Works by Workman, Paul

Results: 85

Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy.

Published in:

Nature Communications, 2025, v. 16, p. 1, doi. 10.1038/s41467-025-56213-1

By:

Newman, Joseph A.;
Gavard, Angeline E.;
Imprachim, Nergis;
Aitkenhead, Hazel;
Sheppard, Hadley E.;
te Poele, Robert;
Clarke, Paul A.;
Hossain, Mohammad Anwar;
Temme, Louisa;
Oh, Hans J.;
Wells, Carrow I.;
Davis-Gilbert, Zachary W.;
Workman, Paul;
Gileadi, Opher;
Drewry, David H.

Publication type:

Article

A HIF-Regulated VHL-PTP1B-Src Signaling Axis Identifies a Therapeutic Target in Renal Cell Carcinoma.

Published in:

Science Translational Medicine, 2011, v. 3, n. 85, p. 1, doi. 10.1126/scitranslmed.3002004

By:

Suwaki, Natsuko;
Vanhecke, Elsa;
Atkins, Katelyn M.;
Graf, Manuela;
Swabey, Katherine;
Huang, Paul;
Schraml, Peter;
Moch, Holger;
Cassidy, Amy Mulick;
Brewer, Daniel;
Al-Lazikani, Bissan;
Workman, Paul;
De-Bono, Johann;
Kaye, Stan B.;
Larkin, James;
Gore, Martin. E.;
Sawyers, Charles L.;
Nelson, Peter;
Beer, Tomasz M.;
Geng, Hao

Publication type:

Article

Corrigendum: Drugging the PI3 kinome.

Published in:

2006

By:

Workman, Paul;
Clarke, Paul A;
Guillard, Sandrine;
Raynaud, Florence I

Publication type:

Correction Notice

Drugging the PI3 kinome.

Published in:

Nature Biotechnology, 2006, v. 24, n. 7, p. 794, doi. 10.1038/nbt0706-794

By:

Workman, Paul;
Clarke, Paul A.;
Guillard, Sandrine;
Raynaud, Florence I.

Publication type:

Article

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.

Published in:

Molecular Oncology, 2018, v. 12, n. 3, p. 287, doi. 10.1002/1878-0261.12148

By:

Whittaker, Steven R.;
Barlow, Clare;
Martin, Mathew P.;
Mancusi, Caterina;
Wagner, Steve;
Self, Annette;
Barrie, Elaine;
Te Poele, Robert;
Sharp, Swee;
Brown, Nathan;
Wilson, Stuart;
Jackson, Wayne;
Fischer, Peter M.;
Clarke, Paul A.;
Walton, Michael I.;
McDonald, Edward;
Blagg, Julian;
Noble, Martin;
Garrett, Michelle D.;
Workman, Paul

Publication type:

Article

Discovery of small molecule cancer drugs: Successes, challenges and opportunities

Published in:

Molecular Oncology, 2012, v. 6, n. 2, p. 155, doi. 10.1016/j.molonc.2012.02.004

By:

Hoelder, Swen;
Clarke, Paul A.;
Workman, Paul

Publication type:

Article

RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.

Published in:

British Journal of Cancer, 2017, v. 117, n. 7, p. 954, doi. 10.1038/bjc.2017.277

By:

Dolly, Saoirse O;
Gurden, Mark D;
Drosopoulos, Konstantinos;
Clarke, Paul;
de Bono, Johann;
Kaye, Stan;
Workman, Paul;
Linardopoulos, Spiros

Publication type:

Article

RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.

Published in:

2017

By:

Dolly, Saoirse O;
Gurden, Mark D;
Drosopoulos, Konstantinos;
Clarke, Paul;
de Bono, Johann;
Kaye, Stan;
Workman, Paul;
Linardopoulos, Spiros

Publication type:

journal article

Bench to Bedside, Gene to Drug Discovery Defines New Era of Precision Medicine.

Published in:

2013

By:

Workman, Paul

Publication type:

Proceeding

Effects of HSP90 inhibitor 17-allylamino-17 -demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy.

Published in:

BMC Research Notes, 2012, v. 5, n. 1, p. 250, doi. 10.1186/1756-0500-5-250

By:

Rodrigues, Loretta M;
Chung, Yuen-Li;
Al Saffar, Nada M;
Sharp, Swee Y;
Jackson, Laura E;
Banerji, Udai;
Stubbs, Marion;
Leach, Martin O;
Griffiths, John R;
Workman, Paul

Publication type:

Article

Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer.

Published in:

PLoS ONE, 2020, v. 15, n. 7, p. 1, doi. 10.1371/journal.pone.0234103

By:

Frame, Sheelagh;
Saladino, Chiara;
MacKay, Craig;
Atrash, Butrus;
Sheldrake, Peter;
McDonald, Edward;
Clarke, Paul A.;
Workman, Paul;
Blake, David;
Zheleva, Daniella

Publication type:

Article

Analysis of tumour gene expression following chemotherapeutic treatment of patients with bowel cancer.

Published in:

1999

By:

Clarke, Paul A.;
George, Mark;
Cunningham, David;
Swift, Ian;
Workman, Paul

Publication type:

Abstract

Array technology in the molecular pharmacology of anticancer agents.

Published in:

1999

By:

Workman, Paul;
Pestell, Katharine E.;
Hostein, Isabelle;
Maloney, Alison;
Medlow, Clare;
Walton, Mike;
Clarke, Paul A.

Publication type:

Abstract

Correction to: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.

Published in:

2018

By:

Banerji, Udai;
Sain, Nivedita;
Sharp, Swee Y.;
Valenti, Melanie;
Asad, Yasmin;
Ruddle, Ruth;
Raynaud, Florence;
Walton, Michael;
Eccles, Suzanne A.;
Judson, Ian;
Jackman, Ann L.;
Workman, Paul

Publication type:

Correction Notice

Correction to: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.

Published in:

2018

By:

Banerji, Udai;
Sain, Nivedita;
Sharp, Swee Y;
Valenti, Melanie;
Asad, Yasmin;
Ruddle, Ruth;
Raynaud, Florence;
Walton, Michael;
Eccles, Suzanne A;
Judson, Ian;
Jackman, Ann L;
Workman, Paul

Publication type:

corrected article

An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.

Published in:

Cancer Chemotherapy & Pharmacology, 2008, v. 62, n. 5, p. 769, doi. 10.1007/s00280-007-0662-x

By:

Banerji, Udai;
Sain, Nivedita;
Sharp, Swee Y.;
Valenti, Melanie;
Asad, Yasmin;
Ruddle, Ruth;
Raynaud, Florence;
Walton, Michael;
Eccles, Suzanne A.;
Judson, Ian;
Jackman, Ann L.;
Workman, Paul

Publication type:

Article

Application of Meso Scale Technology for the Measurement of Phosphoproteins in Human Tumor Xenografts.

Published in:

Assay & Drug Development Technologies, 2007, v. 5, n. 3, p. 391, doi. 10.1089/adt.2006.044

By:

Sharon M. Gowan;
Anthea Hardcastle;
Albert E. Hallsworth;
Melanie R. Valenti;
Lisa-Jane K. Hunter;
Alexis K. de Haven Brandon;
Michelle D. Garrett;
Florence Raynaud;
Paul Workman;
Wynne Aherne;
Suzanne A. Eccles

Publication type:

Article

Solid-Phase Immunoassays in Mechanism-Based Drug Discovery: Their Application in the Development of Inhibitors of the Molecular Chaperone Heat-Shock Protein 90.

Published in:

Assay & Drug Development Technologies, 2005, v. 3, n. 3, p. 273

By:

Anthea Hardcastle;
Kathy Boxall;
Juliet Richards;
Peter Tomlin;
Swee Sharp;
Paul Clarke;
Paul Workman;
Wynne Aherne

Publication type:

Article

Non-invasive MRS in new anticancer drug development.

Published in:

NMR in Biomedicine, 1992, v. 5, n. 5, p. 270, doi. 10.1002/nbm.1940050513

By:

Workman, Paul;
Maxwell, Ross J.;
Griffiths, John R.

Publication type:

Article

A selective PIKfyve inhibitor blocks PtdIns(3,5)P<sub>2</sub> production and disrupts endomembrane transport and retroviral budding.

Published in:

EMBO Reports, 2008, v. 9, n. 2, p. 164, doi. 10.1038/sj.embor.7401155

By:

Jefferies, Harold B J;
Cooke, Frank T;
Jat, Parmjit;
Boucheron, Christine;
Koizumi, Tomonobu;
Hayakawa, Masahiko;
Kaizawa, Hiroyuki;
Ohishi, Takahide;
Workman, Paul;
Waterfield, Michael D;
Parker, Peter J

Publication type:

Article

Differential intracellular processing of the anthracycline drug ME2303 in doxorubicin-sensitive (A2780) and -resistant (A2780AD) human ovarian cancer cells as studied with confocal laser scanning microscopy and image analysis.

Published in:

International Journal of Cancer, 1994, v. 59, n. 1, p. 94, doi. 10.1002/ijc.2910590118

By:

Huxham, Ian M.;
Barlow, Andrew L.;
Lewis, Alex D.;
Plumb, Jane;
Mairs, Robert J.;
Gaze, Mark N.;
Workman, Paul

Publication type:

Article

Unusually marked hypoxic sensitization to indoloquinone E09 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.

Published in:

International Journal of Cancer, 1994, v. 56, n. 1, p. 134, doi. 10.1002/ijc.2910560124

By:

Plumb, Jane A.;
Workman, Paul

Publication type:

Article

In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells.

Published in:

PLoS ONE, 2017, v. 12, n. 7, p. 1, doi. 10.1371/journal.pone.0180263

By:

Al-Saffar, Nada M. S.;
Agliano, Alice;
Marshall, Lynley V.;
Jackson, L. Elizabeth;
Balarajah, Geetha;
Sidhu, Jasmin;
Clarke, Paul A.;
Jones, Chris;
Workman, Paul;
Pearson, Andrew D. J.;
Leach, Martin O.

Publication type:

Article

SiGNet: A signaling network data simulator to enable signaling network inference.

Published in:

PLoS ONE, 2017, v. 12, n. 5, p. 1, doi. 10.1371/journal.pone.0177701

By:

Coker, Elizabeth A.;
Mitsopoulos, Costas;
Workman, Paul;
Al-Lazikani, Bissan

Publication type:

Article

Sensitization of (colon) cancer cells to death receptor related therapies.

Published in:

Cancer Biology & Therapy, 2012, v. 13, n. 7, p. 458, doi. 10.4161/cbt.19600

By:

Pintzas, Alexander;
Zhivotovsky, Boris;
Workman, Paul;
Clarke, Paul A.;
Linardopoulos, Spiros;
Martinou, Jean-Claude;
Lacal, Juan Carlos;
Robine, Sylvie;
Nasioulas, George;
Andera, Ladislav

Publication type:

Article

Development and validation of a liquid chromatography/tandem mass spectrometry method for the determination of the novel anticancer agent 17-DMAG in human plasma.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2006, v. 20, n. 19, p. 2845, doi. 10.1002/rcm.2668

By:

Moreno-Farre, Javier;
Asad, Yasmin;
Pacey, Simon;
Workman, Paul;
Raynaud, Florence I.

Publication type:

Article

Drugging cancer genomes.

Published in:

Nature Reviews Drug Discovery, 2013, v. 12, n. 12, p. 889, doi. 10.1038/nrd4184

By:

Workman, Paul;
Al-Lazikani, Bissan

Publication type:

Article

Objective assessment of cancer genes for drug discovery.

Published in:

Nature Reviews Drug Discovery, 2013, v. 12, n. 1, p. 35, doi. 10.1038/nrd3913

By:

Patel, Mishal N.;
Halling-Brown, Mark D.;
Tym, Joseph E.;
Workman, Paul;
Al-Lazikani, Bissan

Publication type:

Article

The kinase polypharmacology landscape of clinical PARP inhibitors.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-59074-4

By:

Antolin, Albert A.;
Ameratunga, Malaka;
Banerji, Udai;
Clarke, Paul A.;
Workman, Paul;
Al-Lazikani, Bissan

Publication type:

Article

The role of high expectations of self and social desirability in emotional processing in individuals with irritable bowel syndrome: A qualitative study.

Published in:

British Journal of Health Psychology, 2017, v. 22, n. 4, p. 737, doi. 10.1111/bjhp.12264

By:

Sibelli, Alice;
Chalder, Trudie;
Everitt, Hazel;
Workman, Paul;
Bishop, Felicity L.;
Moss-Morris, Rona

Publication type:

Article

The role of high expectations of self and social desirability in emotional processing in individuals with irritable bowel syndrome: A qualitative study.

Published in:

2017

By:

Sibelli, Alice;
Chalder, Trudie;
Everitt, Hazel;
Workman, Paul;
Bishop, Felicity L;
Moss-Morris, Rona

Publication type:

journal article

The expanding proteome of the molecular chaperone HSP90.

Published in:

Cell Cycle, 2012, v. 11, n. 7, p. 1301, doi. 10.4161/cc.19722

By:

Samant, Rahul S.;
Clarke, Paul A.;
Workman, Paul

Publication type:

Article

Exploiting tumor metabolism for non-invasive imaging of the therapeutic activity of molecularly targeted anticancer agents.

Published in:

Cell Cycle, 2011, v. 10, n. 17, p. 2883, doi. 10.4161/cc.10.17.17192

By:

Beloueche-Babari, Mounia;
Workman, Paul;
Leach, Martin O.

Publication type:

Article

Targeting HSP70.

Published in:

Cell Cycle, 2010, v. 9, n. 8, p. 1542, doi. 10.4161/cc.9.8.11204

By:

Powers, Marissa V.;
Jones, Keith;
Barillari, Caterina;
Westwood, Isaac;
van Montfort, Rob L. M.;
Workman, Paul

Publication type:

Article

Drugging the heat shock factor 1 pathway.

Published in:

Cell Cycle, 2009, v. 8, n. 23, p. 3806, doi. 10.4161/cc.8.23.10423

By:

de Billy, Emmanuel;
Powers, Marissa V.;
Smith, Jennifer R.;
Workman, Paul

Publication type:

Article

Death by chaperone.

Published in:

Cell Cycle, 2009, v. 8, n. 4, p. 518, doi. 10.4161/cc.8.4.7583

By:

Powers, Marissa V.;
Clarke, Paul A.;
Workman, Paul

Publication type:

Article

Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma.

Published in:

Cell Cycle, 2009, v. 8, n. 3, p. 443, doi. 10.4161/cc.8.3.7643

By:

Guillard, Sandrine;
Clarke, Paul A.;
Poele, Robert te;
Mohri, Zahra;
Bjerke, Lynn;
Valenti, Melanie;
Raynaud, Florence;
Eccles, Suzanne A.;
Workman, Paul

Publication type:

Article

Targeting CDC37.

Published in:

Cell Cycle, 2009, v. 8, n. 3, p. 362, doi. 10.4161/cc.8.3.7531

By:

Smith, Jennifer R.;
Workman, Paul

Publication type:

Article

The Cyclin-Dependent Kinase Inhibitor Seliciclib (R-roscovitine; CYC202) Decreases the Expression of Mitotic Control Genes and Prevents Entry into Mitosis.

Published in:

Cell Cycle, 2007, v. 6, n. 24, p. 3114, doi. 10.4161/cc.6.24.5142

By:

Whittaker, Steven R.;
Te Poele, Robert H.;
Chan, Florence;
Linardopoulos, Spiros;
Walton, Michael I.;
Garrett, Michelle D.;
Workman, Paul

Publication type:

Article

Inhibitors of the heat shock response: Biology and pharmacology

Published in:

FEBS Letters, 2007, v. 581, n. 19, p. 3758, doi. 10.1016/j.febslet.2007.05.040

By:

Powers, Marissa V.;
Workman, Paul

Publication type:

Article

Correlation of Overall Survival With Gene Expression Profiles in a Prospective Study of Resectable Esophageal Cancer.

Published in:

Clinical Colorectal Cancer, 2011, v. 10, n. 1, p. 48, doi. 10.3816/CCC.2011.n.007

By:

Rao, Sheela;
Welsh, Lyndsey;
Cunningham, David;
te-Poele, Robert H.;
Benson, Martin;
Norman, Andrew;
Saffery, Claire;
Giddings, Ian;
Workman, Paul;
Clarke, Paul A.

Publication type:

Article

A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma.

Published in:

Investigational New Drugs, 2012, v. 30, n. 1, p. 341, doi. 10.1007/s10637-010-9493-4

By:

Pacey, Simon;
Gore, Martin;
Chao, David;
Banerji, Udai;
Larkin, James;
Sarker, Sarah;
Owen, Karen;
Asad, Yasmin;
Raynaud, Florence;
Walton, Mike;
Judson, Ian;
Workman, Paul;
Eisen, Tim

Publication type:

Article

Envisioning the future of early anticancer drug development.

Published in:

2010

By:

Yap, Timothy A.;
Sandhu, Shahneen K.;
Workman, Paul;
de Bono, Johann S.

Publication type:

research

Distinctive Behaviors of Druggable Proteins in Cellular Networks.

Published in:

PLoS Computational Biology, 2015, v. 11, n. 12, p. 1, doi. 10.1371/journal.pcbi.1004597

By:

Mitsopoulos, Costas;
Schierz, Amanda C.;
Workman, Paul;
Al-Lazikani, Bissan

Publication type:

Article

Drugging the Cancer Chaperone HSP90.

Published in:

Annals of the New York Academy of Sciences, 2007, v. 1113, p. 202, doi. 10.1196/annals.1391.012

By:

WORKMAN, PAUL;
BURROWS, FRANCIS;
NECKERS, LEN;
ROSEN, NEAL

Publication type:

Article

Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.

Published in:

Oncogene, 2000, v. 19, n. 36, p. 4125, doi. 10.1038/sj.onc.1203753

By:

Clarke, Paul A;
Hostein, Isabelle;
Banerji, Udai;
Stefano, Francesca Di;
Maloney, Alison;
Walton, Mike;
Judson, Ian;
Workman, Paul

Publication type:

Article

The Chemical Probes Portal – 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research.

Published in:

Nucleic Acids Research, 2025, v. 53, n. D1, p. D1663, doi. 10.1093/nar/gkae1062

By:

Sanfelice, Domenico;
Antolin, Albert A;
Crisp, Alisa;
Chen, Yi;
Bellenie, Benjamin;
Brennan, Paul E;
Edwards, Aled;
Müller, Susanne;
Al-Lazikani, Bissan;
Workman, Paul

Publication type:

Article

canSAR 2024—an update to the public drug discovery knowledgebase.

Published in:

Nucleic Acids Research, 2025, v. 53, n. D1, p. D1287, doi. 10.1093/nar/gkae1050

By:

Gingrich, Phillip W;
Chitsazi, Rezvan;
Biswas, Ansuman;
Jiang, Chunjie;
Zhao, Li;
Tym, Joseph E;
Brammer, Kevin M;
Li, Jun;
Shu, Zhigang;
Maxwell, David S;
Tacy, Jeffrey A;
Mica, Ioan L;
Darkoh, Michael;
di Micco, Patrizio;
Russell, Kaitlyn P;
Workman, Paul;
Al-Lazikani, Bissan

Publication type:

Article

Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and use.

Published in:

Nucleic Acids Research, 2023, v. 51, n. D1, p. D1492, doi. 10.1093/nar/gkac909

By:

Antolin, Albert A;
Sanfelice, Domenico;
Crisp, Alisa;
Villasclaras Fernandez, Eloy;
Mica, Ioan L;
Chen, Yi;
Collins, Ian;
Edwards, Aled;
Müller, Susanne;
Al-Lazikani, Bissan;
Workman, Paul

Publication type:

Article

canSAR: update to the cancer translational research and drug discovery knowledgebase.

Published in:

Nucleic Acids Research, 2023, v. 51, n. D1, p. D1212, doi. 10.1093/nar/gkac1004

By:

di Micco, Patrizio;
Antolin, Albert A;
Mitsopoulos, Costas;
Villasclaras-Fernandez, Eloy;
Sanfelice, Domenico;
Dolciami, Daniela;
Ramagiri, Pradeep;
Mica, Ioan L;
Tym, Joseph E;
Gingrich, Philip W;
Hu, Huabin;
Workman, Paul;
Al-Lazikani, Bissan

Publication type:

Article