eosinophilic Airway Inflammation.

Published in:

Pharmacology, 2012, v. 90, n. 3/4, p. 223, doi. 10.1159/000342380

By:

Kobayashi, Miki;
Kubo, Satoshi;
Shiraki, Katsuhisa;
Iwata, Masahiro;
Hirano, Yasuno;
Ohtsu, Yoshiaki;
Takahashi, Koichiro;
Shimizu, Yasuaki

Publication type:

Article

Therapeutic Potential of ASP3258, a Selective Phosphodiesterase 4 Inhibitor, on Chronic Eosinophilic Airway Inflammation.

Published in:

Pharmacology, 2012, v. 90, n. 3/4, p. 223, doi. 10.1159/000342380

By:

Kobayash, Miki;
Kubo, Satoshi;
Shiraki, Katsuhisa;
Lwata, Masahiro;
Hirano, Yasuno;
Ohtsu, Yoshiaki;
Takahashi, Koichiro;
Shimizu, Yasuaki

Publication type:

Article

(Epi)genetic and clinical characteristics in 84 patients with pseudohypoparathyroidism type 1B.

Published in:

European Journal of Endocrinology, 2023, v. 189, n. 6, p. 590, doi. 10.1093/ejendo/lvad163

By:

Tatsuki Urakawa;
Shinichiro Sano;
Sayaka Kawashima;
Akie Nakamura;
Hirohito Shima;
Motoki Ohta;
Yuki Yamada;
Ai Nishida;
Hiromune Narusawa;
Yoshiaki Ohtsu;
Keiko Matsubara;
Sumito Dateki;
Yoshihiro Maruo;
Maki Fukami;
Tsutomu Ogata;
Masayo Kagami

Publication type:

Article

FGF23‐related hypophosphatemic rickets preceding the onset of systemic lupus erythematosus: A juvenile case.

Published in:

2024

By:

tabei, Yoko;
Ohtsu, Yoshiaki;
Shimada, Masaharu;
Wada, Aya;
Hamajima, Emi;
Osawa, Yoshimitsu;
Takizawa, Takumi

Publication type:

Case Study

CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15857-x

By:

Shimokawa, Chikako;
Kato, Tamotsu;
Takeuchi, Tadashi;
Ohshima, Noriyasu;
Furuki, Takao;
Ohtsu, Yoshiaki;
Suzue, Kazutomo;
Imai, Takashi;
Obi, Seiji;
Olia, Alex;
Izumi, Takashi;
Sakurai, Minoru;
Arakawa, Hirokazu;
Ohno, Hiroshi;
Hisaeda, Hajime

Publication type:

Article

Determination of ASP3258, a novel phosphodiesterase type 4 inhibitor, in rat plasma by high-performance liquid chromatography with fluorescence detection and its application to pharmacokinetic study.

Published in:

Biomedical Chromatography, 2015, v. 29, n. 2, p. 161, doi. 10.1002/bmc.3262

By:

Ohtsu, Yoshiaki;
Takanuki, Fumiyo;
Fukunaga, Yasuhisa;
Noguchi, Kiyoshi

Publication type:

Article

Hidden MODY in Young Lean Women with Mild Glucose Intolerance Detected during Health Check-ups: Potential for Improved Pregnancy Outcomes through Preconception Care.

Published in:

Internal Medicine, 2025, v. 64, n. 10, p. 1603, doi. 10.2169/internalmedicine.4244-24

By:

Aya Osaki;
Atsushi Ozawa;
Akihito Morita;
Daisuke Higeta;
Shunpei Suda;
Yoshiaki Ohtsu;
Satoshi Yoshino;
Syunichi Matsumoto;
Kazuhiko Horiguchi;
Eijiro Yamada

Publication type:

Article