Works by Yoon, Seongkyu

Results: 60

Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV Manufacturing.

Published in:

Biotechnology & Bioengineering, 2025, v. 122, n. 7, p. 1640, doi. 10.1002/bit.28980

By:

Green, Erica A.;
Fu, Qiang;
Ndahiro, Nelson;
Leibiger, Thomas M.;
Wang, Yongdan;
Lee, Yongsuk;
Lee, Kelvin H.;
Betenbaugh, Michael;
Yoon, Seongkyu;
McNally, David J.

Publication type:

Article

Trace metal optimization in CHO cell culture through statistical design of experiments.

Published in:

Biotechnology Progress, 2023, v. 39, n. 6, p. 1, doi. 10.1002/btpr.3368

By:

Polanco, Ashli;
Liang, George;
Park, SoYoung;
Wang, Yongdan;
Graham, Ryan J.;
Yoon, Seongkyu

Publication type:

Article

Transcriptomic features reveal molecular signatures associated with recombinant adeno‐associated virus production in HEK293 cells.

Published in:

Biotechnology Progress, 2023, v. 39, n. 4, p. 1, doi. 10.1002/btpr.3346

By:

Wang, Yongdan;
Fu, Qiang;
Lee, Yong Suk;
Sha, Sha;
Yoon, Seongkyu

Publication type:

Article

Modulation of nutrient precursors for controlling metabolic inhibitors by genome‐scale flux balance analysis.

Published in:

Biotechnology Progress, 2023, v. 39, n. 2, p. 1, doi. 10.1002/btpr.3313

By:

Hoang, Duc;
Kuang, Bingyu;
Liang, George;
Wang, Zhao;
Yoon, Seongkyu

Publication type:

Article

Characterization of Chinese hamster ovary cell culture feed media precipitate.

Published in:

Biotechnology Progress, 2021, v. 37, n. 5, p. 1, doi. 10.1002/btpr.3188

By:

Hoang, Duc;
Galbraith, Shaun;
Kuang, Bingyu;
Johnson, Amy;
Yoon, Seongkyu

Publication type:

Article

Effect of iron addition on mAb productivity and oxidative stress in Chinese hamster ovary culture.

Published in:

Biotechnology Progress, 2021, v. 37, n. 5, p. 1, doi. 10.1002/btpr.3181

By:

Graham, Ryan J.;
Mohammad, Adil;
Liang, George;
Fu, Qiang;
Kuang, Bingyu;
Polanco, Ashli;
Lee, Yong Suk;
Marcus, R. Kenneth;
Yoon, Seongkyu

Publication type:

Article

Real‐time quantification and supplementation of bioreactor amino acids to prolong culture time and maintain antibody product quality.

Published in:

Biotechnology Progress, 2019, v. 35, n. 6, p. N.PAG, doi. 10.1002/btpr.2894

By:

Powers, David N.;
Wang, Yifan;
Fratz‐Berilla, Erica J.;
Velugula‐Yellela, Sai Rashmika;
Chavez, Brittany;
Angart, Phillip;
Trunfio, Nicholas;
Yoon, Seongkyu;
Agarabi, Cyrus

Publication type:

Article

Amphotericin B release rate is the link between drug status in the liposomal bilayer and toxicity.

Published in:

Asian Journal of Pharmaceutical Sciences, 2022, v. 17, n. 4, p. 544, doi. 10.1016/j.ajps.2022.04.007

By:

Yuri Svirkin;
Jaeweon Lee;
Marx, Richard;
Seongkyu Yoon;
Landrau, Nelson;
Kaisar, Md Abul;
Bin Qin;
Park, Jin H.;
Alam, Khondoker;
Kozak, Darby;
Yan Wang;
Xiaoming Xu;
Jiwen Zheng;
Rivnay, Benjamin

Publication type:

Article

Robustness of chemometrics-based feature selection methods in early cancer detection and biomarker discovery.

Published in:

Statistical Applications in Genetics & Molecular Biology, 2013, v. 12, n. 2, p. 207, doi. 10.1515/sagmb-2012-0067

By:

Lee, Hae Woo;
Lawton, Carl;
Na, Young Jeong;
Yoon, Seongkyu

Publication type:

Article

Principal-Component Analysis of Multiscale Data for Process Monitoring and Fault Diagnosis.

Published in:

AIChE Journal, 2004, v. 50, n. 11, p. 2891, doi. 10.1002/aic.10260

By:

Seongkyu Yoon;
MacGregor, John F.

Publication type:

Article

Letter to the Editor.

Published in:

AIChE Journal, 2000, v. 46, n. 9, p. 1897, doi. 10.1002/aic.690460918

By:

Gertler, Janos;
Yoon, Seongkyu;
MacGregor, John F.

Publication type:

Article

Statistical and causal model-based approaches to fault detection and isolation.

Published in:

AIChE Journal, 2000, v. 46, n. 9, p. 1813, doi. 10.1002/aic.690460910

By:

Yoon, Seongkyu;
MacGregor, John F.

Publication type:

Article

Integrated continuous biomanufacturing platform with ATF perfusion and one column chromatography operation for optimum resin utilization and productivity.

Published in:

Preparative Biochemistry & Biotechnology, 2018, v. 48, n. 5, p. 383, doi. 10.1080/10826068.2018.1446151

By:

Kamga, Mark-Henry;
Cattaneo, Maurizio;
Yoon, Seongkyu

Publication type:

Article

Protein a resin lifetime study: Evaluation of protein a resin performance with a model-based approach in continuous capture.

Published in:

Preparative Biochemistry & Biotechnology, 2018, v. 48, n. 3, p. 242, doi. 10.1080/10826068.2018.1425711

By:

Behere, Ketki;
Cha, Bumjoon;
Yoon, Seongkyu

Publication type:

Article

Effects of process parameters on tablet critical quality attributes in continuous direct compression: a case study of integrating data-driven statistical models and mechanistic compaction models.

Published in:

Pharmaceutical Development & Technology, 2020, v. 25, n. 10, p. 1204, doi. 10.1080/10837450.2020.1805760

By:

Huang, Zhuangrong;
Galbraith, Shaun C.;
Cha, Bumjoon;
Liu, Huolong;
Park, Seoyoung;
Flamm, Matthew H.;
Metzger, Matt;
Tantuccio, Anthony;
Yoon, Seongkyu

Publication type:

Article

Assessment of spatial heterogeneity in continuous twin screw wet granulation process using three-compartmental population balance model.

Published in:

Pharmaceutical Development & Technology, 2019, v. 24, n. 1, p. 105, doi. 10.1080/10837450.2018.1427106

By:

Liu, Huolong;
Galbraith, Shaun C.;
Park, Seo-Young;
Cha, Bumjoon;
Huang, Zhuangrong;
Meyer, Robert Frederick;
Flamm, Matthew H.;
O'Connor, Thomas;
Lee, Sau;
Yoon, Seongkyu

Publication type:

Article

Modeling and simulation of continuous powder blending applied to a continuous direct compression process.

Published in:

Pharmaceutical Development & Technology, 2018, v. 23, n. 10, p. 1097, doi. 10.1080/10837450.2018.1425429

By:

Galbraith, Shaun C.;
Liu, Huolong;
Cha, Bumjoon;
Park, Seo-Young;
Huang, Zhuangrong;
Yoon, Seongkyu

Publication type:

Article

Cellular and metabolic engineering of oleaginous yeast Yarrowia lipolytica for bioconversion of hydrophobic substrates into high‐value products.

Published in:

Engineering in Life Sciences, 2019, v. 19, n. 6, p. 423, doi. 10.1002/elsc.201800147

By:

Soong, Ya‐Hue Valerie;
Liu, Na;
Yoon, Seongkyu;
Lawton, Carl;
Xie, Dongming

Publication type:

Article

In-line monitoring of amino acids in mammalian cell cultures using raman spectroscopy and multivariate chemometrics models.

Published in:

Engineering in Life Sciences, 2018, v. 18, n. 1, p. 55, doi. 10.1002/elsc.201700084

By:

Bhatia, Hemlata;
Mehdizadeh, Hamidreza;
Drapeau, Denis;
Yoon, Seongkyu

Publication type:

Article

A high-resolution measurement of nucleotide sugars by using ion-pair reverse chromatography and tandem columns.

Published in:

Analytical & Bioanalytical Chemistry, 2020, v. 412, n. 15, p. 3683, doi. 10.1007/s00216-020-02608-6

By:

Sha, Sha;
Handelman, Garry;
Agarabi, Cyrus;
Yoon, Seongkyu

Publication type:

Article

Three-dimensional computational fluid dynamics (CFD) study of the gas–particle circulation pattern within a fluidized bed granulator: By full factorial design of fluidization velocity and particle size.

Published in:

Drying Technology, 2017, v. 35, n. 9, p. 1043, doi. 10.1080/07373937.2016.1230628

By:

Liu, Huolong;
Yoon, Seongkyu;
Li, Mingzhong

Publication type:

Article

Considerations Regarding High Oil Density Bioreactor‐Scale Fermentations of Yarrowia lipolytica Using CFD Modeling and Experimental Validation.

Published in:

Biotechnology Journal, 2024, v. 19, n. 12, p. 1, doi. 10.1002/biot.202400506

By:

Coleman, Sarah M.;
Marx, Richard J.;
Martinez, Morgan K.;
Silvera, Ashli J.;
Park, Junwon;
Ramanan, Esha;
Kaown, Geena;
Yoon, Seongkyu;
Xie, Dongming;
Alper, Hal S.

Publication type:

Article

CFD evaluation of hydrophobic feedstock bench‐scale fermenters for efficient high agitation volumetric mass transfer.

Published in:

Biotechnology Journal, 2024, v. 19, n. 2, p. 1, doi. 10.1002/biot.202300384

By:

Marx, Richard;
Liu, Huolong;
Yoon, Seongkyu;
Xie, Dongming

Publication type:

Article

CFD evaluation of hydrophobic feedstock bench‐scale fermenters for efficient high agitation volumetric mass transfer.

Published in:

Biotechnology Journal, 2024, v. 19, n. 2, p. 1, doi. 10.1002/biot.202300384

By:

Marx, Richard;
Liu, Huolong;
Yoon, Seongkyu;
Xie, Dongming

Publication type:

Article

Single in‐line biomass probe detects CHO cell growth by capacitance and bacterial contamination by conductivity in bioreactor.

Published in:

Biotechnology Journal, 2021, v. 16, n. 12, p. 1, doi. 10.1002/biot.202100126

By:

Morris, Caitlin;
Madhavarao, Chikkathur N.;
Yoon, Seongkyu;
Ashraf, Muhammad

Publication type:

Article

Kinetic Modeling of Mammalian Cell Culture Bioprocessing: The Quest to Advance Biomanufacturing.

Published in:

Biotechnology Journal, 2018, v. 13, n. 3, p. 1, doi. 10.1002/biot.201700229

By:

Kyriakopoulos, Sarantos;
Ang, Kok Siong;
Lakshmanan, Meiyappan;
Huang, Zhuangrong;
Yoon, Seongkyu;
Gunawan, Rudiyanto;
Lee, Dong‐Yup

Publication type:

Article

Effects of process intensification on homogeneity of an IgG1:κ monoclonal antibody during perfusion culture.

Published in:

Applied Microbiology & Biotechnology, 2024, v. 108, n. 1, p. 1, doi. 10.1007/s00253-024-13110-9

By:

Liang, George;
Madhavarao, Chikkathur N.;
Morris, Caitlin;
O’Connor, Thomas;
Ashraf, Muhammad;
Yoon, Seongkyu

Publication type:

Article

Zinc supplementation improves the harvest purity of β-glucuronidase from CHO cell culture by suppressing apoptosis.

Published in:

Applied Microbiology & Biotechnology, 2020, v. 104, n. 3, p. 1097, doi. 10.1007/s00253-019-10296-1

By:

Graham, Ryan J.;
Ketcham, Stephanie;
Mohammad, Adil;
Bandaranayake, Bandaranayake M. B.;
Cao, Ty;
Ghosh, Bidesh;
Weaver, James;
Yoon, Seongkyu;
Faustino, Patrick J.;
Ashraf, Muhammad;
Cruz, Celia N.;
Madhavarao, Chikkathur N.

Publication type:

Article

Integration of Time-Series Transcriptomic Data with Genome-Scale CHO Metabolic Models for mAb Engineering.

Published in:

Processes, 2020, v. 8, n. 3, p. 331, doi. 10.3390/pr8030331

By:

Huang, Zhuangrong;
Yoon, Seongkyu

Publication type:

Article

Prediction of N-linked Glycoform Profiles of Monoclonal Antibody with Extracellular Metabolites and Two-Step Intracellular Models.

Published in:

Processes, 2019, v. 7, n. 4, p. 227, doi. 10.3390/pr7040227

By:

Sha, Sha;
Huang, Zhuangrong;
Agarabi, Cyrus D.;
Lute, Scott C.;
Brorson, Kurt A.;
Yoon, Seongkyu

Publication type:

Article

MicroRNA-146a inhibits epithelial mesenchymal transition in non-small cell lung cancer by targeting insulin receptor substrate 2.

Published in:

International Journal of Oncology, 2015, v. 47, n. 4, p. 1545, doi. 10.3892/ijo.2015.3111

By:

DONG HO PARK;
HYO SUNG JEON;
SOO YOUNG LEE;
YI YOUNG CHOI;
HAE WOO LEE;
SEONGKYU YOON;
JAE CHEL LEE;
YOO SANG YOON;
DAE SUNG KIM;
MOON JUN NA;
SUN JUNG KWON;
DONG SUN KIM;
JAEKU KANG;
JAE YONG PARK;
JI WOONG SON

Publication type:

Article

Development of a Single Vial Mass Flow Rate Monitor to Assess Pharmaceutical Freeze Drying Heterogeneity.

Published in:

AAPS PharmSciTech, 2024, v. 25, n. 8, p. 1, doi. 10.1208/s12249-024-02961-0

By:

Yu, Tiffany;
Marx, Richard;
Hinds, Michael;
Schott, Nicholas;
Gong, Emily;
Yoon, Seongkyu;
Kessler, William

Publication type:

Article

A Compact Model for Lyophilizer Equipment Capability Estimation.

Published in:

AAPS PharmSciTech, 2022, v. 23, n. 1, p. 1, doi. 10.1208/s12249-021-02167-8

By:

Kazarin, Petr;
Kessler, William;
Gong, Emily;
Yoon, Seongkyu;
Liu, Huolong;
Marx, Richard;
Bogner, Robin;
Alexeenko, Alina

Publication type:

Article

A Software Tool for Lyophilization Primary Drying Process Development and Scale-up Including Process Heterogeneity, I: Laboratory-Scale Model Testing.

Published in:

AAPS PharmSciTech, 2021, v. 22, n. 8, p. 1, doi. 10.1208/s12249-021-02134-3

By:

Bogner, Robin;
Gong, Emily;
Kessler, William;
Hinds, Michael;
Manchanda, Arushi;
Yoon, Seongkyu;
Liu, Huolong;
Marx, Richard;
Zhao, Jessie;
Sharma, Puneet;
Bhambhani, Akhilesh;
Stanbro, Justin;
Alexeenko, Alina;
Kazarin, Petr

Publication type:

Article

Optimization of Critical Quality Attributes in Tablet Film Coating and Design Space Determination Using Pilot-Scale Experimental Data.

Published in:

AAPS PharmSciTech, 2021, v. 22, n. 1, p. 1, doi. 10.1208/s12249-020-01884-w

By:

Liu, Huolong;
Meyer, Robert;
Flamm, Matthew;
Wareham, Laura;
Metzger, Matthew;
Tantuccio, Anthony;
Yoon, Seongkyu

Publication type:

Article

A Thermodynamic Balance Model for Liquid Film Drying Kinetics of a Tablet Film Coating and Drying Process.

Published in:

AAPS PharmSciTech, 2019, v. 20, n. 5, p. N.PAG, doi. 10.1208/s12249-019-1398-8

By:

Cha, Bumjoon;
Galbraith, Shaun C.;
Liu, Huolong;
Park, Seo-Young;
Huang, Zhuangrong;
O’Connor, Thomas;
Lee, Sau;
Yoon, Seongkyu

Publication type:

Article

Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process.

Published in:

Bioresources & Bioprocessing, 2020, v. 7, n. 1, p. 1, doi. 10.1186/s40643-020-00318-6

By:

Morris, Caitlin;
Polanco, Ashli;
Yongky, Andrew;
Xu, Jianlin;
Huang, Zhuangrong;
Zhao, Jia;
McFarland, Kevin S.;
Park, Seoyoung;
Warrack, Bethanne;
Reily, Michael;
Borys, Michael C.;
Li, Zhengjian;
Yoon, Seongkyu

Publication type:

Article

Process Analytical Technologies in Biopharmaceutical Process Development.

Published in:

2015

By:

Rathore, Anurag S.;
Gernaey, Krist V.;
Calado, Cecília R.C.;
Yoon, Seongkyu

Publication type:

Editorial

Dielectric spectroscopy-based estimation of VCD in CHO cell culture.

Published in:

Journal of Chemical Technology & Biotechnology, 2015, v. 90, n. 2, p. 273, doi. 10.1002/jctb.4522

By:

Lee, Hae Woo;
Carvell, John;
Brorson, Kurt;
Yoon, Seongkyu

Publication type:

Article

Intracellular metabolic flux analysis of CHO cells supplemented with wheat hydrolysates for improved mAb production and cell-growth.

Published in:

Journal of Chemical Technology & Biotechnology, 2015, v. 90, n. 2, p. 291, doi. 10.1002/jctb.4523

By:

Lee, Hae Woo;
Christie, Andrew;
Starkey, Jason A.;
Read, Erik K.;
Yoon, Seongkyu

Publication type:

Article

Regeneration of Spent Culture Media for Sustainable and Continuous mAb Production via Ion Concentration Polarization.

Published in:

Biotechnology & Bioengineering, 2025, v. 122, n. 2, p. 373, doi. 10.1002/bit.28888

By:

Wynne, Eric;
Yoon, Junghyo;
Park, Dohyun;
Cui, Mingyang;
Morris, Caitlin;
Lee, Jaeweon;
Wang, Zhao;
Yoon, Seongkyu;
Han, Jongyoon

Publication type:

Article

Design space determination to optimize DNA complexation and full capsid formation in transient rAAV manufacturing.

Published in:

Biotechnology & Bioengineering, 2023, v. 120, n. 11, p. 3148, doi. 10.1002/bit.28508

By:

Fu, Qiang;
Lee, Yong Suk;
Green, Erica A.;
Wang, Yongdan;
Park, So Young;
Polanco, Ashli;
Lee, Kelvin H.;
Betenbaugh, Michael;
McNally, David;
Yoon, Seongkyu

Publication type:

Article

Critical challenges and advances in recombinant adeno‐associated virus (rAAV) biomanufacturing.

Published in:

Biotechnology & Bioengineering, 2023, v. 120, n. 9, p. 2601, doi. 10.1002/bit.28412

By:

Fu, Qiang;
Polanco, Ashli;
Lee, Yong Suk;
Yoon, Seongkyu

Publication type:

Article

Addressing amino acid‐derived inhibitory metabolites and enhancing CHO cell culture performance through DOE‐guided media modifications.

Published in:

Biotechnology & Bioengineering, 2023, v. 120, n. 9, p. 2542, doi. 10.1002/bit.28403

By:

Ladiwala, Pranay;
Dhara, Venkata Gayatri;
Jenkins, Jackson;
Kuang, Bingyu;
Hoang, Duc;
Yoon, Seongkyu;
Betenbaugh, Michael J.

Publication type:

Article

Generation of reference cell lines, media, and a process platform for CHO cell biomanufacturing.

Published in:

Biotechnology & Bioengineering, 2023, v. 120, n. 3, p. 715, doi. 10.1002/bit.28290

By:

Cordova, Lauren T.;
Dahodwala, Hussain;
Elliott, Kathryn S.;
Baik, Jongyoun;
Odenewelder, Daniel C.;
Nmagu, Douglas;
Skelton, Bradley A.;
Uy, Lisa;
Klaubert, Stephanie R.;
Synoground, Benjamin F.;
Chitwood, Dylan G.;
Dhara, Venkata Gayatri;
Naik, Harnish Mukesh;
Morris, Caitlin S.;
Yoon, Seongkyu;
Betenbaugh, Michael;
Coffman, Jon;
Swartzwelder, Frank;
Gillmeister, Michael P.;
Harcum, Sarah W.

Publication type:

Article

Consequences of trace metal variability and supplementation on Chinese hamster ovary (CHO) cell culture performance: A review of key mechanisms and considerations.

Published in:

Biotechnology & Bioengineering, 2019, v. 116, n. 12, p. 3446, doi. 10.1002/bit.27140

By:

Graham, Ryan J.;
Bhatia, Hemlata;
Yoon, Seongkyu

Publication type:

Article

Cover Image, Volume 114, Number 12, December 2017.

Published in:

2017

By:

Huang, Zhuangrong;
Lee, Dong‐Yup;
Yoon, Seongkyu

Publication type:

Other

Quantitative intracellular flux modeling and applications in biotherapeutic development and production using CHO cell cultures.

Published in:

Biotechnology & Bioengineering, 2017, v. 114, n. 12, p. 2717, doi. 10.1002/bit.26384

By:

Huang, Zhuangrong;
Lee, Dong‐Yup;
Yoon, Seongkyu

Publication type:

Article

Data fusion-based assessment of raw materials in mammalian cell culture.

Published in:

Biotechnology & Bioengineering, 2012, v. 109, n. 11, p. 2819, doi. 10.1002/bit.24548

By:

Lee, Hae Woo;
Christie, Andrew;
Xu, Jin;
Yoon, Seongkyu

Publication type:

Article

Enhanced ER protein processing gene expression increases rAAV yield and full capsid ratio in HEK293 cells.

Published in:

Applied Microbiology & Biotechnology, 2024, v. 108, n. 1, p. 1, doi. 10.1007/s00253-024-13281-5

By:

Fu, Qiang;
Wang, Yongdan;
Qin, Jiansong;
Xie, Dongming;
McNally, David;
Yoon, Seongkyu

Publication type:

Article