Works by Williams, Robert O.

Results: 88

Comment on Hermeling et al. Nano-Dry-Melting: A Novel Technology for Manufacturing of Pharmaceutical Amorphous Solid Dispersions. Pharmaceutics 2022, 14 , 2145.

Published in:

Pharmaceutics, 2025, v. 17, n. 6, p. 714, doi. 10.3390/pharmaceutics17060714

By:

Miller, Dave A.;
Kucera, Sandra U.;
Ellenberger, Daniel;
Davis, Daniel;
Williams III, Robert O.

Publication type:

Article

Homogeneity of amorphous solid dispersions - an example with KinetiSol<sup>®</sup>.

Published in:

Drug Development & Industrial Pharmacy, 2019, v. 45, n. 5, p. 724, doi. 10.1080/03639045.2019.1569037

By:

Jermain, Scott V.;
Miller, Dave;
Spangenberg, Angela;
Lu, Xingyu;
Moon, Chaeho;
Su, Yongchao;
Williams, Robert O.

Publication type:

Article

Formulation for a novel inhaled peptide therapeutic for idiopathic pulmonary fibrosis.

Published in:

Drug Development & Industrial Pharmacy, 2018, v. 44, n. 2, p. 184, doi. 10.1080/03639045.2017.1371736

By:

Hengsawas Surasarang, Soraya;
Florova, Galina;
Komissarov, Andrey A.;
Shetty, Sreerama;
Idell, Steven;
Williams III, Robert O.

Publication type:

Article

Hot melt extrusion versus spray drying: hot melt extrusion degrades albendazole.

Published in:

Drug Development & Industrial Pharmacy, 2017, v. 43, n. 5, p. 797, doi. 10.1080/03639045.2016.1220577

By:

Hengsawas Surasarang, Soraya;
Keen, Justin M.;
Huang, Siyuan;
Zhang, Feng;
McGinity, James W.;
Williams III, Robert O.

Publication type:

Article

Modified release itraconazole amorphous solid dispersion to treat Aspergillus fumigatus : importance of the animal model selection.

Published in:

Drug Development & Industrial Pharmacy, 2017, v. 43, n. 2, p. 264, doi. 10.1080/03639045.2016.1236811

By:

Maincent, Julien P.;
Najvar, Laura K.;
Kirkpatrick, William R.;
Huang, Siyuan;
Patterson, Thomas F.;
Wiederhold, Nathan P.;
Peters, Jay I.;
Williams III, Robert O.

Publication type:

Article

Effect of hydrophilic additives on the dissolution and pharmacokinetic properties of itraconazole-enteric polymer hot-melt extruded amorphous solid dispersions.

Published in:

Drug Development & Industrial Pharmacy, 2016, v. 42, n. 3, p. 429, doi. 10.3109/03639045.2015.1075031

By:

Lang, Bo;
Liu, Sha;
McGinity, James W.;
Williams III, Robert O.

Publication type:

Article

Preparation of amorphous solid dispersions by rotary evaporation and KinetiSol Dispersing: approaches to enhance solubility of a poorly water-soluble gum extract.

Published in:

Drug Development & Industrial Pharmacy, 2015, v. 41, n. 3, p. 382, doi. 10.3109/03639045.2013.866142

By:

Bennett, Ryan C.;
Brough, Chris;
Miller, Dave A.;
O'Donnell, Kevin P.;
Keen, Justin M.;
Hughey, Justin R.;
Williams III, Robert O.;
McGinity, James W.

Publication type:

Article

Hot-melt extrusion - basic principles and pharmaceutical applications.

Published in:

Drug Development & Industrial Pharmacy, 2014, v. 40, n. 9, p. 1133, doi. 10.3109/03639045.2013.838577

By:

Lang, Bo;
McGinity, James W.;
Williams III, Robert O.

Publication type:

Article

Recent advancements in mechanical reduction methods: particulate systems.

Published in:

Drug Development & Industrial Pharmacy, 2014, v. 40, n. 3, p. 289, doi. 10.3109/03639045.2013.828217

By:

Leleux, Jardin;
Williams, Robert O.

Publication type:

Article

Pulmonary dispersion formulations: The impact of dispersed powder properties on pressurized metered dose inhaler stability.

Published in:

Drug Development & Industrial Pharmacy, 2013, v. 39, n. 3, p. 413, doi. 10.3109/03639045.2012.664145

By:

O'Donnell, Kevin P.;
Williams III, Robert O.

Publication type:

Article

Flocculated amorphous itraconazole nanoparticles for enhanced in vitro supersaturation and in vivo bioavailability.

Published in:

Drug Development & Industrial Pharmacy, 2012, v. 38, n. 5, p. 557, doi. 10.3109/03639045.2011.616513

By:

Miller, Maria A.;
DiNunzio, James;
Matteucci, Michal E.;
Ludher, Baltej S.;
Williams, Robert O.;
Johnston, Keith P.

Publication type:

Article

Has nanotechnology led to improved therapeutic outcomes??

Published in:

Drug Development & Industrial Pharmacy, 2012, v. 38, n. 2, p. 158, doi. 10.3109/03639045.2011.597764

By:

Bosselmann, Stephanie;
Williams III, Robert O.

Publication type:

Article

Production of advanced solid dispersions for enhanced bioavailability of itraconazole using KinetiSol® Dispersing.

Published in:

Drug Development & Industrial Pharmacy, 2010, v. 36, n. 9, p. 1064, doi. 10.3109/03639041003652973

By:

DiNunzio, James C.;
Hughey, Justin R.;
Brough, Chris;
Miller, Dave A.;
Williams III, Robert O.;
McGinity, James W.

Publication type:

Article

Advances in the pulmonary delivery of poorly water-soluble drugs: influence of solubilization on pharmacokinetic properties.

Published in:

Drug Development & Industrial Pharmacy, 2010, v. 36, n. 1, p. 1, doi. 10.3109/03639040903092319

By:

Tolman, Justin A.;
Williams III, Robert O.

Publication type:

Article

Recent Developments in Drug Delivery to Prolong Allograft Survival in Lung Transplant Patients.

Published in:

Drug Development & Industrial Pharmacy, 2009, v. 35, n. 3, p. 259, doi. 10.1080/03639040802282904

By:

Watts, Alan B.;
Williams III, Robert O.;
Peters, Jay I.

Publication type:

Article

Flocculation of Polymer Stabilized Nanocrystal Suspensions to Produce Redispersible Powders.

Published in:

Drug Development & Industrial Pharmacy, 2009, v. 35, n. 3, p. 283, doi. 10.1080/03639040802282896

By:

Chen, Xiaoxia;
Matteucci, Michal E.;
Lo, Connie Y.;
Johnston, Keith P.;
Williams III, Robert O.

Publication type:

Article

CNS Disorders—Current Treatment Options and the Prospects for Advanced Therapies.

Published in:

Drug Development & Industrial Pharmacy, 2008, v. 34, n. 11, p. 1141, doi. 10.1080/03639040802020536

By:

DiNunzio, James C.;
Williams III, Robert O.

Publication type:

Article

Current Therapies and Technological Advances in Aqueous Aerosol Drug Delivery.

Published in:

Drug Development & Industrial Pharmacy, 2008, v. 34, n. 9, p. 913, doi. 10.1080/03639040802144211

By:

Watts, Alan B.;
McConville, Jason T.;
Williams III, Robert O.

Publication type:

Article

Enhanced In Vivo Absorption of Itraconazole via Stabilization of Supersaturation Following Acidic-to-Neutral pH Transition.

Published in:

Drug Development & Industrial Pharmacy, 2008, v. 34, n. 8, p. 890, doi. 10.1080/03639040801929273

By:

Miller, Dave A.;
DiNunzio, James C.;
Yang, Wei;
McGinity, James W.;
Williams III, Robert O.

Publication type:

Article

Advanced Formulation Design: Improving Drug Therapies for the Management of Severe and Chronic Pain.

Published in:

Drug Development & Industrial Pharmacy, 2008, v. 34, n. 2, p. 117, doi. 10.1080/03639040701542200

By:

Miller, Dave A.;
DiNunzio, James C.;
Williams III, Robert O.

Publication type:

Article

A Review of: “HPCL Methods for Recently Approved Pharmaceuticals”.

Published in:

2006

By:

Williams III, Robert O.

Publication type:

Book Review

Supersaturation Produces High Bioavailability of Amorphous Danazol Particles Formed by Evaporative Precipitation into Aqueous Solution and Spray Freezing into Liquid Technologies.

Published in:

Drug Development & Industrial Pharmacy, 2006, v. 32, n. 5, p. 559, doi. 10.1080/03639040500529176

By:

Vaughn, Jason M.;
McConville, Jason T.;
Crisp, Matthew T.;
Johnston, Keith P.;
Williams III, Robert O.

Publication type:

Article

A Review of: “Pharmaceutical Dissolution Testing”.

Published in:

2006

By:

(Bill) Williams III, Robert O.

Publication type:

Book Review

Design and Evaluation of a Restraint-Free Small Animal Inhalation Dosing Chamber.

Published in:

Drug Development & Industrial Pharmacy, 2005, v. 31, n. 1, p. 35, doi. 10.1081/DDC-43983

By:

McConville, Jason T.;
Carvalho, Thiago C.;
Iberg, Aimee N.;
Talbert, Robert L.;
Burgess, David;
Peters, Jay I.;
Johnston, Keith P.;
Williams III, Robert O.

Publication type:

Article

Stable Amorphous Danazol Nanostructured Powders with Rapid Dissolution Rates Produced by Spray Freezing into Liquid.

Published in:

Drug Development & Industrial Pharmacy, 2004, v. 30, n. 7, p. 695, doi. 10.1081/DDC-120039212

By:

Hu, Jiahui;
Johnston, Keith P.;
Williams III, Robert O.

Publication type:

Article

Nanoparticle Engineering Processes for Enhancing the Dissolution Rates of Poorly Water Soluble Drugs.

Published in:

Drug Development & Industrial Pharmacy, 2004, v. 30, n. 3, p. 233, doi. 10.1081/DDC-120030422

By:

Hu, Jiahui;
Johnston, Keith P.;
Williams III, Robert O.

Publication type:

Article

Solution-Based Particle Formation of Pharmaceutical Powders by Supercritical or Compressed Fluid Co2 and Cryogenic Spray-Freezing Technologies.

Published in:

Drug Development & Industrial Pharmacy, 2001, v. 27, n. 10, p. 1003, doi. 10.1081/DDC-100108363

By:

Rogers, True L.;
Johnston, Keith P.;
Williams III, Robert O.

Publication type:

Article

Investigation of Some Commercially Available Spacer Devices for the Delivery of Glucocorticoid Steroids from a pMDI.

Published in:

Drug Development & Industrial Pharmacy, 2001, v. 27, n. 5, p. 401, doi. 10.1081/DDC-100104315

By:

Williams III, Robert O.;
Patel, Akshaya M.;
Barron, Melisa K.;
Rogers, True L.

Publication type:

Article

Influence of Water on the Solubility of Two Steroid Drugs in Hydrofluoroalkane (HFA) Propellants.

Published in:

Drug Development & Industrial Pharmacy, 2001, v. 27, n. 1, p. 71, doi. 10.1081/DDC-100000130

By:

Williams III, Robert. O.;
Hu, Chengjiu.

Publication type:

Article

Study of Solubility of Steroids in Hydrofluoroalkane Propellants.

Published in:

Drug Development & Industrial Pharmacy, 1999, v. 25, n. 12, p. 1227, doi. 10.1081/DDC-100102292

By:

Williams III, Robert O.;
Rogers, True L.;
Liu, Jie

Publication type:

Article

Influence of Temperature on the Emitted Dose of an Oral Metered Dose Inhaler.

Published in:

Drug Development & Industrial Pharmacy, 1998, v. 24, n. 11, p. 1043, doi. 10.3109/03639049809089947

By:

Williams, Robert O.;
Barron, Melisa K.

Publication type:

Article

Influence of Propellant Composition on Drug Delivery from a Pressurized Metered-Dose Inhaler.

Published in:

Drug Development & Industrial Pharmacy, 1998, v. 24, n. 8, p. 763, doi. 10.3109/03639049809082724

By:

Williams, Robert O.;
Repka, Michael;
Liu, Jie

Publication type:

Article

Preformulation Studies on Freund's Incomplete Adjuvant Emulsion.

Published in:

Drug Development & Industrial Pharmacy, 1998, v. 24, n. 2, p. 157, doi. 10.3109/03639049809085600

By:

Williams, Robert O.;
Mahaguna, Vorapann

Publication type:

Article

Compaction Properties of Microcrystalline Cellulose Using Tableting Indices.

Published in:

Drug Development & Industrial Pharmacy, 1997, v. 23, n. 7, p. 695, doi. 10.3109/03639049709150771

By:

Williams, Robert O.;
Sriwongjanya, Mongkol;
Barron, Melisa K.

Publication type:

Article

Pre-Processing a Polymer Blend into a Polymer Alloy by KinetiSol Enables Increased Ivacaftor Amorphous Solid Dispersion Drug Loading and Dissolution.

Published in:

Biomedicines, 2023, v. 11, n. 5, p. 1281, doi. 10.3390/biomedicines11051281

By:

Thompson, Stephen A.;
Davis Jr., Daniel A.;
Miller, Dave A.;
Kucera, Sandra U.;
Williams III, Robert O.

Publication type:

Article

Oral Delivery of Niclosamide as an Amorphous Solid Dispersion That Generates Amorphous Nanoparticles during Dissolution.

Published in:

Pharmaceutics, 2022, v. 14, n. 12, p. 2568, doi. 10.3390/pharmaceutics14122568

By:

Jara, Miguel O.;
Warnken, Zachary N.;
Sahakijpijarn, Sawittree;
Thakkar, Rishi;
Kulkarni, Vineet R.;
Christensen, Dale J.;
Koleng, John J.;
Williams III, Robert O.

Publication type:

Article

Emerging Artificial Intelligence (AI) Technologies Used in the Development of Solid Dosage Forms.

Published in:

Pharmaceutics, 2022, v. 14, n. 11, p. 2257, doi. 10.3390/pharmaceutics14112257

By:

Jiang, Junhuang;
Ma, Xiangyu;
Ouyang, Defang;
Williams III, Robert O.

Publication type:

Article

A Safety and Tolerability Study of Thin Film Freeze-Dried Tacrolimus for Local Pulmonary Drug Delivery in Human Subjects.

Published in:

Pharmaceutics, 2021, v. 13, n. 5, p. 717, doi. 10.3390/pharmaceutics13050717

By:

Sahakijpijarn, Sawittree;
Beg, Moeezullah;
Levine, Stephanie M.;
Peters, Jay I.;
Williams III, Robert O.;
Giovagnoli, Stefano;
Olsson, Bo;
Warnken, Zachary;
Moraga-Espinoza, Daniel

Publication type:

Article

Amorphous Solid Dispersions and the Contribution of Nanoparticles to In Vitro Dissolution and In Vivo Testing: Niclosamide as a Case Study.

Published in:

Pharmaceutics, 2021, v. 13, n. 1, p. 97, doi. 10.3390/pharmaceutics13010097

By:

Jara, Miguel O.;
Warnken, Zachary N.;
Williams III, Robert O.

Publication type:

Article

Bioavailability Improvement of Carbamazepine via Oral Administration of Modified-Release Amorphous Solid Dispersions in Rats.

Published in:

Pharmaceutics, 2020, v. 12, n. 11, p. 1023, doi. 10.3390/pharmaceutics12111023

By:

Li, Houli;
Zhang, Meimei;
Xiong, Lilong;
Feng, Weiyi;
Williams III, Robert O.

Publication type:

Article

Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing.

Published in:

Pharmaceutics, 2020, v. 12, n. 11, p. 1002, doi. 10.3390/pharmaceutics12111002

By:

Sahakijpijarn, Sawittree;
Moon, Chaeho;
Koleng, John J.;
Christensen, Dale J.;
Williams III, Robert O.

Publication type:

Article

Influence of Carbamazepine Dihydrate on the Preparation of Amorphous Solid Dispersions by Hot Melt Extrusion.

Published in:

Pharmaceutics, 2020, v. 12, n. 4, p. 379, doi. 10.3390/pharmaceutics12040379

By:

Ma, Xiangyu;
Müller, Felix;
Huang, Siyuan;
Lowinger, Michael;
Liu, Xu;
Schooler, Rebecca;
Williams III, Robert O.

Publication type:

Article

Improved Dissolution and Pharmacokinetics of Abiraterone through KinetiSol® Enabled Amorphous Solid Dispersions.

Published in:

Pharmaceutics, 2020, v. 12, n. 4, p. 357, doi. 10.3390/pharmaceutics12040357

By:

Gala, Urvi;
Miller, Dave;
Williams III, Robert O.

Publication type:

Article

Formulation Composition and Process Affect Counterion for CSP7 Peptide.

Published in:

Pharmaceutics, 2019, v. 11, n. 10, p. 498, doi. 10.3390/pharmaceutics11100498

By:

Sahakijpijarn, Sawittree;
Moon, Chaeho;
Koleng, John J.;
Williams III, Robert O.

Publication type:

Article

A Repurposed Drug for Brain Cancer: Enhanced Atovaquone Amorphous Solid Dispersion by Combining a Spontaneously Emulsifying Component with a Polymer Carrier.

Published in:

Pharmaceutics, 2018, v. 10, n. 2, p. 60, doi. 10.3390/pharmaceutics10020060

By:

Takabe, Hiroyuki;
Warnken, Zachary N.;
Zhang, Yajie;
Davis, Daniel A.;
Smyth, Hugh D. C.;
Kuhn, John G.;
Weitman, Steve;
Williams Iii, Robert O.

Publication type:

Article

Sustained Release Drug Delivery Applications of Polyurethanes.

Published in:

Pharmaceutics, 2018, v. 10, n. 2, p. 55, doi. 10.3390/pharmaceutics10020055

By:

Lowinger, Michael B.;
Barrett, Stephanie E.;
Zhang, Feng;
Williams, Robert O.

Publication type:

Article

Characterization of mRNA Lipid Nanoparticles by Electron Density Mapping Reconstruction: X-ray Scattering with Density from Solution Scattering (DENSS) Algorithm.

Published in:

Pharmaceutical Research, 2024, v. 41, n. 3, p. 501, doi. 10.1007/s11095-024-03671-9

By:

Dao, Huy M.;
AboulFotouh, Khaled;
Hussain, Aasim Faheem;
Marras, Alexander E.;
Johnston, Keith P.;
Cui, Zhengrong;
Williams III, Robert O.

Publication type:

Article

Aerosolizable Plasmid DNA Dry Powders Engineered by Thin-film Freezing.

Published in:

Pharmaceutical Research, 2023, v. 40, n. 5, p. 1141, doi. 10.1007/s11095-023-03473-5

By:

Xu, Haiyue;
Moon, Chaeho;
Sahakijpijarn, Sawittree;
Dao, Huy M.;
Alzhrani, Riyad F.;
Wang, Jie-liang;
Williams III, Robert O.;
Cui, Zhengrong

Publication type:

Article

Manufacturing Stable Bacteriophage Powders by Including Buffer System in Formulations and Using Thin Film Freeze-drying Technology.

Published in:

Pharmaceutical Research, 2021, v. 38, n. 10, p. 1793, doi. 10.1007/s11095-021-03111-y

By:

Zhang, Yajie;
Soto, Melissa;
Ghosh, Debadyuti;
Williams III, Robert O.

Publication type:

Article

The Development of Thin-Film Freezing and Its Application to Improve Delivery of Biologics as Dry Powder Aerosols.

Published in:

KONA: Powder & Particle Journal, 2022, n. 39, p. 176, doi. 10.14356/kona.2022010

By:

Hufnagel, Stephanie;
Sahakijpijarn, Sawittree;
Moon, Chaeho;
Zhengrong Cui;
Williams III, Robert O.

Publication type:

Article