Works by Xu, Xuankuo

Results: 27

Modeling scalability of impurity precipitation in downstream biomanufacturing.

Published in:

Biotechnology Progress, 2024, v. 40, n. 4, p. 1, doi. 10.1002/btpr.3454

By:

Guo, Jing;
Traylor, Steven J.;
Agoub, Mohamed;
Jin, Weixin;
Hua, Helen;
Diemer, R. Bertrum;
Xu, Xuankuo;
Ghose, Sanchayita;
Li, Zheng Jian;
Lenhoff, Abraham M.

Publication type:

Article

Analytical characterization of host‐cell‐protein‐rich aggregates in monoclonal antibody solutions.

Published in:

Biotechnology Progress, 2023, v. 39, n. 4, p. 1, doi. 10.1002/btpr.3343

By:

Herman, Chase E.;
Min, Lie;
Choe, Leila H.;
Maurer, Ronald W.;
Xu, Xuankuo;
Ghose, Sanchayita;
Lee, Kelvin H.;
Lenhoff, Abraham M.

Publication type:

Article

Untargeted proteomics reveals upregulation of stress response pathways during CHO-based monoclonal antibody manufacturing process leading to disulfide bond reduction.

Published in:

2021

By:

Park, Seo-Young;
Egan, Susan;
Cura, Anthony J.;
Aron, Kathryn L.;
Xu, Xuankuo;
Zheng, Mengyuan;
Borys, Michael;
Ghose, Sanchayita;
Li, Zhengjian;
Lee, Kyongbum

Publication type:

Report

Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics.

Published in:

mAbs (1942-0862), 2020, v. 12, n. 1, p. 1, doi. 10.1080/19420862.2020.1829338

By:

Chen, Zhiqiang;
Qian, Yueming;
Song, Yuanli;
Xu, Xuankuo;
Tao, Li;
Mussa, Nesredin;
Ghose, Sanchayita;
Li, Zheng Jian

Publication type:

Article

Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study.

Published in:

2020

By:

Xu, Jianlin;
Xu, Xuankuo;
Huang, Chao;
Angelo, James;
Oliveira, Christopher L.;
Xu, Mengmeng;
Xu, Xia;
Temel, Deniz;
Ding, Julia;
Ghose, Sanchayita;
Borys, Michael C.;
Li, Zheng Jian

Publication type:

Report

Protein aggregation and mitigation strategy in low pH viral inactivation for monoclonal antibody purification.

Published in:

2019

By:

Jin, Weixin;
Xing, Zizhuo;
Song, Yuanli;
Huang, Chao;
Xu, Xuankuo;
Ghose, Sanchayita;
Li, Zheng Jian

Publication type:

Report

Improving titer while maintaining quality of final formulated drug substance via optimization of CHO cell culture conditions in low-iron chemically defined media.

Published in:

mAbs (1942-0862), 2018, v. 10, n. 3, p. 488, doi. 10.1080/19420862.2018.1433978

By:

Xu, Jianlin;
Rehmann, Matthew S.;
Xu, Xuankuo;
Huang, Chao;
Tian, Jun;
Qian, Nan-Xin;
Li, Zheng Jian

Publication type:

Article

Role of harvest depth filtration in controlling product-related impurities for a bispecific antibody.

Published in:

Antibody Therapeutics, 2022, v. 5, n. 4, p. 268, doi. 10.1093/abt/tbac023

By:

Borujeni, Ehsan Espah;
Jin, Weixin;
Shao, Chun;
Chennamsetty, Naresh;
Xu, Xuankuo;
Ghose, Sanchayita

Publication type:

Article

Impact of Eco‐Friendly Surfactant Structure and Class on Enveloped Virus Inactivation.

Published in:

Biotechnology Journal, 2025, v. 20, n. 4, p. 1, doi. 10.1002/biot.70023

By:

Sharma, Vaishali;
Manchester, Lynn;
Holstein, Melissa;
Xu, Xuankuo;
Ghose, Sanchayita;
Heldt, Caryn L.

Publication type:

Article

Virus inactivation at moderately low pH varies with virus and buffer properties.

Published in:

Biotechnology Journal, 2022, v. 17, n. 2, p. 1, doi. 10.1002/biot.202100320

By:

Joshi, Pratik U.;
Meingast, Christa L.;
Xu, Xuankuo;
Holstein, Melissa;
Feroz, Hasin;
Ranjan, Swarnim;
Ghose, Sanchayita;
Li, Zheng Jian;
Heldt, Caryn L.

Publication type:

Article

Physiochemical properties of enveloped viruses and arginine dictate inactivation.

Published in:

Biotechnology Journal, 2021, v. 16, n. 7, p. 1, doi. 10.1002/biot.202000342

By:

Meingast, Christa L.;
Joshi, Pratik U.;
Turpeinen, Dylan G.;
Xu, Xuankuo;
Holstein, Melissa;
Feroz, Hasin;
Ranjan, Swarnim;
Ghose, Sanchayita;
Li, Zheng Jian;
Heldt, Caryn L.

Publication type:

Article

Metabolic understanding of disulfide reduction during monoclonal antibody production.

Published in:

Applied Microbiology & Biotechnology, 2020, v. 104, n. 22, p. 9655, doi. 10.1007/s00253-020-10916-1

By:

Cura, Anthony J.;
Xu, Xuankuo;
Egan, Susan;
Aron, Kathryn;
Jenkins, Lauren;
Hageman, Tyler;
Huang, Yunping;
Chollangi, Srinivas;
Borys, Michael;
Ghose, Sanchayita;
Li, Zheng Jian

Publication type:

Article

RETRACTED ARTICLE: Simultaneous expression of antibody light and heavy chains in Pichia pastoris: improving retransformation outcome by linearizing vector at a different site.

Published in:

Applied Microbiology & Biotechnology, 2012, v. 96, n. 5, p. 1381, doi. 10.1007/s00253-012-4347-y

By:

Qian, Yueming;
Xu, Xuankuo;
Xing, Zizhuo;
You, Li;
Dhar, Vineeta;
Qian, Nan-Xin;
Huang, Chao;
Eagan, Bruce;
Pan, Shih-Hsie;
Li, Zheng

Publication type:

Article

Comparison of host cell protein removal by depth filters with diatomaceous earth and synthetic silica filter aids using model proteins.

Published in:

Biotechnology & Bioengineering, 2023, v. 120, n. 7, p. 1882, doi. 10.1002/bit.28386

By:

Chu, Liang‐Kai;
Borujeni, Ehsan Espah;
Xu, Xuankuo;
Ghose, Sanchayita;
Zydney, Andrew L.

Publication type:

Article

Productivity improvement and charge variant modulation for intensified cell culture processes by adding a carboxypeptidase B (CpB) treatment step.

Published in:

Biotechnology & Bioengineering, 2021, v. 118, n. 9, p. 3334, doi. 10.1002/bit.27723

By:

Xu, Jianlin;
Zheng, Shun;
Dawood, Zeinab;
Hill, Charles;
Jin, Weixin;
Xu, Xuankuo;
Ding, Julia;
Borys, Michael C.;
Ghose, Sanchayita;
Li, Zheng Jian;
Pendse, Girish

Publication type:

Article

Continued insights into virus clearance validation across continuous capture chromatography.

Published in:

Biotechnology & Bioengineering, 2021, v. 118, n. 9, p. 3604, doi. 10.1002/bit.27674

By:

Angelo, James M.;
Potter, Kevin;
Müller‐Späth, Thomas;
Xu, Xuankuo;
Li, Zheng Jian;
Ghose, Sanchayita

Publication type:

Article

A CFD model for predicting protein aggregation in low‐pH virial inactivation for mAb production.

Published in:

Biotechnology & Bioengineering, 2020, v. 117, n. 11, p. 3400, doi. 10.1002/bit.27505

By:

Xing, Zizhuo;
Jin, Weixin;
Xu, Xuankuo;
Song, Yuanli;
Huang, Chao;
Borys, Michael C.;
Ghose, Sanchayita;
Li, Zheng Jian

Publication type:

Article

Understanding mAb aggregation during low pH viral inactivation and subsequent neutralization.

Published in:

Biotechnology & Bioengineering, 2020, v. 117, n. 3, p. 687, doi. 10.1002/bit.27237

By:

Wälchli, Ruben;
Ressurreição, Mariana;
Vogg, Sebastian;
Feidl, Fabian;
Angelo, James;
Xu, Xuankuo;
Ghose, Sanchayita;
Jian Li, Zheng;
Le Saoût, Xavier;
Souquet, Jonathan;
Broly, Hervé;
Morbidelli, Massimo

Publication type:

Article

Virus clearance validation across continuous capture chromatography.

Published in:

Biotechnology & Bioengineering, 2019, v. 116, n. 9, p. 2275, doi. 10.1002/bit.27012

By:

Angelo, James;
Chollangi, Srinivas;
Müller‐Späth, Thomas;
Jusyte, Simona;
Xu, Xuankuo;
Ghose, Sanchayita;
Li, Zhengjian

Publication type:

Article

Model‐assisted process characterization and validation for a continuous two‐column protein A capture process.

Published in:

Biotechnology & Bioengineering, 2019, v. 116, n. 1, p. 87, doi. 10.1002/bit.26849

By:

Baur, Daniel;
Angelo, James;
Chollangi, Srinivas;
Müller‐Späth, Thomas;
Xu, Xuankuo;
Ghose, Sanchayita;
Li, Zheng Jian;
Morbidelli, Massimo

Publication type:

Article

Mechanisms of precipitate formation during the purification of an Fc‐fusion protein.

Published in:

Biotechnology & Bioengineering, 2018, v. 115, n. 10, p. 2489, doi. 10.1002/bit.26746

By:

Greene, Daniel G.;
Traylor, Steven J.;
Guo, Jing;
Choe, Leila H.;
Modla, Shannon;
Xu, Xuankuo;
Singh, Nripen;
Lock, Lye Lin;
Ghose, Sanchayita;
Li, Zheng Jian;
Lee, Kelvin H.;
Wagner, Norman J.;
Lenhoff, Abraham M.

Publication type:

Article

Early identification of unusually clustered mutations and root causes in therapeutic antibody development.

Published in:

Biotechnology & Bioengineering, 2018, v. 115, n. 9, p. 2377, doi. 10.1002/bit.26728

By:

Qian, Yueming;
Chen, Zhiqiang;
Huang, Xin;
Wang, Xuning;
Xu, Xuankuo;
Kirov, Stefan;
Ludwig, Richard;
Qian, Nan‐Xin;
Ravi, Kandasamy;
Tao, Li;
Borys, Michael C.;
Li, Zheng Jian

Publication type:

Article

High‐efficiency affinity precipitation of multiple industrial mAbs and Fc‐fusion proteins from cell culture harvests using Z‐ELP‐E2 nanocages.

Published in:

Biotechnology & Bioengineering, 2018, v. 115, n. 8, p. 2039, doi. 10.1002/bit.26717

By:

Swartz, Andrew R.;
Xu, Xuankuo;
Traylor, Steven J.;
Li, Zheng Jian;
Chen, Wilfred

Publication type:

Article

Contributions of depth filter components to protein adsorption in bioprocessing.

Published in:

Biotechnology & Bioengineering, 2018, v. 115, n. 8, p. 1938, doi. 10.1002/bit.26707

By:

Khanal, Ohnmar;
Singh, Nripen;
Traylor, Steven J.;
Xu, Xuankuo;
Ghose, Sanchayita;
Li, Zheng J.;
Lenhoff, Abraham M.

Publication type:

Article

One-step affinity capture and precipitation for improved purification of an industrial monoclonal antibody using Z-ELP functionalized nanocages.

Published in:

Biotechnology & Bioengineering, 2018, v. 115, n. 2, p. 423, doi. 10.1002/bit.26467

By:

Swartz, Andrew R.;
Xu, Xuankuo;
Traylor, Steven J.;
Li, Zheng J.;
Chen, Wilfred

Publication type:

Article

Clarification and capture of high-concentration refold pools for E. coli-based therapeutics using expanded bed adsorption chromatography.

Published in:

Biotechnology Progress, 2014, v. 30, n. 1, p. 113, doi. 10.1002/btpr.1833

By:

Xu, Xuankuo;
Hirpara, Jeet;
Epting, Kevin;
Jin, Mi;
Ghose, Sanchayita;
Rieble, Siegfried;
Li, Zheng Jian

Publication type:

Article

Disaggregation of high-molecular weight species during downstream processing to recover functional monomer.

Published in:

Biotechnology Progress, 2010, v. 26, n. 3, p. 717, doi. 10.1002/btpr.373

By:

Xu, Xuankuo;
Didio, David M.;
Leister, Kirk J.;
Ghose, Sanchayita

Publication type:

Article