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Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.
Published in:
2021
By:
- Sean Liu;
- Uyen Ngo;
- Xin-Zi Tang;
- Xin Ren;
- Wenli Qiu;
- Xiaozhu Huang;
- DeGrado, William;
- Allen, Christopher D. C.;
- Hyunil Jo;
- Sheppard, Dean;
- Sundaram, Aparna B.;
- Liu, Sean;
- Ngo, Uyen;
- Tang, Xin-Zi;
- Ren, Xin;
- Qiu, Wenli;
- Huang, Xiaozhu;
- Allen, Christopher Dc;
- Jo, Hyunil
Publication type:
journal article
Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma.
Published in:
2017
By:
- Sundaram, Aparna;
- Chun Chen;
- Khalifeh-Soltani, Amin;
- Atakilit, Amha;
- Xin Ren;
- Wenli Qiu;
- Hyunil Jo;
- DeGrado, William;
- Xiaozhu Huang;
- Sheppard, Dean;
- Chen, Chun;
- Ren, Xin;
- Qiu, Wenli;
- Jo, Hyunil;
- Huang, Xiaozhu
Publication type:
journal article
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.
Published in:
Nature Medicine, 2002, v. 8, n. 8, p. 885, doi. 10.1038/nm734
By:
- Kuperman, Douglas A.;
- Huang, Xiaozhu;
- Koth, Laura L.;
- Chang, Grace H.;
- Dolganov, Gregory M.;
- Zhu, Zhou;
- Elias, Jack A.;
- Sheppard, Dean;
- Erle, David J.
Publication type:
Article
Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins.
Published in:
Nature Medicine, 2002, v. 8, n. 1, p. 27, doi. 10.1038/nm0102-27
By:
- Reynolds, Louise E.;
- Wyder, Lorenza;
- Lively, Julie C.;
- Taverna, Daniela;
- Robinson, Stephen D.;
- Huang, Xiaozhu;
- Sheppard, Dean;
- Hynes, Richard O.;
- Hodivala-Dilke, Kairbaan M.
Publication type:
Article
IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 11, p. 4895, doi. 10.1172/JCI76658
By:
- Bhattacharya, Mallar;
- Sundaram, Aparna;
- Kudo, Makoto;
- Farmer, Jessica;
- Ganesan, Previn;
- Khalifeh-Soltani, Amin;
- Arjomandi, Mehrdad;
- Atabai, Kamran;
- Huang, Xiaozhu;
- Sheppard, Dean
Publication type:
Article
The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.
Published in:
Journal of Clinical Investigation, 2013, v. 123, n. 5, p. 2037, doi. 10.1172/JCI66397
By:
- Tamiko R. Katsumoto;
- Makoto Kudo;
- Chun Chen;
- Sundaram, Aparna;
- Callahan, Elliott C.;
- Jing W. Zhu;
- Lin, Joseph;
- Rosen, Connor E.;
- Manz, Boryana N.;
- Jae W. Lee;
- Matthay, Michael A.;
- Xiaozhu Huang;
- Sheppard, Dean;
- Weiss, Arthur
Publication type:
Article
Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.
Published in:
Journal of Clinical Investigation, 2012, v. 122, n. 8, p. 2916, doi. 10.1172/JCI60387
By:
- Chun Chen;
- Kudo, Makoto;
- Rutaganira, Florentine;
- Takano, Hiromi;
- Lee, Candace;
- Atakilit, Amha;
- Robinett, Kathryn S.;
- Uede, Toshimitsu;
- Wolters, Paul J.;
- Shokat, Kevan M.;
- Xiaozhu Huang;
- Sheppard, Dean
Publication type:
Article
The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.
Published in:
Journal of Clinical Investigation, 2012, v. 122, n. 2, p. 748, doi. 10.1172/JCI58815
By:
- Sugimoto, Kotaro;
- Kudo, Makoto;
- Sundaram, Aparna;
- Xin Ren;
- Huang, Katherine;
- Bernstein, Xin;
- Yanli Wang;
- Raymond, Wilfred W.;
- Erle, David J.;
- Åbrink, Magnus;
- Caughey, George H.;
- Xiaozhu Huang;
- Sheppard, Dean
Publication type:
Article
Mice Lacking the Integrin β5 Subunit Have Accelerated Osteoclast Maturation and Increased Activity in the Estrogen-Deficient State.
Published in:
Journal of Bone & Mineral Research, 2005, v. 20, n. 1, p. 58, doi. 10.1359/JBMR.041017
By:
- Lane, Nancy E;
- Yao, Wei;
- Nakamura, Mary C;
- Humphrey, Mary Beth;
- Kimmel, Donald;
- Huang, Xiaozhu;
- Sheppard, Dean;
- Ross, F Patrick;
- Teitelbaum, Steven L
Publication type:
Article
IL-17A produced by ?? T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.
Published in:
Nature Medicine, 2012, v. 18, n. 4, p. 547, doi. 10.1038/nm.2684
By:
- Kudo, Makoto;
- Melton, Andrew C;
- Chen, Chun;
- Engler, Mary B;
- Huang, Katherine E;
- Ren, Xin;
- Wang, Yanli;
- Bernstein, Xin;
- Li, John T;
- Atabai, Kamran;
- Huang, Xiaozhu;
- Sheppard, Dean
Publication type:
Article
Src-mediated coupling of focal adhesion kinase to integrin αvΒ5 in vascular endothelial growth factor signaling.
Published in:
Journal of Cell Biology, 2002, v. 157, n. 1, p. 149, doi. 10.1083/jcb.200109079
By:
- Eliceiri, Brian P.;
- Puente, Xose S.;
- Hood, John D.;
- Stupack, Dwayne G.;
- Schlaepfer, David D.;
- Huang, Xiaozhu Z.;
- Sheppard, Dean;
- Cheresh, David A.
Publication type:
Article
Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation.
Published in:
PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0061961
By:
- Barron, Luke;
- Smith, Amber M.;
- El Kasmi, Karim C.;
- Qualls, Joseph E.;
- Huang, Xiaozhu;
- Cheever, Allen;
- Borthwick, Lee A.;
- Wilson, Mark S.;
- Murray, Peter J.;
- Wynn, Thomas A.
Publication type:
Article
Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2.
Published in:
Respiratory Research, 2004, v. 5, p. 1, doi. 10.1186/1465-9921-5-12
By:
- Koth, Laura L.;
- Rodriguez, Madeleine W.;
- Xin Liu Bernstein;
- Chan, Salina;
- Xiaozhu Huang;
- Charo, Israel F.;
- Rollins, Barrett J.;
- Erle, David J.
Publication type:
Article
AGR2 Is Induced in Asthma and Promotes Allergen-Induced Mucin Overproduction.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2012, v. 47, n. 2, p. 178, doi. 10.1165/rcmb.2011-0421OC
By:
- Schroeder, Bradley W.;
- Verhaeghe, Catherine;
- Park, Sung-Woo;
- Nguyenvu, Louis T.;
- Xiaozhu Huang;
- Guohua Zhen;
- Erle, David J.
Publication type:
Article
Expression Profiling Identifies Klf15 as a Glucocorticoid Target That Regulates Airway Hyperresponsiveness.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2011, v. 45, n. 3, p. 642, doi. 10.1165/rcmb.2010-0369OC
By:
- Masuno, Kiriko;
- Haldar, Saptarsi M.;
- Jeyaraj, Darwin;
- Mailloux, Christina M.;
- Xiaozhu Huang;
- Panettieri Jr, Rey A.;
- Jain, Mukesh K.;
- Gerber, Anthony N.
Publication type:
Article
Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice.
Published in:
Nature, 2007, v. 449, n. 7160, p. 361, doi. 10.1038/nature06110
By:
- Travis, Mark A.;
- Reizis, Boris;
- Melton, Andrew C.;
- Masteller, Emma;
- Tang, Qizhi;
- Proctor, John M.;
- Wang, Yanli;
- Bernstein, Xin;
- Huang, Xiaozhu;
- Reichardt, Louis F.;
- Bluestone, Jeffrey A.;
- Sheppard, Dean
Publication type:
Article
Characterization of integrin β6 and thrombospondin-1 double-null mice.
Published in:
Journal of Cellular & Molecular Medicine, 2005, v. 9, n. 2, p. 421, doi. 10.1111/j.1582-4934.2005.tb00367.x
By:
- Ludlow, Anna;
- Yee, Karen O.;
- Lipman, Ruth;
- Bronson, R.;
- Weinreb, P.;
- Huang, Xiaozhu;
- Sheppard, D.;
- Lawler, J.
Publication type:
Article
A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production.
Published in:
Nature Immunology, 2014, v. 15, n. 12, p. 1162, doi. 10.1038/ni.3026
By:
- Simpson, Laura J;
- Patel, Sana;
- Bhakta, Nirav R;
- Choy, David F;
- Brightbill, Hans D;
- Ren, Xin;
- Wang, Yanli;
- Pua, Heather H;
- Baumjohann, Dirk;
- Montoya, Misty M;
- Panduro, Marisella;
- Remedios, Kelly A;
- Huang, Xiaozhu;
- Fahy, John V;
- Arron, Joseph R;
- Woodruff, Prescott G;
- Ansel, K Mark
Publication type:
Article
Lymph node–resident dendritic cells drive TH2 cell development involving MARCH1.
Published in:
Science Immunology, 2021, v. 6, n. 64, p. 1, doi. 10.1126/sciimmunol.abh0707
By:
- Castellanos, Carlos A.;
- Ren, Xin;
- Gonzalez, Steven Lomeli;
- Li, Hong Kun;
- Schroeder, Andrew W.;
- Liang, Hong-Erh;
- Laidlaw, Brian J.;
- Hu, Donglei;
- Mak, Angel C.Y.;
- Eng, Celeste;
- Rodríguez-Santana, José R.;
- LeNoir, Michael;
- Yan, Qi;
- Celedón, Juan C.;
- Burchard, Esteban G.;
- Zamvil, Scott S.;
- Ishido, Satoshi;
- Locksley, Richard M.;
- Cyster, Jason G.;
- Huang, Xiaozhu
Publication type:
Article
Oxidation increases mucin polymer cross-links to stiffen airway mucus gels.
Published in:
Science Translational Medicine, 2015, v. 7, n. 276, p. 1, doi. 10.1126/scitranslmed.3010525
By:
- Shaopeng Yuan;
- Hollinger, Martin;
- Lachowicz-Scroggins, Marrah E.;
- Kerr, Sheena C.;
- Dunican, Eleanor M.;
- Daniel, Brian M.;
- Ghosh, Sudakshina;
- Erzurum, Serpel C.;
- Willard, Belinda;
- Hazen, Stanley L.;
- Xiaozhu Huang;
- Carrington, Stephen D.;
- Oscarson, Stefan;
- Fahy, John V.
Publication type:
Article
Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.
Published in:
2009
By:
- Park SW;
- Verhaeghe C;
- Nguyenvu LT;
- Barbeau R;
- Eisley CJ;
- Nakagami Y;
- Huang X;
- Woodruff PG;
- Fahy JV;
- Erle DJ;
- Park, Sung-Woo;
- Verhaeghe, Catherine;
- Nguyenvu, Louis T;
- Barbeau, Rebecca;
- Eisley, Christopher J;
- Nakagami, Yasuhiro;
- Huang, Xiaozhu;
- Woodruff, Prescott G;
- Fahy, John V;
- Erle, David J
Publication type:
journal article
Loss of integrin avB6-mediated TGF-B activation causes Mmp12-dependent emphysema.
Published in:
Nature, 2003, v. 422, n. 6928, p. 169, doi. 10.1038/nature01413
By:
- Morris, David G.;
- Huang, Xiaozhu;
- Kaminski, Naftali;
- Wang, Yanli;
- Shapiro, Steven D.;
- Dolganov, Gregory;
- Glick, Adam;
- Sheppard, Dean
Publication type:
Article
Role of Organic Cation Transporter 1, OCT1 in the Pharmacokinetics and Toxicity of cis-Diammine(pyridine)chloroplatinum(II) and Oxaliplatin in Mice.
Published in:
Pharmaceutical Research, 2011, v. 28, n. 3, p. 610, doi. 10.1007/s11095-010-0312-6
By:
- Li, Shuanglian;
- Chen, Ying;
- Zhang, Shuzhong;
- More, Swati;
- Huang, Xiaozhu;
- Giacomini, Kathleen
Publication type:
Article

Found: 23

Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.

Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma.

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.

Enhanced pathological angiogenesis in mice lacking β<sub>3</sub> integrin or β<sub>3</sub> and β<sub>5</sub> integrins.

IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction.

The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.

Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.

The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.

Mice Lacking the Integrin β5 Subunit Have Accelerated Osteoclast Maturation and Increased Activity in the Estrogen-Deficient State.

IL-17A produced by ?? T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.

Src-mediated coupling of focal adhesion kinase to integrin αvΒ5 in vascular endothelial growth factor signaling.

Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation.

Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2.

AGR2 Is Induced in Asthma and Promotes Allergen-Induced Mucin Overproduction.

Expression Profiling Identifies Klf15 as a Glucocorticoid Target That Regulates Airway Hyperresponsiveness.

Loss of integrin α<sub>v</sub>β<sub>8</sub> on dendritic cells causes autoimmunity and colitis in mice.

Characterization of integrin β6 and thrombospondin-1 double-null mice.

A microRNA upregulated in asthma airway T cells promotes T<sub>H</sub>2 cytokine production.

Lymph node–resident dendritic cells drive T<sub>H</sub>2 cell development involving MARCH1.

Oxidation increases mucin polymer cross-links to stiffen airway mucus gels.

Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.

Loss of integrin avB6-mediated TGF-B activation causes Mmp12-dependent emphysema.

Role of Organic Cation Transporter 1, OCT1 in the Pharmacokinetics and Toxicity of cis-Diammine(pyridine)chloroplatinum(II) and Oxaliplatin in Mice.