Works by Wischik, Claude M.

Results: 48

Hydromethylthionine sustains truncated tau‐dependent inflammation‐lowering effects in mouse brain.

Published in:

FEBS Journal, 2025, v. 292, n. 10, p. 2602, doi. 10.1111/febs.70021

By:

Santos, Renato X.;
Lee, Sophie H.;
Lofthouse, Richard;
Melis, Valeria;
Robinson, Lianne;
Leith, Michael;
Dreesen, Eline;
Armstrong, Paul;
Vorley, Thomas;
Goatman, Elizabeth A.;
Hull, Claire;
Riedel, Gernot;
Wischik, Claude M.;
Harrington, Charles R.

Publication type:

Article

Significant dose‐dependent reduction in neurofilament light chain concentration in plasma with oral tau aggregation inhibitor hydromethylthionine mesylate.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.083153

By:

Wischik, Claude M;
Schelter, Bjoern;
Penny, Lewis Kirk;
Miller, Sonya;
Stefanacci, Richard;
Heslegrave, Amanda;
Zetterberg, Henrik

Publication type:

Article

HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine.

Published in:

Biomedicines, 2022, v. 10, n. 4, p. 867, doi. 10.3390/biomedicines10040867

By:

Santos, Renato X.;
Melis, Valeria;
Goatman, Elizabeth A.;
Leith, Michael;
Baddeley, Thomas C.;
Storey, John M. D.;
Riedel, Gernot;
Wischik, Claude M.;
Harrington, Charles R.

Publication type:

Article

Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model.

Published in:

Cells (2073-4409), 2024, v. 13, n. 7, p. 642, doi. 10.3390/cells13070642

By:

Zadrozny, Maciej;
Drapich, Patrycja;
Gasiorowska-Bien, Anna;
Niewiadomski, Wiktor;
Harrington, Charles R.;
Wischik, Claude M.;
Riedel, Gernot;
Niewiadomska, Grazyna

Publication type:

Article

Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer's Disease: Systematic Review and Meta-Analysis.

Published in:

Cells (2073-4409), 2023, v. 12, n. 8, p. 1184, doi. 10.3390/cells12081184

By:

Zabala-Findlay, Alex;
Penny, Lewis K.;
Lofthouse, Richard A.;
Porter, Andrew J.;
Palliyil, Soumya;
Harrington, Charles R.;
Wischik, Claude M.;
Arastoo, Mohammad

Publication type:

Article

Proteomic Analysis of Hydromethylthionine in the Line 66 Model of Frontotemporal Dementia Demonstrates Actions on Tau-Dependent and Tau-Independent Networks.

Published in:

Cells (2073-4409), 2021, v. 10, n. 8, p. 2162, doi. 10.3390/cells10082162

By:

Schwab, Karima;
Melis, Valeria;
Harrington, Charles R.;
Wischik, Claude M.;
Magbagbeolu, Mandy;
Theuring, Franz;
Riedel, Gernot

Publication type:

Article

Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates.

Published in:

Cells (2073-4409), 2021, v. 10, n. 3, p. 703, doi. 10.3390/cells10030703

By:

Maina, Mahmoud B.;
Al-Hilaly, Youssra K.;
Burra, Gunasekhar;
Rickard, Janet E.;
Harrington, Charles R.;
Wischik, Claude M.;
Serpell, Louise C.;
Perego, Carla

Publication type:

Article

Tau (297‐391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain.

Published in:

FEBS Letters, 2020, v. 594, n. 5, p. 944, doi. 10.1002/1873-3468.13675

By:

Al‐Hilaly, Youssra K.;
Foster, Bronwen E.;
Biasetti, Luca;
Lutter, Liisa;
Pollack, Saskia J.;
Rickard, Janet E.;
Storey, John M. D.;
Harrington, Charles R.;
Xue, Wei‐Feng;
Wischik, Claude M.;
Serpell, Louise C.

Publication type:

Article

LATE PARAPHRENIA, ADVANCED SCHIZOPHRENIC DETERIORATION AND DEMENTIA.

Published in:

1993

By:

Charlesworth, Georgina M.;
Hymas, Nigel;
Wischik, Claude M.;
Hodges, John R.;
Sahakian, Barbara J.

Publication type:

Conference Paper/Materials

Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 18, p. 13747, doi. 10.3390/ijms241813747

By:

Arastoo, Mohammad;
Mazanetz, Michael P.;
Miller, Sonya;
Shiells, Helen;
Hull, Claire;
Robinson, Keith;
Storey, John M. D.;
Harrington, Charles R.;
Wischik, Claude M.

Publication type:

Article

Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 13, p. 10810, doi. 10.3390/ijms241310810

By:

Kondak, Constantin;
Leith, Michael;
Baddeley, Thomas C.;
Santos, Renato X.;
Harrington, Charles R.;
Wischik, Claude M.;
Riedel, Gernot;
Klein, Jochen

Publication type:

Article

Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer's Disease.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 22, p. 8673, doi. 10.3390/ijms21228673

By:

Arastoo, Mohammad;
Lofthouse, Richard;
Penny, Lewis K.;
Harrington, Charles R.;
Porter, Andy;
Wischik, Claude M.;
Palliyil, Soumya

Publication type:

Article

A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy.

Published in:

Frontiers in Molecular Neuroscience, 2018, p. 1, doi. 10.3389/fnmol.2017.00447

By:

Schwab, Karima;
Frahm, Silke;
Horsley, David;
Rickard, Janet E.;
Melis, Valeria;
Goatman, Elizabeth A.;
Magbagbeolu, Mandy;
Douglas, Morag;
Leith, Michael G.;
Baddeley, Thomas C.;
Storey, John M. D.;
Riedel, Gernot;
Wischik, Claude M.;
Harrington, Charles R.;
Theuring, Franz

Publication type:

Article

Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine.

Published in:

Journal of Neurochemistry, 2022, v. 160, n. 2, p. 172, doi. 10.1111/jnc.15553

By:

Kondak, Constantin;
Riedel, Gernot;
Harrington, Charles R.;
Wischik, Claude M.;
Klein, Jochen

Publication type:

Article

Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease.

Published in:

Biomolecules (2218-273X), 2016, v. 6, n. 2, p. 19, doi. 10.3390/biom6020019

By:

Lai, Robert Y. K.;
Harrington, Charles R.;
Wischik, Claude M.

Publication type:

Article

The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease.

Published in:

Frontiers in Neuroscience, 2015, v. 9, p. 1, doi. 10.3389/fnins.2015.00033

By:

Flores-Rodríguez, Paola;
Ontiveros-Torres, Miguel A.;
Cárdenas-Aguayo, María C.;
Luna-Arias, Juan P.;
Meraz-Ríos, Marco A.;
Viramontes-Pintos, Amparo;
Harrington, Charles R.;
Wischik, Claude M.;
Mena, Raúl;
Florán-Garduño, Benjamin;
Luna-Muñoz, José

Publication type:

Article

Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer’s disease in tissue imprints.

Published in:

Acta Neuropathologica, 2008, v. 116, n. 5, p. 507, doi. 10.1007/s00401-008-0431-x

By:

Luna-Muñoz, José;
Peralta-Ramirez, Janneth;
Chávez-Macías, Laura;
Harrington, Charles R.;
Wischik, Claude M.;
Mena, Raúl

Publication type:

Article

The impact of genetic and environmental factors on the pathobiology of Alzheimer's disease: A...

Published in:

International Review of Psychiatry, 1995, v. 7, n. 3/4, p. 361, doi. 10.3109/09540269509022988

By:

Harrington, Charles R.;
Wischik, Claude M.

Publication type:

Article

Molecular determinants of paired helical filament assembly and its therapeutic implications in...

Published in:

International Review of Psychiatry, 1995, v. 7, n. 3/4, p. 299, doi. 10.3109/09540269509022985

By:

Wischik, Claude M.;
Harrington, Charles R.

Publication type:

Article

Obituary for Professor Sir Martin Roth, FRS.

Published in:

2007

By:

Wischik, Claude M.

Publication type:

Obituary

Memorial Service for Professor Sir Martin Roth.

Published in:

2007

By:

Wischik, Claude M.

Publication type:

Obituary

Solubility of α-synuclein species in the L62 mouse model of synucleinopathy.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-56735-6

By:

Schwab, Karima;
Magbagbeolu, Mandy;
Theuring, Franz;
Harrington, Charles R.;
Wischik, Claude M.;
Riedel, Gernot

Publication type:

Article

Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.

Published in:

Frontiers in Neurology, 2020, v. 11, p. N.PAG, doi. 10.3389/fneur.2020.590754

By:

Oakley, Sebastian S.;
Maina, Mahmoud B.;
Marshall, Karen E.;
Al-Hilaly, Youssra K.;
Harrington, Charlie R.;
Wischik, Claude M.;
Serpell, Louise C.

Publication type:

Article

High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer's disease.

Published in:

Alzheimer's Research & Therapy, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13195-024-01561-1

By:

Arastoo, Mohammad;
Penny, Lewis K.;
Lofthouse, Richard;
Abdallah, Aya;
Abrahamsson, Anna;
Marini, Pietro;
Melis, Valeria;
Riedel, Gernot;
Harrington, Charles R.;
Wischik, Claude M.;
Porter, Andrew;
Palliyil, Soumya

Publication type:

Article

Degeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia.

Published in:

Brain Communications, 2021, v. 3, n. 4, p. 1, doi. 10.1093/braincomms/fcab241

By:

Vuksanović, Vesna;
Staff, Roger T.;
Morson, Suzannah;
Ahearn, Trevor;
Bracoud, Luc;
Murray, Alison D.;
Bentham, Peter;
Kipps, Christopher M.;
Harrington, Charles R.;
Wischik, Claude M.

Publication type:

Article

Cortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer's Disease and Behavioral Variant Fronto-Temporal Dementia.

Published in:

International Journal of Neural Systems, 2019, v. 29, n. 6, p. N.PAG, doi. 10.1142/S0129065718500557

By:

Vuksanović, Vesna;
Staff, Roger T;
Ahearn, Trevor;
Murray, Alison D;
Wischik, Claude M

Publication type:

Article

Back‐translation of clinical tau‐aggregation inhibitor trials to experimental models: negative interactions of dementia therapies.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076153

By:

Riedel, Gernot;
Melis, Valeria;
Schwab, Karima;
Klein, Jochen;
Niewiadomska, Grazyna;
Niewiadomski, Wiktor;
Wischik, Claude M;
Harrington, Charles R

Publication type:

Article

Causal association of cardiovascular risk factors with Alzheimer's disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.071305

By:

Tripathi, Shailendra Mohan;
Murray, Alison D.;
Wischik, Claude M;
Schelter, Bjoern

Publication type:

Article

Causal association of cardiovascular risk factors with Alzheimer's disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.071305

By:

Tripathi, Shailendra Mohan;
Murray, Alison D.;
Wischik, Claude M;
Schelter, Bjoern

Publication type:

Article

Template impact in nucleus basalis segmentation.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.053912

By:

Conklin, Chris;
Scott, David;
Bracoud, Luc;
Vuksanovic, Vesna;
Wischik, Claude M;
Suhy, Joyce;
Staff, Roger

Publication type:

Article

Neuroprotection of cholinergic neurons with tau aggregation inhibitor and rivastigmine in L1 mice with Alzheimer's‐like tauopathy: Development of new models and analysis methods/tau.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.042986

By:

Steczkowska, Marta;
Zadrozny, Maciej;
Wydrych, Malgorzata;
Gasiorowska, Anna;
Niewiadomski, Wiktor;
Riedel, Gernot;
Wischik, Claude M.;
Niewiadomska, Grazyna

Publication type:

Article

LMTM DECREASES α-SYNUCLEIN PATHOLOGY AND REDUCES BEHAVIOURAL DEFECTS IN α-SYNUCLEIN TRANSGENIC MICE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P945, doi. 10.1016/j.jalz.2017.06.1854

By:

Schwab, Karima;
Frahm, Silke;
Magbagbeolu, Mandy;
Goatman, Elizabeth A.;
Harrington, Charles R.;
Wischik, Claude M.;
Theuring, Franz

Publication type:

Article

PHASE 3 TRIAL OF THE TAU AGGREGATION INHIBITOR LEUCO-METHYLTHIONINIUM-BIS (HYDROMETHANESULFONATE) (LMTM) IN MILD TO MODERATE ALZHEIMER'S DISEASE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P351, doi. 10.1016/j.jalz.2016.06.650

By:

Gauthier, Serge;
Feldman, Howard H.;
Schneider, Lon S.;
Wilcock, Gordon;
Frisoni, Giovanni B.;
Hardlund, Jiri;
Kook, Karin;
Wischik, Damon J.;
Schelter, Bjoern O.;
Storey, John M.;
Harrington, Charles R.;
Wischik, Claude M.

Publication type:

Article

The first disease-modifying drug trial in frontotemporal dementia: initial experiences.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2014, v. 10, p. P138, doi. 10.1016/j.jalz.2014.04.519

By:

Diehl-Schmid, Janine;
Hardlund, Jiri;
Bentham, Peter;
Wischik, Claude M.

Publication type:

Article

Hyperphosphorylation along the C-terminal of tau protein is associated with PHF assembly resulting from truncation at Glu-391, in AlzheimerÂś disease

Published in:

2011

By:

Luna-Muñoz, José;
Flores, Paola;
Zamudio, Sergio Zamudio;
De la Cruz De la Cruz, Fidel;
Harrington, Charles R;
Wischik, Claude M.;
López, Raúl Mena

Publication type:

Abstract

Overexpression of mutant tau in mice leads to tau aggregation and deterioration of motor skills

Published in:

2009

By:

Zabke, Claudia;
Dietze, Silke;
Melis, Valeria;
Stamer, Karsten;
Riedel, Gernot;
Harrington, Charles R.;
Wischik, Claude M.;
Theuring, Franz

Publication type:

Abstract

Age-related impairments in tau transgenic mice using two different water maze training protocols

Published in:

2009

By:

Melis, Valeria;
Zabke, Claudia;
Harrington, Charles R.;
Theuring, Franz;
Wischik, Claude M.;
Riedel, Gernot

Publication type:

Abstract

P2-428: Methylthioninium chloride versus rivastigmine and their co-administration efficacy in reversing scopolamine-induced cognitive deficits in a pharmacological mouse model of Alzheimer's disease

Published in:

2008

By:

Deiana, Serena;
Harrington, Charles;
Riedel, Gernot;
Seng, Kwang Meng;
Wischik, Claude M.

Publication type:

Abstract

P2-383: Reversal of spatial problem-solving cognitive deficit in a transgenic mouse line overexpressing the repeat domain of Tau by treatment with the Tau aggregation inhibitor methylthioninium chloride

Published in:

2008

By:

Melis, Valeria;
Deiana, Serena;
Zabke, Claudia;
Stamer, Karsten;
Harrington, Charles R.;
Riedel, Gernot;
Theuring, Franz;
Seng, Kwang Meng;
Wischik, Claude M.

Publication type:

Abstract

P1-109: Subtle behavioural changes in transgenic mice with amorphous Tau aggregates

Published in:

2008

By:

Dietze, Silke;
Zabke, Claudia;
Deiana, Serena;
Riedel, Gernot;
Harrington, Charles R.;
Theuring, Franz;
Wischik, Claude M.

Publication type:

Abstract

P1-054: Early and advanced stages of Tau aggregation in transgenic mouse models

Published in:

2008

By:

Zabke, Claudia;
Dietze, Silke;
Stamer, Karsten;
Rickard, Janet E.;
Harrington, Charles R.;
Theuring, Franz;
Seng, Kwang Meng;
Wischik, Claude M.

Publication type:

Abstract

O3-04-07: Tau aggregation inhibitor (TAI) therapy with rember<sup>™</sup> arrests disease progression in mild and moderate Alzheimer's disease over 50 weeks

Published in:

2008

By:

Wischik, Claude M.;
Bentham, Peter;
Wischik, Damon J.;
Seng, Kwang Meng

Publication type:

Abstract

O1-06-04: Methylthioninium chloride (MTC) acts as a Tau aggregation inhibitor (TAI) in a cellular model and reverses Tau pathology in transgenic mouse models of Alzheimer's disease

Published in:

2008

By:

Harrington, Charles;
Rickard, Janet E.;
Horsley, David;
Harrington, Kathleen A.;
Hindley, Kathleen P.;
Riedel, Gernot;
Theuring, Franz;
Seng, Kwang Meng;
Wischik, Claude M.

Publication type:

Abstract

The extent of neurofibrillary pathology in perforant pathway neurons is the key determinant of dementia in the very old.

Published in:

Acta Neuropathologica, 2000, v. 100, n. 1, p. 29

By:

García-Sierra, Francisco;
Hauw, Jean J.;
Duyckaerts, Charles;
Wischik, Claude M.;
Luna-Muñoz, José;
Mena, Raúl

Publication type:

Article

Staging the pathological assembly of truncated tau protein into paired helical filaments in Alzheimer's disease.

Published in:

Acta Neuropathologica, 1996, v. 91, n. 6, p. 633, doi. 10.1007/s004010050477

By:

Mena, R.;
Edwards, Patricia C.;
Harrington, Charles R.;
Mukaetova-Ladinska, Elizabeta B.;
Wischik, Claude M.

Publication type:

Article

Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease.

Published in:

Translational Neurodegeneration, 2024, v. 13, n. 1, p. 1, doi. 10.1186/s40035-024-00417-w

By:

Penny, Lewis K.;
Lofthouse, Richard;
Arastoo, Mohammad;
Porter, Andy;
Palliyil, Soumya;
Harrington, Charles R.;
Wischik, Claude M.

Publication type:

Article

The Repeat Region of Microtubule-Associated Protein Tau Forms Part of the Core of the Paired Helical Filament of Alzheimer's Disease.

Published in:

Annals of Medicine, 1989, v. 21, n. 2, p. 127, doi. 10.3109/07853898909149199

By:

Crowther, Tony;
Goedert, Michel;
Wischik, Claude M.

Publication type:

Article

Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391).

Published in:

Frontiers in Neuroscience, 2022, v. 16, p. 1, doi. 10.3389/fnins.2022.988074

By:

Al-Hilaly, Youssra K.;
Hurt, Connor;
Rickard, Janet E.;
Harrington, Charles R.;
Storey, John M. D.;
Wischik, Claude M.;
Serpell, Louise C.;
Siemer, Ansgar B.

Publication type:

Article