Works by Wiman, Klas G.

Results: 53

Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells.

Published in:

Cell Death Discovery, 2020, v. 6, n. 1, p. 1, doi. 10.1038/s41420-020-0272-5

By:

Cheteh, Emarndeena H.;
Sarne, Victoria;
Ceder, Sophia;
Bianchi, Julie;
Augsten, Martin;
Rundqvist, Helene;
Egevad, Lars;
Östman, Arne;
Wiman, Klas G.

Publication type:

Article

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-31048-7

By:

Haffo, Lena;
Lu, Jun;
Bykov, Vladimir J. N.;
Martin, Sebastin S.;
Ren, Xiaoyuan;
Coppo, Lucia;
Wiman, Klas G.;
Holmgren, Arne

Publication type:

Article

Wild-type p53-induced apoptosis in a Burkitt lymphoma cell line is inhibited by interferon gamma.

Published in:

International Journal of Cancer, 1996, v. 67, n. 1, p. 106, doi. 10.1002/(SICI)1097-0215(19960703)67:1<106::AID-IJC18>3.0.CO;2-C

By:

Sangfelt, Olle;
Einhorn, Stefan;
Björklund, Ann Charlotte;
Wiman, Klas G.;
Okan, Ismail;
Grandér, Dan

Publication type:

Article

Frequent expression of Bcl-2 in renal-cell carcinomas carrying wild-type p53.

Published in:

International Journal of Cancer, 1996, v. 66, n. 3, p. 322, doi. 10.1002/(SICI)1097-0215(19960503)66:3<322::AID-IJC9>3.0.CO;2-0

By:

Tomita, Yoshihiko;
Bilim, Vladimir;
Kawasaki, Takashi;
Takahashi, Kota;
Okan, Ismail;
Magnusson, Kristinn P.;
Wiman, Klas G.

Publication type:

Article

RB-reconstituted human retinoblastoma cells form RB-positive intraocular and intracerebral but not subcutaneous tumors in scid mice.

Published in:

International Journal of Cancer, 1995, v. 61, n. 5, p. 683, doi. 10.1002/ijc.2910610516

By:

Szekely, Laszlo;
Wang, Yisong;
Klein, George;
Wiman, Klas G.

Publication type:

Article

Progressive B-cell chronic lymphocytic leukaemia frequently exhibits aberrant p53 expression.

Published in:

International Journal of Cancer, 1994, v. 58, n. 4, p. 474, doi. 10.1002/ijc.2910580403

By:

Aguilar-Santelises, Miguel;
Magnusson, Kristinn P.;
Wiman, Klas G.;
Mellstedt, Håkan;
Jondal, Mikael

Publication type:

Article

Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog.

Published in:

Cell Death & Disease, 2022, v. 13, n. 3, p. 1, doi. 10.1038/s41419-022-04653-8

By:

Zhang, Qiang;
Balourdas, Dimitrios-Ilias;
Baron, Bruno;
Senitzki, Alon;
Haran, Tali E.;
Wiman, Klas G.;
Soussi, Thierry;
Joerger, Andreas C.

Publication type:

Article

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells.

Published in:

Cell Death & Disease, 2021, v. 12, n. 7, p. 1, doi. 10.1038/s41419-021-03988-y

By:

Ceder, Sophia;
Eriksson, Sofi E.;
Liang, Ying Yu;
Cheteh, Emarndeena H.;
Zhang, Si Min;
Fujihara, Kenji M.;
Bianchi, Julie;
Bykov, Vladimir J. N.;
Abrahmsen, Lars;
Clemons, Nicholas J.;
Nordlund, Pär;
Rudd, Sean G.;
Wiman, Klas G.

Publication type:

Article

Correction: APR-246 reactivates mutant p53 by targeting cysteines 124 and 277.

Published in:

2019

By:

Zhang, Qiang;
Bykov, Vladimir J. N.;
Wiman, Klas G.;
Zawacka-Pankau, Joanna

Publication type:

Correction Notice

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277.

Published in:

Cell Death & Disease, 2018, v. 9, n. 5, p. 1, doi. 10.1038/s41419-018-0463-7

By:

Zhang, Qiang;
Bykov, Vladimir J. N.;
Wiman, Klas G.;
Zawacka-Pankau, Joanna

Publication type:

Article

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

Published in:

Nature Medicine, 2002, v. 8, n. 3, p. 282, doi. 10.1038/nm0302-282

By:

Bykov, Vladimir J.N.;
Issaeva, Natalia;
Shilov, Alexandre;
Hultcrantz, Monica;
Pugacheva, Elena;
Chumakov, Peter;
Bergman, Jan;
Wiman, Klas G.;
Selivanova, Galina

Publication type:

Article

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors.

Published in:

Frontiers in Oncology, 2018, p. 1, doi. 10.3389/fonc.2017.00323

By:

Zhang, Meiqiongzi;
Heldin, Angelos;
Palomar-Siles, Mireia;
Öhlin, Susanne;
Bykov, Vladimir J. N.;
Wiman, Klas G.

Publication type:

Article

Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein.

Published in:

Carcinogenesis, 2010, v. 31, n. 8, p. 1475, doi. 10.1093/carcin/bgq118

By:

Gouas, Doriane A.;
Hong Shi;
Hautefeuille, Agnès H.;
Ortiz-Cuaran, Sandra L.;
Legros, Pénélope C.;
Szymanska, Katarzyna J.;
Galy, Olivier;
Egevad, Lars A.;
Abedi-Ardekani, Behnoush;
Wiman, Klas G.;
Hantz, Olivier;
de Fromentel, Claude Caron;
Chemin, Isabelle A.;
Hainaut, Pierre L.

Publication type:

Article

Extract from Asteraceae Brachylaena ramiflora induces apoptosis preferentially in mutant p53-expressing human tumor cells.

Published in:

Carcinogenesis, 2010, v. 31, n. 6, p. 1045, doi. 10.1093/carcin/bgq084

By:

Karimi, Masoud;
Conserva, Francesca;
Mahmoudi, Salah;
Bergman, Jan;
Wiman, Klas G.;
Bykov, Vladimir J. N.

Publication type:

Article

Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine.

Published in:

Cell Death & Disease, 2022, v. 13, n. 11, p. 1, doi. 10.1038/s41419-022-05431-2

By:

Palomar-Siles, Mireia;
Heldin, Angelos;
Zhang, Meiqiongzi;
Strandgren, Charlotte;
Yurevych, Viktor;
van Dinter, Jip T.;
Engels, Sem A. G.;
Hofman, Damon A.;
Öhlin, Susanne;
Meineke, Birthe;
Bykov, Vladimir J. N.;
van Heesch, Sebastiaan;
Wiman, Klas G.

Publication type:

Article

Novel cancer therapy by reactivation of the p53 apoptosis pathway.

Published in:

Annals of Medicine, 2003, v. 35, n. 7, p. 458, doi. 10.1080/07853890310017152

By:

Bykov, Vladimir J.N.;
Wiman, Klas G.

Publication type:

Article

Expression of the p53 Target Wig-1 Is Associated with HPV Status and Patient Survival in Cervical Carcinoma.

Published in:

PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0111125

By:

Xu, Li-Di;
Muller, Susanne;
Thoppe, Srinivasan R.;
Hellborg, Fredrik;
Kanter, Lena;
Lerner, Mikael;
Zheng, Biying;
Lagercrantz, Svetlana Bajalica;
Grandér, Dan;
Wallin, Keng Ling;
Wiman, Klas G.;
Larsson, Catharina;
Andersson, Sonia

Publication type:

Article

Functional characterization of novel germline TP53 variants in Swedish families.

Published in:

Clinical Genetics, 2019, v. 96, n. 3, p. 216, doi. 10.1111/cge.13564

By:

Kharaziha, Pedram;
Ceder, Sophia;
Axell, Olga;
Krall, Moritz;
Fotouhi, Omid;
Böhm, Stefanie;
Lain, Sonia;
Borg, Åke;
Larsson, Catharina;
Wiman, Klas G.;
Tham, Emma;
Bajalica‐Lagercrantz, Svetlana

Publication type:

Article

Wig-1, a new p53-induced gene encoding a zinc finger protein.

Published in:

Oncogene, 1997, v. 15, n. 22, p. 2699, doi. 10.1038/sj.onc.1201454

By:

Varmeh-Ziaie, Shohreh;
Okan, Ismail;
Wang, Yisong;
Magnusson, Kristinn P;
Warthoe, Peter;
Strauss, Michael;
Wiman, Klas G

Publication type:

Article

The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs

Published in:

FEBS Letters, 2006, v. 580, n. 18, p. 4401, doi. 10.1016/j.febslet.2006.07.005

By:

Méndez Vidal, Cristina;
Prahl, Magdalena;
Wiman, Klas G.

Publication type:

Article

Identification of functional p53-binding motifs in the mouse wig-1 promoter

Published in:

FEBS Letters, 2002, v. 524, n. 1-3, p. 69, doi. 10.1016/S0014-5793(02)03004-1

By:

Wilhelm, Margareta T.;
Méndez-Vidal, Cristina;
Wiman, Klas G.

Publication type:

Article

WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies.

Published in:

PLoS Biology, 2010, v. 8, n. 11, p. 1, doi. 10.1371/journal.pbio.1000521

By:

Mahmoudi, Salah;
Henriksson, Sofia;
Weibrecht, Irene;
Smith, Stephen;
Söderberg, Ola;
Strömblad, Staffan;
Wiman, Klas G.;
Farnebo, Marianne

Publication type:

Article

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

Published in:

Oncogene, 2002, v. 21, n. 14, p. 2119, doi. 10.1038/sj.onc.1205362

By:

Rippin, Thomas M.;
Bykov, Vladimir J. N.;
Freund, Stefan M. V.;
Selivanova, Galina;
Wiman, Klas G.;
Fersht, Alan R.

Publication type:

Article

Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein.

Published in:

Oncogene, 2001, v. 20, n. 39, p. 5466, doi. 10.1038/sj.onc.1204722

By:

Hellborg, Fredrik;
Qian, Wang;
Mendez-Vidal, Cristina;
Asker, Charlotte;
Kost-Alimova, Maria;
Wilhelm, Margareta;
Imreh, Stefan;
Wiman, Klas G

Publication type:

Article

p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53.

Published in:

Oncogene, 2001, v. 20, n. 17, p. 2171

By:

Lindström, Mikael S;
Klangby, Ulf;
Wiman, Klas G

Publication type:

Article

Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells.

Published in:

Oncogene, 2000, v. 19, n. 45, p. 5123, doi. 10.1038/sj.onc.1203890

By:

Xu, Dawei;
Wang, Qian;
Gruber, Astrid;
Björkholm, Magnus;
Chen, Zhiguo;
Zaid, Ahmed;
Selivanova, Galina;
Peterson, Curt;
Wiman, Klas G;
Pisa, Pavel

Publication type:

Article

Is conversion of solid into more anoxic ascites tumors associated with p53 inactivation?

Published in:

Oncogene, 1998, v. 17, n. 18, p. 2333, doi. 10.1038/sj.onc.1202149

By:

Magnusson, Kristinn P;
Satalino, Rosa;
Qian, Wang;
Klein, George;
Wiman, Klas G

Publication type:

Article

Strong synergy with APR-246 and DNAdamaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer.

Published in:

Journal of Ovarian Research, 2016, v. 9, p. 1, doi. 10.1186/s13048-016-0239-6

By:

Fransson, Åsa;
Glaessgen, Daria;
Alfredsson, Jessica;
Wiman, Klas G.;
Bajalica-Lagercrantz, Svetlana;
Mohell, Nina

Publication type:

Article

p53 as a hub in cellular redox regulation and therapeutic target in cancer.

Published in:

Journal of Molecular Cell Biology, 2019, v. 11, n. 4, p. 330, doi. 10.1093/jmcb/mjz005

By:

Eriksson, Sofi E;
Ceder, Sophia;
Bykov, Vladimir J N;
Wiman, Klas G

Publication type:

Article

cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response.

Published in:

Cell Cycle, 2016, v. 15, n. 9, p. 1267, doi. 10.1080/15384101.2016.1160975

By:

Madapura, Harsha S.;
Salamon, Daniel;
Wiman, Klas G.;
Lain, Sonia;
Klein, Eva;
Nagy, Noémi

Publication type:

Article

p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAP.

Published in:

Cell Cycle, 2012, v. 11, n. 24, p. 4563, doi. 10.4161/cc.22810

By:

Madapura, Harsha S.;
Salamon, Daniel;
Wiman, Klas G.;
Lain, Sonia;
Klein, George;
Klein, Eva;
Nagy, Noémi

Publication type:

Article

Correction: WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies.

Published in:

2018

By:

Mahmoudi, Salah;
Henriksson, Sofia;
Weibrecht, Irene;
Smith, Stephen;
Söderberg, Ola;
Strömblad, Staffan;
Wiman, Klas G.;
Farnebo, Marianne

Publication type:

Correction Notice

Position-dependent nuclear accumulation of the retinoblastoma (RB) protein during in vitro myogenesis.

Published in:

Journal of Cellular Physiology, 1993, v. 155, n. 2, p. 313, doi. 10.1002/jcp.1041550212

By:

Szekely, Laszlo;
Jin, Pei;
Jiang, Wei-Qin;
Rosén, Anders;
Wiman, Klas G.;
Klein, George;
Ringertz, Nils

Publication type:

Article

A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death.

Published in:

EMBO Molecular Medicine, 2021, v. 13, n. 2, p. 1, doi. 10.15252/emmm.201910852

By:

Ceder, Sophia;
Eriksson, Sofi E;
Cheteh, Emarndeena H;
Dawar, Swati;
Corrales Benitez, Mariana;
Bykov, Vladimir J N;
Fujihara, Kenji M;
Grandin, Mélodie;
Li, Xiaodun;
Ramm, Susanne;
Behrenbruch, Corina;
Simpson, Kaylene J;
Hollande, Frédéric;
Abrahmsen, Lars;
Clemons, Nicholas J;
Wiman, Klas G

Publication type:

Article

Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene.

Published in:

PLoS ONE, 2023, v. 18, n. 11, p. 1, doi. 10.1371/journal.pone.0292468

By:

Palomar-Siles, Mireia;
Yurevych, Viktor;
Bykov, Vladimir J. N.;
Wiman, Klas G.

Publication type:

Article

Mutant p53 reactivation by small molecules makes its way to the clinic.

Published in:

FEBS Letters, 2014, v. 588, n. 16, p. 2622, doi. 10.1016/j.febslet.2014.04.017

By:

Bykov, Vladimir J. N.;
Wiman, Klas G.

Publication type:

Article

The p53 target protein Wig-1 binds hnRNP A2/B1 and RNA Helicase A via RNA

Published in:

FEBS Letters, 2008, v. 582, n. 15, p. 2173, doi. 10.1016/j.febslet.2008.04.065

By:

Prahl, Magdalena;
Vilborg, Anna;
Palmberg, Carina;
Jörnvall, Hans;
Asker, Charlotte;
Wiman, Klas G.

Publication type:

Article

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for efficient Cancer Therapy.

Published in:

Frontiers in Oncology, 2016, p. 1, doi. 10.3389/fonc.2016.00021

By:

Bykov, Vladimir J. N.;
Qiang Zhang;
Meiqiongzi Zhang;
Ceder, Sophia;
Abrahmsen, Lars;
Wiman, Klas G.

Publication type:

Article

PRIMA-1MET synergizes with cisplatin to induce tumor cell apoptosis.

Published in:

Oncogene, 2005, v. 24, n. 21, p. 3484, doi. 10.1038/sj.onc.1208419

By:

Bykov, Vladimir J. N.;
Zache, Nicole;
Stridh, Helene;
Westman, Jacob;
Bergman, Jan;
Selivanova, Galina;
Wiman, Klas G.

Publication type:

Article

hTERT antagonizes p53-induced apoptosis independently of telomerase activity.

Published in:

Oncogene, 2005, v. 24, n. 8, p. 1320, doi. 10.1038/sj.onc.1208232

By:

Rahman, Rubaiyat;
Latonen, Leena;
Wiman, Klas G.

Publication type:

Article

Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts.

Published in:

Oncogene, 2003, v. 22, n. 32, p. 4993, doi. 10.1038/sj.onc.1206659

By:

Lindström, Mikael S;
Wiman, Klas G

Publication type:

Article

Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation.

Published in:

Nature Communications, 2017, v. 8, n. 3, p. 14844, doi. 10.1038/ncomms14844

By:

Liu, David S.;
Duong, Cuong P.;
Haupt, Sue;
Montgomery, Karen G.;
House, Colin M.;
Azar, Walid J.;
Pearson, Helen B.;
Fisher, Oliver M.;
Read, Matthew;
Guerra, Glen R.;
Haupt, Ygal;
Cullinane, Carleen;
Wiman, Klas G.;
Abrahmsen, Lars;
Phillips, Wayne A.;
Clemons, Nicholas J.

Publication type:

Article

Novel compounds that synergize with aminoglycoside G418 or eRF3 degraders for translational readthrough of nonsense mutant TP53 and PTEN.

Published in:

RNA Biology, 2023, v. 20, n. 1, p. 368, doi. 10.1080/15476286.2023.2222250

By:

Heldin, Angelos;
Cancer, Matko;
Palomar-Siles, Mireia;
Öhlin, Susanne;
Zhang, Meiqiongzi;
Sun-Zhang, Alexander;
Mariani, Anna;
Liu, Jianping;
Bykov, Vladimir J.N.;
Wiman, Klas G.

Publication type:

Article

PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein.

Published in:

Molecular Cancer, 2009, v. 8, p. 1, doi. 10.1186/1476-4598-8-23

By:

Stuber, György;
Flaberg, Emilie;
Petranyi, Gabor;
Ötvös, Rita;
Rökaeus, Nina;
Kashuba, Elena;
Wiman, Klas G.;
Klein, George;
Szekely, Laszlo

Publication type:

Article

The p53-induced mouse zinc finger protein wig-1 binds double-stranded RNA with high affinity.

Published in:

Nucleic Acids Research, 2002, v. 30, n. 9, p. 1991, doi. 10.1093/nar/30.9.1991

By:

Méndez-Vidal, Cristina;
Wilhelm, Margareta T.;
Hellborg, Fredrik;
Qian, Wang;
Wiman, Klas G.

Publication type:

Article

The Single-Stranded DNA end Binding Site of p53 Coincides With the C-Terminal Regulatory Region.

Published in:

Nucleic Acids Research, 1996, v. 24, n. 18, p. 3560, doi. 10.1093/nar/24.18.3560

By:

Selivanova, Galina;
Iotsova, Violetta;
Kiseleva, Elena;
Ström, Marika;
Bakalkin, Georgy;
Grafström, Roland C.;
Wiman, Klas G.

Publication type:

Article

Mutant p53 rescue and modulation of p53 redox state.

Published in:

Cell Cycle, 2009, v. 8, n. 16, p. 2509, doi. 10.4161/cc.8.16.9382

By:

Bykov, Vladimir J. N.;
Lambert, Jeremy M. R.;
Hainaut, Pierre;
Wiman, Klas G.

Publication type:

Article

In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249.

Published in:

Carcinogenesis, 2008, v. 29, n. 7, p. 1428, doi. 10.1093/carcin/bgm266

By:

Hong Shi;
Jeremy M.R. Lambert;
Agnes Hautefeuille;
Vladimir J.N. Bykov;
Klas G. Wiman;
Pierre Hainaut;
Claude Caron de Fromentel

Publication type:

Article

Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

Published in:

Carcinogenesis, 2002, v. 23, n. 12, p. 2011, doi. 10.1093/carcin/23.12.2011

By:

Bykov, Vladimir J.N.;
Issaeva, Natalia;
Selivanova, Galina;
Wiman, Klas G.

Publication type:

Article

Regulation of tumor suppressor p53 at the RNA level.

Published in:

Journal of Molecular Medicine, 2010, v. 88, n. 7, p. 645, doi. 10.1007/s00109-010-0609-2

By:

Vilborg, Anna;
Wilhelm, Margareta T.;
Wiman, Klas G.

Publication type:

Article