Works by Winkler, Malcolm E.

Results: 31

FtsZ-Ring Regulation and Cell Division Are Mediated by Essential EzrA and Accessory Proteins ZapA and ZapJ in Streptococcus pneumoniae.
Published in:
Frontiers in Microbiology, 2021, v. 12, p. 1, doi. 10.3389/fmicb.2021.780864
By:
- Perez, Amilcar J.;
- Villicana, Jesus Bazan;
- Tsui, Ho-Ching T.;
- Danforth, Madeline L.;
- Benedet, Mattia;
- Massidda, Orietta;
- Winkler, Malcolm E.
Publication type:
Article
The Pneumococcal Divisome: Dynamic Control of Streptococcus pneumoniae Cell Division.
Published in:
Frontiers in Microbiology, 2021, v. 12, p. 1, doi. 10.3389/fmicb.2021.737396
By:
- Briggs, Nicholas S.;
- Bruce, Kevin E.;
- Naskar, Souvik;
- Winkler, Malcolm E.;
- Roper, David I.
Publication type:
Article
Physiological Roles of the Dual Phosphate Transporter Systems in Low and High Phosphate Conditions and in Capsule Maintenance of Streptococcus pneumoniae D39.
Published in:
Frontiers in Cellular & Infection Microbiology, 2016, v. 6, p. 1, doi. 10.3389/fcimb.2016.00063
By:
- Jiaqi J. Zheng;
- Sinha, Dhriti;
- Wayne, Kyle J.;
- Winkler, Malcolm E.
Publication type:
Article
Light-dependent modulation of protein localization and function in living bacteria cells.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-54974-9
By:
- McQuillen, Ryan;
- Perez, Amilcar J.;
- Yang, Xinxing;
- Bohrer, Christopher H.;
- Smith, Erika L.;
- Chareyre, Sylvia;
- Tsui, Ho-Ching Tiffany;
- Bruce, Kevin E.;
- Hla, Yin Mon;
- McCausland, Joshua W.;
- Winkler, Malcolm E.;
- Goley, Erin D.;
- Ramamurthi, Kumaran S.;
- Xiao, Jie
Publication type:
Article
The five homologous CiaR-controlled Ccn sRNAs of Streptococcus pneumoniae modulate Zn-resistance.
Published in:
PLoS Pathogens, 2024, v. 20, n. 10, p. 1, doi. 10.1371/journal.ppat.1012165
By:
- De Lay, Nicholas R.;
- Verma, Nidhi;
- Sinha, Dhriti;
- Garrett, Abigail;
- Osterberg, Maximillian K.;
- Porter, Daisy;
- Reiling, Spencer;
- Giedroc, David P.;
- Winkler, Malcolm E.
Publication type:
Article
1H, 13C, 15N resonance assignments of the extracellular loop 1 domain (ECL1) of Streptococcus pneumoniae D39 FtsX, an essential cell division protein.
Published in:
Biomolecular NMR Assignments, 2016, v. 10, n. 1, p. 89, doi. 10.1007/s12104-015-9644-9
By:
- Fu, Yue;
- Bruce, Kevin E.;
- Rued, Britta;
- Winkler, Malcolm E.;
- Giedroc, David P.
Publication type:
Article
The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08056-2
By:
- Cleverley, Robert M.;
- Rutter, Zoe J.;
- Rismondo, Jeanine;
- Corona, Federico;
- Tsui, Ho-Ching Tiffany;
- Alatawi, Fuad A.;
- Daniel, Richard A.;
- Halbedel, Sven;
- Massidda, Orietta;
- Winkler, Malcolm E.;
- Lewis, Richard J.
Publication type:
Article
Absence of the KhpA and KhpB (JAG/EloR) RNA-binding proteins suppresses the requirement for PBP2b by overproduction of FtsA in Streptococcus pneumoniae D39.
Published in:
Molecular Microbiology, 2017, v. 106, n. 5, p. 793, doi. 10.1111/mmi.13847
By:
- Zheng, Jiaqi J.;
- Perez, Amilcar J.;
- Tsui, Ho-Ching Tiffany;
- Massidda, Orietta;
- Winkler, Malcolm E.
Publication type:
Article
The zinc efflux activator Scz A protects S treptococcus pneumoniae serotype 2 D39 from intracellular zinc toxicity.
Published in:
Molecular Microbiology, 2017, v. 104, n. 4, p. 636, doi. 10.1111/mmi.13654
By:
- Martin, Julia E.;
- Edmonds, Katherine A.;
- Bruce, Kevin E.;
- Campanello, Gregory C.;
- Eijkelkamp, Bart A.;
- Brazel, Erin B.;
- McDevitt, Christopher A.;
- Winkler, Malcolm E.;
- Giedroc, David P.
Publication type:
Article
Perturbation of manganese metabolism disrupts cell division in Streptococcus pneumoniae.
Published in:
Molecular Microbiology, 2017, v. 104, n. 2, p. 334, doi. 10.1111/mmi.13630
By:
- Martin, Julia E.;
- Lisher, John P.;
- Winkler, Malcolm E.;
- Giedroc, David P.
Publication type:
Article
Suppression and synthetic-lethal genetic relationships of Δ gps B mutations indicate that Gps B mediates protein phosphorylation and penicillin-binding protein interactions in S treptococcus pneumoniae D39.
Published in:
Molecular Microbiology, 2017, v. 103, n. 6, p. 931, doi. 10.1111/mmi.13613
By:
- Rued, Britta E.;
- Zheng, Jiaqi J.;
- Mura, Andrea;
- Tsui, Ho‐Ching T.;
- Boersma, Michael J.;
- Mazny, Jeffrey L.;
- Corona, Federico;
- Perez, Amilcar J.;
- Fadda, Daniela;
- Doubravová, Linda;
- Buriánková, Karolína;
- Branny, Pavel;
- Massidda, Orietta;
- Winkler, Malcolm E.
Publication type:
Article
Suppression of a deletion mutation in the gene encoding essential PBP2b reveals a new lytic transglycosylase involved in peripheral peptidoglycan synthesis in S treptococcus pneumoniae D39.
Published in:
Molecular Microbiology, 2016, v. 100, n. 6, p. 1039, doi. 10.1111/mmi.13366
By:
- Tsui, Ho‐Ching Tiffany;
- Zheng, Jiaqi J.;
- Magallon, Ariel N.;
- Ryan, John D.;
- Yunck, Rachel;
- Rued, Britta E.;
- Bernhardt, Thomas G.;
- Winkler, Malcolm E.
Publication type:
Article
A new quorum-sensing system ( TprA/ PhrA) for S treptococcus pneumoniae D39 that regulates a lantibiotic biosynthesis gene cluster.
Published in:
Molecular Microbiology, 2015, v. 97, n. 2, p. 229, doi. 10.1111/mmi.13029
By:
- Hoover, Sharon E.;
- Perez, Amilcar J.;
- Tsui, Ho‐Ching T.;
- Sinha, Dhriti;
- Smiley, David L.;
- DiMarchi, Richard D.;
- Winkler, Malcolm E.;
- Lazazzera, Beth A.
Publication type:
Article
Pbp2x localizes separately from Pbp2b and other peptidoglycan synthesis proteins during later stages of cell division of S treptococcus pneumoniae D39.
Published in:
Molecular Microbiology, 2014, v. 94, n. 1, p. 21, doi. 10.1111/mmi.12745
By:
- Tsui, Ho‐Ching T.;
- Boersma, Michael J.;
- Vella, Stephen A.;
- Kocaoglu, Ozden;
- Kuru, Erkin;
- Peceny, Julia K.;
- Carlson, Erin E.;
- VanNieuwenhze, Michael S.;
- Brun, Yves V.;
- Shaw, Sidney L.;
- Winkler, Malcolm E.
Publication type:
Article
Requirement of essential Pbp2x and GpsB for septal ring closure in Streptococcus pneumoniae D39.
Published in:
Molecular Microbiology, 2013, v. 90, n. 5, p. 939, doi. 10.1111/mmi.12408
By:
- Land, Adrian D.;
- Tsui, Ho‐Ching T.;
- Kocaoglu, Ozden;
- Vella, Stephen A.;
- Shaw, Sidney L.;
- Keen, Susan K.;
- Sham, Lok‐To;
- Carlson, Erin E.;
- Winkler, Malcolm E.
Publication type:
Article
Involvement of WalK ( VicK) phosphatase activity in setting WalR ( VicR) response regulator phosphorylation level and limiting cross-talk in Streptococcus pneumoniae D39 cells Involvement of WalK ( VicK) phosphatase activity in setting WalR ( VicR) response regulator phosphorylation level and limiting cross-talk in Streptococcus pneumoniae D39 cells
Published in:
Molecular Microbiology, 2012, v. 86, n. 3, p. 645, doi. 10.1111/mmi.12006
By:
- Wayne, Kyle J.;
- Li, Shuo;
- Kazmierczak, Krystyna M.;
- Tsui, Ho-Ching T.;
- Winkler, Malcolm E.
Publication type:
Article
DegU-phosphate activates expression of the anti-sigma factor FlgM in Bacillus subtilis.
Published in:
Molecular Microbiology, 2011, v. 81, n. 4, p. 1092, doi. 10.1111/j.1365-2958.2011.07755.x
By:
- Hsueh, Yi-Huang;
- Cozy, Loralyn M.;
- Sham, Lok-To;
- Calvo, Rebecca A.;
- Gutu, Alina D.;
- Winkler, Malcolm E.;
- Kearns, Daniel B.
Publication type:
Article
Roles of rel Spn in stringent response, global regulation and virulence of serotype 2 Streptococcus pneumoniae D39.
Published in:
Molecular Microbiology, 2009, v. 72, n. 3, p. 590, doi. 10.1111/j.1365-2958.2009.06669.x
By:
- Kazmierczak, Krystyna M.;
- Wayne, Kyle J.;
- Rechtsteiner, Andreas;
- Winkler, Malcolm E.
Publication type:
Article
Polymorphism and regulation of the spxB (pyruvate oxidase) virulence factor gene by a CBS-HotDog domain protein (SpxR) in serotype 2 Streptococcus pneumoniae.
Published in:
Molecular Microbiology, 2008, v. 67, n. 4, p. 729, doi. 10.1111/j.1365-2958.2007.06082.x
By:
- Ramos-Montañez, Smirla;
- Tsui, Ho-Ching Tiffany;
- Wayne, Kyle J.;
- Morris, Jordan L.;
- Peters, Lindsey E.;
- Zhang, Faming;
- Kazmierczak, Krystyna M.;
- Lok-To Sham;
- Winkler, Malcolm E.
Publication type:
Article
Secrets of getting started: Regulation of the first committed step of peptidoglycan synthesis by protein phosphorylation in Enterococcus and other Gram‐positive bacteria.
Published in:
Molecular Microbiology, 2023, v. 120, n. 6, p. 805, doi. 10.1111/mmi.15204
By:
- Winkler, Malcolm E.;
- Joseph, Merrin;
- Tsui, Ho‐Ching T.
Publication type:
Article
Negative regulation of MurZ and MurA underlies the essentiality of GpsB‐ and StkP‐mediated protein phosphorylation in Streptococcus pneumoniaeD39.
Published in:
Molecular Microbiology, 2023, v. 120, n. 3, p. 351, doi. 10.1111/mmi.15122
By:
- Tsui, Ho‐Ching Tiffany;
- Joseph, Merrin;
- Zheng, Jiaqi J.;
- Perez, Amilcar J.;
- Manzoor, Irfan;
- Rued, Britta E.;
- Richardson, John D.;
- Branny, Pavel;
- Doubravová, Linda;
- Massidda, Orietta;
- Winkler, Malcolm E.
Publication type:
Article
Roles of RodZ and class A PBP1b in the assembly and regulation of the peripheral peptidoglycan elongasome in ovoid‐shaped cells of Streptococcus pneumoniaeD39.
Published in:
Molecular Microbiology, 2022, v. 118, n. 4, p. 336, doi. 10.1111/mmi.14969
By:
- Lamanna, Melissa M.;
- Manzoor, Irfan;
- Joseph, Merrin;
- Ye, Ziyun A.;
- Benedet, Mattia;
- Zanardi, Alessia;
- Ren, Zhongqing;
- Wang, Xindan;
- Massidda, Orietta;
- Tsui, Ho‐Ching T.;
- Winkler, Malcolm E.
Publication type:
Article
Organization of peptidoglycan synthesis in nodes and separate rings at different stages of cell division of Streptococcus pneumoniae.
Published in:
Molecular Microbiology, 2021, v. 115, n. 6, p. 1152, doi. 10.1111/mmi.14659
By:
- Perez, Amilcar J.;
- Boersma, Michael J.;
- Bruce, Kevin E.;
- Lamanna, Melissa M.;
- Shaw, Sidney L.;
- Tsui, Ho‐Ching T.;
- Taguchi, Atsushi;
- Carlson, Erin E.;
- VanNieuwenhze, Michael S.;
- Winkler, Malcolm E.
Publication type:
Article
Biochemical characterization of essential cell division proteins FtsX and FtsE that mediate peptidoglycan hydrolysis by PcsB in Streptococcus pneumoniae.
Published in:
MicrobiologyOpen, 2016, v. 5, n. 5, p. 738, doi. 10.1002/mbo3.366
By:
- Bajaj, Ruchika;
- Bruce, Kevin E.;
- Davidson, Amy L.;
- Rued, Britta E.;
- Stauffacher, Cynthia V.;
- Winkler, Malcolm E.
Publication type:
Article
Mn-sensing riboswitch activates expression of a Mn 2+ /Ca 2+ ATPase transporter in Streptococcus.
Published in:
Nucleic Acids Research, 2019, v. 47, n. 13, p. 6885, doi. 10.1093/nar/gkz494
By:
- Martin, Julia E;
- Le, My T;
- Bhattarai, Nabin;
- Capdevila, Daiana A;
- Shen, Jiangchuan;
- Winkler, Malcolm E;
- Giedroc, David P
Publication type:
Article
Defective cell wall synthesis in Streptococcus pneumoniae R6 depleted for the essential PcsB putative murein hydrolase or the VicR (YycF) response regulator.
Published in:
Molecular Microbiology, 2004, v. 53, n. 4, p. 1161, doi. 10.1111/j.1365-2958.2004.04196.x
By:
- Ng, Wai-Leung;
- Kazmierczak, Krystyna M.;
- Winkler, Malcolm E.
Publication type:
Article
Constitutive expression of PcsB suppresses the requirement for the essential VicR (YycF) response regulator in Streptococcus pneumoniae R6.
Published in:
Molecular Microbiology, 2003, v. 50, n. 5, p. 1647, doi. 10.1046/j.1365-2958.2003.03806.x
By:
- Wai-Leung Ng;
- Robertson, Gregory T.;
- Kazmierczak, Krystyna M.;
- Jingyong Zhao;
- Gilmour, Raymond;
- Winkler, Malcolm E.
Publication type:
Article
Characterization of broadly pleiotropic phenotypes caused by an hfq insertion mutation in Escherichia colt K--12.
Published in:
Molecular Microbiology, 1994, v. 13, n. 1, p. 35, doi. 10.1111/j.1365-2958.1994.tb00400.x
By:
- Tsui, Ho-Ching Tiffany;
- Leung, Hon-Chiu Eastwood;
- Winkler, Malcolm E.
Publication type:
Article
The mutL repair gene of Escherichia coll K--12 forms a superoperon with a gene encoding a new cell--wall amidase.
Published in:
Molecular Microbiology, 1994, v. 11, n. 1, p. 189, doi. 10.1111/j.1365-2958.1994.tb00300.x
By:
- Tsui, Ho-Ching Tiffany;
- Genshi Zhao;
- Gang Feng;
- Leung, Hon-Chiu Eastwood;
- Winkler, Malcolm E.
Publication type:
Article
Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-020-20873-y
By:
- McCausland, Joshua W.;
- Yang, Xinxing;
- Squyres, Georgia R.;
- Lyu, Zhixin;
- Bruce, Kevin E.;
- Lamanna, Melissa M.;
- Söderström, Bill;
- Garner, Ethan C.;
- Winkler, Malcolm E.;
- Xiao, Jie;
- Liu, Jian
Publication type:
Article
A new structural paradigm in copper resistance in Streptococcus pneumoniae.
Published in:
Nature Chemical Biology, 2013, v. 9, n. 3, p. 177, doi. 10.1038/nchembio.1168
By:
- Fu, Yue;
- Tsui, Ho-Ching Tiffany;
- Bruce, Kevin E;
- Sham, Lok-To;
- Higgins, Khadine A;
- Lisher, John P;
- Kazmierczak, Krystyna M;
- Maroney, Michael J;
- Dann, Charles E;
- Winkler, Malcolm E;
- Giedroc, David P
Publication type:
Article

Works by Winkler, Malcolm E.

FtsZ-Ring Regulation and Cell Division Are Mediated by Essential EzrA and Accessory Proteins ZapA and ZapJ in Streptococcus pneumoniae.

The Pneumococcal Divisome: Dynamic Control of Streptococcus pneumoniae Cell Division.

Physiological Roles of the Dual Phosphate Transporter Systems in Low and High Phosphate Conditions and in Capsule Maintenance of Streptococcus pneumoniae D39.

Light-dependent modulation of protein localization and function in living bacteria cells.

The five homologous CiaR-controlled Ccn sRNAs of Streptococcus pneumoniae modulate Zn-resistance.

<sup>1</sup>H, <sup>13</sup>C, <sup>15</sup>N resonance assignments of the extracellular loop 1 domain (ECL1) of Streptococcus pneumoniae D39 FtsX, an essential cell division protein.

The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes.

Absence of the KhpA and KhpB (JAG/EloR) RNA-binding proteins suppresses the requirement for PBP2b by overproduction of FtsA in Streptococcus pneumoniae D39.

The zinc efflux activator Scz A protects S treptococcus pneumoniae serotype 2 D39 from intracellular zinc toxicity.

Perturbation of manganese metabolism disrupts cell division in Streptococcus pneumoniae.

Suppression and synthetic-lethal genetic relationships of Δ gps B mutations indicate that Gps B mediates protein phosphorylation and penicillin-binding protein interactions in S treptococcus pneumoniae D39.

Suppression of a deletion mutation in the gene encoding essential PBP2b reveals a new lytic transglycosylase involved in peripheral peptidoglycan synthesis in S treptococcus pneumoniae D39.

A new quorum-sensing system ( TprA/ PhrA) for S treptococcus pneumoniae D39 that regulates a lantibiotic biosynthesis gene cluster.

Pbp2x localizes separately from Pbp2b and other peptidoglycan synthesis proteins during later stages of cell division of S treptococcus pneumoniae D39.

Requirement of essential Pbp2x and GpsB for septal ring closure in Streptococcus pneumoniae D39.

DegU-phosphate activates expression of the anti-sigma factor FlgM in Bacillus subtilis.

Roles of rel<sub> Spn</sub> in stringent response, global regulation and virulence of serotype 2 Streptococcus pneumoniae D39.

Polymorphism and regulation of the spxB (pyruvate oxidase) virulence factor gene by a CBS-HotDog domain protein (SpxR) in serotype 2 Streptococcus pneumoniae.

Secrets of getting started: Regulation of the first committed step of peptidoglycan synthesis by protein phosphorylation in Enterococcus and other Gram‐positive bacteria.

Negative regulation of MurZ and MurA underlies the essentiality of GpsB‐ and StkP‐mediated protein phosphorylation in Streptococcus pneumoniaeD39.

Roles of RodZ and class A PBP1b in the assembly and regulation of the peripheral peptidoglycan elongasome in ovoid‐shaped cells of Streptococcus pneumoniaeD39.

Organization of peptidoglycan synthesis in nodes and separate rings at different stages of cell division of Streptococcus pneumoniae.

Biochemical characterization of essential cell division proteins FtsX and FtsE that mediate peptidoglycan hydrolysis by PcsB in Streptococcus pneumoniae.

Mn-sensing riboswitch activates expression of a Mn 2+ /Ca 2+ ATPase transporter in Streptococcus.

Defective cell wall synthesis in Streptococcus pneumoniae R6 depleted for the essential PcsB putative murein hydrolase or the VicR (YycF) response regulator.

Constitutive expression of PcsB suppresses the requirement for the essential VicR (YycF) response regulator in Streptococcus pneumoniae R6.

Characterization of broadly pleiotropic phenotypes caused by an hfq insertion mutation in Escherichia colt K--12.

The mutL repair gene of Escherichia coll K--12 forms a superoperon with a gene encoding a new cell--wall amidase.

Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism.

A new structural paradigm in copper resistance in Streptococcus pneumoniae.