Works by Xu, Heping

Results: 112

Peripheral blood mononuclear cells from neovascular age-related macular degeneration patients produce higher levels of chemokines CCL2 (MCP-1) and CXCL8 (IL-8).

Published in:

2017

By:

Lechner, Judith;
Mei Chen;
Hogg, Ruth E.;
Toth, Levente;
Silvestri, Giuliana;
Chakravarthy, Usha;
Heping Xu;
Chen, Mei;
Xu, Heping

Publication type:

journal article

Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration.

Published in:

2015

By:

Scholz, Rebecca;
Caramoy, Albert;
Bhuckory, Mohajeet B.;
Rashid, Khalid;
Mei Chen;
Heping Xu;
Grimm, Christian;
Langmann, Thomas;
Chen, Mei;
Xu, Heping

Publication type:

journal article

The multi-organ landscape of B cells highlights dysregulated memory B cell responses in Crohn's disease.

Published in:

National Science Review, 2025, v. 12, n. 4, p. 1, doi. 10.1093/nsr/nwaf009

By:

Chen, Dianyu;
Xu, Song;
Li, Shuyan;
Wang, Qiuying;
Li, Hui;
He, Danyang;
Chen, Yan;
Xu, Heping

Publication type:

Article

Associations between triglyceride-glucose body mass index and all-cause mortality in ICU patients with sepsis and acute heart failure.

Published in:

BMC Cardiovascular Disorders, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12872-025-04804-7

By:

Xu, Heping;
Xie, Jinyuan;
Niu, Huan;
Cai, Xiongwei;
He, Ping

Publication type:

Article

Retinal pigment epithelial cell multinucleation in the aging eye - a mechanism to repair damage and maintain homoeostasis.

Published in:

Aging Cell, 2016, v. 15, n. 3, p. 436, doi. 10.1111/acel.12447

By:

Chen, Mei;
Rajapakse, Dinusha;
Fraczek, Monika;
Luo, Chang;
Forrester, John V.;
Xu, Heping

Publication type:

Article

Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice.

Published in:

Aging Cell, 2008, v. 7, n. 1, p. 58, doi. 10.1111/j.1474-9726.2007.00351.x

By:

Heping Xu;
Mei Chen;
Manivannan, Ayyakkannu;
Lois, Noemi;
Forrester, John V.

Publication type:

Article

Effect of anti-macrophage inflammatory protein-1α on leukocyte trafficking and disease progression in experimental autoimmune uveoretinitis.

Published in:

European Journal of Immunology, 2003, v. 33, n. 2, p. 402, doi. 10.1002/immu.200310014

By:

Crane, Isabel J.;
Xu, Heping;
Manivannan, Ayyakkannu;
McKillop-Smith, Susan;
Lamont, Graeme;
Wallace, Carol;
Liversidge, Janet;
Sharp, Peter F.;
Forrester, John V.

Publication type:

Article

Relaxation of mitochondrial hyperfusion in the diabetic retina via N6-furfuryladenosine confers neuroprotection regardless of glycaemic status.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-45387-9

By:

Anderson, Aidan;
Alfahad, Nada;
Wimalachandra, Dulani;
Bouzinab, Kaouthar;
Rudzinska, Paula;
Wood, Heather;
Fazey, Isabel;
Xu, Heping;
Lyons, Timothy J.;
Barnes, Nicholas M.;
Narendran, Parth;
Lord, Janet M.;
Rauz, Saaeha;
Ganley, Ian G.;
Curtis, Tim M.;
Wallace, Graham R.;
Hombrebueno, Jose R.

Publication type:

Article

Sustained intraocular vascular endothelial growth factor neutralisation does not affect retinal and choroidal vasculature in Ins2 Akita diabetic mice.

Published in:

Diabetes & Vascular Disease Research, 2019, v. 16, n. 5, p. 440, doi. 10.1177/1479164119843092

By:

Lechner, Judith;
Hombrebueno, Jose R;
Pedrini, Edoardo;
Chen, Mei;
Xu, Heping

Publication type:

Article

Old age promotes retinal fibrosis in choroidal neovascularization through circulating fibrocytes and profibrotic macrophages.

Published in:

Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-023-02731-y

By:

Yi, Caijiao;
Liu, Jian;
Deng, Wen;
Luo, Chang;
Qi, Jinyan;
Chen, Mei;
Xu, Heping

Publication type:

Article

Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis.

Published in:

Immunity & Ageing, 2020, v. 17, n. 1, p. 1, doi. 10.1186/s12979-020-00205-w

By:

Chen, Mei;
Yang, Nan;
Lechner, Judith;
Toth, Levente;
Hogg, Ruth;
Silvestri, Giuliana;
Chakravarthy, Usha;
Xu, Heping

Publication type:

Article

Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration.

Published in:

Immunity & Ageing, 2016, v. 13, p. 1, doi. 10.1186/s12979-016-0060-5

By:

Lechner, Judith;
Mei Chen;
Hogg, Ruth E.;
Toth, Levente;
Silvestri, Giuliana;
Chakravarthy, Usha;
Heping Xu

Publication type:

Article

Ileum tissue single-cell mRNA sequencing elucidates the cellular architecture of pathophysiological changes associated with weaning in piglets.

Published in:

BMC Biology, 2022, v. 20, n. 1, p. 1, doi. 10.1186/s12915-022-01321-3

By:

Tang, Wenjie;
Zhong, Yifan;
Wei, Yusen;
Deng, Zhaoxi;
Mao, Jiangdi;
Liu, Jingliang;
Valencak, Teresa G.;
Liu, Jianxin;
Xu, Heping;
Wang, Haifeng

Publication type:

Article

Cowpea Chlorotic Mottle Virus‐Like Particles as Potential Platform for Antisense Oligonucleotide Delivery in Posterior Segment Ocular Diseases.

Published in:

Macromolecular Bioscience, 2021, v. 21, n. 8, p. 1, doi. 10.1002/mabi.202100095

By:

Pretto, Chiara;
Tang, Miao;
Chen, Mei;
Xu, Heping;
Subrizi, Astrid;
Urtti, Arto;
van Hest, Jan C. M.

Publication type:

Article

Para-inflammation-mediated retinal recruitment of bone marrow-derived myeloid cells following whole-body irradiation is CCL2 dependent.

Published in:

Glia (0894-1491), 2012, v. 60, n. 5, p. 833, doi. 10.1002/glia.22315

By:

Chen, Mei;
Zhao, Jiawu;
Luo, Chang;
Pandi, Sudha Priya Soundara;
Penalva, Rosana G.;
Fitzgerald, Denise C.;
Xu, Heping

Publication type:

Article

Turnover of resident retinal microglia in the normal adult mouse.

Published in:

Glia (0894-1491), 2007, v. 55, n. 11, p. 1189, doi. 10.1002/glia.20535

By:

Xu, Heping;
Chen, Mei;
Mayer, Eric J.;
Forrester, John V.;
Dick, Andrew D.

Publication type:

Article

Effect of continuous nursing based on life network on anxiety state and quality of life of patients with coronary heart disease.

Published in:

Minerva Surgery, 2023, v. 78, n. 3, p. 341, doi. 10.23736/S2724-5691.21.09198-X

By:

Jinyuan XIE;
Yan XIA;
Shuai MAO;
Siyuan HUANG;
Heping XU

Publication type:

Article

Minocycline Inhibits Microglial Activation and Improves Visual Function in a Chronic Model of Age-Related Retinal Degeneration.

Published in:

Biomedicines, 2022, v. 10, n. 12, p. 3222, doi. 10.3390/biomedicines10123222

By:

Du, Xuan;
Byrne, Eimear M.;
Chen, Mei;
Xu, Heping

Publication type:

Article

Wedelolactone Attenuates N-methyl-N-nitrosourea-Induced Retinal Neurodegeneration through Suppression of the AIM2/CASP11 Pathway.

Published in:

Biomedicines, 2022, v. 10, n. 2, p. 311, doi. 10.3390/biomedicines10020311

By:

Harkin, Kevin;
Augustine, Josy;
Stitt, Alan W.;
Xu, Heping;
Chen, Mei

Publication type:

Article

IL-17A Damages the Blood–Retinal Barrier through Activating the Janus Kinase 1 Pathway.

Published in:

Biomedicines, 2021, v. 9, n. 7, p. 831, doi. 10.3390/biomedicines9070831

By:

Byrne, Eimear M.;
Llorián-Salvador, María;
Tang, Miao;
Margariti, Andriana;
Chen, Mei;
Xu, Heping

Publication type:

Article

Natural killer cells promote neutrophil extracellular traps and restrain macular degeneration in mice.

Published in:

Science Translational Medicine, 2024, v. 16, n. 760, p. 1, doi. 10.1126/scitranslmed.adi6626

By:

Dong, Xue;
Song, Yinting;
Liu, Yuming;
Kou, Xuejing;
Yang, Tianjing;
Shi, Samuel X.;
He, Kai;
Li, Yiming;
Li, Ziqi;
Yao, Xueming;
Guo, Ju;
Cui, Bohao;
Wu, Ziru;
Lei, Yi;
Du, Mei;
Chen, Mei;
Xu, Heping;
Liu, Qiang;
Shi, Fu-Dong;
Wang, Xiaohong

Publication type:

Article

Modulation of three key innate immune pathways for the most common retinal degenerative diseases.

Published in:

EMBO Molecular Medicine, 2018, v. 10, n. 10, p. N.PAG, doi. 10.15252/emmm.201708259

By:

Akhtar‐Schäfer, Isha;
Wang, Luping;
Krohne, Tim U;
Xu, Heping;
Langmann, Thomas

Publication type:

Article

MALDI-TOF MS-Based Clustering and Antifungal Susceptibility Tests of Talaromyces marneffei Isolates from Fujian and Guangxi (China).

Published in:

Infection & Drug Resistance, 2022, v. 15, p. 3449, doi. 10.2147/IDR.S364439

By:

Fang, Lili;
Liu, Minxue;
Huang, Chunlan;
Ma, Xiaobo;
Zheng, Yanqing;
Wu, Wenjuan;
Guo, Jian;
Huang, Jiangshan;
Xu, Heping

Publication type:

Article

Acute Post-Cataract Endophthalmitis Due to Phialemoniopsis curvata: A Rare Case Report.

Published in:

2022

By:

Tang, Mengli;
Li, Jun;
Xia, Fengjun;
Min, Changhang;
Liu, Zhaojun;
Hu, Yongmei;
Wang, Haichen;
Xu, Heping;
Zou, Mingxiang

Publication type:

Case Study

Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology.

Published in:

Journal of Cellular & Molecular Medicine, 2018, v. 22, n. 11, p. 5552, doi. 10.1111/jcmm.13829

By:

Cao, Lin;
Liu, Jie;
Pu, Jin;
Milne, Gillian;
Chen, Mei;
Xu, Heping;
Shipley, Alan;
Forrester, John V;
McCaig, Colin D;
Lois, Noemi

Publication type:

Article

Wnt signaling in age-related macular degeneration: human macular tissue and mouse model.

Published in:

2015

By:

Jingsheng Tuo;
Yujuan Wang;
Rui Cheng;
Yichao Li;
Mei Chen;
Fangfang Qiu;
Haohua Qian;
Defen Shen;
Penalva, Rosana;
Heping Xu;
Jian-Xing Ma;
Chi-Chao Chan;
Tuo, Jingsheng;
Wang, Yujuan;
Cheng, Rui;
Li, Yichao;
Chen, Mei;
Qiu, Fangfang;
Qian, Haohua;
Shen, Defen

Publication type:

journal article

Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration.

Published in:

2022

By:

Tabel, Mona;
Wolf, Anne;
Szczepan, Manon;
Xu, Heping;
Jägle, Herbert;
Moehle, Christoph;
Chen, Mei;
Langmann, Thomas

Publication type:

journal article

Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells.

Published in:

Journal of Neuroinflammation, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12974-022-02546-3

By:

Llorián-Salvador, María;
Byrne, Eimear M.;
Szczepan, Manon;
Little, Karis;
Chen, Mei;
Xu, Heping

Publication type:

Article

Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells.

Published in:

2022

By:

Llorián-Salvador, María;
Byrne, Eimear M.;
Szczepan, Manon;
Little, Karis;
Chen, Mei;
Xu, Heping

Publication type:

journal article

Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis.

Published in:

2022

By:

Yi, Caijiao;
Liu, Jian;
Deng, Wen;
Luo, Chang;
Qi, Jinyan;
Chen, Mei;
Xu, Heping

Publication type:

journal article

Macrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration.

Published in:

2020

By:

Little, Karis;
Llorián-Salvador, Maria;
Tang, Miao;
Du, Xuan;
Marry, Stephen;
Chen, Mei;
Xu, Heping

Publication type:

journal article

Sustained high glucose exposure sensitizes macrophage responses to cytokine stimuli but reduces their phagocytic activity.

Published in:

BMC Immunology, 2018, v. 19, n. 1, p. N.PAG, doi. 10.1186/s12865-018-0261-0

By:

Pavlou, Sofia;
Lindsay, Jaime;
Ingram, Rebecca;
Xu, Heping;
Chen, Mei

Publication type:

Article

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility.

Published in:

Nature, 2013, v. 496, n. 7446, p. 523, doi. 10.1038/nature12058

By:

Xu, Heping;
Li, Xuanying;
Liu, Dan;
Li, Jianfu;
Zhang, Xu;
Chen, Xin;
Hou, Shiyue;
Peng, Lixia;
Xu, Chenguang;
Liu, Wanli;
Zhang, Lianfeng;
Qi, Hai

Publication type:

Article

Protein O-GlcNAcylation coupled to Hippo signaling drives vascular dysfunction in diabetic retinopathy.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-53601-x

By:

Lei, Yi;
Liu, Qiangyun;
Chen, Binggui;
Wu, Fangfang;
Li, Yiming;
Dong, Xue;
Ma, Nina;
Wu, Ziru;
Zhu, Yanfang;
Wang, Lu;
Fu, Yuxin;
Liu, Yuming;
Song, Yinting;
Du, Mei;
Zhang, Heng;
Zhu, Jidong;
Lyons, Timothy J.;
Wang, Ting;
Hu, Junhao;
Xu, Heping

Publication type:

Article

Expert consensus on prevention and cardiopulmonary resuscitation for cardiac arrest in COVID-19.

Published in:

Asian Pacific Journal of Tropical Medicine, 2021, v. 14, n. 6, p. 241, doi. 10.4103/1995-7645.315897

By:

Song, Wei;
Wei, Jie;
Jian, Xiangdong;
Wang, Deren;
Ouyang, Yanhong;
Liu, Yuanshui;
Du, Xianjin;
Chen, Ying;
Zhang, Yingqi;
Xu, Heping;
Xianyu, Shuming;
Ning, Qiong;
Li, Xiang;
Han, Xiaotong;
Zhan, Feng;
Yu, Tao;
Chen, Wenteng;
Zhang, Jun;
Cai, Wenwei;
Zhou, Sheng'ang

Publication type:

Article

Immune Cells in Subretinal Wound Healing and Fibrosis.

Published in:

Frontiers in Cellular Neuroscience, 2022, v. 16, p. 1, doi. 10.3389/fncel.2022.916719

By:

Szczepan, Manon;
Llorián-Salvador, María;
Chen, Mei;
Xu, Heping

Publication type:

Article

Preparation, mechanical properties of waterborne polyurethane and crosslinked polyurethane-acrylate composite.

Published in:

Journal of Applied Polymer Science, 2012, v. 124, n. 2, p. 958, doi. 10.1002/app.35127

By:

Xu, Heping;
Qiu, Fengxian;
Wang, Yingying;
Yang, Dongya;
Wu, Wenling;
Chen, Zusheng;
Zhu, Junhua

Publication type:

Article

Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes.

Published in:

Diabetologia, 2018, v. 61, n. 11, p. 2433, doi. 10.1007/s00125-018-4682-3

By:

Hombrebueno, Jose R.;
Ali, Imran H. A.;
Ma, Jian-xing;
Chen, Mei;
Xu, Heping

Publication type:

Article

Association of PIV value with early mortality in ICU patients with sepsis-associated acute kidney injury from the MIMIC IV database.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-96320-z

By:

Xu, Heping;
Cai, Xinyi;
Niu, Huan;
Cai, Xiongwei;
He, Ping;
Ouyang, Yanhong

Publication type:

Article

Epidemiology and Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae and Subsequent MALDI-TOF MS as a Tool to Cluster KPC-2-Producing Klebsiella Pneumoniae , a Retrospective Study.

Published in:

Frontiers in Cellular & Infection Microbiology, 2020, v. 10, p. N.PAG, doi. 10.3389/fcimb.2020.00462

By:

Fang, Lili;
Xu, Heping;
Ren, Xiaoying;
Li, Xun;
Ma, Xiaobo;
Zhou, Haijian;
Hong, Guolin;
Liang, Xianming

Publication type:

Article

Comprehensive analysis of mouse retinal mononuclear phagocytes.

Published in:

Nature Protocols, 2017, v. 12, n. 6, p. 1136, doi. 10.1038/nprot.2017.032

By:

Lückoff, Anika;
Scholz, Rebecca;
Sennlaub, Florian;
Xu, Heping;
Langmann, Thomas

Publication type:

Article

Single‐cell RNA sequencing study of retinal immune regulators identified CD47 and CD59a expression in photoreceptors—Implications in subretinal immune regulation.

Published in:

Journal of Neuroscience Research, 2020, v. 98, n. 7, p. 1498, doi. 10.1002/jnr.24618

By:

Liu, Jian;
Tang, Miao;
Harkin, Kevin;
Du, Xuan;
Luo, Chang;
Chen, Mei;
Xu, Heping

Publication type:

Article

Intraocular complement activation is related to retinal vascular and neuronal degeneration in myopic retinopathy.

Published in:

Frontiers in Cellular Neuroscience, 2023, p. 1, doi. 10.3389/fncel.2023.1187400

By:

Ling Zeng;
Xiaoning Li;
Wei Pan;
Yao Tang;
Ding Lin;
Min Wang;
Wang Cai;
Ruiling Zhu;
Jianbo Wan;
Linghua Huang;
Heping Xu;
Zhikuan Yang

Publication type:

Article

Increased intraocular inflammation in retinal vein occlusion is independent of circulating immune mediators and is involved in retinal oedema.

Published in:

Frontiers in Neuroscience, 2023, p. 1, doi. 10.3389/fnins.2023.1186025

By:

Yufan Zhou;
Jinyan Qi;
Hengwei Liu;
Shengnan Liang;
Tingting Guo;
Juan Chen;
Wei Pan;
Huanhuan Tan;
Jie Wang;
Heping Xu;
Zhongping Chen

Publication type:

Article

Deletion of Socs3 in LysM+ cells and Cx3cr1 resulted in age-dependent development of retinal microgliopathy.

Published in:

Molecular Neurodegeneration, 2021, v. 16, n. 1, p. 1, doi. 10.1186/s13024-021-00432-9

By:

Du, Xuan;
Penalva, Rosana;
Little, Karis;
Kissenpfennig, Adrien;
Chen, Mei;
Xu, Heping

Publication type:

Article

Subcutaneous phaeohyphomycosis caused by Hongkongmyces snookiorum in a kidney transplant patient: a case report.

Published in:

2020

By:

Linqiang, Deng;
Yiguo, Chen;
Heping, Xu;
Dongke, Chen;
Longhua, Hu;
Xiaomei, Gui;
Xia, Zou

Publication type:

journal article

T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction.

Published in:

Nature, 2015, v. 517, n. 7533, p. 214, doi. 10.1038/nature13803

By:

Liu, Dan;
Xu, Heping;
Shih, Changming;
Wan, Zurong;
Ma, Xiaopeng;
Ma, Weiwei;
Luo, Dan;
Qi, Hai

Publication type:

Article

Good newsbad news: the Yin and Yang of immune privilege in the eye.

Published in:

Frontiers in Immunology, 2012, v. 3, p. 1, doi. 10.3389/fimmu.2012.00338

By:

Forrester, John V.;
Heping Xu

Publication type:

Article

Good news - bad news: the Yin and Yang of immune privilege in the eye.

Published in:

Frontiers in Immunology, 2012, v. 3, p. 1, doi. 10.3389/fimmu.2012.00338

By:

Forrester, John V.;
Heping Xu

Publication type:

Article

Listeriosis Cases and Genetic Diversity of Their L. monocytogenes Isolates in China, 2008–2019.

Published in:

Frontiers in Cellular & Infection Microbiology, 2021, v. 11, p. N.PAG, doi. 10.3389/fcimb.2021.608352

By:

Lu, Binghuai;
Yang, Junwen;
Gao, Chunyan;
Li, Dong;
Cui, Yanchao;
Huang, Lei;
Chen, Xingchun;
Wang, Duochun;
Wang, Aiping;
Liu, Yulei;
Li, Yi;
Zhang, Zhijun;
Jiao, Mingyuan;
Xu, Heping;
Song, Yu;
Fu, Baoqing;
Xu, Lili;
Yang, Qing;
Ning, Yongzhong;
Wang, Lijun

Publication type:

Article