Works by Xiukun LIN

Results: 61

Interaction between Maslinic acid and HSF1 enhances the ubiquitin degradation of HSF1, resulting in the inhibitory effect of pancreatic cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02786-8

By:

Cheng, Li;
Guo, Mingyue;
Farooqi, Ammad Ahmad;
Wang, Linlin;
Zhang, Yuxi;
Ye, Hanlin;
Qiao, Gan;
Lin, Xiukun

Publication type:

Article

Alpinia katsumadai Hayata induces growth inhibition and autophagy-related apoptosis by regulating the AMPK and Akt/mTOR/p70S6K signaling pathways in cancer cells.

Published in:

Oncology Reports, 2022, v. 48, n. 2, p. N.PAG, doi. 10.3892/or.2022.8353

By:

An, Weixiao;
Zhang, Yuxi;
Lai, Honglin;
Zhang, Yangyang;
Zhang, Hongmei;
Zhao, Ge;
Liu, Minghua;
Li, Yang;
Lin, Xiukun;
Cao, Shousong

Publication type:

Article

Oleanolic acid arrests cell cycle and induces apoptosis via ROS-mediated mitochondrial depolarization and lysosomal membrane permeabilization in human pancreatic cancer cells.

Published in:

Journal of Applied Toxicology, 2013, v. 33, n. 8, p. 756, doi. 10.1002/jat.2725

By:

Wei, Jianteng;
Liu, Ming;
Liu, Haizhou;
Wang, Hui;
Wang, Fengxia;
Zhang, Yuyan;
Han, Lijun;
Lin, Xiukun

Publication type:

Article

Role of cysteine amino acid residues on the RNA binding activity of human thymidylate synthase.

Published in:

Nucleic Acids Research, 2003, v. 31, n. 16, p. 4882, doi. 10.1093/nar/gkg678

By:

Lin, Xiukun;
Liu, Jun;
Maley, Frank;
Chu, Edward

Publication type:

Article

In vitro studies of polyethyleneimine coated miRNA microspheres as anticancer agents.

Published in:

Nano Research, 2016, v. 9, n. 6, p. 1609, doi. 10.1007/s12274-016-1055-4

By:

Rytblat, Irena;
Wu, Ning;
Xu, Huangli;
Gedanken, Aharon;
Lin, Xiukun

Publication type:

Article

Sequence Analysis and Functional Study of Thymidylate Synthase from Zebrafish, Danio rerio.

Published in:

Journal of Biochemistry, 2006, v. 139, n. 5, p. 913, doi. 10.1093/jb/mvj100

By:

Changqing Du;
Rongli Niu;
Chu, Edward;
Peijun Zhang;
Xiukun Lin

Publication type:

Article

Enolase 1, a Moonlighting Protein, as a Potential Target for Cancer Treatment.

Published in:

International Journal of Biological Sciences, 2021, v. 17, n. 14, p. 3981, doi. 10.7150/ijbs.63556

By:

Gan Qiao;
Anguo Wu;
Xiaoliang Chen;
Ye Tian;
Xiukun Lin

Publication type:

Article

Active fraction of clove induces apoptosis via PI3K/Akt/mTOR-mediated autophagy in human colorectal cancer HCT-116 cells.

Published in:

International Journal of Oncology, 2018, v. 53, n. 3, p. 1363, doi. 10.3892/ijo.2018.4465

By:

Liu, Minghua;
Zhao, Ge;
Zhang, Dan;
An, Weixiao;
Lai, Honglin;
Li, Xiaofang;
Cao, Shousong;
Lin, Xiukun

Publication type:

Article

Exosomes-Coated miR-34a Displays Potent Antitumor Activity in Pancreatic Cancer Both in vitro and in vivo.

Published in:

Drug Design, Development & Therapy, 2020, v. 14, p. 3495, doi. 10.2147/DDDT.S265423

By:

Zuo, Ling;
Tao, Hongyu;
Xu, Huanli;
Li, Cong;
Qiao, Gan;
Guo, Mingyue;
Cao, Shousong;
Liu, Minghua;
Lin, Xiukun

Publication type:

Article

Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 2735, doi. 10.2147/DDDT.S80902

By:

Huanli Xu;
Xin Zhao;
Xiaohui Liu;
Pingxiang Xu;
Keming Zhang;
Xiukun Lin

Publication type:

Article

Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells.

Published in:

Drug Design, Development & Therapy, 2015, v. 9, p. 1797, doi. 10.2147/DDDT.S77341

By:

Xiukun Lin;
Farooqi, Ammad Ahmad;
Ismail, Muhammad

Publication type:

Article

Prostate Cancer Stem Cells: Viewing Signaling Cascades at a Finer Resolution.

Published in:

Archivum Immunologiae & Therapiae Experimentalis, 2016, v. 64, n. 3, p. 217, doi. 10.1007/s00005-016-0383-0

By:

Lin, Xiukun;
Farooqi, Ammad;
Qureshi, Muhammad;
Romero, Mirna;
Tabassum, Sobia;
Ismail, Muhammad

Publication type:

Article

Granulin A Synergizes with Cisplatin to Inhibit the Growth of Human Hepatocellular Carcinoma.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 10, p. 3060, doi. 10.3390/ijms19103060

By:

Qiao, Gan;
Xu, Huanli;
Li, Cong;
Li, Xiao;
Farooqi, Ammad Ahmad;
Zhao, Yuming;
Liu, Xiaohui;
Liu, Ming;
Stagos, Dimitrios;
Lin, Xiukun

Publication type:

Article

Transcriptome and proteome analysis reveals the anti-cancer properties of Hypnea musciformis marine macroalga extract in liver and intestinal cancer cells.

Published in:

Human Genomics, 2023, v. 17, n. 1, p. 1, doi. 10.1186/s40246-023-00517-0

By:

Begolli, Rodiola;
Chatziangelou, Myrto;
Samiotaki, Martina;
Goutas, Andreas;
Barda, Sofia;
Goutzourelas, Nikolaos;
Kevrekidis, Dimitrios Phaedon;
Malea, Paraskevi;
Trachana, Varvara;
Liu, Ming;
Lin, Xiukun;
Kollatos, Nikolaos;
Stagos, Dimitrios;
Giakountis, Antonis

Publication type:

Article

Antioxidant Activity and Inhibition of Liver Cancer Cells' Growth of Extracts from 14 Marine Macroalgae Species of the Mediterranean Sea.

Published in:

Foods, 2023, v. 12, n. 6, p. 1310, doi. 10.3390/foods12061310

By:

Goutzourelas, Nikolaos;
Kevrekidis, Dimitrios Phaedon;
Barda, Sofia;
Malea, Paraskevi;
Trachana, Varvara;
Savvidi, Stavroula;
Kevrekidou, Alkistis;
Assimopoulou, Andreana N.;
Goutas, Andreas;
Liu, Ming;
Lin, Xiukun;
Kollatos, Nikolaos;
Amoutzias, Grigorios D.;
Stagos, Dimitrios

Publication type:

Article

Mere15, a novel polypeptide from Meretrix meretrix, inhibits proliferation and metastasis of human non-small cell lung cancer cells through regulating the PI3K/Akt/mTOR signaling pathway.

Published in:

Neoplasma, 2021, v. 68, n. 6, p. 1181, doi. 10.4149/neo_2021_210509N628

By:

Biantiao XU;
Mingyue GUO;
Li MA;
FAROOQI, Ammad Ahmad;
Linlin WANG;
Gan QIAO;
Minghua LIU;
Ling ZUO;
Hanlin YE;
Xiukun LIN;
Shousong CAO

Publication type:

Article

Suppression of zebrafish VEGF gene by cytomegalovirus promoter-driven short hairpin constructs induces vascular development defects and down regulation NRP1 expression.

Published in:

Biologia, 2009, v. 64, n. 5, p. 1025, doi. 10.2478/s11756-009-0154-z

By:

Yang, ShaoLi;
Yan, Song;
Qin, Song;
Lin, XiuKun

Publication type:

Article

A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma.

Published in:

Experimental Biology & Medicine, 2012, v. 237, n. 4, p. 442, doi. 10.1258/ebm.2012.011337

By:

Cuicui Wang;
Ming Liu;
Linyou Cheng;
Jianteng Wei;
Ning Wu;
Lanhong Zheng;
Xiukun Lin

Publication type:

Article

Identification of Streptomyces sp. nov. WH26 producing cytotoxic compounds isolated from marine solar saltern in China.

Published in:

World Journal of Microbiology & Biotechnology, 2013, v. 29, n. 7, p. 1271, doi. 10.1007/s11274-013-1290-8

By:

Liu, Haizhou;
Xiao, Lin;
Wei, Jianteng;
Schmitz, John;
Liu, Ming;
Wang, Cuicui;
Cheng, Linyou;
Wu, Ning;
Chen, Lei;
Zhang, Yuyan;
Lin, Xiukun

Publication type:

Article

Characterization of the high cytochalasin E and rosellichalasin producing- Aspergillus sp. nov. F1 isolated from marine solar saltern in China.

Published in:

World Journal of Microbiology & Biotechnology, 2013, v. 29, n. 1, p. 11, doi. 10.1007/s11274-012-1152-9

By:

Xiao, Lin;
Liu, Haizhou;
Wu, Ning;
Liu, Ming;
Wei, Jianteng;
Zhang, Yuyan;
Lin, Xiukun

Publication type:

Article

Phylogenetic analysis and screening of antimicrobial and cytotoxic activities of moderately halophilic bacteria isolated from the Weihai Solar Saltern (China).

Published in:

World Journal of Microbiology & Biotechnology, 2010, v. 26, n. 5, p. 879, doi. 10.1007/s11274-009-0247-4

By:

Lei Chen;
Guangyu Wang;
Tong Bu;
Yunbin Zhang;
Yixin Wang;
Ming Liu;
Xiukun Lin

Publication type:

Article

In vitro selection of an RNA sequence that interacts with high affinity with thymidylate synthase.

Published in:

Nucleic Acids Research, 2000, v. 28, n. 21, p. 4266, doi. 10.1093/nar/28.21.4266

By:

Lin, Xiukun;
Mizunuma, Nobuyuki;
Chen, Tian-men;
Copur, Sitki M.;
Maley, Gladys F.;
Liu, Jun;
Maley, Frank;
Chu, Edward

Publication type:

Article

Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA.

Published in:

Nucleic Acids Research, 2000, v. 28, n. 6, p. 1381, doi. 10.1093/nar/28.6.1381

By:

Lin, Xiukun;
Parsels, Leslie A.;
Voeller, Donna M.;
Allegra, Carmen J.;
Maley, Gladys F.;
Maley, Frank;
Chu, Edward

Publication type:

Article

Synthesis of butyl-isobutyl-phthalate and its interaction with α-glucosidase in vitro.

Published in:

Journal of Biochemistry, 2011, v. 149, n. 1, p. 27, doi. 10.1093/jb/mvq110

By:

Liu, Ming;
Zhang, Wei;
Qiu, Lin;
Lin, Xiukun

Publication type:

Article

miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2

Published in:

FEBS Letters, 2012, v. 586, n. 21, p. 3831, doi. 10.1016/j.febslet.2012.08.023

By:

Wu, Ning;
Xiao, Lin;
Zhao, Xiangzhong;
Zhao, Jin;
Wang, Jianpeng;
Wang, Fengxia;
Cao, Shousong;
Lin, XiuKun

Publication type:

Article

Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment

Published in:

FEBS Letters, 2012, v. 586, n. 8, p. 1220, doi. 10.1016/j.febslet.2012.03.025

By:

Zhao, Xiangzhong;
Wu, Ning;
Ding, Lili;
Liu, Ming;
Liu, Haizhou;
Lin, Xiukun

Publication type:

Article

A Novel Polypeptide Extracted From Ciona savignyi Induces Apoptosis Through a Mitochondrial-Mediated Pathway in Human Colorectal Carcinoma Cells.

Published in:

2012

By:

Cheng, Linyou;
Wang, Chunguang;
Liu, Haizhou;
Wang, Fengxia;
Zheng, Lanhong;
Zhao, Jin;
Chu, Edward;
Lin, Xiukun

Publication type:

Journal Article

Regulation of signaling pathways by β‐elemene in cancer progression and metastasis.

Published in:

Journal of Cellular Biochemistry, 2019, v. 120, n. 8, p. 12091, doi. 10.1002/jcb.28624

By:

Qureshi, Muhammad Z.;
Attar, Rukset;
Romero, Mirna A.;
Sabitaliyevich, Uteuliyev Y.;
Nurmurzayevich, Sadykov B.;
Ozturk, Ozlem;
Wakim, Lara H.;
Lin, Xiukun;
Ozbey, Ulku;
Yelekenova, Armida Bakhytbekovna;
Farooqi, Ammad A.

Publication type:

Article

Alnustone inhibits the growth of hepatocellular carcinoma via ROS‐ mediated PI3K/Akt/mTOR/p70S6K axis.

Published in:

Phytotherapy Research, 2022, v. 36, n. 1, p. 525, doi. 10.1002/ptr.7337

By:

Wang, Linlin;
Cheng, Li;
Ma, Li;
Ahmad Farooqi, Ammad;
Qiao, Gan;
Zhang, Yuxi;
Ye, Hanlin;
Liu, Minghua;
Huang, Jianlin;
Yang, Xiaohui;
Lin, Xiukun;
Cao, Shousong

Publication type:

Article

Antioxidant and Anticancer Activities of Synthesized Methylated and Acetylated Derivatives of Natural Bromophenols.

Published in:

Antioxidants, 2022, v. 11, n. 4, p. N.PAG, doi. 10.3390/antiox11040786

By:

Dong, Hui;
Wang, Li;
Guo, Meng;
Stagos, Dimitrios;
Giakountis, Antonis;
Trachana, Varvara;
Lin, Xiukun;
Liu, Yankai;
Liu, Ming

Publication type:

Article

Bromophenol Bis (2,3,6-Tribromo-4,5-dihydroxybenzyl) Ether Protects HaCaT Skin Cells from Oxidative Damage via Nrf2-Mediated Pathways.

Published in:

Antioxidants, 2021, v. 10, n. 9, p. 1436, doi. 10.3390/antiox10091436

By:

Dong, Hui;
Liu, Mingfei;
Wang, Li;
Liu, Yankai;
Lu, Xuxiu;
Stagos, Dimitrios;
Lin, Xiukun;
Liu, Ming

Publication type:

Article

Role of melatonin in carcinogenesis and metastasis: From mechanistic insights to intermeshed networks of noncoding RNAs.

Published in:

Cell Biochemistry & Function, 2024, v. 42, n. 4, p. 1, doi. 10.1002/cbf.3995

By:

Lin, Xiukun;
Qureshi, Muhammad Zahid;
Tahir, Fatima;
Yilmaz, Seher;
Romero, Mirna Azalea;
Attar, Rukset;
Farooqi, Ammad A.

Publication type:

Article

Micelle encapsulation zinc‐doped copper oxide nanocomposites reverse Olaparib resistance in ovarian cancer by disrupting homologous recombination repair.

Published in:

Bioengineering & Translational Medicine, 2023, v. 8, n. 3, p. 1, doi. 10.1002/btm2.10507

By:

Yi, Jingyan;
Luo, Xin;
Xing, Jinshan;
Gedanken, Aharon;
Lin, Xiukun;
Zhang, Chunxiang;
Qiao, Gan

Publication type:

Article

Development of Certain Protein Kinase Inhibitors with the Components from Traditional Chinese Medicine.

Published in:

Frontiers in Pharmacology, 2017, v. 7, p. 1, doi. 10.3389/fphar.2016.00523

By:

Minghua Liu;
Ge Zhao;
Shousong Cao;
Yangyang Zhang;
Xiaofang Li;
Xiukun Lin

Publication type:

Article

Correction: Zheng, L., et al. PBN11-8, a Cytotoxic Polypeptide Purified from Marine Bacillus , Suppresses Invasion and Migration of Human Hepatocellular Carcinoma Cells by Targeting Focal Adhesion Kinase Pathways. Polymers 2018, 10 , 1043.

Published in:

2021

By:

Zheng, Lanhong;
Zhu, Xiangjie;
Yang, Kangli;
Zhu, Meihong;
Farooqi, Ammad Ahmad;
Kang, Daole;
Sun, Mi;
Xu, Yixin;
Lin, Xiukun;
Feng, Yingang;
Liang, Fangfang;
Zhang, Fuming;
Linhardt, Robert J.

Publication type:

Correction Notice

PBN11-8, a Cytotoxic Polypeptide Purified from Marine Bacillus, Suppresses Invasion and Migration of Human Hepatocellular Carcinoma Cells by Targeting Focal Adhesion Kinase Pathways.

Published in:

Polymers (20734360), 2018, v. 10, n. 9, p. 1043, doi. 10.3390/polym10091043

By:

Zheng, Lanhong;
Zhu, Xiangjie;
Yang, Kangli;
Zhu, Meihong;
Farooqi, Ammad Ahmad;
Kang, Daole;
Sun, Mi;
Xu, Yixin;
Lin, Xiukun;
Feng, Yingang;
Liang, Fangfang;
Zhang, Fuming;
Linhardt, Robert J.

Publication type:

Article

Culture at a Higher Temperature Mildly Inhibits Cancer Cell Growth but Enhances Chemotherapeutic Effects by Inhibiting Cell-Cell Collaboration.

Published in:

PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0137042

By:

Zhu, Shengming;
Wang, Jiangang;
Xie, Bingkun;
Luo, Zhiguo;
Lin, Xiukun;
Liao, D. Joshua

Publication type:

Article

Isolation and Characterization of Marine Brevibacillus sp. S-1 Collected from South China Sea and a Novel Antitumor Peptide Produced by the Strain.

Published in:

PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0111270

By:

Zheng, Lanhong;
Yi, Yao;
Liu, Jia;
Lin, Xiukun;
Yang, Kangli;
Lv, Mei;
Zhou, Xinwen;
Hao, Jianhua;
Liu, Junzhong;
Zheng, Yuan;
Sun, Mi

Publication type:

Article

Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms.

Published in:

PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0091606

By:

Liu, Jia;
Wu, Ning;
Ma, Leina;
Liu, Ming;
Liu, Ge;
Zhang, Yuyan;
Lin, Xiukun

Publication type:

Article

Role of MicroRNA-26b in Glioma Development and Its Mediated Regulation on EphA2.

Published in:

PLoS ONE, 2011, v. 6, n. 1, p. 1, doi. 10.1371/journal.pone.0016264

By:

Ning Wu;
Xiangzhong Zhao;
Ming Liu;
Haizhou Liu;
Weicheng Yao;
Yuyan Zhang;
Shousong Cao;
Xiukun Lin

Publication type:

Article

Interaction between Thymidylate Synthase and Its Cognate mRNA in Zebrafish Embryos.

Published in:

PLoS ONE, 2010, v. 5, n. 5, p. 1, doi. 10.1371/journal.pone.0010618

By:

Yuyan Zhang;
Shaoli Yang;
Ming Liu;
Chunxia Song;
NingWu;
Peixue Ling;
Chu, Edward;
Xiukun Lin

Publication type:

Article

Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways.

Published in:

Oncology Reports, 2014, v. 32, n. 2, p. 567, doi. 10.3892/or.2014.3239

By:

JIA LIU;
LANHONG ZHENG;
JIATENG ZHONG;
NING WU;
GE LIU;
XIUKUN LIN

Publication type:

Article

Apoptotic Pathway as the Therapeutic Target for Anticancer Traditional Chinese Medicines.

Published in:

Frontiers in Pharmacology, 2019, p. 1, doi. 10.3389/fphar.2019.00758

By:

An, Weixiao;
Lai, Honglin;
Zhang, Yangyang;
Liu, Minghua;
Lin, Xiukun;
Cao, Shousong

Publication type:

Article

Zinc-Doped Copper Oxide Nanocomposites Inhibit the Growth of Pancreatic Cancer by Inducing Autophagy Through AMPK/mTOR Pathway.

Published in:

Frontiers in Pharmacology, 2019, p. N.PAG, doi. 10.3389/fphar.2019.00319

By:

Li, Xiao;
Xu, Huanli;
Li, Cong;
Qiao, Gan;
Farooqi, Ammad Ahmad;
Gedanken, Aharon;
Liu, Xiaohui;
Lin, Xiukun

Publication type:

Article

Cloning, expression and cytotoxicity of granulin A, a novel polypeptide contained in human progranulin.

Published in:

BioScience Trends, 2016, v. 10, n. 3, p. 181, doi. 10.5582/bst.2016.01036

By:

Xuan Wang;
Huanli Xu;
Xiaoliang Chen;
Ye Tian;
Fengshan Wang;
Xiukun Lin

Publication type:

Article

Cytotoxicity of the compounds isolated from Pulsatilla chinensis saponins and apoptosis induced by 23-hydroxybetulinic acid.

Published in:

Pharmaceutical Biology, 2015, v. 53, n. 1, p. 1, doi. 10.3109/13880209.2014.907323

By:

Liu, Ming;
Zhao, Xingzeng;
Xiao, Lin;
Liu, Ge;
Liu, Haizhou;
Wang, Xiangyun;
Feng, Xu;
Lin, Xiukun

Publication type:

Article

Mere15, a novel polypeptide from Meretrix meretrix, inhibits adhesion, migration and invasion of human lung cancer A549 cells via down-regulating MMPs.

Published in:

Pharmaceutical Biology, 2013, v. 51, n. 2, p. 145, doi. 10.3109/13880209.2012.715169

By:

Wang, Hui;
Wei, Jianteng;
Wu, Ning;
Liu, Ming;
Wang, Cuicui;
Zhang, Yuyan;
Wang, Fengxia;
Liu, Haizhou;
Lin, Xiukun

Publication type:

Article

Marine Bromophenol Bis(2,3,6-Tribromo-4,5-Dihydroxybenzyl)ether Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells and Reduces Vasculogenic Mimicry in Human Lung Cancer A549 Cells.

Published in:

Marine Drugs, 2021, v. 19, n. 11, p. 641, doi. 10.3390/md19110641

By:

Dong, Songtao;
Chen, Zhongyuan;
Wang, Li;
Liu, Yankai;
Stagos, Dimitrios;
Lin, Xiukun;
Liu, Ming

Publication type:

Article

Progress of Bromophenols in Marine Algae from 2011 to 2020: Structure, Bioactivities, and Applications.

Published in:

Marine Drugs, 2020, v. 18, n. 8, p. 411, doi. 10.3390/md18080411

By:

Dong, Hui;
Dong, Songtao;
Erik Hansen, Poul;
Stagos, Dimitrios;
Lin, Xiukun;
Liu, Ming

Publication type:

Article

Preparation and Antitumor Activity of CS5931, A Novel Polypeptide from Sea Squirt Ciona Savignyi.

Published in:

Marine Drugs, 2016, v. 14, n. 3, p. 47, doi. 10.3390/md14030047

By:

Xiaoshuang Chen;
Huanli Xu;
Bo Li;
Feng Wang;
Xiaoliang Chen;
Dexin Kong;
Xiukun Lin

Publication type:

Article