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Efficient enzymatic synthesis of (S)-1-(3ʹ-bromo-2ʹ-methoxyphenyl)ethanol, the key building block of lusutrombopag.
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- Green Synthesis & Catalysis, 2023, v. 4, n. 3, p. 268, doi. 10.1016/j.gresc.2022.06.010
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- Article
Stereocomplementary Synthesis of β‐Aryl Propanamines by Enzymatic Dynamic Kinetic Resolution‐Reductive Amination.
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- European Journal of Organic Chemistry, 2023, v. 26, n. 28, p. 1, doi. 10.1002/ejoc.202300476
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- Article
Asymmetric Synthesis of Both Enantiomers of Dimethyl 2-Methylsuccinate by the Ene-Reductase-Catalyzed Reduction at High Substrate Concentration.
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- Catalysts (2073-4344), 2022, v. 12, n. 10, p. 1133, doi. 10.3390/catal12101133
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- Article
Stereocomplementary Synthesis of a Key Intermediate for Tofacitinib via Enzymatic Dynamic Kinetic Resolution‐Reductive Amination.
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- Advanced Synthesis & Catalysis, 2022, v. 364, n. 14, p. 2380, doi. 10.1002/adsc.202200361
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- Article
Asymmetric Synthesis of N‐Substituted 1,2‐Amino Alcohols from Simple Aldehydes and Amines by One‐Pot Sequential Enzymatic Hydroxymethylation and Asymmetric Reductive Amination.
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- Angewandte Chemie, 2022, v. 134, n. 17, p. 1, doi. 10.1002/ange.202116344
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- Article
Asymmetric Synthesis of N‐Substituted 1,2‐Amino Alcohols from Simple Aldehydes and Amines by One‐Pot Sequential Enzymatic Hydroxymethylation and Asymmetric Reductive Amination.
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- Angewandte Chemie International Edition, 2022, v. 61, n. 17, p. 1, doi. 10.1002/anie.202116344
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- Article
Asymmetric Synthesis of N‐Substituted γ‐Amino Esters and γ‐Lactams Containing α,γ‐Stereogenic Centers via a Stereoselective Enzymatic Cascade.
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- Advanced Synthesis & Catalysis, 2022, v. 364, n. 2, p. 372, doi. 10.1002/adsc.202100953
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- Article
Improving Catalytic Activity and Reversing Enantio‐Specificity of ω‐Transaminase by Semi‐Rational Engineering en Route to Chiral Bulky β‐Amino Esters.
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- ChemCatChem, 2021, v. 13, n. 15, p. 3396, doi. 10.1002/cctc.202100503
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- Article
Asymmetric Synthesis of N‐Substituted α‐Amino Esters from α‐Ketoesters via Imine Reductase‐Catalyzed Reductive Amination.
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- Angewandte Chemie, 2021, v. 133, n. 16, p. 8799, doi. 10.1002/ange.202016589
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- Article
Asymmetric Synthesis of N‐Substituted α‐Amino Esters from α‐Ketoesters via Imine Reductase‐Catalyzed Reductive Amination.
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- Angewandte Chemie International Edition, 2021, v. 60, n. 16, p. 8717, doi. 10.1002/anie.202016589
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- Article
Inverting the Enantiopreference of Nitrilase‐Catalyzed Desymmetric Hydrolysis of Prochiral Dinitriles by Reshaping the Binding Pocket with a Mirror‐Image Strategy.
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- Angewandte Chemie, 2021, v. 133, n. 7, p. 3723, doi. 10.1002/ange.202012243
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- Article
Inverting the Enantiopreference of Nitrilase‐Catalyzed Desymmetric Hydrolysis of Prochiral Dinitriles by Reshaping the Binding Pocket with a Mirror‐Image Strategy.
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- Angewandte Chemie International Edition, 2021, v. 60, n. 7, p. 3679, doi. 10.1002/anie.202012243
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- Article
Chemoenzymatic Stereoselective Synthesis of Substituted γ‐ or δ‐lactams with Two Chiral Centers via Transaminase‐catalysed Dynamic Kinetic Resolution.
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- ChemCatChem, 2020, v. 12, n. 24, p. 6311, doi. 10.1002/cctc.202001142
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- Article
2,3‐Dihydroxybenzoic Acid Decarboxylase from Fusarium oxysporum: Crystal Structures and Substrate Recognition Mechanism.
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- ChemBioChem, 2020, v. 21, n. 20, p. 2950, doi. 10.1002/cbic.202000244
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- Article
Manipulating the stereoselectivity of a thermostable alcohol dehydrogenase by directed evolution for efficient asymmetric synthesis of arylpropanols.
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- Biological Chemistry, 2019, v. 400, n. 3, p. 313, doi. 10.1515/hsz-2018-0299
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- Article
Imine Reductase‐Catalyzed Enantioselective Reduction of Bulky α,β‐Unsaturated Imines en Route to a Pharmaceutically Important Morphinan Skeleton.
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- Advanced Synthesis & Catalysis, 2019, v. 361, n. 3, p. 556, doi. 10.1002/adsc.201801326
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- Article
One‐Pot Enzymatic Synthesis of Cyclic Vicinal Diols from Aliphatic Dialdehydes via Intramolecular C−C Bond Formation and Carbonyl Reduction Using Pyruvate Decarboxylases and Alcohol Dehydrogenases.
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- Advanced Synthesis & Catalysis, 2018, v. 360, n. 21, p. 4191, doi. 10.1002/adsc.201800455
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- Article
Methodology Development in Directed Evolution: Exploring Options when Applying Triple‐Code Saturation Mutagenesis.
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- ChemBioChem, 2018, v. 19, n. 3, p. 239, doi. 10.1002/cbic.201700562
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- Article
Accessing d‐Valine Synthesis by Improved Variants of Bacterial Cyclohexylamine Oxidase.
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- ChemCatChem, 2018, v. 10, n. 2, p. 387, doi. 10.1002/cctc.201701229
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- Article
Efficient Biosynthesis of ( R)- or ( S)-2-Hydroxybutyrate from l-Threonine through a Synthetic Biology Approach.
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- Advanced Synthesis & Catalysis, 2016, v. 358, n. 18, p. 2923, doi. 10.1002/adsc.201600468
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- Article
New recombinant cyclohexylamine oxidase variants for deracemization of secondary amines by orthogonally assaying designed mutants with structurally diverse substrates.
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- Scientific Reports, 2016, p. 24973, doi. 10.1038/srep24973
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- Article
Efficient Biosynthesis of Ethyl (R)-3-Hydroxyglutarate through a One-Pot Bienzymatic Cascade of Halohydrin Dehalogenase and Nitrilase.
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- 2015
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- Publication type:
- Interview
Enzymatic Synthesis of a Key Intermediate for Rosuvastatin by Nitrilase-Catalyzed Hydrolysis of Ethyl ( R)-4-Cyano-3-hydroxybutyate at High Substrate Concentration.
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- ChemCatChem, 2015, v. 7, n. 2, p. 271, doi. 10.1002/cctc.201402877
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- Article