Works by Woodhead, Jeffrey L.

Results: 13

Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition.

Published in:

Frontiers in Pharmacology, 2023, v. 14, p. 1, doi. 10.3389/fphar.2022.1085621

By:

Beaudoin, James J.;
Yang, Kyunghee;
Adiwidjaja, Jeffry;
Taneja, Guncha;
Watkins, Paul B.;
Siler, Scott Q.;
Howell, Brett A.;
Woodhead, Jeffrey L.

Publication type:

Article

Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling.

Published in:

CTS: Clinical & Translational Science, 2018, v. 11, n. 5, p. 498, doi. 10.1111/cts.12560

By:

Woodhead, Jeffrey L.;
Paech, Franziska;
Maurer, Martina;
Engelhardt, Marc;
Schmitt‐Hoffmann, Anne H.;
Spickermann, Jochen;
Messner, Simon;
Wind, Mathias;
Witschi, Anne‐Therese;
Krähenbühl, Stephan;
Siler, Scott Q.;
Watkins, Paul B.;
Howell, Brett A.

Publication type:

Article

Modeling and Simulation of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended‐Release and Immediate‐Release Formulations in Healthy Adults Using the Quantitative Systems Toxicology Software Platform DILIsym.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2025, v. 14, n. 4, p. 681, doi. 10.1002/psp4.13304

By:

Beaudoin, James J.;
Yang, Kyunghee;
Howell, Brett A.;
Kenz, Zackary;
Lakhani, Vinal V.;
Woodhead, Jeffrey L.;
Lai, John C. K.;
Gelotte, Cathy K.;
Sista, Sury;
Atillasoy, Evren

Publication type:

Article

Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling.

Published in:

Pharmaceutical Research, 2019, v. 36, n. 3, p. 1, doi. 10.1007/s11095-019-2582-y

By:

Woodhead, Jeffrey L.;
Yang, Kyunghee;
Oldach, David;
MacLauchlin, Chris;
Fernandes, Prabhavathi;
Watkins, Paul B.;
Siler, Scott Q.;
Howell, Brett A.

Publication type:

Article

Linking physiology to toxicity using DILIsym<sup>®</sup>, a mechanistic mathematical model of drug-induced liver injury.

Published in:

Biopharmaceutics & Drug Disposition, 2014, v. 35, n. 1, p. 33, doi. 10.1002/bdd.1878

By:

Shoda, Lisl K. M.;
Woodhead, Jeffrey L.;
Siler, Scott Q.;
Watkins, Paul B.;
Howell, Brett A.

Publication type:

Article

Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator.

Published in:

Toxicological Sciences, 2023, v. 194, n. 2, p. 235, doi. 10.1093/toxsci/kfad057

By:

Zhuo, Xiaoliang;
Howell, Brett A;
Shen, Hong;
Woodhead, Jeffrey L;
Mosure, Kathy;
Zhang, Yueping;
Scialis, Renato J;
Iyer, Ramaswamy;
Sun, Yongnian;
Boy, Kenneth M;
Lentz, Kimberley A;
Denton, R Rex;
Soars, Matthew G;
Johnson, Benjamin M;
Humphreys, W Griffith

Publication type:

Article

Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling.

Published in:

Toxicological Sciences, 2022, v. 188, n. 1, p. 108, doi. 10.1093/toxsci/kfac051

By:

Woodhead, Jeffrey L;
Siler, Scott Q;
Howell, Brett A;
Watkins, Paul B;
Conway, Charles

Publication type:

Article

Mechanistic Investigations Support Liver Safety of Ubrogepant.

Published in:

Toxicological Sciences, 2020, v. 177, n. 1, p. 84, doi. 10.1093/toxsci/kfaa093

By:

Smith, Brenda;
Rowe, Josh;
Watkins, Paul B;
Ashina, Messoud;
Woodhead, Jeffrey L;
Sistare, Frank D;
Goadsby, Peter J

Publication type:

Article

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 458, doi. 10.1093/toxsci/kfy253

By:

Longo, Diane M;
Woodhead, Jeffrey L;
Walker, Paul;
Herédi-Szabó, Krisztina;
Mogyorósi, Károly;
Wolenski, Francis S;
Dragan, Yvonne P;
Mosedale, Merrie;
Siler, Scott Q;
Watkins, Paul B;
Howell, Brett A

Publication type:

Article

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.

Published in:

Toxicological Sciences, 2017, v. 155, n. 1, p. 61, doi. 10.1093/toxsci/kfw193

By:

Woodhead, Jeffrey L.;
Brock, William J.;
Roth, Sharin E.;
Shoaf, Susan E.;
Brouwer, Kim L. R.;
Church, Rachel;
Grammatopoulos, Tom N.;
Stiles, Linsey;
Siler, Scott Q.;
Howell, Brett A.;
Mosedale, Merrie;
Watkins, Paul B.;
Shoda, Lisl K. M.

Publication type:

Article

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury.

Published in:

Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00240

By:

Woodhead, Jeffrey L.;
Kyunghee Yang;
Siler, Scott Q.;
Watkins, Paul B.;
Brouwer, Kim L. R.;
Barton, Hugh A.;
Howel, Brett A.;
Maggi, Adriana;
Lohman, Rink-Jan

Publication type:

Article

Modeling drug- and chemical- induced hepatotoxicity with systems biology approaches.

Published in:

Frontiers in Physiology, 2012, v. 3, p. 1, doi. 10.3389/fphys.2012.00462

By:

Bhattacharya, Sudin;
Shoda, Lisl K. M.;
Zhang, Qiang;
Woods, Courtney G.;
Howell, Brett A.;
Siler, Scott Q.;
Woodhead, Jeffrey L.;
Yang, Yuching;
McMullen, Patrick;
Watkins, Paul B.;
Andersen, Melvin E.

Publication type:

Article

Prediction of the liver safety profile of a first-in-class myeloperoxidase inhibitor using quantitative systems toxicology modeling.

Published in:

Xenobiotica, 2024, v. 54, n. 7, p. 401, doi. 10.1080/00498254.2024.2361027

By:

Woodhead, Jeffrey L.;
Gebremichael, Yeshi;
Macwan, Joyce;
Qureshi, Irfan A.;
Bertz, Richard;
Wirtz, Victoria;
Howell, Brett A.

Publication type:

Article