Works by Wyllie, Susan

Results: 23

The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis.

Published in:

Science Translational Medicine, 2012, v. 4, n. 119, p. 1, doi. 10.1126/scitranslmed.3003326

By:

Wyllie, Susan;
Patterson, Stephen;
Stojanovski, Laste;
Simeons, Frederick R. C.;
Norval, Suzanne;
Kime, Robert;
Read, Kevin D.;
Fairlamb, Alan H.

Publication type:

Article

Identifying regulators of transcription in an obligate intracellular pathogen: a metal-dependent repressor in Chlamydia trachomatis.

Published in:

Molecular Microbiology, 2001, v. 40, n. 4, p. 1027, doi. 10.1046/j.1365-2958.2001.02453.x

By:

Wyllie, Susan;
Raulston, Jane E.

Publication type:

Article

Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential.

Published in:

Pharmaceuticals (14248247), 2024, v. 17, n. 7, p. 878, doi. 10.3390/ph17070878

By:

Khoumeri, Omar;
Hutter, Sébastien;
Primas, Nicolas;
Castera-Ducros, Caroline;
Carvalho, Sandra;
Wyllie, Susan;
Efrit, Mohamed Lotfi;
Fayolle, Dimitri;
Since, Marc;
Vanelle, Patrice;
Verhaeghe, Pierre;
Azas, Nadine;
El-Kashef, Hussein

Publication type:

Article

A comparative study of methylglyoxal metabolism in trypanosomatids.

Published in:

FEBS Journal, 2009, v. 276, n. 2, p. 376, doi. 10.1111/j.1742-4658.2008.06788.x

By:

Greig, Neil;
Wyllie, Susan;
Patterson, Stephen;
Fairlamb, Alan H.

Publication type:

Article

ATP-dependent ligases in trypanothione biosynthesis – kinetics of catalysis and inhibition by phosphinic acid pseudopeptides.

Published in:

FEBS Journal, 2008, v. 275, n. 21, p. 5408, doi. 10.1111/j.1742-4658.2008.06670.x

By:

Oza, Sandra L.;
Chen, Shoujun;
Wyllie, Susan;
Coward, James K.;
Fairlamb, Alan H.

Publication type:

Article

Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium.

Published in:

Frontiers in Cellular & Infection Microbiology, 2023, v. 13, p. 01, doi. 10.3389/fcimb.2023.1236814

By:

Hanna, Jack C.;
Corpas-Lopez, Victor;
Seizova, Simona;
Colon, Beatrice L.;
Bacchetti, Ross;
Hall, Grant M. J.;
Sands, Emma M.;
Robinson, Lee;
Baragaña, Beatriz;
Wyllie, Susan;
Pawlowic, Mattie C.

Publication type:

Article

Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay.

Published in:

PLoS Neglected Tropical Diseases, 2021, v. 15, n. 10, p. 1, doi. 10.1371/journal.pntd.0009870

By:

Svensen, Nina;
Wyllie, Susan;
Gray, David W.;
De Rycker, Manu

Publication type:

Article

Visceral Leishmaniasis and Arsenic: An Ancient Poison Contributing to Antimonial Treatment Failure in the Indian Subcontinent?

Published in:

PLoS Neglected Tropical Diseases, 2011, v. 5, n. 9, p. 1, doi. 10.1371/journal.pntd.0001227

By:

Perry, Meghan R.;
Wyllie, Susan;
Prajapati, Vijay Kumar;
Feldmann, Joerg;
Sundar, Shyam;
Boelaert, Marleen;
Fairlamb, Alan H.

Publication type:

Article

Visceral Leishmaniasis and Arsenic: An Ancient Poison Contributing to Antimonial Treatment Failure in the Indian Subcontinent?

Published in:

2011

By:

Perry, Meghan R.;
Wyllie, Susan;
Prajapati, Vijay Kumar;
Feldmann, Joerg;
Sundar, Shyam;
Boelaert, Marleen;
Fairlamb, Alan H.

Publication type:

Opinion

Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei.

Published in:

Molecular Microbiology, 2015, v. 95, n. 1, p. 143, doi. 10.1111/mmi.12853

By:

Ong, Han B.;
Lee, Wai S.;
Patterson, Stephen;
Wyllie, Susan;
Fairlamb, Alan H.

Publication type:

Article

Trypanosoma brucei ( UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy.

Published in:

Molecular Microbiology, 2013, v. 90, n. 2, p. 443, doi. 10.1111/mmi.12376

By:

Ong, Han B.;
Sienkiewicz, Natasha;
Wyllie, Susan;
Patterson, Stephen;
Fairlamb, Alan H.

Publication type:

Article

Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome.

Published in:

Molecular Microbiology, 2012, v. 86, n. 1, p. 51, doi. 10.1111/j.1365-2958.2012.08189.x

By:

Jones, Deuan C.;
Alphey, Magnus S.;
Wyllie, Susan;
Fairlamb, Alan H.

Publication type:

Article

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods.

Published in:

Molecular Microbiology, 2009, v. 74, n. 3, p. 529, doi. 10.1111/j.1365-2958.2009.06761.x

By:

Wyllie, Susan;
Oza, Sandra L.;
Patterson, Stephen;
Spinks, Daniel;
Thompson, Stephen;
Fairlamb, Alan H.

Publication type:

Article

Chemical and genetic validation of dihydrofolate reductase–thymidylate synthase as a drug target in African trypanosomes.

Published in:

Molecular Microbiology, 2008, v. 69, n. 2, p. 520, doi. 10.1111/j.1365-2958.2008.06305.x

By:

Sienkiewicz, Natasha;
Jarosławski, Szymon;
Wyllie, Susan;
Fairlamb, Alan H.

Publication type:

Article

Antitrypanosomatid Pharmacomodulation at Position 3 of the 8‐Nitroquinolin‐2(1H)‐one Scaffold Using Palladium‐Catalysed Cross‐Coupling Reactions.

Published in:

ChemMedChem, 2018, v. 13, n. 20, p. 2217, doi. 10.1002/cmdc.201800456

By:

Pedron, Julien;
Boudot, Clotilde;
Bourgeade‐Delmas, Sandra;
Sournia‐Saquet, Alix;
Paloque, Lucie;
Rastegari, Maryam;
Abdoulaye, Mansour;
El‐Kashef, Hussein;
Bonduelle, Colin;
Pratviel, Geneviève;
Wyllie, Susan;
Fairlamb, Alan H.;
Courtioux, Bertrand;
Verhaeghe, Pierre;
Valentin, Alexis

Publication type:

Article

Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1.

Published in:

PLoS Pathogens, 2024, v. 20, n. 7, p. 1, doi. 10.1371/journal.ppat.1012382

By:

Tulloch, Lindsay B.;
Tinti, Michele;
Wall, Richard J.;
Weidt, Stefan K.;
Corpas- Lopez, Victoriano;
Dey, Gourav;
Smith, Terry K.;
Fairlamb, Alan H.;
Barrett, Michael P.;
Wyllie, Susan

Publication type:

Article

Oligo targeting for profiling drug resistance mutations in the parasitic trypanosomatids.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 14, p. e79, doi. 10.1093/nar/gkac319

By:

Altmann, Simone;
Rico, Eva;
Carvalho, Sandra;
Ridgway, Melanie;
Trenaman, Anna;
Donnelly, Hannah;
Tinti, Michele;
Wyllie, Susan;
Horn, David

Publication type:

Article

Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase.

Published in:

Biochemical Journal, 2014, v. 459, n. 2, p. 323, doi. 10.1042/BJ20131033

By:

ROBERTS, Adam J.;
TORRIE, Leah S.;
WYLLIE, Susan;
FAIRLAMB, Alan H.

Publication type:

Article

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.09744

By:

Patterson, Stephen;
Wyllie, Susan;
Norval, Suzanne;
Stojanovski, Laste;
Simeons, Frederick R. C.;
Auer, Jennifer L.;
Osuna-Cabello, Maria;
Read, Kevin D.;
Fairlamb, Alan H.

Publication type:

Article

Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes.

Published in:

2016

By:

Bruhn, David F.;
Wyllie, Susan;
Rodríguez-Cortés, Adaris;
Carrillo, Angela K.;
Rakesh;
Kiplin Guy, R.;
Fairlamb, Alan H.;
Lee, Richard E.;
Guy, R Kiplin

Publication type:

journal article

Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei.

Published in:

2016

By:

Wyllie, Susan;
Foth, Bernardo J.;
Kelner, Anna;
Sokolova, Antoaneta Y.;
Berriman, Matthew;
Fairlamb, Alan H.

Publication type:

journal article

Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series.

Published in:

Microorganisms, 2021, v. 9, n. 7, p. 1408, doi. 10.3390/microorganisms9071408

By:

Van den Kerkhof, Magali;
Leprohon, Philippe;
Mabille, Dorien;
Hendrickx, Sarah;
Tulloch, Lindsay B.;
Wall, Richard J.;
Wyllie, Susan;
Chatelain, Eric;
Mowbray, Charles E.;
Braillard, Stéphanie;
Ouellette, Marc;
Maes, Louis;
Caljon, Guy

Publication type:

Article

Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania.

Published in:

PLoS Pathogens, 2016, v. 12, n. 11, p. 1, doi. 10.1371/journal.ppat.1005971

By:

Wyllie, Susan;
Roberts, Adam J.;
Norval, Suzanne;
Patterson, Stephen;
Foth, Bernardo J.;
Berriman, Matthew;
Read, Kevin D.;
Fairlamb, Alan H.

Publication type:

Article