Works by Wiebe, Leonard I.

Results: 46

Effect of acyclovir on the uptake of 131 I-labelled 1-(2′fluoro-2′-deoxy-βD-D-arabinofuranosyl)-5-lodouracil in herpes infected cells.
Published in:
Journal of Medical Virology, 1987, v. 22, n. 2, p. 183, doi. 10.1002/jmv.1890220210
By:
- Tovell, Dorothy R.;
- Yacyshyn, Harold P.;
- Misra, Hemant K.;
- Knaus, Edward E.;
- Wiebe, Leonard I.;
- Samuel, John;
- Gill, M. John;
- Tyrrell, D. Lorne J.
Publication type:
Article
Dose-dependent pharmacokinetics of 1-(2-Deoxy-β-D- ribofuranosyl)-2,4-difluoro-5-iodobenzene: A potential mimic of 5-iodo-2'-deoxyuridine.
Published in:
Biopharmaceutics & Drug Disposition, 2003, v. 24, n. 9, p. 385, doi. 10.1002/bdd.375
By:
- Panteha Khalili;
- Ebrahim Naimi;
- Wei Yan Sun;
- Edward E. Knaus;
- Leonard I. Wiebe
Publication type:
Article
Pharmacokinetics and metabolism of the novel synthetic C-nucleoside, 1-(2-deoxy- β-D-ribofuranosyl)-2,4-difluoro- 5-iodobenzene: a potential mimic of 5-iodo-2′-deoxyuridine.
Published in:
Biopharmaceutics & Drug Disposition, 2002, v. 23, n. 3, p. 105, doi. 10.1002/bdd.301
By:
- Khalili, Panteha;
- Naimi, Ebrahim;
- Knaus, Edward E.;
- Wiebe, Leonard I.
Publication type:
Article
Synthesis and Biological Evaluation of Butanoate, Retinoate, and Bis(2,2,2-trichloroethyl)phosphate Derivatives of 5-Fluoro-2′-deoxyuridine and 2′,5-Difluoro-2′-deoxyuridine as Potential Dual Action Anticancer Prodrugs.
Published in:
Archiv der Pharmazie, 1999, v. 332, n. 8, p. 286, doi. 10.1002/(SICI)1521-4184(19998)332:8<286::AID-ARDP286>3.0.CO;2-9
By:
- Xia, Zuping;
- Wiebe, Leonard I.;
- Miller, Gerald G.;
- Knaus, Edward E.
Publication type:
Article
Synthesis and Antiviral Activity of 5-Ethyl-5-halo-6-alkoxy-(or Azido)-5,6-dihydro-2′-deoxyuridine Diastereomers as Potential Prodrugs to 5-Ethyl-2′-deoxyuridine.
Published in:
Archiv der Pharmazie, 1997, v. 330, n. 8, p. 259, doi. 10.1002/ardp.19973300806
By:
- Kumar, Rakesh;
- Wiebe, Leonard I.;
- Knaus, Edward E.
Publication type:
Article
Synthesis and Antifungal Activities of Myristic Acid Analogs.
Published in:
Archiv der Pharmazie, 1996, v. 329, n. 11, p. 475, doi. 10.1002/ardp.19963291102
By:
- Parang, Keykavous;
- Knaus, Edward E.;
- Wiebe, Leonard I.;
- Sardari, Soroush;
- Daneshtalab, Mohsen;
- Csizmadia, Ferenc
Publication type:
Article
Syntheses of 1-[(2-Hydroxyethoxy)methyl]- and 1-[(1,3-Dihydroxy-2-Propoxy)methyl]- Derivatives of 5-Substituted-2,4-difluorobenzene: Unnatural Acyclo Thymidine Mimics for Evaluation as Anticancer and Antiviral Agents.
Published in:
Nucleosides, Nucleotides & Nucleic Acids, 2000, v. 19, n. 9, p. 1397, doi. 10.1080/15257770008033850
By:
- Wang, Zhi-Xian;
- Duan, Weili;
- Wiebe, Leonard I.;
- Clercq, Erik De;
- Balzarini, Jan;
- Knaus, Edward E.
Publication type:
Article
A Simple Computational Tool for Accurate, Quantitative Prediction of One-Electron Reduction Potentials of Hypoxia-Activated Tirapazamine Analogues.
Published in:
Journal of Pharmacy & Pharmaceutical Sciences, 2020, v. 23, p. 231, doi. 10.18433/jpps30602
By:
- Elsaidi, Hassan R. H.;
- Wiebe, Leonard I.;
- Kumar, Piyush
Publication type:
Article
A Simple Computational Tool for Accurate, Quantitative Prediction of One-Electron Reduction Potentials of Hypoxia-Activated Tirapazamine Analogues.
Published in:
2020
By:
- Elsaidi, Hassan R. H.;
- Wiebe, Leonard I.;
- Kumar, Piyush;
- Elsaidi, Hassan Rh
Publication type:
journal article
Positron Emission Tomography (PET) and Pharmacokinetics: Classical Blood Sampling Versus Image-Derived Analysis of [18F]FAZA and [18F]FDG in a Murine Tumor Bearing Model.
Published in:
2018
By:
- Jans, Hans-Soenke;
- Xiao-Hong Yang;
- Brocks, Dion R.;
- Kumar, Piyush;
- Wuest, Melinda;
- Wiebe, Leonard I.;
- Yang, Xiao-Hong
Publication type:
journal article
Electrophysiological characterization of a recombinant human Na+-coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes.
Published in:
Journal of Physiology, 2004, v. 558, n. 3, p. 807, doi. 10.1113/jphysiol.2004.068189
By:
- Smith, Kyla M.;
- Ng, Amy M. L.;
- Yao, Sylvia Y. M.;
- Labedz, Kathy A.;
- Knaus, Edward E.;
- Wiebe, Leonard I.;
- Cass, Carol E.;
- Baldwin, Stephen A.;
- Xing-Zhen Chen;
- Karpinski, Edward;
- Young, James D.
Publication type:
Article
18F-FESB: synthesis and automated radiofluorination of a novel 18F-labeled pet tracer for β-amyloid plaques.
Published in:
Journal of Labelled Compounds & Radiopharmaceuticals, 2005, v. 48, n. 13, p. 983, doi. 10.1002/jlcr.1011
By:
- Kumar, Piyush;
- Zheng, Weizhong;
- McQuarrie, Stephen A.;
- Jhamandas, Jack H.;
- Wiebe, Leonard I.
Publication type:
Article
CycloSaligenyl Pronucleotides of 5-Iodo and 5-Trifluoromethyl-1-(2-deoxy-β-D-ribofuranosyl)-2,4-difluorobenzene Mimics of Thymidine:‡ Synthesis and Evaluation of this Pronucleotide Monophosphate Delivery System for Compounds with Potential Anticancer Activity#
Published in:
Nucleosides, Nucleotides & Nucleic Acids, 2003, v. 22, n. 12, p. 2121, doi. 10.1081/NCN-120026634
By:
- Yan Sun, Wei;
- Zhou, Aihua;
- Wiebe, Leonard I.;
- Knaus, Edward E.
Publication type:
Article
Synthesis and Biological Evaluation of Iodoglucoazomycin (I-GAZ), an Azomycin-Glucose Adduct with Putative Applications in Diagnostic Imaging and Radiotherapy of Hypoxic Tumors.
Published in:
ChemMedChem, 2016, v. 11, n. 15, p. 1638, doi. 10.1002/cmdc.201600213
By:
- Kumar, Piyush;
- Elsaidi, Hassan R. H.;
- Zorniak, Bohdarianna;
- Laurens, Evelyn;
- Yang, Jennifer;
- Bacchu, Veena;
- Wang, Monica;
- Wiebe, Leonard I.
Publication type:
Article
Synthesis of [ 18 F]F-γ-T-3, a Redox-Silent γ-Tocotrienol (γ-T-3) Vitamin E Analogue for Image-Based In Vivo Studies of Vitamin E Biodistribution and Dynamics.
Published in:
Molecules, 2020, v. 25, n. 23, p. 5700, doi. 10.3390/molecules25235700
By:
- Roselt, Peter;
- Cullinane, Carleen;
- Noonan, Wayne;
- Elsaidi, Hassan;
- Eu, Peter;
- Wiebe, Leonard I.;
- Roivainen, Anne
Publication type:
Article
654. Targeting Adenoviral Vectors for Use in Breast Cancer Gene Therapy.
Published in:
Molecular Therapy, 2006, v. 13, p. S252, doi. 10.1016/j.ymthe.2006.08.730
By:
- DeSilva, Alan D.;
- Wiebe, Leonard I.;
- Chang-Xin Shi;
- Elgadi, Mabrouk M.;
- Bossi, Gianluca;
- Hitt, Mary M.
Publication type:
Article
Synthesis and Preliminary Evaluation of an ASGPr-Targeted Polycationic β -Cyclodextrin Carrier for Nucleosides and Nucleotides.
Published in:
Pharmaceutics, 2024, v. 16, n. 3, p. 323, doi. 10.3390/pharmaceutics16030323
By:
- Ryu, Jang-Ha;
- Zheng, Weizhong;
- Yang, Xiao-Hong;
- Elsaidi, Hassan;
- Diakur, Jim;
- Wiebe, Leonard I.
Publication type:
Article
Radiation Dosimetry of Theragnostic Pairs for Isotopes of Iodine in IAZA.
Published in:
Pharmaceutics, 2022, v. 14, n. 8, p. 1655, doi. 10.3390/pharmaceutics14081655
By:
- Jans, Hans-S.;
- Stypinski, Daria;
- Kumar, Piyush;
- Mercer, John R.;
- McQuarrie, Stephen A.;
- McEwan, Alexander J. B.;
- Wiebe, Leonard I.
Publication type:
Article
Improved Formulation of 224 Ra-Labeled Calcium Carbonate Microparticles by Surface Layer Encapsulation and Addition of EDTMP.
Published in:
Pharmaceutics, 2021, v. 13, n. 5, p. 634, doi. 10.3390/pharmaceutics13050634
By:
- Li, Ruth Gong;
- Lindland, Kim;
- Tonstad, Sandra Karen;
- Bønsdorff, Tina Bjørnlund;
- Juzeniene, Asta;
- Westrøm, Sara;
- Larsen, Roy Hartvig;
- Wiebe, Leonard I.
Publication type:
Article
Pharmacokinetics and Scintigraphic Imaging of the Hypoxia-Imaging Agent [123I]IAZA in Healthy Adults Following Exercise-Based Cardiac Stress.
Published in:
Pharmaceutics, 2018, v. 10, n. 1, p. 25, doi. 10.3390/pharmaceutics10010025
By:
- Stypinski, Daria;
- McQuarrie, Stephen A.;
- McEwan, Alexander J. B.;
- Wiebe, Leonard I.
Publication type:
Article
Development of [131I]I-EOE-TPZ and [131I]I-EOE-TPZMO: Novel Tirapazamine (TPZ)-Based Radioiodinated Pharmaceuticals for Application in Theranostic Management of Hypoxia.
Published in:
Pharmaceuticals (14248247), 2019, v. 12, n. 1, p. 3, doi. 10.3390/ph12010003
By:
- Elsaidi, Hassan;
- Ahmadi, Fatemeh;
- Wiebe, Leonard I.;
- Kumar, Piyush
Publication type:
Article
Synthesis of 1-(2-deoxy-β- D-ribofuranosyl)-2,4- difluoro-5-(2-halo-1-hydroxyethyl)benzenes and related derivatives: 'thymine replacement' analogs of deoxythymidine for evaluation as antiviral and anticancer agents.
Published in:
Drug Development Research, 2001, v. 52, n. 3, p. 492, doi. 10.1002/ddr.1151
By:
- Naimi, Ebrahim;
- Wiebe, Leonard I.;
- Balzarini, Jan;
- De Clercq, Erik;
- Knaus, Edward E.
Publication type:
Article
Synthesis and radioiodination of 3-( E)-(2-iodovinyl)-N-acetyl-4-cysteaminylphenol, a putative tyrosinase substrate for imaging neural crest tumours.
Published in:
Journal of Labelled Compounds & Radiopharmaceuticals, 1998, v. 41, n. 5, p. 355, doi. 10.1002/(SICI)1099-1344(199805)41:5<355::AID-JLCR88>3.0.CO;2-K
By:
- Singh, Shradha;
- Jimbow, Kowichi;
- Kumar, Piyush;
- McEwan, Alexander J.;
- Wiebe, Leonard I.
Publication type:
Article
Syntheses of [2-2H]-5-ethynyl-1-(β-D-ribofuranosyl)imidazole-4-carboxamide and 5-ethynyl-1-([5-3H]-β-D-ribofuranosyl)imidazole-4-carboxamide (EICAR).
Published in:
Journal of Labelled Compounds & Radiopharmaceuticals, 1996, v. 38, n. 9, p. 809, doi. 10.1002/(SICI)1099-1344(199609)38:9<809::AID-JLCR899>3.0.CO;2-0
By:
- Minakawa, Noriaki;
- Matsuda, Akira;
- Xia, Zuping;
- Wiebe, Leonard I.;
- Knaus, Edward E.
Publication type:
Article
An efficient, high specific activity radioiodination of 5-(1-hydroxy/methoxy-2-iodoethyl)-2′-deoxyuridine by isotope exchange labelling in pivalic acid melt.
Published in:
Journal of Labelled Compounds & Radiopharmaceuticals, 1990, v. 28, n. 3, p. 247, doi. 10.1002/jlcr.2580280302
By:
- Iwashina, Takashi;
- Kumar, Rakesh;
- Knaus, Edward E.;
- Wiebe, Leonard I.
Publication type:
Article
Synthesis of [5-14C]-1,1,12,12-tetraethoxy-4,9-diazadodecane dinitrate.
Published in:
Journal of Labelled Compounds & Radiopharmaceuticals, 1989, v. 27, n. 4, p. 449, doi. 10.1002/jlcr.2580270412
By:
- Somayaji, Vijayalakshmi V.;
- Hall, Tse W.;
- Wiebe, Leonard I.;
- Knaus, Edward E.;
- Demers, James P.
Publication type:
Article
An improved synthesis of [1-14C]-labelled 2-butynedioic acid, succinic acid and succinyl chloride.
Published in:
Journal of Labelled Compounds & Radiopharmaceuticals, 1988, v. 25, n. 12, p. 1325, doi. 10.1002/jlcr.2580251206
By:
- Somayaji, Vijayalakshmi V.;
- Hall, Tse W.;
- Wiebe, Leonard I.;
- Knaus, Edward E.
Publication type:
Article
Synthesis of [2-14C]-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro(chloro)uracil.
Published in:
Journal of Labelled Compounds & Radiopharmaceuticals, 1987, v. 24, n. 9, p. 1107, doi. 10.1002/jlcr.2580240912
By:
- Misra, Hemant K.;
- Wiebe, Leonard I.;
- Knaus, Edward E.
Publication type:
Article
Initial results of hypoxia imaging using 1-α-D-(5-deoxy-5-[18F]-fluoroarabinofuranosyl)-2-nitroimidazole (18F-FAZA).
Published in:
European Journal of Nuclear Medicine & Molecular Imaging, 2009, v. 36, n. 10, p. 1565, doi. 10.1007/s00259-009-1154-5
By:
- Postema, Ernst J.;
- McEwan, Alexander J. B.;
- Riauka, Terence A.;
- Kumar, Piyush;
- Richmond, Dacia A.;
- Abrams, Douglas N.;
- Wiebe, Leonard I.
Publication type:
Article
Radiolabeling with Organomercury Compounds: Part 2. High Specific Activity Synthesis of Iodine-125 and Iodine-131-6-Iodocholest-5-en-3β-ol and Its Tissue Distribution in Rats.
Published in:
Journal of Nuclear Medicine, 1986, v. 27, n. 7, p. 1165
By:
- Flanagan, Richard J.;
- Charleson, F. Peter;
- Synnes, Eyvind I.;
- Wiebe, Leonard I.
Publication type:
Article
Aziridination of the uracil 5,6-olefinic bond of 3- N-3′,5′-Di- O-tribenzoyl-5-vinyl-2′-deoxyuridine.
Published in:
Journal of Heterocyclic Chemistry, 1991, v. 28, n. 5, p. 1467, doi. 10.1002/jhet.5570280549
By:
- Kumar, Rakesh;
- Wiebe, Leonard I.;
- Knaus, Edward E.;
- Nakashima, Thomas T.
Publication type:
Article
Synthesis of brain-targeted 5-iodo-, 5-vinyl- and ( E)-5-(2-iodovinyl)-2′-deoxyuridines coupled to a dihydropyridine ⇌ pyridinium salt redox chemical delivery system.
Published in:
Journal of Heterocyclic Chemistry, 1991, v. 28, n. 3, p. 711, doi. 10.1002/jhet.5570280327
By:
- Kumar, Rakesh;
- Ji, Gueijun;
- Wiebe, Leonard I.;
- Knaus, Edward E.
Publication type:
Article
Design and synthesis of the 3′-aminocarbonylamino, aminothiocarbonylamino and N-(Hydroxy)guanidinyl derivatives of thymidine as potential anti-HIV agents.
Published in:
Journal of Heterocyclic Chemistry, 1991, v. 28, n. 3, p. 807, doi. 10.1002/jhet.5570280346
By:
- Morin, Kevin W.;
- Kumar, Rakesh;
- Knaus, Edward E.;
- Wiebe, Leonard I.
Publication type:
Article
Synthesis and biological evaluation of 5-(1-alkoxy-2-haloethyl)-2′-deoxyuridines and related uracil analogues.
Published in:
Journal of Heterocyclic Chemistry, 1991, v. 28, n. 2, p. 237, doi. 10.1002/jhet.5570280206
By:
- Kumar, Rakesh;
- Wiebe, Leonard I.;
- Knaus, E. E.;
- Tempest, Mark L.
Publication type:
Article
Reaction of 1-(2′,3′-epoxy-β- D-lyxofuranosyl)uracil with hydrogen fluoride. The unexpected formation of 1-(3′-fluoro-3′-deoxy-β- D-ribofuranosyl)uracil.
Published in:
Journal of Heterocyclic Chemistry, 1984, v. 21, n. 3, p. 773, doi. 10.1002/jhet.5570210327
By:
- Misra, Hemant K.;
- Gati, Wendy P.;
- Knaus, Edward E.;
- Wiebe, Leonard I.
Publication type:
Article
Labelling of Small Biomolecules Using Novel Technetium-99m Cores.
Published in:
Journal of Nuclear Medicine, 2008, v. 49, n. 11, p. 1901, doi. 10.2967/jnumed.108.054338
By:
- Wiebe, Leonard I.
Publication type:
Article
Comparative Evaluation of Therapeutic Radiopharmaceuticals.
Published in:
Journal of Nuclear Medicine, 2008, v. 49, n. 11, p. 1900, doi. 10.2967/jnumed.108.054288
By:
- Wiebe, Leonard I.
Publication type:
Article
Hypoxia-Specific Tumor Imaging with 18F-Fluoroazomycin Arabinoside.
Published in:
Journal of Nuclear Medicine, 2005, v. 46, n. 1, p. 106
By:
- Piert, Morand;
- Machulla, Hans-Jürgen;
- Picchio, Maria;
- Reischl, Gerald;
- Ziegler, Sybille;
- Kumar, Piyush;
- Wester, Hans-Jürgen;
- Beck, Roswitha;
- McEwan, Alexander J. B.;
- Wiebe, Leonard I.;
- Schwaiger, Markus
Publication type:
Article
FDG Metabolism: Quaecumque Sunt Vera….
Published in:
Journal of Nuclear Medicine, 2001, v. 42, n. 11, p. 1679
By:
- Wiebe, Leonard I.
Publication type:
Article
Dosimetry Estimations for 123I-IAZA in Healthy Volunteers.
Published in:
Journal of Nuclear Medicine, 2001, v. 42, n. 9, p. 1418
By:
- Stypinski, Daria;
- McQuarrie, Steve A.;
- Wiebe, Leonard I.;
- Tam, Yun K.;
- Mercer, John R.;
- McEwan, Alexander J. B.
Publication type:
Article
Imaging Tumor Hypoxia and Tumor Perfusion.
Published in:
Journal of Nuclear Medicine, 1993, v. 34, n. 6, p. 885
By:
- Groshar, David;
- McEwan, Alexander J. B.;
- Parliament, Matthew B.;
- Urtasun, Raul C.;
- Golberg, Lon E.;
- Hoskinson, Michael;
- Mercer, John R.;
- Mannan, Rezaul H.;
- Wiebe, Leonard I.;
- Chapman, J. Donald
Publication type:
Article
Measurement of PDT-Induced Hypoxia in Dunning Prostate Tumors by Iodine-123-Iodoazomycin Arabinoside.
Published in:
Journal of Nuclear Medicine, 1993, v. 34, n. 3, p. 405
By:
- Moore, Ronald B.;
- Chapman, J. Donald;
- Mercer, John R.;
- Mannan, Rezaul H.;
- Wiebe, Leonard I.;
- McEwan, Alexander J.;
- McPhee, Malcolm S.
Publication type:
Article
Radioiodinated 1-(5-Iodo-5-deoxy-β-D-arabinofuranosyl)-2-nitroimidazole (Iodoazomycin Arabinoside: IAZA): A Novel Marker of Tissue Hypoxia.
Published in:
Journal of Nuclear Medicine, 1991, v. 32, n. 9, p. 1764
By:
- Mannan, Rezaul H.;
- Somayaji, Vijayalakashmi V.;
- Lee, Jane;
- Mercer, John R.;
- Chapman, J. Donald;
- Wiebe, Leonard I.
Publication type:
Article
High Specific Activity [Samarium-153] EDTA for Imaging of Experimental Tumor Models.
Published in:
Journal of Nuclear Medicine, 1989, v. 30, n. 2, p. 202
By:
- Tse, John W.;
- Wiebe, Leonard I.;
- Noujaim, Antoine A.
Publication type:
Article
Synthesis of 5-(1-azido-2-haloethyl)arabinouridines.
Published in:
Journal of Heterocyclic Chemistry, 1997, v. 34, n. 4, p. 1369, doi. 10.1002/jhet.5570340445
By:
- Kumar, Rakesh;
- Wiebe, Leonard I.;
- Knaus, Edward E.
Publication type:
Article
Synthesis and properties of 5-(1,2-dihaloethyl)-2′-deoxyuridines and related analogues.
Published in:
Journal of Heterocyclic Chemistry, 1991, v. 28, n. 8, p. 1917, doi. 10.1002/jhet.5570280819
By:
- Kumar, Rakesh;
- Knaus, Edward E.;
- Wiebe, Leonard I.
Publication type:
Article