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Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem.
- Published in:
- 2017
- By:
- Publication type:
- journal article
Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity.
- Published in:
- Human Reproduction, 2014, v. 29, n. 10, p. 2123, doi. 10.1093/humrep/deu196
- By:
- Publication type:
- Article
Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity.
- Published in:
- Human Reproduction, 2014, v. 29, n. 10, p. 2123, doi. 10.1093/humrep/deu196
- By:
- Publication type:
- Article
Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.
- Published in:
- PLoS ONE, 2021, v. 16, n. 7, p. 1, doi. 10.1371/journal.pone.0253364
- By:
- Publication type:
- Article
A Continuous Flow Strategy for the Facile Synthesis and Elaboration of Semi‐Saturated Heterobicyclic Fragments.
- Published in:
- European Journal of Organic Chemistry, 2019, v. 2019, n. 6, p. 1341, doi. 10.1002/ejoc.201801684
- By:
- Publication type:
- Article
Application of an NMR/Crystallography Fragment Screening Platform for the Assessment and Rapid Discovery of New HIV‐CA Binding Fragments.
- Published in:
- ChemMedChem, 2024, v. 19, n. 13, p. 1, doi. 10.1002/cmdc.202400025
- By:
- Publication type:
- Article
Screening of a Novel Fragment Library with Functional Complexity against <italic>Mycobacterium tuberculosis</italic> InhA.
- Published in:
- ChemMedChem, 2018, v. 13, n. 7, p. 672, doi. 10.1002/cmdc.201700774
- By:
- Publication type:
- Article
Ligand binding: evaluating the contribution of the water molecules network using the Fragment Molecular Orbital method.
- Published in:
- Journal of Computer-Aided Molecular Design, 2021, v. 35, n. 10, p. 1025, doi. 10.1007/s10822-021-00416-3
- By:
- Publication type:
- Article
Correction: Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.
- Published in:
- 2024
- By:
- Publication type:
- Correction Notice
Detection of Ligands from a Dynamic Combinatorial Library by X-ray Crystallography ( The authors thank Professor Chris Abell, Dr. Robin Carr, Dr. David Rees, and Dr. Chris Murray for useful suggestions and discussions. DCX is a Trade Mark of Astex Technology, Ltd. )
- Published in:
- Angewandte Chemie, 2003, v. 115, n. 37, p. 4617, doi. 10.1002/ange.200351951
- By:
- Publication type:
- Article
A Target Repurposing Approach Identifies N-myristoyltransferase as a New Candidate Drug Target in Filarial Nematodes.
- Published in:
- PLoS Neglected Tropical Diseases, 2014, v. 8, n. 9, p. 1, doi. 10.1371/journal.pntd.0003145
- By:
- Publication type:
- Article
A Target Repurposing Approach Identifies N-myristoyltransferase as a New Candidate Drug Target in Filarial Nematodes.
- Published in:
- PLoS Neglected Tropical Diseases, 2014, v. 8, n. 9, p. 1, doi. 10.1371/journal.pntd.0003145
- By:
- Publication type:
- Article
Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design.
- Published in:
- PLoS Neglected Tropical Diseases, 2013, v. 7, n. 10, p. 1, doi. 10.1371/journal.pntd.0002492
- By:
- Publication type:
- Article
Exploring the <i>Trypanosoma brucei</i> Hsp83 Potential as a Target for Structure Guided Drug Design.
- Published in:
- PLoS Neglected Tropical Diseases, 2013, v. 7, n. 10, p. 1, doi. 10.1371/journal.pntd.0002492
- By:
- Publication type:
- Article
Targeting N-myristoylation for therapy of B-cell lymphomas.
- Published in:
- Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18998-1
- By:
- Publication type:
- Article
Self-Assembling Cyclophanes and Catenanes Possessing Elements of Planar Chirality.
- Published in:
- Chemistry - A European Journal, 1998, v. 4, n. 2, p. 299, doi. 10.1002/(SICI)1521-3765(19980210)4:2<299::AID-CHEM299>3.0.CO;2-Z
- By:
- Publication type:
- Article
Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase.
- Published in:
- Acta Crystallographica: Section F, Structural Biology Communications, 2015, v. 71, n. 5, p. 586, doi. 10.1107/S2053230X15003040
- By:
- Publication type:
- Article
Design of the Global Health chemical diversity library v2 for screening against infectious diseases.
- Published in:
- PLoS Neglected Tropical Diseases, 2023, v. 17, n. 12, p. 1, doi. 10.1371/journal.pntd.0011799
- By:
- Publication type:
- Article
Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library.
- Published in:
- ChemMedChem, 2015, v. 10, n. 11, p. 1809, doi. 10.1002/cmdc.201500300
- By:
- Publication type:
- Article
Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.
- Published in:
- ChemMedChem, 2015, v. 10, n. 11, p. 1821, doi. 10.1002/cmdc.201500301
- By:
- Publication type:
- Article
Cover Picture: Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode (ChemMedChem 11/2015).
- Published in:
- ChemMedChem, 2015, v. 10, n. 11, p. 1769, doi. 10.1002/cmdc.201500397
- By:
- Publication type:
- Article
Structure-Activity Relationship Studies of Pyrrolone Antimalarial Agents.
- Published in:
- ChemMedChem, 2013, v. 8, n. 9, p. 1537, doi. 10.1002/cmdc.201300177
- By:
- Publication type:
- Article
Back Cover: From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti- Trypanosoma brucei Drug Discovery Lead Molecules (ChemMedChem 7/2013).
- Published in:
- ChemMedChem, 2013, v. 8, n. 7, p. 1228, doi. 10.1002/cmdc.201390029
- By:
- Publication type:
- Article
From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti- Trypanosoma brucei Drug Discovery Lead Molecules.
- Published in:
- ChemMedChem, 2013, v. 8, n. 7, p. 1127, doi. 10.1002/cmdc.201300072
- By:
- Publication type:
- Article
Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors.
- Published in:
- ChemMedChem, 2012, v. 7, n. 1, p. 95, doi. 10.1002/cmdc.201100420
- By:
- Publication type:
- Article
Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3.
- Published in:
- ChemMedChem, 2011, v. 6, n. 12, p. 2214, doi. 10.1002/cmdc.201100344
- By:
- Publication type:
- Article
Optimisation of the Anti- Trypanosoma brucei Activity of the Opioid Agonist U50488.
- Published in:
- ChemMedChem, 2011, v. 6, n. 10, p. 1832, doi. 10.1002/cmdc.201100278
- By:
- Publication type:
- Article
Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1.
- Published in:
- ChemMedChem, 2011, v. 6, n. 2, p. 302, doi. 10.1002/cmdc.201000450
- By:
- Publication type:
- Article
Cover Picture: Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase / Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 / Modified 5′-Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase (ChemMedChem 2/2011)
- Published in:
- ChemMedChem, 2011, v. 6, n. 2, p. 209, doi. 10.1002/cmdc.201190000
- By:
- Publication type:
- Article
Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei.
- Published in:
- ChemMedChem, 2009, v. 4, n. 12, p. 2060, doi. 10.1002/cmdc.200900262
- By:
- Publication type:
- Article
Cover Picture: Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis / Synthesis and Evaluation of 1-(1-(Benzo[ b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase (ChemMedChem 8/2009)
- Published in:
- ChemMedChem, 2009, v. 4, n. 8, p. 1209, doi. 10.1002/cmdc.200990035
- By:
- Publication type:
- Article
Synthesis and Evaluation of 1-(1-(Benzo[ b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase.
- Published in:
- ChemMedChem, 2009, v. 4, n. 8, p. 1341, doi. 10.1002/cmdc.200900098
- By:
- Publication type:
- Article
Generation of Polar Semi‐Saturated Bicyclic Pyrazoles for Fragment‐Based Drug‐Discovery Campaigns.
- Published in:
- Chemistry - A European Journal, 2018, v. 24, n. 41, p. 10443, doi. 10.1002/chem.201801313
- By:
- Publication type:
- Article
Axially Chiral Catenanes and π-Electron-Deficient Receptors.
- Published in:
- Chemistry - A European Journal, 1997, v. 3, n. 3, p. 463, doi. 10.1002/chem.19970030319
- By:
- Publication type:
- Article
Detection of Ligands from a Dynamic Combinatorial Library by X-ray Crystallography ( The authors thank Professor Chris Abell, Dr. Robin Carr, Dr. David Rees, and Dr. Chris Murray for useful suggestions and discussions. DCX is a Trade Mark of Astex Technology, Ltd. )
- Published in:
- Angewandte Chemie International Edition, 2003, v. 42, n. 37, p. 4479, doi. 10.1002/anie.200351951
- By:
- Publication type:
- Article
Screening a protein kinase inhibitor library against Plasmodium falciparum.
- Published in:
- Malaria Journal, 2017, v. 16, p. 1, doi. 10.1186/s12936-017-2085-4
- By:
- Publication type:
- Article