Works by Yaghootkar, Hanieh

Results: 54
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    Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.

    Published in:
    2020
    By:
    • Yaghootkar, Hanieh;
    • Zhang, Yiying;
    • Spracklen, Cassandra N.;
    • Karaderi, Tugce;
    • Huang, Lam Opal;
    • Bradfield, Jonathan;
    • Schurmann, Claudia;
    • Fine, Rebecca S.;
    • Preuss, Michael H.;
    • Kutalik, Zoltan;
    • Wittemans, Laura B.L.;
    • Lu, Yingchang;
    • Metz, Sophia;
    • Willems, Sara M.;
    • Li-Gao, Ruifang;
    • Grarup, Niels;
    • Wang, Shuai;
    • Molnos, Sophie;
    • Sandoval-Zárate, América A.;
    • Nalls, Mike A.
    Publication type:
    journal article
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    Cell Specific eQTL Analysis without Sorting Cells.

    Published in:
    PLoS Genetics, 2015, v. 11, n. 5, p. 1, doi. 10.1371/journal.pgen.1005223
    By:
    • Westra, Harm-Jan;
    • Arends, Danny;
    • Esko, Tõnu;
    • Peters, Marjolein J.;
    • Schurmann, Claudia;
    • Schramm, Katharina;
    • Kettunen, Johannes;
    • Yaghootkar, Hanieh;
    • Fairfax, Benjamin P.;
    • Andiappan, Anand Kumar;
    • Li, Yang;
    • Fu, Jingyuan;
    • Karjalainen, Juha;
    • Platteel, Mathieu;
    • Visschedijk, Marijn;
    • Weersma, Rinse K.;
    • Kasela, Silva;
    • Milani, Lili;
    • Tserel, Liina;
    • Peterson, Pärt
    Publication type:
    Article
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    A homozygous TARS2 variant is a novel cause of syndromic neonatal diabetes.

    Published in:
    Diabetic Medicine, 2025, v. 42, n. 3, p. 1, doi. 10.1111/dme.15471
    By:
    • Donis, Russell;
    • Patel, Kashyap A.;
    • Wakeling, Matthew N.;
    • Johnson, Matthew B.;
    • Amoli, Masha M.;
    • Yildiz, Melek;
    • Akçay, Teoman;
    • Aspi, Irani;
    • Yong, James;
    • Yaghootkar, Hanieh;
    • Weedon, Michael N.;
    • Hattersley, Andrew T.;
    • Flanagan, Sarah E.;
    • De Franco, Elisa
    Publication type:
    Article
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    Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile.

    Published in:
    Diabetic Medicine, 2021, v. 38, n. 9, p. 1, doi. 10.1111/dme.14531
    By:
    • Heald, Adrian H.;
    • Martin, Susan;
    • Fachim, Helene;
    • Green, Harry D.;
    • Young, Katherine G.;
    • Malipatil, Nagaraj;
    • Siddals, Kirk;
    • Cortes, Gabriela;
    • Tyrrell, Jessica;
    • Wood, Andrew R;
    • Beaumont, Robin N.;
    • Frayling, Timothy M.;
    • Donn, Rachelle;
    • Narayanan, Ram Prakash;
    • Ollier, William;
    • Gibson, Martin;
    • Yaghootkar, Hanieh
    Publication type:
    Article
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    Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight.

    Published in:
    Human Molecular Genetics, 2022, v. 31, n. 11, p. 1762, doi. 10.1093/hmg/ddab356
    By:
    • Thompson, William D;
    • Beaumont, Robin N;
    • Kuang, Alan;
    • Warrington, Nicole M;
    • Ji, Yingjie;
    • Tyrrell, Jessica;
    • Wood, Andrew R;
    • Scholtens, Denise M;
    • Knight, Bridget A;
    • Evans, David M;
    • Jr, William L Lowe;
    • Santorelli, Gillian;
    • Azad, Raq;
    • Mason, Dan;
    • Hattersley, Andrew T;
    • Frayling, Timothy M;
    • Yaghootkar, Hanieh;
    • Borges, Maria Carolina;
    • Lawlor, Deborah A;
    • Freathy, Rachel M
    Publication type:
    Article
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    Systematic identification of trans eQTLs as putative drivers of known disease associations.

    Published in:
    Nature Genetics, 2013, v. 45, n. 10, p. 1238, doi. 10.1038/ng.2756
    By:
    • Westra, Harm-Jan;
    • Peters, Marjolein J;
    • Esko, Tõnu;
    • Yaghootkar, Hanieh;
    • Schurmann, Claudia;
    • Kettunen, Johannes;
    • Christiansen, Mark W;
    • Fairfax, Benjamin P;
    • Schramm, Katharina;
    • Powell, Joseph E;
    • Zhernakova, Alexandra;
    • Zhernakova, Daria V;
    • Veldink, Jan H;
    • Van den Berg, Leonard H;
    • Karjalainen, Juha;
    • Withoff, Sebo;
    • Uitterlinden, André G;
    • Hofman, Albert;
    • Rivadeneira, Fernando;
    • 't Hoen, Peter A C
    Publication type:
    Article
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    New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

    Published in:
    Nature Genetics, 2013, v. 45, n. 1, p. 76, doi. 10.1038/ng.2477
    By:
    • Horikoshi, Momoko;
    • Yaghootkar, Hanieh;
    • Mook-Kanamori, Dennis O;
    • Sovio, Ulla;
    • Taal, H Rob;
    • Hennig, Branwen J;
    • Bradfield, Jonathan P;
    • St Pourcain, Beate;
    • Evans, David M;
    • Charoen, Pimphen;
    • Kaakinen, Marika;
    • Cousminer, Diana L;
    • Lehtimäki, Terho;
    • Kreiner-Møller, Eskil;
    • Warrington, Nicole M;
    • Bustamante, Mariona;
    • Feenstra, Bjarke;
    • Berry, Diane J;
    • Thiering, Elisabeth;
    • Pfab, Thiemo
    Publication type:
    Article
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    Using genetics to understand the causal influence of higher BMI on depression.

    Published in:
    2019
    By:
    • Tyrrell, Jessica;
    • Mulugeta, Anwar;
    • Wood, Andrew R;
    • Zhou, Ang;
    • Beaumont, Robin N;
    • Tuke, Marcus A;
    • Jones, Samuel E;
    • Ruth, Katherine S;
    • Yaghootkar, Hanieh;
    • Sharp, Seth;
    • Thompson, William D;
    • Ji, Yingjie;
    • Harrison, Jamie;
    • Freathy, Rachel M;
    • Murray, Anna;
    • Weedon, Michael N;
    • Lewis, Cathryn;
    • Frayling, Timothy M;
    • Hyppönen, Elina
    Publication type:
    journal article
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    Gene-obesogenic environment interactions in the UK Biobank study.

    Published in:
    2017
    By:
    • Tyrrell, Jessica;
    • Wood, Andrew R.;
    • Ames, Ryan M.;
    • Yaghootkar, Hanieh;
    • Beaumont, Robin N.;
    • Jones, Samuel E.;
    • Tuke, Marcus A.;
    • Ruth, Katherine S.;
    • Freathy, Rachel M.;
    • Smith, George Davey;
    • Joost, Stéphane;
    • Guessous, Idris;
    • Murray, Anna;
    • Strachan, David P.;
    • Kutalik, Zolt_n;
    • Weedon, Michael N.;
    • Frayling, Timothy M.;
    • Davey Smith, George;
    • Kutalik, Zoltán
    Publication type:
    journal article
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    A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.

    Published in:
    Science Translational Medicine, 2016, v. 8, n. 341, p. 1, doi. 10.1126/scitranslmed.aad3744
    By:
    • Scott, Robert A.;
    • Freitag, Daniel F.;
    • Li Li;
    • Chu, Audrey Y.;
    • Surendran, Praveen;
    • Young, Robin;
    • Grarup, Niels;
    • Stancáková, Alena;
    • Yuning Chen;
    • Varga, Tibor V.;
    • Yaghootkar, Hanieh;
    • Jian’an Luan;
    • Jing Hua Zhao;
    • Willems, Sara M.;
    • Wessel, Jennifer;
    • Shuai Wang;
    • Maruthur, Nisa;
    • Michailidou, Kyriaki;
    • Pirie, Ailith;
    • van der Lee, Sven J.
    Publication type:
    Article
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    Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.

    Published in:
    PLoS ONE, 2017, v. 12, n. 9, p. 1, doi. 10.1371/journal.pone.0185083
    By:
    • Pilling, Luke C.;
    • Atkins, Janice L.;
    • Duff, Michael O.;
    • Beaumont, Robin N.;
    • Jones, Samuel E.;
    • Tyrrell, Jessica;
    • Kuo, Chia-Ling;
    • Ruth, Katherine S.;
    • Tuke, Marcus A.;
    • Yaghootkar, Hanieh;
    • Wood, Andrew R.;
    • Murray, Anna;
    • Weedon, Michael N.;
    • Harries, Lorna W.;
    • Kuchel, George A.;
    • Ferrucci, Luigi;
    • Frayling, Timothy M.;
    • Melzer, David
    Publication type:
    Article
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    Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci.

    Published in:
    PLoS Genetics, 2016, v. 12, n. 8, p. 1, doi. 10.1371/journal.pgen.1006125
    By:
    • Jones, Samuel E.;
    • Tyrrell, Jessica;
    • Wood, Andrew R.;
    • Beaumont, Robin N.;
    • Ruth, Katherine S.;
    • Tuke, Marcus A.;
    • Yaghootkar, Hanieh;
    • Hu, Youna;
    • Teder-Laving, Maris;
    • Hayward, Caroline;
    • Roenneberg, Till;
    • Wilson, James F.;
    • Del Greco, Fabiola;
    • Hicks, Andrew A.;
    • Shin, Chol;
    • Yun, Chang-Ho;
    • Lee, Seung Ku;
    • Metspalu, Andres;
    • Byrne, Enda M.;
    • Gehrman, Philip R.
    Publication type:
    Article
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    Higher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile.

    Published in:
    Diabetologia, 2021, v. 64, n. 12, p. 2790, doi. 10.1007/s00125-021-05570-9
    By:
    • Thompson, William D.;
    • Beaumont, Robin N.;
    • Kuang, Alan;
    • Warrington, Nicole M.;
    • Ji, Yingjie;
    • Tyrrell, Jessica;
    • Wood, Andrew R.;
    • Scholtens, Denise M.;
    • Knight, Bridget A.;
    • Evans, David M.;
    • Lowe Jr, William L.;
    • Santorelli, Gillian;
    • Azad, Rafaq;
    • Mason, Dan;
    • Hattersley, Andrew T.;
    • Frayling, Timothy M.;
    • Yaghootkar, Hanieh;
    • Borges, Maria Carolina;
    • Lawlor, Deborah A.;
    • Freathy, Rachel M.
    Publication type:
    Article
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    Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.

    Published in:
    Nature Communications, 2015, v. 6, n. 1, p. 5897, doi. 10.1038/ncomms6897
    By:
    • Wessel, Jennifer;
    • Chu, Audrey Y;
    • Willems, Sara M;
    • Wang, Shuai;
    • Yaghootkar, Hanieh;
    • Brody, Jennifer A;
    • Dauriz, Marco;
    • Hivert, Marie-France;
    • Raghavan, Sridharan;
    • Lipovich, Leonard;
    • Hidalgo, Bertha;
    • Fox, Keolu;
    • Huffman, Jennifer E;
    • An, Ping;
    • Lu, Yingchang;
    • Rasmussen-Torvik, Laura J;
    • Grarup, Niels;
    • Ehm, Margaret G;
    • Li, Li;
    • Baldridge, Abigail S
    Publication type:
    Article
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    Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease.

    Published in:
    2016
    By:
    • Yaghootkar, Hanieh;
    • Lotta, Luca A.;
    • Tyrrell, Jessica;
    • Smit, Roelof A. J.;
    • Jones, Sam E.;
    • Donnelly, Louise;
    • Beaumont, Robin;
    • Campbell, Archie;
    • Tuke, Marcus A.;
    • Hayward, Caroline;
    • Ruth, Katherine S.;
    • Padmanabhan, Sandosh;
    • Wouter Jukema, J.;
    • Palmer, Colin C.;
    • Hattersley, Andrew;
    • Freathy, Rachel M.;
    • Langenberg, Claudia;
    • Wareham, Nicholas J.;
    • Wood, Andrew R.;
    • Murray, Anna
    Publication type:
    journal article
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    Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion.

    Published in:
    Diabetes, 2015, v. 64, n. 6, p. 2279, doi. 10.2337/db14-1456
    By:
    • Yaghootkar, Hanieh;
    • Stancáková, Alena;
    • Freathy, Rachel M.;
    • Vangipurapu, Jagadish;
    • Weedon, Michael N.;
    • Weijia Xie;
    • Wood, Andrew R.;
    • Ferrannini, Ele;
    • Mari, Andrea;
    • Ring, Susan M.;
    • Lawlor, Debbie A.;
    • Smith, George Davey;
    • Jørgensen, Torben;
    • Hansen, Torben;
    • Pedersen, Oluf;
    • Steinthorsdottir, Valgerdur;
    • Guðbjartsson, Daniel F.;
    • Thorleifsson, Gudmar;
    • Thorsteinsdottir, Unnur;
    • Stefansson, Kari
    Publication type:
    Article
    36

    Genetic Evidence for a Normal-Weight "Metabolically Obese" Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes.

    Published in:
    Diabetes, 2014, v. 63, n. 12, p. 4369, doi. 10.2337/db14-0318
    By:
    • Yaghootkar, Hanieh;
    • Scott, Robert A.;
    • White, Charles C.;
    • Weihua Zhang;
    • Speliotes, Elizabeth;
    • Munroe, Patricia B.;
    • Ehret, Georg B.;
    • Bis, Joshua C.;
    • Fox, Caroline S.;
    • Walker, Mark;
    • Borecki, Ingrid B.;
    • Knowles, Joshua W.;
    • Yerges-Armstrong, Laura;
    • Ohlsson, Claes;
    • Perry, John R. B.;
    • Chambers, John C.;
    • Kooner, Jaspal S.;
    • Franceschini, Nora;
    • Langenberg, Claudia;
    • Hivert, Marie-France
    Publication type:
    Article
    37

    Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes.

    Published in:
    Diabetes, 2013, v. 62, n. 10, p. 3589, doi. 10.2337/db13-0128
    By:
    • Yaghootkar, Hanieh;
    • Lamina, Claudia;
    • Scott, Robert A.;
    • Dastani, Zari;
    • Hivert, Marie-France;
    • Warren, Liling L.;
    • Stancáková, Alena;
    • Buxbaum, Sarah G.;
    • Lyytikäinen, Leo-Pekka;
    • Henneman, Peter;
    • Ying Wu;
    • Cheung, Chloe Y. Y.;
    • Pankow, James S.;
    • Jackson, Anne U.;
    • Gustafsson, Stefan;
    • Jing Hua Zhao;
    • Ballantyne, Christie M.;
    • Weijia Xie;
    • Bergman, Richard N.;
    • Boehnke, Michael
    Publication type:
    Article
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    Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits.

    Published in:
    PLoS Computational Biology, 2020, v. 16, n. 8, p. 1, doi. 10.1371/journal.pcbi.1008044
    By:
    • Glastonbury, Craig A.;
    • Pulit, Sara L.;
    • Honecker, Julius;
    • Censin, Jenny C.;
    • Laber, Samantha;
    • Yaghootkar, Hanieh;
    • Rahmioglu, Nilufer;
    • Pastel, Emilie;
    • Kos, Katerina;
    • Pitt, Andrew;
    • Hudson, Michelle;
    • Nellåker, Christopher;
    • Beer, Nicola L.;
    • Hauner, Hans;
    • Becker, Christian M.;
    • Zondervan, Krina T.;
    • Frayling, Timothy M.;
    • Claussnitzer, Melina;
    • Lindgren, Cecilia M.
    Publication type:
    Article
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    Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.

    Published in:
    Diabetes, 2020, v. 69, n. 12, p. 2806, doi. 10.2337/db20-0070
    By:
    • Yaghootkar, Hanieh;
    • Zhang, Yiying;
    • Spracklen, Cassandra N.;
    • Karaderi, Tugce;
    • Huang, Lam Opal;
    • Bradfield, Jonathan;
    • Schurmann, Claudia;
    • Fine, Rebecca S.;
    • Preuss, Michael H.;
    • Kutalik, Zoltan;
    • Wittemans, Laura B.L.;
    • Lu, Yingchang;
    • Metz, Sophia;
    • Willems, Sara M.;
    • Li-Gao, Ruifang;
    • Grarup, Niels;
    • Wang, Shuai;
    • Molnos, Sophie;
    • Sandoval-Zárate, América A.;
    • Nalls, Mike A.
    Publication type:
    Article
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    A Genetic Variant in the Seed Region of mi R-4513 Shows Pleiotropic Effects on Lipid and Glucose Homeostasis, Blood Pressure, and Coronary Artery Disease.

    Published in:
    Human Mutation, 2014, v. 35, n. 12, p. 1524, doi. 10.1002/humu.22706
    By:
    • Ghanbari, Mohsen;
    • de Vries, Paul S.;
    • de Looper, Hans;
    • Peters, Marjolein J.;
    • Schurmann, Claudia;
    • Yaghootkar, Hanieh;
    • Dörr, Marcus;
    • Frayling, Timothy M.;
    • Uitterlinden, Andre G.;
    • Hofman, Albert;
    • van Meurs, Joyce B. J.;
    • Erkeland, Stefan J.;
    • Franco, Oscar H.;
    • Dehghan, Abbas
    Publication type:
    Article
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    Quantifying the extent to which index event biases influence large genetic association studies.

    Published in:
    Human Molecular Genetics, 2017, v. 26, n. 5, p. 1018, doi. 10.1093/hmg/ddw433
    By:
    • Yaghootkar, Hanieh;
    • Bancks, Michael P.;
    • Jones, Sam E.;
    • McDaid, Aaron;
    • Beaumont, Robin;
    • Donnelly, Louise;
    • Wood, Andrew R.;
    • Campbell, Archie;
    • Tyrrell, Jessica;
    • Hocking, Lynne J.;
    • Tuke, Marcus A.;
    • Ruth, Katherine S.;
    • Pearson, Ewan R.;
    • Murray, Anna;
    • Freathy, Rachel M.;
    • Munroe, Patricia B.;
    • Hayward, Caroline;
    • Palmer, Colin;
    • Weedon, Michael N.;
    • Pankow, James S.
    Publication type:
    Article
    50

    Analysis with the exome array identifies multiple new independent variants in lipid loci.

    Published in:
    Human Molecular Genetics, 2016, v. 25, n. 18, p. 4094, doi. 10.1093/hmg/ddw227
    By:
    • Kanoni, Stavroula;
    • Masca, Nicholas G. D.;
    • Stirrups, Kathleen E.;
    • Varga, Tibor V.;
    • Warren, Helen R.;
    • Scott, Robert A.;
    • Southam, Lorraine;
    • Zhang, Weihua;
    • Yaghootkar, Hanieh;
    • Müller-Nurasyid, Martina;
    • Couto Alves, Alexessander;
    • Strawbridge, Rona J.;
    • Lataniotis, Lazaros;
    • Hashim, Nikman An;
    • Besse, Céline;
    • Boland, Anne;
    • Braund, Peter S.;
    • Connell, John M.;
    • Dominiczak, Anna;
    • Farmaki, Aliki-Eleni
    Publication type:
    Article