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Reforms of regulatory pathways for approval of new antineoplastic drugs in Japan from 2004 to 2019 and accompanying changes in pivotal clinical trial designs.
- Published in:
- Investigational New Drugs, 2022, v. 40, n. 1, p. 142, doi. 10.1007/s10637-021-01165-8
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- Publication type:
- Article
In vitro multifaceted activities of a specific group of novel phosphatidylinositol 3-kinase inhibitors on hotspot mutant PIK3CA.
- Published in:
- Investigational New Drugs, 2014, v. 32, n. 6, p. 1134, doi. 10.1007/s10637-014-0152-z
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- Publication type:
- Article
A novel thiophene-3-carboxamide analog of annonaceous acetogenin exhibits antitumor activity via inhibition of mitochondrial complex I.
- Published in:
- Pharmacology Research & Perspectives, 2016, v. 4, n. 4, p. 1, doi. 10.1002/prp2.246
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- Publication type:
- Article
M- COPA, a novel Golgi system disruptor, suppresses apoptosis induced by Shiga toxin.
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- Genes to Cells, 2016, v. 21, n. 8, p. 901, doi. 10.1111/gtc.12386
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- Publication type:
- Article
Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors.
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- Oncogene, 1999, v. 18, n. 3, p. 813, doi. 10.1038/sj.onc.1202367
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- Publication type:
- Article
Reduced sialidase expression in highly metastatic variants of mouse colon adenocarcinoma 26 and retardation of their metastatic ability by sialidase overexpression.
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- International Journal of Cancer, 2002, v. 97, n. 2, p. 180, doi. 10.1002/ijc.1598
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- Publication type:
- Article
Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca2+ pumps with a unique mode of binding.
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- FEBS Letters, 2015, v. 589, n. 13, p. 1406, doi. 10.1016/j.febslet.2015.04.056
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- Publication type:
- Article
Total Synthesis and Biological Assessment of (−)-Exiguolide and Analogues.
- Published in:
- Chemistry - A European Journal, 2011, v. 17, n. 9, p. 2678, doi. 10.1002/chem.201003135
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- Publication type:
- Article
Total Synthesis of the Bicyclic Depsipeptide HDAC Inhibitors Spiruchostatins A and B, 5′′- epi-Spiruchostatin B, FK228 (FR901228) and Preliminary Evaluation of Their Biological Activity.
- Published in:
- Chemistry - A European Journal, 2009, v. 15, n. 42, p. 11174, doi. 10.1002/chem.200901552
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- Publication type:
- Article
Inhibitory Activity of Flavonoids against Class I Phosphatidylinositol 3-Kinase Isoforms.
- Published in:
- Molecules, 2011, v. 16, n. 6, p. 5159, doi. 10.3390/molecules16065159
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- Publication type:
- Article
Correlation between Cytotoxic Activities and Reduction Potentials of Heterocyclic Quinones.
- Published in:
- Molecules, 2010, v. 15, n. 9, p. 6559, doi. 10.3390/molecules15096559
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- Publication type:
- Article
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.
- Published in:
- Journal of Cell Biology, 2002, v. 158, n. 2, p. 227, doi. 10.1083/jcb.200204026
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- Publication type:
- Article
Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.
- Published in:
- Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-33139-x
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- Publication type:
- Article
Total Synthesis of the Depsipeptide FR901375 and Preliminary Evaluation of Its Biological Activity.
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- European Journal of Organic Chemistry, 2016, v. 2016, n. 34, p. 5667, doi. 10.1002/ejoc.201601023
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- Publication type:
- Article
Up-regulation of p27<sup>Kip1</sup> Correlates Inversely with Anchorage-independent Growth of Human Cancer Cell Lines.
- Published in:
- Cancer Science, 1998, v. 89, n. 2, p. 110, doi. 10.1111/j.1349-7006.1998.tb00537.x
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- Publication type:
- Article
Anti-tumor Efficacy of Paclitaxel against Human Lung Cancer Xenografts.
- Published in:
- Cancer Science, 1997, v. 88, n. 12, p. 1205, doi. 10.1111/j.1349-7006.1997.tb00350.x
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- Publication type:
- Article
Isolation of a Novel Gene Showing Reduced Expression in Metastatic Colorectal Carcinoma Cell Lines and Carcinomas.
- Published in:
- Cancer Science, 1997, v. 88, n. 8, p. 725, doi. 10.1111/j.1349-7006.1997.tb00443.x
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- Publication type:
- Article
Establishment of a Hepatocyte Cell Line Producing Growth-promoting Factors for Liver-colonizing Tumor Cells.
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- Cancer Science, 1996, v. 87, n. 2, p. 146, doi. 10.1111/j.1349-7006.1996.tb03152.x
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- Publication type:
- Article
Expression of Sulfomucins in Normal Mucosae, Colorectal Adenocarcinomas and Metastases.
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- Cancer Science, 1995, v. 86, n. 11, p. 1060, doi. 10.1111/j.1349-7006.1995.tb03021.x
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- Publication type:
- Article
Insulin and Insulin-like Growth Factor 1 Stimulate Proliferation of Metastatic Variants of Colon Carcinoma 26.
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- Cancer Science, 1989, v. 80, n. 1, p. 51, doi. 10.1111/j.1349-7006.1989.tb02244.x
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- Publication type:
- Article
Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis.
- Published in:
- Genes, Chromosomes & Cancer, 2000, v. 29, n. 1, p. 9, doi. 10.1002/1098-2264(2000)9999:9999<::AID-GCC1001>3.0.CO;2-#
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- Publication type:
- Article
Spiromarienonols A and B: Two New 7(8→9)abeo-Lanostane-Type Triterpene Lactones from the Stem Bark of Abies mariesii.
- Published in:
- Helvetica Chimica Acta, 2004, v. 87, n. 1, p. 240
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- Publication type:
- Article
Candicanoside A, a Novel Cytotoxic Rearranged Cholestane Glycoside from Galtonia candicans.
- Published in:
- Helvetica Chimica Acta, 2000, v. 83, n. 10, p. 2698, doi. 10.1002/1522-2675(20001004)83:10<2698::AID-HLCA2698>3.0.CO;2-4
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- Publication type:
- Article
Antitumor Activity of ZSTK474, a New Phosphatidylinositol 3-Kinase Inhibitor.
- Published in:
- JNCI: Journal of the National Cancer Institute, 2006, v. 98, n. 8, p. 545, doi. 10.1093/jnci/djj133
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- Article
p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.
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- 2005
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- Publication type:
- journal article
Effect on tumor cells of blocking survival response to glucose deprivation.
- Published in:
- 2004
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- Publication type:
- journal article
Negative regulation of transforming growth factor-ß(TGF-ß) signaling by WW domain-containing protein 1 (WWP1).
- Published in:
- Oncogene, 2004, v. 23, n. 41, p. 6914, doi. 10.1038/sj.onc.1207885
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- Publication type:
- Article
Csk defines the ability of integrin-mediated cell adhesion and migration in human colon cancer cells: implication for a potential role in cancer metastasis.
- Published in:
- Oncogene, 2004, v. 23, n. 1, p. 289, doi. 10.1038/sj.onc.1207041
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- Publication type:
- Article
The relationship of collagenolytic activity to stage of human colorectal carcinoma.
- Published in:
- International Journal of Cancer, 1987, v. 40, n. 1, p. 24, doi. 10.1002/ijc.2910400106
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- Publication type:
- Article
Possible Contribution of Drug Approval Summaries Published by Drug Regulatory Authorities on Scientific Discussion and Drug Development.
- Published in:
- Clinical Pharmacology in Drug Development, 2020, v. 9, n. 1, p. 6, doi. 10.1002/cpdd.744
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- Publication type:
- Article
Enhanced cytocidal action of methotrexate by conjugation to concanavalin A.
- Published in:
- International Journal of Cancer, 1980, v. 26, n. 5, p. 655, doi. 10.1002/ijc.2910260518
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- Publication type:
- Article
Increased content of chondroitin sulfate proteoglycan in human colorectal carcinoma metastases compared with the primary tumor as determined by an anti-chondroitin-sulfate monoclonal antibody.
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- Journal of Cellular Biochemistry, 1988, v. 36, n. 4, p. 405, doi. 10.1002/jcb.240360409
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- Publication type:
- Article
Extensive analysis of signaling pathway molecules in breast cancer: association with clinicopathological characteristics.
- Published in:
- International Journal of Clinical Oncology, 2015, v. 20, n. 3, p. 490, doi. 10.1007/s10147-014-0753-8
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- Publication type:
- Article
Discovery of ortho-Carborane-Conjugated Triazines as Selective Topoisomerase I/II Inhibitors.
- Published in:
- Australian Journal of Chemistry, 2011, v. 64, n. 11, p. 16, doi. 10.1071/CH11295
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- Publication type:
- Article
Antiproliferative and Antiangiogenic Activities of Smenospongine, a Marine Sponge Sesquiterpene Aminoquinone.
- Published in:
- Marine Drugs, 2011, v. 9, n. 2, p. 154, doi. 10.3390/md9020154
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- Publication type:
- Article
A novel method for analyzing phosphoproteins using SELDI-TOF MS in combination with a series of recombinant proteins.
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- Proteomics, 2007, v. 7, n. 14, p. 2350, doi. 10.1002/pmic.200700157
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- Publication type:
- Article
Enantioselective Total Synthesis of (+)-Ottelione A, (−)-Ottelione B, (+)-3- epi-Ottelione A and Preliminary Evaluation of Their Antitumor Activity.
- Published in:
- Chemistry - A European Journal, 2007, v. 13, n. 35, p. 9866, doi. 10.1002/chem.200700789
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- Publication type:
- Article
Total Synthesis of Murisolins and Evaluation of Tumor-Growth Inhibitory Activity.
- Published in:
- Chemistry - A European Journal, 2005, v. 11, n. 21, p. 6237, doi. 10.1002/chem.200500462
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- Publication type:
- Article
Structural Revision of Sulfated Polysaccharide B-1 Isolated from a Marine Pseudomonas Species and Its Cytotoxic Activity Against Human Cancer Cell Lines.
- Published in:
- Marine Biotechnology, 2003, v. 5, n. 1, p. 13, doi. 10.1007/s10126-002-0046-5
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- Publication type:
- Article
Improving Drug Potency and Efficacy by Nanocarrier-Mediated Subcellular Targeting.
- Published in:
- Science Translational Medicine, 2011, v. 3, n. 64, p. 1, doi. 10.1126/scitranslmed.3001385
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- Publication type:
- Article
Synthesis and Biological Evaluation of Boronic Acid Containing cis-Stilbenes as Apoptotic Tubulin Polymerization Inhibitors.
- Published in:
- ChemMedChem, 2006, v. 1, n. 7, p. 729, doi. 10.1002/cmdc.200600068
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- Publication type:
- Article
Identification of Interleukin-6 as a Factor That Induces Neurite Outgrowth by PC12 Cells Primed with NGF1.
- Published in:
- Journal of Biochemistry, 1996, v. 120, n. 5, p. 865, doi. 10.1093/oxfordjournals.jbchem.a021499
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- Publication type:
- Article
Expression of Carbohydrate-Binding Protein p33/41 in Human Tumor Cell Lines.
- Published in:
- Journal of Biochemistry, 1996, v. 119, n. 2, p. 346, doi. 10.1093/oxfordjournals.jbchem.a021246
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- Publication type:
- Article
Pyrrocidine A, a metabolite of endophytic fungi, has a potent apoptosis-inducing activity against HL60 cells through caspase activation via the Michael addition.
- Published in:
- Journal of Antibiotics, 2016, v. 69, n. 3, p. 133, doi. 10.1038/ja.2015.103
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- Publication type:
- Article
The polar neutral and basic taxoids isolated from needles and twigs of Taxus cuspidata and their biological activity.
- Published in:
- Journal of Wood Science, 2008, v. 54, n. 5, p. 390, doi. 10.1007/s10086-008-0964-6
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- Publication type:
- Article
Inhibitory effects of ZSTK474, a phosphatidylinositol 3-kinase inhibitor, on adjuvant-induced arthritis in rats.
- Published in:
- Inflammation Research, 2012, v. 61, n. 6, p. 551, doi. 10.1007/s00011-012-0444-8
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- Publication type:
- Article
Abdominal Infection Suppresses the Number and Activity of Intrahepatic Natural Killer Cells and Promotes Tumor Growth in a Murine Liver Metastasis Model.
- Published in:
- Annals of Surgical Oncology: An Oncology Journal for Surgeons, 2016, v. 23, p. 257, doi. 10.1245/s10434-015-4466-7
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- Publication type:
- Article
Urukthapelstatin A, a Novel Cytotoxic Substance from Marine-derived Mechercharimyces asporophorigenens YM11-542.
- Published in:
- Journal of Antibiotics, 2007, v. 60, n. 4, p. 251, doi. 10.1038/ja.2007.30
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- Publication type:
- Article
YM-216391, a Novel Cytotoxic Cyclic Peptide from Streptomyces nobilis.
- Published in:
- Journal of Antibiotics, 2005, v. 58, n. 1, p. 27, doi. 10.1038/ja.2005.2
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- Publication type:
- Article
Identification of Chrysoplenetin from Vitex negundo as a Potential Cytotoxic Agent against PANC-1 and a Panel of 39 Human Cancer Cell Lines (JFCR-39).
- Published in:
- Phytotherapy Research, 2011, v. 25, n. 12, p. 1770, doi. 10.1002/ptr.3441
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- Publication type:
- Article