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Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.
Published in:
2016
By:
- Spangenberg, Elizabeth E.;
- Lee, Rafael J.;
- Najafi, Allison R.;
- Rice, Rachel A.;
- Elmore, Monica R. P.;
- Blurton-Jones, Mathew;
- West, Brian L.;
- Green, Kim N.
Publication type:
journal article
Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot-Marie-Tooth disease in mice.
Published in:
2015
By:
- Klein, Dennis;
- Patzkó, Ágnes;
- Schreiber, David;
- van Hauwermeiren, Anemoon;
- Baier, Michaela;
- Groh, Janos;
- West, Brian L.;
- Martini, Rudolf
Publication type:
journal article
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation.
Published in:
2011
By:
- Chakravarty, Debyani;
- Santos, Elmer;
- Ryder, Mabel;
- Knauf, Jeffrey A.;
- Xiao-Hui Liao;
- West, Brian L.;
- Bollag, Gideon;
- Kolesnick, Richard;
- Tin Htwe Thin;
- Rosen, Neal;
- Zanzonico, Pat;
- Larson, Steven M.;
- Refetoff, Samuel;
- Ghossein, Ronald;
- Fagin, James A.;
- Liao, Xiao-Hui;
- Thin, Tin Htwe
Publication type:
journal article
Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone β receptor inhibits mitotic progression.
Published in:
Journal of Clinical Investigation, 2006, v. 116, n. 11, p. 2972, doi. 10.1172/JCI28598
By:
- Hao Ying;
- Furuya, Fumihiko;
- Li Zhao;
- Araki, Osamu;
- West, Brian L.;
- Hanover, John A.;
- Willingham, Mark C.;
- Sheue-yann Cheng
Publication type:
Article
The Molecular Biology of Thyroid Hormone Action.
Published in:
Annals of the New York Academy of Sciences, 1995, v. 758, n. 1, p. 366, doi. 10.1111/j.1749-6632.1995.tb24843.x
By:
- RIBEIRO, RALFF C. J.;
- APRILETTI, JAMES W.;
- WEST, BRIAN L.;
- WAGNER, RICHARD L.;
- FLETTERICK, ROBERT J.;
- SCHAUFELE, FRED;
- BAXTER, JOHN D.
Publication type:
Article
Targeting microglia attenuates neuroinflammation‐related neural damage in mice carrying human PLP1 mutations.
Published in:
Glia, 2019, v. 67, n. 2, p. 277, doi. 10.1002/glia.23539
By:
- Groh, Janos;
- Klein, Dennis;
- Berve, Kristina;
- West, Brian L.;
- Martini, Rudolf
Publication type:
Article
A limited capacity for microglial repopulation in the adult brain.
Published in:
Glia, 2018, v. 66, n. 11, p. 2385, doi. 10.1002/glia.23477
By:
- Najafi, Allison R.;
- Crapser, Joshua;
- Jiang, Shan;
- Ng, Winnie;
- Mortazavi, Ali;
- West, Brian L.;
- Green, Kim N.
Publication type:
Article
Microglial repopulation resolves inflammation and promotes brain recovery after injury.
Published in:
Glia, 2017, v. 65, n. 6, p. 931, doi. 10.1002/glia.23135
By:
- Rice, Rachel A.;
- Pham, Jason;
- Lee, Rafael J.;
- Najafi, Allison R.;
- West, Brian L.;
- Green, Kim N.
Publication type:
Article
MICROGLIAL MODULATION OF ASTROGLIOSIS AND Aβ PLAQUE COMPACTION IN 5XFAD MICE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P981, doi. 10.1016/j.jalz.2017.06.1333
By:
- Spangenberg, Elizabeth E.;
- West, Brian L.;
- Green, Kim N.
Publication type:
Article
CHARACTERIZING THE EFFECTS OF MICROGLIAL ELIMINATION AND REPOPULATION ON ABETA AND TAU PATHOLOGY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P321, doi. 10.1016/j.jalz.2017.06.027
By:
- Hohsfield, Lindsay A.;
- Green, Kim N.;
- West, Brian L.
Publication type:
Article
CHARACTERIZING THE EFFECTS OF MICROGLIAL ELIMINATION AND REPOPULATION ON ABETA AND TAU PATHOLOGY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P241, doi. 10.1016/j.jalz.2017.06.089
By:
- Hohsfield, Lindsay A.;
- Green, Kim N.;
- West, Brian L.
Publication type:
Article
Reductions in LPS- and Alzheimer's disease neuropathology-induced CNS inflammation with selective colony stimulating factor-1 receptor kinase inhibitors
Published in:
2010
By:
- Green, Kim N.;
- Kitazawa, Masashi;
- Dagher, Nabil N.;
- Koike, Maya;
- Rezvani, Rod;
- West, Brian L.;
- LaFerla, Frank M.
Publication type:
Abstract
Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice.
Published in:
2020
By:
- Berve, Kristina;
- West, Brian L.;
- Martini, Rudolf;
- Groh, Janos
Publication type:
journal article
Mitigation of helium irradiation-induced brain injury by microglia depletion.
Published in:
2020
By:
- Allen, Barrett D.;
- Syage, Amber R.;
- Maroso, Mattia;
- Baddour, Al Anoud D.;
- Luong, Valerie;
- Minasyan, Harutyun;
- Giedzinski, Erich;
- West, Brian L.;
- Soltesz, Ivan;
- Limoli, Charles L.;
- Baulch, Janet E.;
- Acharya, Munjal M.
Publication type:
journal article
Elimination of microglia improves cognitive function following cranial irradiation.
Published in:
Scientific Reports, 2016, p. 31545, doi. 10.1038/srep31545
By:
- Acharya, Munjal M.;
- Green, Kim N.;
- Allen, Barrett D.;
- Najafi, Allison R.;
- Syage, Amber;
- Minasyan, Harutyun;
- Le, Mi T.;
- Kawashita, Takumi;
- Giedzinski, Erich;
- Parihar, Vipan K.;
- West, Brian L.;
- Baulch, Janet E.;
- Limoli, Charles L.
Publication type:
Article
MOLECULAR AND STRUCTURAL BIOLOGY OF THYROID HORMONE RECEPTORS.
Published in:
Clinical & Experimental Pharmacology & Physiology, 1998, v. 25, p. S2, doi. 10.1111/j.1440-1681.1998.tb02293.x
By:
- Apriletti, James W.;
- Ribeiro, Ralff CJ;
- Wagner, Richard L.;
- Feng, Weijun;
- Webb, Paul;
- Kushner, Peter J.;
- West, Brian L.;
- Nilsson, Stefan;
- Scanlan, Thomas S.;
- Fletterick, Robert J.;
- Baxter, John D.
Publication type:
Article
Characterizing Newly Repopulated Microglia in the Adult Mouse: Impacts on Animal Behavior, Cell Morphology, and Neuroinflammation.
Published in:
PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0122912
By:
- Elmore, Monica R. P.;
- Lee, Rafael J.;
- West, Brian L.;
- Green, Kim N.
Publication type:
Article
Inhibition of CSF-1R Supports T-Cell Mediated Melanoma Therapy.
Published in:
PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0104230
By:
- Sluijter, Marjolein;
- van der Sluis, Tetje C.;
- van der Velden, Pieter A.;
- Versluis, Mieke;
- West, Brian L.;
- van der Burg, Sjoerd H.;
- van Hall, Thorbald
Publication type:
Article
Attenuation of neuroinflammation reverses Adriamycin-induced cognitive impairments.
Published in:
Acta Neuropathologica Communications, 2019, v. 7, n. 1, p. N.PAG, doi. 10.1186/s40478-019-0838-8
By:
- Allen, Barrett D.;
- Apodaca, Lauren A.;
- Syage, Amber R.;
- Markarian, Mineh;
- Baddour, Al Anoud D.;
- Minasyan, Harutyun;
- Alikhani, Leila;
- Lu, Celine;
- West, Brian L.;
- Giedzinski, Erich;
- Baulch, Janet E.;
- Acharya, Munjal M.
Publication type:
Article
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.
Published in:
Nature, 2010, v. 467, n. 7315, p. 596, doi. 10.1038/nature09454
By:
- Bollag, Gideon;
- Hirth, Peter;
- Tsai, James;
- Zhang, Jiazhong;
- Ibrahim, Prabha N.;
- Cho, Hanna;
- Spevak, Wayne;
- Chao Zhang;
- Ying Zhang;
- Habets, Gaston;
- Burton, Elizabeth A.;
- Bernice Wong;
- Garson Tsang;
- West, Brian L.;
- Powell, Ben;
- Shellooe, Rafe;
- Marimuthu, Adhirai;
- Nguyen, Hoa;
- Zhang, Kam Y. J.;
- Artis, Dean R.
Publication type:
Article
Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization.
Published in:
Neuro-Oncology, 2016, v. 18, n. 6, p. 797, doi. 10.1093/neuonc/nov272
By:
- Stafford, Jason H.;
- Takahisa Hirai;
- Lei Deng;
- Chernikova, Sophia B.;
- Kimiko Urata;
- West, Brian L.;
- Brown, J. Martin
Publication type:
Article
Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study.
Published in:
Neuro-Oncology, 2016, v. 18, n. 4, p. 557, doi. 10.1093/neuonc/nov245
By:
- Butowski, Nicholas;
- Colman, Howard;
- De Groot, John F.;
- Omuro, Antonio M.;
- Nayak, Lakshmi;
- Wen, Patrick Y.;
- Cloughesy, Timothy F.;
- Marimuthu, Adhirai;
- Haidar, Sam;
- Perry, Arie;
- Huse, Jason;
- Phillips, Joanna;
- West, Brian L.;
- Nolop, Keith B.;
- Hsu, Henry H.;
- Ligon, Keith L.;
- Molinaro, Annette M.;
- Prados, Michael
Publication type:
Article
Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors.
Published in:
Therapeutic Advances in Medical Oncology, 2019, v. 11, p. 1, doi. 10.1177/1758835919854238
By:
- Wesolowski, Robert;
- Sharma, Neelesh;
- Reebel, Laura;
- Rodal, Mary Beth;
- Peck, Alexandra;
- West, Brian L.;
- Marimuthu, Adhirai;
- Severson, Paul;
- Karlin, David A.;
- Dowlati, Afshin;
- Le, Mai H.;
- Coussens, Lisa M.;
- Rugo, Hope S.
Publication type:
Article
Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors.
Published in:
Therapeutic Advances in Medical Oncology, 2019, v. 11, p. N.PAG, doi. 10.1177/1758835919854238
By:
- Wesolowski, Robert;
- Sharma, Neelesh;
- Reebel, Laura;
- Rodal, Mary Beth;
- Peck, Alexandra;
- West, Brian L.;
- Marimuthu, Adhirai;
- Severson, Paul;
- Karlin, David A.;
- Dowlati, Afshin;
- Le, Mai H.;
- Coussens, Lisa M.;
- Rugo, Hope S.
Publication type:
Article
Microglia ablation alleviates myelin-associated catatonic signs in mice.
Published in:
2018
By:
- Janova, Hana;
- Arinrad, Sahab;
- Balmuth, Evan;
- Mitjans, Marina;
- Hertel, Johannes;
- Habes, Mohamad;
- Bittner, Robert A;
- Pan, Hong;
- Goebbels, Sandra;
- Begemann, Martin;
- Gerwig, Ulrike C;
- Langner, Sönke;
- Werner, Hauke B;
- Kittel-Schneider, Sarah;
- Homuth, Georg;
- Davatzikos, Christos;
- Völzke, Henry;
- West, Brian L;
- Reif, Andreas;
- Grabe, Hans Jörgen
Publication type:
journal article
Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke.
Published in:
Nature Communications, 2016, v. 7, n. 5, p. 11499, doi. 10.1038/ncomms11499
By:
- Szalay, Gergely;
- Martinecz, Bernadett;
- Lénárt, Nikolett;
- Környei, Zsuzsanna;
- Orsolits, Barbara;
- Judák, Linda;
- Császár, Eszter;
- Fekete, Rebeka;
- West, Brian L.;
- Katona, Gergely;
- Rózsa, Balázs;
- Dénes, Ádám
Publication type:
Article
Cellular Localization of Kynurenine 3-Monooxygenase in the Brain: Challenging the Dogma.
Published in:
Antioxidants, 2022, v. 11, n. 2, p. 315, doi. 10.3390/antiox11020315
By:
- Sathyasaikumar, Korrapati V.;
- Pérez de la Cruz, Verónica;
- Pineda, Benjamín;
- Vázquez Cervantes, Gustavo Ignacio;
- Ramírez Ortega, Daniela;
- Donley, David W.;
- Severson, Paul L.;
- West, Brian L.;
- Giorgini, Flaviano;
- Fox, Jonathan H.;
- Schwarcz, Robert
Publication type:
Article
Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Factor Receptor (EGFR) and Colony Stimulating Factor 1 Receptor (CSF-1R) Signaling.
Published in:
Molecular Medicine, 2012, v. 18, n. 3, p. 519, doi. 10.2119/molmed.2011.00217
By:
- Coniglio, Salvatore J.;
- Eugenin, Eliseo;
- Dobrenis, Kostantin;
- Stanley, E. Richard;
- West, Brian L.;
- Symons, Marc H.;
- Segall, Jeffrey E.
Publication type:
Article
Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition.
Published in:
Acta Neuropathologica, 2013, v. 125, n. 1, p. 159, doi. 10.1007/s00401-012-1056-7
By:
- Prada, Carlos E.;
- Jousma, Edwin;
- Rizvi, Tilat A.;
- Jianqiang Wu;
- Dunn, R. Scott;
- Mayes, Debra A.;
- Cancelas, Jose A.;
- Dombi, Eva;
- Mi-Ok Kim;
- West, Brian L.;
- Bollag, Gideon;
- Ratner, Nancy
Publication type:
Article
Macrophage Depletion Ameliorates Peripheral Neuropathy in Aging Mice.
Published in:
Journal of Neuroscience, 2018, v. 38, n. 19, p. 4610, doi. 10.1523/JNEUROSCI.3030-17.2018
By:
- Xidi Yuan;
- Klein, Dennis;
- Kerscher, Susanne;
- West, Brian L.;
- Weis, Joachim;
- Katona, Istvan;
- Martini, Rudolf
Publication type:
Article
ERβ Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus.
Published in:
Nuclear Receptor, 2003, v. 1, p. 4, doi. 10.1186/1478-1336-1-4
By:
- Webb, Paul;
- Valentine, Cathleen;
- Nguyen, Phuong;
- Price Jr., Richard H.;
- Marimuthu, Adhirai;
- West, Brian L.;
- Baxter, John D.;
- Kushner, Peter J.
Publication type:
Article
Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits.
Published in:
2016
By:
- Xi Feng;
- Jopson, Timothy D.;
- Paladini, Maria Serena;
- Liu, Sharon;
- West, Brian L.;
- Gupta, Nalin;
- Rosi, Susanna;
- Feng, Xi
Publication type:
journal article
Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice.
Published in:
Journal of Neuroinflammation, 2015, v. 12, n. 1, p. 1, doi. 10.1186/s12974-015-0366-9
By:
- Dagher, Nabil N.;
- Najafi, Allison R.;
- Neely Kayala, Kara M.;
- Elmore, Monica R. P.;
- White, Terra E.;
- Medeiros, Rodrigo;
- West, Brian L.;
- Green, Kim N.
Publication type:
Article
Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice.
Published in:
2015
By:
- Dagher, Nabil N;
- Najafi, Allison R;
- Kayala, Kara M Neely;
- Elmore, Monica R P;
- White, Terra E;
- Medeiros, Rodrigo;
- West, Brian L;
- Green, Kim N
Publication type:
journal article
Activated microglia drive demyelination via CSF1R signaling.
Published in:
Glia, 2021, v. 69, n. 6, p. 1583, doi. 10.1002/glia.23980
By:
- Marzan, Dave E.;
- Brügger‐Verdon, Valérie;
- West, Brian L.;
- Liddelow, Shane;
- Samanta, Jayshree;
- Salzer, James L.
Publication type:
Article
Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition.
Published in:
BMC Cancer, 2015, v. 15, n. 1, p. 1, doi. 10.1186/s12885-015-1377-8
By:
- Mok, Stephen;
- Tsoi, Jennifer;
- Koya, Richard C.;
- Hu-Lieskovan, Siwen;
- West, Brian L.;
- Bollag, Gideon;
- Graeber, Thomas G.;
- Ribas, Antoni
Publication type:
Article
Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition.
Published in:
2015
By:
- Mok, Stephen;
- Tsoi, Jennifer;
- Koya, Richard C;
- Hu-Lieskovan, Siwen;
- West, Brian L;
- Bollag, Gideon;
- Graeber, Thomas G;
- Ribas, Antoni
Publication type:
journal article
Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice.
Published in:
Aging Cell, 2018, v. 17, n. 6, p. 1, doi. 10.1111/acel.12832
By:
- Elmore, Monica R. P.;
- Hohsfield, Lindsay A.;
- Kramár, Enikö A.;
- Soreq, Lilach;
- Lee, Rafael J.;
- Pham, Stephanie T.;
- Najafi, Allison R.;
- Spangenberg, Elizabeth E.;
- Wood, Marcelo A.;
- West, Brian L.;
- Green, Kim N.
Publication type:
Article
Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus.
Published in:
Journal of Neuroscience, 2015, v. 35, n. 27, p. 9977, doi. 10.1523/JNEUROSCI.0336-15.2015
By:
- Rice, Rachel A.;
- Spangenberg, Elizabeth E.;
- Yamate-Morgan, Hana;
- Lee, Rafael J.;
- Arora, Rajan P. S.;
- Hernandez, Michael X.;
- Tenner, Andrea J.;
- West, Brian L.;
- Green, Kim N.
Publication type:
Article

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