Works by Withers, Stephen

Results: 140
    1

    Ligand‐Directed Chemistry on Glycoside Hydrolases – A Proof of Concept Study.

    Published in:
    ChemBioChem, 2023, v. 24, n. 23, p. 1, doi. 10.1002/cbic.202300480
    By:
    • Prasch, Herwig;
    • Wolfsgruber, Andreas;
    • Thonhofer, Martin;
    • Culum, André;
    • Mandl, Christoph;
    • Weber, Patrick;
    • Zündel, Melanie;
    • Nasseri, Seyed A.;
    • Gonzalez Santana, Andres;
    • Tegl, Gregor;
    • Nidetzky, Bernd;
    • Gruber, Karl;
    • Stütz, Arnold E.;
    • Withers, Stephen G.;
    • Wrodnigg, Tanja M.
    Publication type:
    Article
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    Self-Immobilizing Fluorogenic Imaging Agents of Enzyme Activity.

    Published in:
    Angewandte Chemie, 2011, v. 123, n. 1, p. 314, doi. 10.1002/ange.201005705
    By:
    • Kwan, David H.;
    • Chen, Hong-Ming;
    • Ratananikom, Khakhanang;
    • Hancock, Susan M.;
    • Watanabe, Yoichiro;
    • Kongsaeree, Prachumporn T.;
    • Samuels, A. Lacey;
    • Withers, Stephen G.
    Publication type:
    Article
    7

    Chitinase Inhibition by Chitobiose and Chitotriose Thiazolines.

    Published in:
    Angewandte Chemie, 2010, v. 122, n. 14, p. 2653, doi. 10.1002/ange.200906644
    By:
    • Macdonald, James M.;
    • Tarling, Chris A.;
    • Taylor, Edward J.;
    • Dennis, Rebecca J.;
    • Myers, David S.;
    • Knapp, Spencer;
    • Davies, Gideon J.;
    • Withers, Stephen G.
    Publication type:
    Article
    8

    Family 4 Glycosidases Carry Out Efficient Hydrolysis of Thioglycosides by an α,β-Elimination MechanismWe thank Dr. Gideon Davies for providing the BglT plasmid, Dr. John Thompson for providing the kinase BglK, Dr. J. Müllegger for providing the thioglycoligase Abg E170Q, and Dr. Hongming Chen for providing p-nitrophenyl 4-deoxy-4-thio-D-glucoside. We also thank the Natural Sciences and Engineering Research Council of Canada for financial support. V.L.Y.Y. is funded by graduate fellowships from the Natural Sciences and Engineering Research Council of Canada and the Michael Smith Foundation for Health Research.

    Published in:
    Angewandte Chemie, 2006, v. 118, n. 37, p. 6325, doi. 10.1002/ange.200601421
    By:
    • Vivian L. Y. Yip;
    • Stephen G. Withers
    Publication type:
    Article
    9

    Glycosylation of a Neoglycoprotein by Using Glycosynthase and Thioglycoligase Approaches: The Generation of a ThioglycoproteinThe authors would like to thank Prof. L. P. McIntosh and Prof. W. W. Wakarchuk for Bcx clones, Dr. Y. W. Kim for Abg 2F6 glycosynthase, and L. Lairson for glycosyl transferases, as well as the proteomics core facility of UBC for providing assistance with, and access to, the mass spectrometer. The project was funded by the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Protein Engineering Network of Centres of Excellence of Canada (PENCE). J.M. was financed by a Schrödinger Fellowship from the Austrian FWF.

    Published in:
    Angewandte Chemie, 2006, v. 118, n. 16, p. 2647
    By:
    • Johannes Müllegger;
    • Hong Ming Chen;
    • R. Antony J. Warren;
    • Stephen G. Withers
    Publication type:
    Article
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    Directed evolution of bacterial polysialyltransferases.

    Published in:
    Glycobiology, 2019, v. 29, n. 7, p. 588, doi. 10.1093/glycob/cwz021
    By:
    • Janesch, Bettina;
    • Baumann, Lars;
    • Mark, Alison;
    • Thompson, Nicole;
    • Rahmani, Sadia;
    • Sim, Lyann;
    • Withers, Stephen G;
    • Wakarchuk, Warren W
    Publication type:
    Article
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    Self-Immobilizing Fluorogenic Imaging Agents of Enzyme Activity.

    Published in:
    Angewandte Chemie International Edition, 2011, v. 50, n. 1, p. 300, doi. 10.1002/anie.201005705
    By:
    • Kwan, David H.;
    • Chen, Hong-Ming;
    • Ratananikom, Khakhanang;
    • Hancock, Susan M.;
    • Watanabe, Yoichiro;
    • Kongsaeree, Prachumporn T.;
    • Samuels, A. Lacey;
    • Withers, Stephen G.
    Publication type:
    Article