Works by Yegutkin, Gennady G.

Results: 29

Structure activity relationship of 3‐methylcytidine‐5'‐α,β‐methylenediphosphates as CD73 inhibitors.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R3981

By:

Jacobson, Kenneth A.;
Scortichini, Mirko;
Idris, Riham M.;
Moschütz, Susanne;
Keim, Antje;
Salmaso, Veronica A.;
Dobelmann, Clemens;
Oliva, Paola A.;
Losenkova, Karolina;
Irjala, Heikki;
Vaittinen, Samuli;
Sandholm, Jouko;
Yegutkin, Gennady G.;
Sträter, Norbert;
Junker, Anna;
Müller, Christa E.

Publication type:

Article

X‐Ray Co‐Crystal Structure Guides the Way to Subnanomolar Competitive Ecto‐5′‐Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy.

Published in:

Advanced Therapeutics, 2019, v. 2, n. 10, p. N.PAG, doi. 10.1002/adtp.201900075

By:

Bhattarai, Sanjay;
Pippel, Jan;
Meyer, Anne;
Freundlieb, Marianne;
Schmies, Constanze;
Abdelrahman, Aliaa;
Fiene, Amelie;
Lee, Sang‐Yong;
Zimmermann, Herbert;
El‐Tayeb, Ali;
Yegutkin, Gennady G.;
Sträter, Norbert;
Müller, Christa E.

Publication type:

Article

Increased intravitreal adenosine 5′-triphosphate, adenosine 5′-diphosphate and adenosine 5′-monophosphate levels in patients with proliferative diabetic retinopathy.

Published in:

Acta Ophthalmologica (1755375X), 2015, v. 93, n. 1, p. 67, doi. 10.1111/aos.12507

By:

Loukovaara, Sirpa;
Sahanne, Sari;
Jalkanen, Sirpa;
Yegutkin, Gennady G.

Publication type:

Article

Dinucleotide polyphosphates contribute to purinergic signalling via inhibition of adenylate kinase activity.

Published in:

Bioscience Reports, 2008, v. 28, n. 4, p. 189, doi. 10.1042/BSR20080052

By:

YEGUTKIN, Gennady G.;
JANKOWSKI, Joachim;
JALKANEN, Sirpa;
GÜNTHNER, Thomas;
ZIDEK, Walter;
JANKOWSKI, Vera

Publication type:

Article

Steady-State Binding of Adenine Nucleotides ATP, ADP and AMP to Rat Liver and Adipose Plasma Membranes.

Published in:

Journal of Receptors & Signal Transduction, 1999, v. 19, n. 1-4, p. 437, doi. 10.3109/10799899909036663

By:

Yegutkin, Gennady G.;
Burnstock, Geoffrey

Publication type:

Article

Ecto-5′-nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature.

Published in:

European Journal of Immunology, 2015, v. 45, n. 2, p. 562, doi. 10.1002/eji.201444856

By:

Yegutkin, Gennady G.;
Auvinen, Kaisa;
Rantakari, Pia;
Hollmén, Maija;
Karikoski, Marika;
Grénman, Reidar;
Elima, Kati;
Jalkanen, Sirpa;
Salmi, Marko

Publication type:

Article

Activation of ATP/UTP-selective receptors increases blood flow and blunts sympathetic vasoconstriction in human skeletal muscle.

Published in:

Journal of Physiology, 2008, v. 586, n. 20, p. 4993, doi. 10.1113/jphysiol.2008.155432

By:

Rosenmeier, Jaya B.;
Yegutkin, Gennady G.;
González-Alonso, Jos

Publication type:

Article

Intravascular ADP and soluble nucleotidases contribute to acute prothrombotic state during vigorous exercise in humans.

Published in:

Journal of Physiology, 2007, v. 579, n. 2, p. 553, doi. 10.1113/jphysiol.2006.119453

By:

Yegutkin, Gennady G.;
Samburski, Sergei S.;
Mortensen, Stefan P.;
Jalkanen, Sirpa;
González-Alonso, Jos

Publication type:

Article

Consequences of the Lack of CD73 and Prostatic Acid Phosphatase in the Lymphoid Organs.

Published in:

Mediators of Inflammation, 2014, v. 2014, p. 1, doi. 10.1155/2014/485743

By:

Yegutkin, Gennady G.;
Auvinen, Kaisa;
Karikoski, Marika;
Rantakari, Pia;
Gerke, Heidi;
Elima, Kati;
Maksimow, Mikael;
Quintero, Ileana B.;
Vihko, Pirkko;
Salmi, Marko;
Jalkanen, Sirpa

Publication type:

Article

Pravastatin-induced improvement in coronary reactivity and circulating ATP and ADP levels in young adults with type 1 diabetes.

Published in:

Frontiers in Physiology, 2012, v. 3, p. 1, doi. 10.3389/fphys.2012.00338

By:

Kiviniemi, Tuomas O.;
Yegutkin, Gennady G.;
Toikka, Jyri O.;
Paul, Subhadeep;
Aittokallio, Tero;
Janatuinen, Tuula;
Knuuti, Juhani;
Rönnemaa, Tapani;
Koskenvuo, Juha W.;
Hartiala, Jaakko J.;
Jalkanen, Sirpa;
Raitakari, Olli T.

Publication type:

Article

Pravastatin-induced improvement in coronary reactivity and circulating ATP and ADP levels in young adults with type 1 diabetes.

Published in:

Frontiers in Physiology, 2012, v. 3, p. 1, doi. 10.3389/fphys.2012.00338

By:

Kiviniemi, Tuomas O.;
Yegutkin, Gennady G.;
Toikka, Jyri O.;
Paul, Subhadeep;
Aittokallio, Tero;
Janatuinen, Tuula;
Knuuti, Juhani;
Rönnemaa, Tapani;
Koskenvuo, Juha W.;
Hartiala, Jaakko J.;
Jalkanen, Sirpa;
Raitakari, Olli T.

Publication type:

Article

Spatiotemporal diversity in molecular and functional abnormalities in the mdx dystrophic brain.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01109-5

By:

Pomeroy, Joanna;
Borczyk, Malgorzata;
Kawalec, Maria;
Hajto, Jacek;
Carlson, Emma;
Svärd, Samuel;
Verma, Suraj;
Bareke, Eric;
Boratyńska-Jasińska, Anna;
Dymkowska, Dorota;
Mellado-Ibáñez, Alvaro;
Laight, David;
Zabłocki, Krzysztof;
Occhipinti, Annalisa;
Majewska, Loydie;
Angione, Claudio;
Majewski, Jacek;
Yegutkin, Gennady G.;
Korostynski, Michal;
Zabłocka, Barbara

Publication type:

Article

Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent.

Published in:

Nature Communications, 2017, v. 8, n. 2, p. 14108, doi. 10.1038/ncomms14108

By:

Song, Anren;
Zhang, Yujin;
Han, Leng;
Yegutkin, Gennady G.;
Liu, Hong;
Sun, Kaiqi;
D'Alessandro, Angelo;
Li, Jessica;
Karmouty-Quintana, Harry;
Iriyama, Takayuki;
Weng, Tingting;
Zhao, Shushan;
Wang, Wei;
Wu, Hongyu;
Nemkov, Travis;
Subudhi, Andrew W.;
Jameson-Van Houten, Sonja;
Julian, Colleen G.;
Lovering, Andrew T.;
Hansen, Kirk C.

Publication type:

Article

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage.

Published in:

Journal of Molecular Medicine, 2019, v. 97, n. 3, p. 341, doi. 10.1007/s00109-018-01734-0

By:

Zeiner, Julian;
Loukovaara, Sirpa;
Losenkova, Karolina;
Zuccarini, Mariachiara;
Korhonen, Ani M.;
Lehti, Kaisa;
Kauppinen, Anu;
Kaarniranta, Kai;
Müller, Christa E.;
Jalkanen, Sirpa;
Yegutkin, Gennady G.

Publication type:

Article

Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities.

Published in:

FASEB Journal, 2012, v. 26, n. 9, p. 3875, doi. 10.1096/fj.12-205658

By:

Yegutkin, Gennady G.;
Wieringa, Bé;
Robson, Simon C.;
Jalkanen, Sirpa

Publication type:

Article

Semicarbazide sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complications.

Published in:

FASEB Journal, 2004, v. 18, n. 6, p. 702, doi. 10.1096/fj.03-0562fje

By:

Stolen, Craig M.;
Madanat, Rami;
Marti, Luc;
Kari, Seppo;
Yegutkin, Gennady G.;
Sariola, Hannu;
Zorzano, Antonio;
Jalkanen, Sirpa

Publication type:

Article

Soluble purine‐converting enzymes circulate in human blood and regulate extracellular ATP level via counteracting pyrophosphatase and phosphotransfer reactions.

Published in:

FASEB Journal, 2003, v. 17, n. 10, p. 1328, doi. 10.1096/fj.02-1136fje

By:

Yegutkin, Gennady G.;
Samburski, Sergei S.;
Jalkanen, Sirpa

Publication type:

Article

CD73 facilitates EMT progression and promotes lung metastases in triple-negative breast cancer.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-85379-z

By:

Petruk, Nataliia;
Tuominen, Sanni;
Åkerfelt, Malin;
Mattsson, Jesse;
Sandholm, Jouko;
Nees, Matthias;
Yegutkin, Gennady G.;
Jukkola, Arja;
Tuomela, Johanna;
Selander, Katri S.

Publication type:

Article

Primary Amine Oxidase of Escherichia coli Is a Metabolic Enzyme that Can Use a Human Leukocyte Molecule as a Substrate.

Published in:

PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0142367

By:

Elovaara, Heli;
Huusko, Teija;
Maksimow, Mikael;
Elima, Kati;
Yegutkin, Gennady G.;
Skurnik, Mikael;
Dobrindt, Ulrich;
Siitonen, Anja;
McPherson, Michael J.;
Salmi, Marko;
Jalkanen, Sirpa

Publication type:

Article

CD73 Is a Major Regulator of Adenosinergic Signalling in Mouse Brain.

Published in:

PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0066896

By:

Kulesskaya, Natalia;
Võikar, Vootele;
Peltola, Marjaana;
Yegutkin, Gennady G.;
Salmi, Marko;
Jalkanen, Sirpa;
Rauvala, Heikki

Publication type:

Article

Adenosine activates brown adipose tissue and recruits beige adipocytes via A<sub>2A</sub> receptors.

Published in:

Nature, 2014, v. 516, n. 7531, p. 395, doi. 10.1038/nature13816

By:

Gnad, Thorsten;
Scheibler, Saskia;
von Kügelgen, Ivar;
Scheele, Camilla;
Kilić, Ana;
Glöde, Anja;
Hoffmann, Linda S.;
Reverte-Salisa, Laia;
Horn, Philipp;
Mutlu, Samet;
El-Tayeb, Ali;
Kranz, Mathias;
Deuther-Conrad, Winnie;
Brust, Peter;
Lidell, Martin E.;
Betz, Matthias J.;
Enerbäck, Sven;
Schrader, Jürgen;
Yegutkin, Gennady G.;
Müller, Christa E.

Publication type:

Article

Extracellular ATP Limits Homeostatic T Cell Migration Within Lymph Nodes.

Published in:

Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.786595

By:

Kobayashi, Daichi;
Sugiura, Yuki;
Umemoto, Eiji;
Takeda, Akira;
Ueta, Hisashi;
Hayasaka, Haruko;
Matsuzaki, Shinsuke;
Katakai, Tomoya;
Suematsu, Makoto;
Hamachi, Itaru;
Yegutkin, Gennady G.;
Salmi, Marko;
Jalkanen, Sirpa;
Miyasaka, Masayuki

Publication type:

Article

Altered purinergic signaling in CD73-deficient mice inhibits tumor progression.

Published in:

European Journal of Immunology, 2011, v. 41, n. 5, p. 1231, doi. 10.1002/eji.201041292

By:

Yegutkin, Gennady G.;
Marttila-Ichihara, Fumiko;
Karikoski, Marika;
Niemelä, Jussi;
Laurila, Juha P.;
Elima, Kati;
Jalkanen, Sirpa;
Salmi, Marko

Publication type:

Article

IFN-β regulates CD73 and adenosine expression at the blood-brain barrier.

Published in:

European Journal of Immunology, 2008, v. 38, n. 10, p. 2718, doi. 10.1002/eji.200838437

By:

Niemelä, Jussi;
Ifergan, Igal;
Yegutkin, Gennady G.;
Jalkanen, Sirpa;
Prat, Alexander;
Airas, Laura

Publication type:

Article

IFN-β protects from vascular leakage via up-regulation of CD73.

Published in:

European Journal of Immunology, 2007, v. 37, n. 12, p. 3334, doi. 10.1002/eji.200737793

By:

Kiss, Jan;
Yegutkin, Gennady G.;
Koskinen, Kaisa;
Savunen, Timo;
Jalkanen, Sirpa;
Salmi, Marko

Publication type:

Article

A peptide inhibitor of vascular adhesion protein-1 (VAP-1) blocks leukocyte-endothelium interactions under shear stress.

Published in:

European Journal of Immunology, 2004, v. 34, n. 8, p. 2276, doi. 10.1002/eji.200424932

By:

Yegutkin, Gennady G.;
Salminen, Tiina;
Koskinen, Kaisa;
Kurtis, Christian;
McPherson, Michael J.;
Jalkanen, Sirpa;
Salmi, Marko

Publication type:

Article

Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism.

Published in:

2020

By:

Spatola, Bradley N.;
Lerner, Alana G.;
Wong, Clifford;
dela Cruz, Tracy;
Welch, Megan;
Fung, Wanchi;
Kovalenko, Maria;
Losenkova, Karolina;
Yegutkin, Gennady G.;
Beers, Courtney;
Corbin, John;
Soros, Vanessa B.

Publication type:

Report

CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity.

Published in:

Cellular & Molecular Life Sciences, 2022, v. 79, n. 3, p. 1, doi. 10.1007/s00018-022-04187-4

By:

Losenkova, Karolina;
Takeda, Akira;
Ragauskas, Symantas;
Cerrada-Gimenez, Marc;
Vähätupa, Maria;
Kaja, Simon;
Paul, Marius L.;
Schmies, Constanze C.;
Rolshoven, Georg;
Müller, Christa E.;
Sandholm, Jouko;
Jalkanen, Sirpa;
Kalesnykas, Giedrius;
Yegutkin, Gennady G.

Publication type:

Article

Enzymes involved in metabolism of extracellular nucleotides and nucleosides: Functional implications and measurement of activities.

Published in:

Critical Reviews in Biochemistry & Molecular Biology, 2014, v. 49, n. 6, p. 473, doi. 10.3109/10409238.2014.953627

By:

Yegutkin, Gennady G.

Publication type:

Article