Works matching AU Withers, Stephen
Results: 139
Vinyl Halide‐Modified Unsaturated Cyclitols are Mechanism‐Based Glycosidase Inhibitors.
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- Angewandte Chemie, 2023, v. 135, n. 21, p. 1, doi. 10.1002/ange.202301258
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Pharmacological Chaperones for GCase that Switch Conformation with pH Enhance Enzyme Levels in Gaucher Animal Models.
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- Angewandte Chemie, 2022, v. 134, n. 38, p. 1, doi. 10.1002/ange.202207974
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Berichtigung: Facile Formation of β‐thioGlcNAc Linkages to Thiol‐Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase.
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- Angewandte Chemie, 2020, v. 132, n. 23, p. 8832, doi. 10.1002/ange.202001582
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Facile Formation of β‐thioGlcNAc Linkages to Thiol‐Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase.
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- Angewandte Chemie, 2019, v. 131, n. 6, p. 1646, doi. 10.1002/ange.201809928
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Mammalian sialyltransferases allow efficient Escherichia coli-based production of mucin-type O-glycoproteins but can also transfer Kdo.
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- Glycobiology, 2022, v. 32, n. 5, p. 429, doi. 10.1093/glycob/cwab130
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Crystal structure of the Propionibacterium acnes surface sialidase, a drug target for P. acnes-associated diseases.
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- Glycobiology, 2022, v. 32, n. 2, p. 162, doi. 10.1093/glycob/cwab094
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Directed evolution of bacterial polysialyltransferases.
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- Glycobiology, 2019, v. 29, n. 7, p. 588, doi. 10.1093/glycob/cwz021
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Identity and role of the non-conserved acid/base catalytic residue in the GH29 fucosidase from the spider Nephilingis cruentata.
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- Glycobiology, 2018, v. 28, n. 12, p. 925, doi. 10.1093/glycob/cwy083
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Introducing transgalactosylation activity into a family 42 β-galactosidase.
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- Glycobiology, 2017, v. 27, n. 5, p. 425, doi. 10.1093/glycob/cwx013
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Mechanisms of the sialidase and trans-sialidase activities of bacterial sialyltransferases from glycosyltransferase family 80.
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- Glycobiology, 2016, v. 26, n. 4, p. 353, doi. 10.1093/glycob/cwv105
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Chemoenzymatic Synthesis of a Type 2 Blood Group A Tetrasaccharide and Development of High-throughput Assays Enables a Platform for Screening Blood Group Antigen-cleaving Enzymes.
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- Glycobiology, 2015, v. 25, n. 8, p. 806, doi. 10.1093/glycob/cwv031
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Probing the role of an invariant active site His in family GH1 β-glycosidases.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 973, doi. 10.1080/14756366.2019.1608198
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Detection of Chromosome X;18 Breakpoints and Translocation of the Xq22.3;18q23 Regions Resulting in Variable Fertility Phenotypes.
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- Case Reports in Genetics, 2012, p. 1, doi. 10.1155/2012/681747
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use of a recombinant deacetylase to convert A1 red blood cells to the acquired b phenotype for quality control purposes.
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- Blood Transfusion (17232007), 2024, v. 22, n. 5, p. 106, doi. 10.2450/BloodTransfus.584
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Use of a recombinant deacetylase to convert A<sub>1</sub> red blood cells to the acquired B phenotype for quality control purposes.
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- Blood Transfusion (17232007), 2024, v. 22, n. 2, p. 106, doi. 10.2450/BloodTransfus.584
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Towards universal red blood cells.
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- Nature Biotechnology, 2007, v. 25, n. 4, p. 427, doi. 10.1038/nbt0407-427
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The synthesis of some mechanistic probes for sialic acid processing enzymes and the labeling of a sialidase from Trypanosoma rangeli.
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- Canadian Journal of Chemistry, 2004, v. 82, n. 11, p. 1581, doi. 10.1139/V04-125
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On expanding the repertoire of glycosynthases: Mutant β-galactosidases forming β-(1,6)-linkages.
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- Canadian Journal of Chemistry, 2002, v. 80, n. 8, p. 866, doi. 10.1139/v02-077
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Synthesis of 5-fluoro-β-D-glucopyranosyluronic acid fluoride and its evaluation as a mechanistic probe of Escherichia coli β-glucuronidase.
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- Canadian Journal of Chemistry, 2001, v. 79, n. 5/6, p. 510, doi. 10.1139/v00-155
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Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs.
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- Nature Structural Biology, 2001, v. 8, n. 2, p. 166, doi. 10.1038/84168
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X-ray structures along the reaction pathway of cyclodextrin glycosyltransferase elucidate catalysis in the α-amylase family.
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- Nature Structural Biology, 1999, v. 6, n. 5, p. 432, doi. 10.1038/8235
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Insights into transition state stabilization of the β-1,4-glycosidase Cex by covalent intermediate accumulation in active site mutants.
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- Nature Structural Biology, 1998, v. 5, n. 9, p. 812, doi. 10.1038/1852
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High-throughput screening methodology for the directed evolution of glycosyltransferases.
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- Nature Methods, 2006, v. 3, n. 8, p. 609, doi. 10.1038/nmeth899
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Ligand‐Directed Chemistry on Glycoside Hydrolases – A Proof of Concept Study.
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- ChemBioChem, 2023, v. 24, n. 23, p. 1, doi. 10.1002/cbic.202300480
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Fungal Glycolipid Hydrolase Inhibitors and Their Effect on Cryptococcus neoformans.
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- ChemBioChem, 2017, v. 18, n. 3, p. 284, doi. 10.1002/cbic.201600538
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Letter to the Editor: Assignment of selectively 13C-labeled cellopentaose synthesized using an engineered glycosynthase.
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- Journal of Biomolecular NMR, 2001, v. 21, n. 1, p. 67, doi. 10.1023/A:1011927400439
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Four cellulose-active lytic polysaccharide monooxygenases from Cellulomonas species.
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- Biotechnology for Biofuels, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s13068-020-01860-3
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Tailoring the Specificity and Reactivity of a Mechanism-Based Inactivator of Glucocerebrosidase for Potential Therapeutic Applications.
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- Angewandte Chemie International Edition, 2011, v. 50, n. 44, p. 10381, doi. 10.1002/anie.201103924
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Self-Immobilizing Fluorogenic Imaging Agents of Enzyme Activity.
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- Angewandte Chemie International Edition, 2011, v. 50, n. 1, p. 300, doi. 10.1002/anie.201005705
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Chitinase Inhibition by Chitobiose and Chitotriose Thiazolines.
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- Angewandte Chemie International Edition, 2010, v. 49, n. 14, p. 2599, doi. 10.1002/anie.200906644
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A New Generation of Specific Trypanosoma cruzi trans-Sialidase Inhibitors.
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- Angewandte Chemie International Edition, 2008, v. 47, n. 14, p. 2700, doi. 10.1002/anie.200705435
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The Structural Basis of Glycosidase Inhibition by Five-Membered Iminocyclitols: The Clan A Glycoside Hydrolase Endoglycoceramidase as a Model System.
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- Angewandte Chemie International Edition, 2007, v. 46, n. 24, p. 4474, doi. 10.1002/anie.200700268
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Family 4 Glycosidases Carry Out Efficient Hydrolysis of Thioglycosides by an α,β-Elimination MechanismWe thank Dr. Gideon Davies for providing the BglT plasmid, Dr. John Thompson for providing the kinase BglK, Dr. J. Müllegger for providing the thioglycoligase Abg E170Q, and Dr. Hongming Chen for providing p-nitrophenyl 4-deoxy-4-thio-D-glucoside. We also thank the Natural Sciences and Engineering Research Council of Canada for financial support. V.L.Y.Y. is funded by graduate fellowships from the Natural Sciences and Engineering Research Council of Canada and the Michael Smith Foundation for Health Research.
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- Angewandte Chemie International Edition, 2006, v. 45, n. 37, p. 6179, doi. 10.1002/anie.200601421
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Characterization of an extradiol dioxygenase involved in the catabolism of lignin-derived biphenyl.
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- FEBS Letters, 2017, v. 591, n. 7, p. 1001, doi. 10.1002/1873-3468.12611
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Evidence of human metapneumovirus in Australian children.
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- Medical Journal of Australia, 2002, v. 176, n. 4, p. 188, doi. 10.5694/j.1326-5377.2002.tb04354.x
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Mechanistic Insights from Substrate Preference in Unsaturated Glucuronyl Hydrolase.
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- ChemBioChem, 2014, v. 15, n. 1, p. 124, doi. 10.1002/cbic.201300547
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Synthesis, Kinetic Evaluation and Cell-Based Analysis of C-Alkylated Isofagomines as Chaperones of β-Glucocerebrosidase.
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- ChemBioChem, 2011, v. 12, n. 14, p. 2151, doi. 10.1002/cbic.201100332
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Glycosynthase-Mediated Assembly of Xylanase Substrates and Inhibitors.
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- ChemBioChem, 2011, v. 12, n. 11, p. 1703, doi. 10.1002/cbic.201100229
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Fluorous Iminoalditols: A New Family of Glycosidase Inhibitors and Pharmacological Chaperones.
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- ChemBioChem, 2010, v. 11, n. 14, p. 2026, doi. 10.1002/cbic.201000192
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- Article
Enzymatic Thioxyloside Synthesis: Characterization of Thioglycoligase Variants Identified from A Site-Saturation Mutagenesis Library of Bacillus Circulans Xylanase.
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- ChemBioChem, 2010, v. 11, n. 4, p. 533, doi. 10.1002/cbic.200900711
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Cover Picture: Enzymatic Thioxyloside Synthesis: Characterization of Thioglycoligase Variants Identified from A Site-Saturation Mutagenesis Library of Bacillus Circulans Xylanase (ChemBioChem 4/2010).
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- ChemBioChem, 2010, v. 11, n. 4, p. 441, doi. 10.1002/cbic.201090010
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Ultrahigh-Throughput FACS-Based Screening for Directed Enzyme Evolution.
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- ChemBioChem, 2009, v. 10, n. 17, p. 2704, doi. 10.1002/cbic.200900384
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Development of New and Selective Trypanosoma cruzi trans-Sialidase Inhibitors from Sulfonamide Chalcones and Their Derivatives.
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- ChemBioChem, 2009, v. 10, n. 15, p. 2475, doi. 10.1002/cbic.200900108
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A β-1,4-Galactosyltransferase from Helicobacter pylori is an Efficient and Versatile Biocatalyst Displaying a Novel Activity for Thioglycoside Synthesis.
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- ChemBioChem, 2008, v. 9, n. 10, p. 1632, doi. 10.1002/cbic.200700775
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The Search for Novel Human Pancreatic α-Amylase Inhibitors: High-Throughput Screening of Terrestrial and Marine Natural Product Extracts.
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- ChemBioChem, 2008, v. 9, n. 3, p. 433, doi. 10.1002/cbic.200700470
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Specificity Fingerprinting of Retaining β-1,4-Glycanases in the Cellulomonas fimi Secretome Using Two Fluorescent Mechanism-Based Probes.
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- ChemBioChem, 2007, v. 8, n. 17, p. 2125, doi. 10.1002/cbic.200700481
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Thioglycoligase-Based Assembly of Thiodisaccharides: Screening as β-Galactosidase Inhibitors.
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- ChemBioChem, 2007, v. 8, n. 13, p. 1495, doi. 10.1002/cbic.200700263
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Facile Synthesis of 2,4-Dinitrophenyl α- D-Glycopyranosides as Chromogenic Substrates for α-Glycosidases.
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- ChemBioChem, 2007, v. 8, n. 7, p. 719, doi. 10.1002/cbic.200700021
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Thermostable Glycosynthases and Thioglycoligases Derived from Thermotoga maritima β-Glucuronidase.
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- ChemBioChem, 2006, v. 7, n. 7, p. 1028, doi. 10.1002/cbic.200600028
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An Atypical Approach Identifies TYR234 as the Key Base Catalyst in Chondroitin AC Lyase.
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- ChemBioChem, 2006, v. 7, n. 4, p. 631, doi. 10.1002/cbic.200500428
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