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canSAR: update to the cancer translational research and drug discovery knowledgebase.
- Published in:
- Nucleic Acids Research, 2023, v. 51, n. D1, p. D1212, doi. 10.1093/nar/gkac1004
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- Publication type:
- Article
Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and use.
- Published in:
- Nucleic Acids Research, 2023, v. 51, n. D1, p. D1492, doi. 10.1093/nar/gkac909
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- Publication type:
- Article
Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-71969-w
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- Publication type:
- Article
Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer.
- Published in:
- PLoS ONE, 2020, v. 15, n. 7, p. 1, doi. 10.1371/journal.pone.0234103
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- Publication type:
- Article
The kinase polypharmacology landscape of clinical PARP inhibitors.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-59074-4
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- Publication type:
- Article
Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release.
- Published in:
- Biochemical Journal, 2019, v. 476, n. 18, p. 2521, doi. 10.1042/BCJ20190383
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- Publication type:
- Article
canSAR: update to the cancer translational research and drug discovery knowledgebase.
- Published in:
- Nucleic Acids Research, 2019, v. 47, n. D1, p. D917, doi. 10.1093/nar/gky1129
- By:
- Publication type:
- Article
Correction to: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.
- Published in:
- 2018
- By:
- Publication type:
- Correction Notice
Correction to: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.
- Published in:
- 2018
- By:
- Publication type:
- corrected article
Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.
- Published in:
- Molecular Oncology, 2018, v. 12, n. 3, p. 287, doi. 10.1002/1878-0261.12148
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- Publication type:
- Article
The role of high expectations of self and social desirability in emotional processing in individuals with irritable bowel syndrome: A qualitative study.
- Published in:
- British Journal of Health Psychology, 2017, v. 22, n. 4, p. 737, doi. 10.1111/bjhp.12264
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- Publication type:
- Article
Structure-based drug design: aiming for a perfect fit.
- Published in:
- Essays in Biochemistry, 2017, v. 61, n. 5, p. 431, doi. 10.1042/EBC20170052
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- Publication type:
- Article
RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.
- Published in:
- British Journal of Cancer, 2017, v. 117, n. 7, p. 954, doi. 10.1038/bjc.2017.277
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- Publication type:
- Article
The role of high expectations of self and social desirability in emotional processing in individuals with irritable bowel syndrome: A qualitative study.
- Published in:
- 2017
- By:
- Publication type:
- journal article
RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.
- Published in:
- 2017
- By:
- Publication type:
- journal article
In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells.
- Published in:
- PLoS ONE, 2017, v. 12, n. 7, p. 1, doi. 10.1371/journal.pone.0180263
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- Publication type:
- Article
SiGNet: A signaling network data simulator to enable signaling network inference.
- Published in:
- PLoS ONE, 2017, v. 12, n. 5, p. 1, doi. 10.1371/journal.pone.0177701
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- Publication type:
- Article
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
- Published in:
- Scientific Reports, 2016, p. 34701, doi. 10.1038/srep34701
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- Publication type:
- Article
Distinctive Behaviors of Druggable Proteins in Cellular Networks.
- Published in:
- PLoS Computational Biology, 2015, v. 11, n. 12, p. 1, doi. 10.1371/journal.pcbi.1004597
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- Publication type:
- Article
Lactate and Choline Metabolites Detected <i>In Vitro</i> by Nuclear Magnetic Resonance Spectroscopy Are Potential Metabolic Biomarkers for PI3K Inhibition in Pediatric Glioblastoma.
- Published in:
- PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0103835
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- Publication type:
- Article
Academia and industry: Successes for UK cancer partnership.
- Published in:
- Nature, 2014, v. 510, n. 7504, p. 218, doi. 10.1038/510218d
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- Publication type:
- Article
Drugging cancer genomes.
- Published in:
- Nature Reviews Drug Discovery, 2013, v. 12, n. 12, p. 889, doi. 10.1038/nrd4184
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- Publication type:
- Article
Bench to Bedside, Gene to Drug Discovery Defines New Era of Precision Medicine.
- Published in:
- 2013
- By:
- Publication type:
- Proceeding
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.
- Published in:
- Nature Chemical Biology, 2013, v. 9, n. 6, p. 406, doi. 10.1038/nchembio0613-406d
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- Publication type:
- Article
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.
- Published in:
- Nature Chemical Biology, 2013, v. 9, n. 5, p. 307, doi. 10.1038/nchembio.1212
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- Publication type:
- Article
Objective assessment of cancer genes for drug discovery.
- Published in:
- Nature Reviews Drug Discovery, 2013, v. 12, n. 1, p. 35, doi. 10.1038/nrd3913
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- Publication type:
- Article
A public-private partnership to unlock the untargeted kinome.
- Published in:
- Nature Chemical Biology, 2012, v. 9, n. 1, p. 3, doi. 10.1038/nchembio.1113
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- Publication type:
- Article
Molecular biology: Choose your protein partners.
- Published in:
- Nature, 2012, v. 490, n. 7420, p. 351, doi. 10.1038/490351a
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- Publication type:
- Article
Co-Crystalization and In VitroBiological Characterization of 5-Aryl-4-(5-Substituted-2-4-Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 Inhibitors.
- Published in:
- PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0044642
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- Publication type:
- Article
Combinatorial drug therapy for cancer in the post-genomic era.
- Published in:
- Nature Biotechnology, 2012, v. 30, n. 7, p. 679, doi. 10.1038/nbt.2284
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- Publication type:
- Article
Discovery of small molecule cancer drugs: Successes, challenges and opportunities
- Published in:
- Molecular Oncology, 2012, v. 6, n. 2, p. 155, doi. 10.1016/j.molonc.2012.02.004
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- Publication type:
- Article
The HSP90 Inhibitor NVP-AUY922 Radiosensitizes by Abrogation of Homologous Recombination Resulting in Mitotic Entry with Unresolved DNA Damage.
- Published in:
- PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0035436
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- Publication type:
- Article
A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma.
- Published in:
- Investigational New Drugs, 2012, v. 30, n. 1, p. 341, doi. 10.1007/s10637-010-9493-4
- By:
- Publication type:
- Article
Effects of HSP90 inhibitor 17-allylamino-17 -demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy.
- Published in:
- BMC Research Notes, 2012, v. 5, n. 1, p. 250, doi. 10.1186/1756-0500-5-250
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- Publication type:
- Article
Mechanism-Based Screen for G1/S Checkpoint Activators Identifies a Selective Activator of EIF2AK3/PERK Signalling.
- Published in:
- PLoS ONE, 2012, v. 7, n. 1, p. 1, doi. 10.1371/journal.pone.0028568
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- Publication type:
- Article
Chemical biology: Many faces of a cancer-supporting protein.
- Published in:
- Nature, 2011, v. 478, n. 7369, p. 334, doi. 10.1038/478334b
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- Publication type:
- Article
Epigenetics: Targeting leukemia on the DOT.
- Published in:
- Nature Chemical Biology, 2011, v. 7, n. 10, p. 663, doi. 10.1038/nchembio.661
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- Publication type:
- Article
A HIF-Regulated VHL-PTP1B-Src Signaling Axis Identifies a Therapeutic Target in Renal Cell Carcinoma.
- Published in:
- Science Translational Medicine, 2011, v. 3, n. 85, p. 1, doi. 10.1126/scitranslmed.3002004
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- Publication type:
- Article
Correlation of Overall Survival With Gene Expression Profiles in a Prospective Study of Resectable Esophageal Cancer.
- Published in:
- Clinical Colorectal Cancer, 2011, v. 10, n. 1, p. 48, doi. 10.3816/CCC.2011.n.007
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- Publication type:
- Article
Inhibition of Hsp90 with Resorcylic Acid Macrolactones: Synthesis and Binding Studies.
- Published in:
- Chemistry - A European Journal, 2010, v. 16, n. 34, p. 10366, doi. 10.1002/chem.201001119
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- Publication type:
- Article
Envisioning the future of early anticancer drug development.
- Published in:
- 2010
- By:
- Publication type:
- research
Cancer: Drug-tolerant insurgents.
- Published in:
- Nature, 2010, v. 464, n. 7290, p. 844, doi. 10.1038/464844a
- By:
- Publication type:
- Article
Revealing the delta lady.
- Published in:
- 2010
- By:
- Publication type:
- Correction notice
Targeting the Hsp90 Chaperone: Synthesis of Novel Resorcylic Acid Macrolactone Inhibitors of Hsp90.
- Published in:
- Chemistry - A European Journal, 2010, v. 16, n. 9, p. 2758, doi. 10.1002/chem.200902766
- By:
- Publication type:
- Article
PI(3) Kinases: Revealing the delta lady.
- Published in:
- Nature Chemical Biology, 2010, v. 6, n. 2, p. 82, doi. 10.1038/nchembio.305
- By:
- Publication type:
- Article
Determinants of response to epidermal growth factor receptor tyrosine kinase inhibition in squamous cell carcinoma of the head and neck.
- Published in:
- Journal of Pathology, 2009, v. 218, n. 1, p. 122, doi. 10.1002/path.2515
- By:
- Publication type:
- Article
Molecular and Phenotypic Characterisation of Paediatric Glioma Cell Lines as Models for Preclinical Drug Development.
- Published in:
- PLoS ONE, 2009, v. 4, n. 4, p. 1, doi. 10.1371/journal.pone.0005209
- By:
- Publication type:
- Article
An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.
- Published in:
- Cancer Chemotherapy & Pharmacology, 2008, v. 62, n. 5, p. 769, doi. 10.1007/s00280-007-0662-x
- By:
- Publication type:
- Article
A selective PIKfyve inhibitor blocks PtdIns(3,5)P<sub>2</sub> production and disrupts endomembrane transport and retroviral budding.
- Published in:
- EMBO Reports, 2008, v. 9, n. 2, p. 164, doi. 10.1038/sj.embor.7401155
- By:
- Publication type:
- Article
Drugging the Cancer Chaperone HSP90.
- Published in:
- Annals of the New York Academy of Sciences, 2007, v. 1113, p. 202, doi. 10.1196/annals.1391.012
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- Publication type:
- Article