Works by Yap, Timothy A.

Results: 126

A phase 1b trial of the combination of an all-oral regimen of capecitabine and erlotinib in advanced non-small cell lung cancer in Caucasian patients.

Published in:

2016

By:

Kumar, Rajiv;
Lu, Shir;
Minchom, Anna;
Sharp, Adam;
Davidson, Michael;
Gunapala, Ranga;
Yap, Timothy;
Bhosle, Jaishree;
Popat, Sanjay;
O'Brien, Mary;
Lu, Shir Kiong;
Yap, Timothy A;
O'Brien, Mary E R

Publication type:

journal article

Exceptional response to the ATR inhibitor, camonsertib, in a patient with ALT+ metastatic melanoma.

Published in:

NPJ Precision Oncology, 2025, v. 9, n. 1, p. 1, doi. 10.1038/s41698-025-01025-1

By:

Ngoi, Natalie Y. L.;
Silverman, Ian M.;
Johnson, Adrienne;
Meng, Chenfeng;
Schonhoft, Joseph D.;
Zimmermann, Michal;
Ulanet, Danielle;
Kim, Hyeyeon;
Torrado, Carlos;
Salguero, Carolina;
Brown, Christian Valladolid;
Rodon, Jordi;
Rimkunas, Victoria;
Koehler, Maria;
Yap, Timothy A.

Publication type:

Article

First‐in‐human phase 1 study of KHK2455 monotherapy and in combination with mogamulizumab in patients with advanced solid tumors.

Published in:

Cancer (0008543X), 2025, v. 131, n. 13, p. 1, doi. 10.1002/cncr.35939

By:

Yap, Timothy A.;
Rixe, Olivier;
Baldini, Capucine;
Brown‐Glaberman, Ursa;
Efuni, Sergey;
Hong, David S.;
Massard, Christophe;
Muzaffar, Jameel;
Varga, Andreea;
Yilmaz, Emrullah;
Ikawa, Yuta;
Shiue, Lisa H.;
Liu, Yi;
Hruska, Matthew W.;
Zhao, Henry;
Tokunaga, Akihiro;
Sahebjam, Solmaz

Publication type:

Article

Charting New Frontiers.

Published in:

2011

By:

Hee Jia Yun;
Fan Jing Jing;
Looi Qin En;
Timothy Yap Shi-Jie;
Wen Qianlin

Publication type:

Proceeding

Directional features and rule-based labeling for real-time network traffic-based android spyware classification.

Published in:

Journal of Supercomputing, 2025, v. 81, n. 8, p. 1, doi. 10.1007/s11227-025-07391-8

By:

Mimi, Mousumi Ahmed;
Ng, Hu;
Yap, Timothy Tzen Vun

Publication type:

Article

Directional features and rule-based labeling for real-time network traffic-based android spyware classification.

Published in:

Journal of Supercomputing, 2025, v. 81, n. 8, p. 1, doi. 10.1007/s11227-025-07391-8

By:

Mimi, Mousumi Ahmed;
Ng, Hu;
Yap, Timothy Tzen Vun

Publication type:

Article

DAP-CBR: enhancing Bitcoin block propagation efficiency using dynamic compact block relay’s prefilling of transactions.

Published in:

Journal of Supercomputing, 2025, v. 81, n. 1, p. 1, doi. 10.1007/s11227-024-06468-0

By:

Chin, Zi Hau;
Baskaran, Vishnu Monn;
Tan, Chee Keong;
Tan, Ian K. T.;
Yap, Timothy T. V.

Publication type:

Article

DAP-CBR: enhancing Bitcoin block propagation efficiency using dynamic compact block relay’s prefilling of transactions.

Published in:

Journal of Supercomputing, 2025, v. 81, n. 1, p. 1, doi. 10.1007/s11227-024-06468-0

By:

Chin, Zi Hau;
Baskaran, Vishnu Monn;
Tan, Chee Keong;
Tan, Ian K. T.;
Yap, Timothy T. V.

Publication type:

Article

Characterisation of the Phosphatidylinositol 3-Kinase Pathway in Non-Small Cell Lung Cancer Cells Isolated from Pleural Effusions.

Published in:

Oncology, 2016, v. 90, n. 5, p. 280, doi. 10.1159/000444928

By:

Puglisi, Martina;
Stewart, adam;
Thavasu, Parames;
Frow, Michael;
Carreira, Suzanne;
Minchom, anna;
Punwani, Ravi;
Bhosle, Jaishree;
Popat, Sanjay;
Ratoff, Jonathan;
de Bono, Johann;
Yap, Timothy anthony;
O''Brien, Mary;
Banerji, Udai

Publication type:

Article

Evaluation of Deviation From Planned Cohort Size and Operating Characteristics of Phase 1 Trials.

Published in:

JAMA Network Open, 2021, v. 4, n. 2, p. e2037563, doi. 10.1001/jamanetworkopen.2020.37563

By:

Park, Minjeong;
Liu, Suyu;
Yap, Timothy Anthony;
Yuan, Ying

Publication type:

Article

Prophylaxis, clinical management, and monitoring of datopotamab deruxtecan-associated oral mucositis/stomatitis.

Published in:

Oncologist, 2025, v. 30, n. 3, p. 1, doi. 10.1093/oncolo/oyaf031

By:

Meric-Bernstam, Funda;
Bardia, Aditya;
Bossi, Paolo;
Bianchini, Giampaolo;
Gatlin, Frances;
Lalla, Rajesh V;
Melosky, Barbara;
Niikura, Naoki;
Yap, Timothy A;
Kim, Sophie S;
Rajagopalan, Rachana;
Fairhurst, Rick M;
Graff, Stephanie L;
Rugo, Hope S

Publication type:

Article

First‐In‐Human, First‐In‐Class, Phase I Trial of the Fucosylation Inhibitor SGN‐2FF in Patients with Advanced Solid Tumors.

Published in:

Oncologist, 2021, v. 26, n. 11, p. 925, doi. 10.1002/onco.13911

By:

Do, Khanh T.;
Chow, Laura Quan Man;
Reckamp, Karen;
Sanborn, Rachel E.;
Burris, Howard;
Robert, Francisco;
Camidge, D. Ross;
Steuer, Conor E.;
Strickler, John H.;
Weise, Amy;
Specht, Jennifer M.;
Gutierrez, Martin;
Haughney, Peter;
Hengel, Shawna;
Derleth, Christina Louise;
Yap, Timothy A.

Publication type:

Article

Patient‐Reported Out‐of‐Pocket Costs and Financial Toxicity During Early‐Phase Oncology Clinical Trials.

Published in:

Oncologist, 2021, v. 26, n. 7, p. 588, doi. 10.1002/onco.13767

By:

Huey, Ryan W.;
George, Goldy C.;
Phillips, Penny;
White, Revenda;
Fu, Siqing;
Janku, Filip;
Karp, Daniel D.;
Naing, Aung;
Piha‐Paul, Sarina;
Subbiah, Vivek;
Tsimberidou, Apostolia M.;
Pant, Shubham;
Yap, Timothy A.;
Rodon, Jordi;
Meric‐Bernstam, Funda;
Shih, Ya‐Chen Tina;
Hong, David S.

Publication type:

Article

Development of Molecularly Driven Targeted Combination Strategies.

Published in:

Oncologist, 2017, v. 22, n. 12, p. 1421, doi. 10.1634/theoncologist.2017-0402

By:

Yap, Timothy A.;
Rodon, Jordi

Publication type:

Article

Intratumor Heterogeneity: Seeing the Wood for the Trees.

Published in:

Science Translational Medicine, 2012, v. 4, n. 127, p. 1, doi. 10.1126/scitranslmed.3003854

By:

Yap, Timothy A.;
Gerlinger, Marco;
Futreal, P. Andrew;
Pusztai, Lajos;
Swanton, Charles

Publication type:

Article

Strategies for modern biomarker and drug development in oncology.

Published in:

Journal of Hematology & Oncology, 2014, v. 7, n. 1, p. 1, doi. 10.1186/s13045-014-0070-8

By:

Smith, Alan D.;
Roda, Desam;
Yap, Timothy A.

Publication type:

Article

Characterization and Management of Paradoxical Upgrading Reactions in HIV-Uninfected Patients with Lymph Node Tuberculosis.

Published in:

Clinical Infectious Diseases, 2005, v. 40, n. 9, p. 1368, doi. 10.1086/429317

By:

Hawkey, Charlotte R.;
Yap, Timothy;
Pereira, Janis;
Moore, David A. J.;
Davidson, Robert N.;
Pasvol, Geoffrey;
Kon, Onn Min;
Wall, Robert A.;
Wilkinson, Robert J.

Publication type:

Article

Phase 1 study of the ATR inhibitor berzosertib in combination with cisplatin in patients with advanced solid tumours.

Published in:

2021

By:

Shapiro, Geoffrey I.;
Wesolowski, Robert;
Devoe, Craig;
Lord, Simon;
Pollard, John;
Hendriks, Bart S.;
Falk, Martin;
Diaz-Padilla, Ivan;
Plummer, Ruth;
Yap, Timothy A.

Publication type:

journal article

The role of Schlafen 11 (SLFN11) as a predictive biomarker for targeting the DNA damage response.

Published in:

2021

By:

Coleman, Niamh;
Zhang, Bingnan;
Byers, Lauren A.;
Yap, Timothy A.

Publication type:

Editorial

Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma.

Published in:

British Journal of Cancer, 2018, v. 119, n. 9, p. 1118, doi. 10.1038/s41416-018-0242-3

By:

Al-Saffar, Nada M. S.;
Troy, Helen;
Wong Te Fong, Anne-Christine;
Paravati, Roberta;
Jackson, L. Elizabeth;
Gowan, Sharon;
Boult, Jessica K. R.;
Robinson, Simon P.;
Eccles, Suzanne A.;
Yap, Timothy A.;
Leach, Martin O.;
Chung, Yuen-Li

Publication type:

Article

Target-based therapeutic matching of phase I trials in patients with metastatic breast cancer in a tertiary referral centre.

Published in:

2018

By:

O’Carrigan, Brent;
Lim, Joline Si Jing;
Jalil, Awais;
Harris, Samuel John;
Papadatos-Pastos, Dionysis;
Banerji, Udai;
Lopez, Juanita;
de Bono, Johann Sebastian;
Yap, Timothy Anthony;
O'Carrigan, Brent

Publication type:

journal article

Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma.

Published in:

2018

By:

Al-Saffar, Nada M S;
Troy, Helen;
Wong Te Fong, Anne-Christine;
Paravati, Roberta;
Jackson, L Elizabeth;
Gowan, Sharon;
Boult, Jessica K R;
Robinson, Simon P;
Eccles, Suzanne A;
Yap, Timothy A;
Leach, Martin O;
Chung, Yuen-Li

Publication type:

journal article

PARP inhibitors: the race is on.

Published in:

2016

By:

Brown, Jessica S;
Kaye, Stan B;
Yap, Timothy A

Publication type:

commentary

Combining targeted therapeutics in the era of precision medicine.

Published in:

British Journal of Cancer, 2015, v. 112, n. 1, p. 1, doi. 10.1038/bjc.2014.558

By:

Papadatos-Pastos, D;
De Miguel Luken, M J;
Yap, Timothy A

Publication type:

Article

A phase I trial of the pan-ERBB inhibitor neratinib combined with the MEK inhibitor trametinib in patients with advanced cancer with EGFR mutation/amplification, HER2 mutation/amplification, HER3/4 mutation or KRAS mutation.

Published in:

Cancer Chemotherapy & Pharmacology, 2023, v. 92, n. 2, p. 107, doi. 10.1007/s00280-023-04545-4

By:

Piha-Paul, Sarina A.;
Tseng, Chieh;
Tran, Hai T.;
Gao, Meng;
Karp, Daniel D.;
Subbiah, Vivek;
Tsimberidou, Apostolia Maria;
Kawedia, Jitesh D.;
Fu, Siqing;
Pant, Shubham;
Yap, Timothy A.;
Morris, Van K.;
Kee, Bryan K.;
Blum Murphy, Mariela;
Lim, JoAnn;
Meric-Bernstam, Funda

Publication type:

Article

Waste Management System Fraud Detection Using Machine Learning Algorithms to Minimize Penalties Avoidance and Redemption Abuse.

Published in:

Recycling (MDPI AG), 2021, v. 6, n. 4, p. 1, doi. 10.3390/recycling6040065

By:

Hewiagh, Ali;
Ramakrishnan, Kannan;
Vun Yap, Timothy Tzen;
Ching Seong Tan

Publication type:

Article

Prevalence of Germline Findings Among Tumors From Cancer Types Lacking Hereditary Testing Guidelines.

Published in:

JAMA Network Open, 2022, v. 5, n. 5, p. e2213070, doi. 10.1001/jamanetworkopen.2022.13070

By:

Yap, Timothy A.;
Ashok, Arya;
Stoll, Jessica;
Mauer, Elizabeth;
Nepomuceno, Vanessa M.;
Blackwell, Kimberly L.;
Garber, Judy E.;
Meric-Bernstam, Funda

Publication type:

Article

Real-Time Imaging of Retinal Ganglion Cell Apoptosis.

Published in:

Cells (2073-4409), 2018, v. 7, n. 6, p. 60, doi. 10.3390/cells7060060

By:

Yap, Timothy E.;
Donna, Piero;
Almonte, Melanie T.;
Cordeiro, Maria Francesca

Publication type:

Article

Advances in the Development of Molecularly Targeted Agents in Non-Small-Cell Lung Cancer.

Published in:

Drugs, 2017, v. 77, n. 8, p. 813, doi. 10.1007/s40265-017-0732-2

By:

Dolly, Saoirse;
Collins, Dearbhaile;
Sundar, Raghav;
Popat, Sanjay;
Yap, Timothy

Publication type:

Article

Genetic-Algorithm-Inspired Difficulty Adjustment for Proof-of-Work Blockchains.

Published in:

Symmetry (20738994), 2022, v. 14, n. 3, p. 609, doi. 10.3390/sym14030609

By:

Chin, Zi Hau;
Yap, Timothy Tzen Vun;
Tan, Ian Kim Teck

Publication type:

Article

The iVAN Project: an innovative solution to meet the challenges in trial recruitment during a global pandemic.

Published in:

Acta Ophthalmologica (1755375X), 2022, v. 100, p. N.PAG, doi. 10.1111/j.1755-3768.2022.117

By:

Abdulhussein, Dalia;
Margai, Gina;
Manzar, Haider;
Yap, Timothy;
Bonetti, Jessica;
Bonetti, Paolo;
Miodragovic, Serge;
Normando, Eduardo;
Cordeiro, Francesca

Publication type:

Article

Glaucoma rose plots: redesigning circumpapillary progression analysis.

Published in:

Acta Ophthalmologica (1755375X), 2022, v. 100, p. N.PAG, doi. 10.1111/j.1755-3768.2022.110

By:

Yap, Timothy;
Davis, Benjamin Michael;
Bloom, Philip;
Cordeiro, M. Francesca;
Normando, Eduardo

Publication type:

Article

Assessing the role of cross‐linked sodium hyaluronate in improving the quality of circumpapillary OCT scans.

Published in:

2022

By:

Yap, Timothy;
Abdulhussein, Dalia;
Ahmed, Faisal;
Francesca Cordeiro, M;
Normando, Eduardo

Publication type:

Abstract

Neuroimaging in normal tension glaucoma: to scan or not to scan?

Published in:

Acta Ophthalmologica (1755375X), 2022, v. 100, p. N.PAG, doi. 10.1111/j.1755-3768.2022.102

By:

Szymanska, Maja;
Capellan, Pamela;
Yap, Timothy;
Cordeiro, Maria F.

Publication type:

Article

Harnessing the power of OCT imaging in clinic by smart data analysis and presentation.

Published in:

Acta Ophthalmologica (1755375X), 2019, v. 97, p. N.PAG, doi. 10.1111/j.1755-3768.2019.8106

By:

Yap, Timothy

Publication type:

Article

Diabetic retinopathy outcomes in patients undergoing pancreatic transplants in West London.

Published in:

Acta Ophthalmologica (1755375X), 2019, v. 97, p. N.PAG, doi. 10.1111/j.1755-3768.2019.5289

By:

Szymanska, Maja;
Yap, Timothy;
Normando, Eduardo;
Cordeiro, Francesca

Publication type:

Article

Longitudinal morphological assessment of macular changes in glaucoma.

Published in:

Acta Ophthalmologica (1755375X), 2019, v. 97, p. N.PAG, doi. 10.1111/j.1755-3768.2019.5211

By:

Mercuri, Stefano;
Davis, Benjamin;
Yap, Timothy;
Cordeiro, Maria Francesca;
Normando, Eduardo Maria

Publication type:

Article

Comparison of Central Corneal Thickness Between Fourier-Domain OCT, Very High-Frequency Digital Ultrasound, and Scheimpflug Imaging Systems.

Published in:

Journal of Refractive Surgery, 2016, v. 32, n. 2, p. 110, doi. 10.3928/1081597X-20151223-01

By:

Yap, Timothy E.;
Archer, Timothy J.;
Gobbe, Marine;
Reinstein, Dan Z.

Publication type:

Article

Development of the PARP inhibitor talazoparib for the treatment of advanced BRCA1 and BRCA2 mutated breast cancer.

Published in:

Expert Opinion on Pharmacotherapy, 2021, v. 22, n. 14, p. 1825, doi. 10.1080/14656566.2021.1952181

By:

Hobbs, Evthokia A.;
Litton, Jennifer K.;
Yap, Timothy A.

Publication type:

Article

Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors.

Published in:

2020

By:

Lulu Wang;
Lin Yang;
Chen Wang;
Wei Zhao;
Zhenlin Ju;
Wei Zhang;
Jianfeng Shen;
Yang Peng;
Clemens An;
Luu, Yen T.;
Shumei Song;
Yap, Timothy A.;
Ajani, Jaffer A.;
Mills, Gordon B.;
Xuetong Shen;
Guang Peng;
Wang, Lulu;
Yang, Lin;
Wang, Chen;
Zhao, Wei

Publication type:

journal article

A phase I study to assess afatinib in combination with carboplatin or with carboplatin plus paclitaxel in patients with advanced solid tumors.

Published in:

2018

By:

O’Brien, Mary E. R.;
Sarker, Debashis;
Bhosle, Jaishree;
Thillai, Kiruthikah;
Yap, Timothy A.;
Uttenreuther-Fischer, Martina;
Pemberton, Karine;
Jin, Xidong;
Wiebe, Sabrina;
de Bono, Johann;
Spicer, James;
O'Brien, Mary E R

Publication type:

journal article

Patient-reported symptom burden in patients with rare cancers receiving pembrolizumab in a phase II Clinical Trial.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-16588-3

By:

Mendoza, Tito R.;
Hong, David S.;
Peterson, Christine B.;
Stephen, Bettzy;
Dumbrava, Ecaterina;
Pant, Shubbam;
Tsimberidou, Apostolia Maria;
Yap, Timothy Anthony;
Sheshadri, Ajay;
Altan, Mehmet;
George, Goldy;
Castillo, Lilibeth;
Rodriguez, Enedelia;
Gong, Jing;
Subbiah, Vivek;
Janku, Filip;
Fu, Siqing;
Piha-Paul, Sarina A.;
Ahnert, Jordi Rodon;
Karp, Daniel D.

Publication type:

Article

Handling class imbalance in education using data-level and deep learning methods.

Published in:

International Journal of Electrical & Computer Engineering (2088-8708), 2025, v. 15, n. 1, p. 741, doi. 10.11591/ijece.v15i1.pp741-754

By:

Kannan, Rithesh;
Hu Ng;
Vun Yap, Timothy Tzen;
Lai Kuan Wong;
Fang Fang Chua;
Vik Tor Goh;
Yee Lien Lee;
Hwee Ling Wong

Publication type:

Article

Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic.

Published in:

CA: A Cancer Journal for Clinicians, 2011, v. 61, n. 1, p. 31, doi. 10.3322/caac.20095

By:

Yap, Timothy A.;
Sandhu, Shahneen K.;
Carden, Craig P.;
de Bono, Johann S.

Publication type:

Article

ReSQoV: A Scalable Resource Allocation Model for QoS-Satisfied Cloud Services.

Published in:

Future Internet, 2022, v. 14, n. 5, p. 131, doi. 10.3390/fi14050131

By:

Khan, Hassan Mahmood;
Chua, Fang-Fang;
Yap, Timothy Tzen Vun

Publication type:

Article

Poly(adenosine diphosphate ribose) polymerase inhibition in isocitrate dehydrogenase 1 and 2–mutant tumors: Bridging science with the clinic.

Published in:

Cancer (0008543X), 2025, v. 131, n. 10, p. 1, doi. 10.1002/cncr.35890

By:

Nassif Haddad, Elise;
Javle, Milind M.;
Yap, Timothy A.

Publication type:

Article

A phase 2 basket study of talabostat, a small‐molecule inhibitor of dipeptidyl peptidases, administered in combination with pembrolizumab in patients with advanced solid cancers.

Published in:

Cancer (0008543X), 2025, v. 131, n. 3, p. 1, doi. 10.1002/cncr.35728

By:

Ahmed, Jibran;
Janku, Filip;
Karp, Daniel D.;
Piha‐Paul, Sarina A.;
Tsimberidou, Apostolia M.;
Yap, Timothy Anthony;
Stephen, Bettzy;
Yang, Yali;
Gurses, Serdar;
Liu, Qian;
Song, Juhee;
Meric‐Bernstam, Funda;
Naing, Aung

Publication type:

Article

Phase 1/2 trial of avelumab combined with utomilumab (4‐1BB agonist), PF‐04518600 (OX40 agonist), or radiotherapy in patients with advanced gynecologic malignancies.

Published in:

Cancer (0008543X), 2024, v. 130, n. 3, p. 400, doi. 10.1002/cncr.35063

By:

Knisely, Anne;
Ahmed, Jibran;
Stephen, Bettzy;
Piha‐Paul, Sarina A.;
Karp, Daniel;
Zarifa, Abdulrazzak;
Fu, Siqing;
Hong, David Sanghyun;
Rodon Ahnert, Jordi;
Yap, Timothy A.;
Tsimberidou, Apostolia M.;
Alshawa, Anas;
Dumbrava, Ecaterina E.;
Yang, Yali;
Song, Juhee;
Meric‐Bernstam, Funda;
Jazaeri, Amir A.;
Naing, Aung

Publication type:

Article

Clinical implications of tumor‐based next‐generation sequencing in high‐grade epithelial ovarian cancer.

Published in:

Cancer (0008543X), 2023, v. 129, n. 11, p. 1672, doi. 10.1002/cncr.34724

By:

Foster, Katherine I.;
Shaw, Kenna R. M.;
Jin, Jeff;
Westin, Shannon N.;
Yap, Timothy A.;
Glassman, Deanna M.;
Jazaeri, Amir A.;
Rauh‐Hain, Jose A.;
Lee, Sanghoon;
Fellman, Bryan M.;
Ju, Zhenlin;
Liu, Yuexin;
Fleming, Nicole D.;
Sood, Anil K.

Publication type:

Article

Recent Advancements in the Medical Treatment of Diabetic Retinal Disease.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 17, p. 9441, doi. 10.3390/ijms22179441

By:

Szymanska, Maja;
Mahmood, Daanyaal;
Yap, Timothy E.;
Cordeiro, Maria F.

Publication type:

Article