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How donanemab data address the coverage with evidence development questions.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 4, p. 3127, doi. 10.1002/alz.13700
By:
- Klein, Eric G.;
- Schroeder, Krista;
- Wessels, Alette M.;
- Phipps, Adam;
- Japha, Maureen;
- Schilling, Traci;
- Zimmer, Jennifer A.
Publication type:
Article
Donanemab in Early Symptomatic Alzheimer's Disease: Efficacy and Safety in TRAILBLAZER‐ALZ 2, a Phase 3 Randomized Clinical Trial.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082733
By:
- Mintun, Mark;
- Ritchie, Craig W;
- Solomon, Paul;
- Sims, John R.;
- Salloway, Stephen;
- Hansson, Oskar;
- Apostolova, Liana G.;
- Zimmer, Jennifer A.;
- Evans, Cynthia D.;
- Lu, Ming;
- Ardayfio, Paul A;
- Sparks, JonDavid;
- Wessels, Alette M;
- Shcherbinin, Sergey;
- Wang, Hong;
- Nery, Emel Serap Monkul;
- Collins, Emily C.;
- Dennehy, Ellen B;
- Brooks, Dawn A.;
- Skovronsky, Daniel M.
Publication type:
Article
Incremental declines in independence associated with disease progression in early symptomatic Alzheimer's disease (AD).
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082395
By:
- Chandler, Julie;
- Ye, Wenyu;
- Mi, Xiaojuan;
- Dennehy, Ellen B;
- Atkins, Alexandra S;
- Wessels, Alette M
Publication type:
Article
Demonstration of the iADRS as an integrated measure of global disease severity in early symptomatic Alzheimer's disease using Rasch measurement theory (RMT).
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082362
By:
- Atkins, Alexandra S;
- Marquis, Sarah;
- Cano, Stefan;
- Delbecque, Laure;
- Ye, Wenyu;
- Wessels, Alette M
Publication type:
Article
Distinct associations between tau PET and cognitive impairment across brain regions and cognitive domains in Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078345
By:
- Rathore, Saima;
- Tronchin, Giulia;
- Higgins, Ixavier A.;
- Wessels, Alette M;
- Iaccarino, Leonardo;
- Sims, John R.;
- Mintun, Mark A.;
- Shcherbinin, Sergey
Publication type:
Article
Disease progression model using the integrated Alzheimer's Disease Rating Scale.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 6, p. 2253, doi. 10.1002/alz.12876
By:
- Gueorguieva, Ivelina;
- Chua, Laiyi;
- Willis, Brian A.;
- Sims, John R.;
- Wessels, Alette M.
Publication type:
Article
Reasons for study exclusion by sex in lanabecestat studies AMARANTH and DAYBREAK‐ALZ: Human/Human trials: Other.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.038663
By:
- Zimmer, Jennifer A.;
- Andersen, Scott W.;
- Wessels, Alette M.;
- Shering, Craig;
- Sims, John R.
Publication type:
Article
Cognitive outcomes in trials of two BACE inhibitors in Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1483, doi. 10.1002/alz.12164
By:
- Wessels, Alette M.;
- Lines, Christopher;
- Stern, Robert A.;
- Kost, James;
- Voss, Tiffini;
- Mozley, Lyn Harper;
- Furtek, Christine;
- Mukai, Yuki;
- Aisen, Paul S.;
- Cummings, Jeffrey L.;
- Tariot, Pierre N.;
- Vellas, Bruno;
- Dupre, Nicole;
- Randolph, Christopher;
- Michelson, David;
- Andersen, Scott W.;
- Shering, Craig;
- Sims, John R.;
- Egan, Michael F.
Publication type:
Article
Clinical meaningfulness addressed at Alzheimer's Association Research Roundtable.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 5, p. 814, doi. 10.1002/alz.12111
By:
- Rentz, Dorene M.;
- Wessels, Alette M.;
- Bain, Lisa J.;
- Weber, Christopher J.;
- Carrillo, Maria C.
Publication type:
Article
FTS3‐01‐03: PERFORMANCE ON EXPLORATORY EFFICACY VARIABLES IN AMARANTH, A RANDOMIZED PHASE 2/3 STUDY IN EARLY ALZHEIMER'S DISEASE WITH LANABECESTAT.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P873, doi. 10.1016/j.jalz.2019.06.4620
By:
- Stern, Robert A.;
- Wessels, Alette M.;
- Selzler, Katherine J.;
- Andersen, Scott W.;
- Mullen, Jamie;
- Sims, John R.
Publication type:
Article
FTS3‐01‐02: SUBGROUP POPULATIONS IN AMARANTH, A RANDOMIZED PHASE 2/3 STUDY IN EARLY ALZHEIMER'S DISEASE WITH LANABECESTAT.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P872, doi. 10.1016/j.jalz.2019.06.4619
By:
- Tariot, Pierre N.;
- Selzler, Katherine J.;
- Wessels, Alette M.;
- Andersen, Scott W.;
- Mullen, Jamie;
- Zimmer, Jennifer A.;
- Sims, John R.
Publication type:
Article
DT‐01‐04: LANABECESTAT: BASELINE CHARACTERISTICS OF PARTICIPANTS RANDOMIZED IN THE PHASE 2/3 AMARANTH STUDY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1666, doi. 10.1016/j.jalz.2018.07.006
By:
- Sims, John R.;
- Downing, AnnCatherine M.;
- Andersen, Scott W.;
- Wessels, Alette M.;
- Zimmer, Jennifer A.;
- Mullen, Jamie;
- Schumi, Jennifer;
- Stern, Robert A.;
- Vellas, Bruno;
- Boada, Mercè;
- Cohen, Sharon;
- MacSweeney, Emer;
- Tariot, Pierre N.
Publication type:
Article
P4‐341: THE COMPUTERIZED COGNITIVE COMPOSITE (C3) AND AMYLOID STATUS AMONG NORMAL OLDER ADULTS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1597, doi. 10.1016/j.jalz.2018.07.164
By:
- Papp, Kathryn V.;
- Rentz, Dorene M.;
- Maruff, Paul;
- Sun, Chung-Kai;
- Raman, Rema;
- Donohue, Michael C.;
- Schembri, Adrian;
- Stark, Craig E.;
- Yassa, Michael A.;
- Holdridge, Karen C.;
- Wessels, Alette M.;
- Yaari, Roy;
- Aisen, Paul S.;
- Sperling, Reisa A.
Publication type:
Article
P4‐210: LANABECESTAT: SCREENING PERFORMANCE FROM THE AMARANTH STUDY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1521, doi. 10.1016/j.jalz.2018.07.031
By:
- Downing, AnnCatherine M.;
- Wessels, Alette M.;
- Zimmer, Jennifer A.;
- Nickell, Laura;
- Monroe, Katharine;
- Andersen, Scott W.;
- Mullen, Jamie;
- Sims, John R.
Publication type:
Article
THE INTEGRATED ALZHEIMER’S DISEASE RATING SCALE (IADRS): FINDINGS FROM THE EXPEDITION3 TRIAL.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1521, doi. 10.1016/j.jalz.2017.07.649
By:
- Wessels, Alette M.;
- Matthews, Brandy R.;
- Dowsett, Sherie A.;
- Andersen, Scott W.;
- Siemers, Eric R.
Publication type:
Article
Diabetes and cognitive decline in elderly African Americans: A 15-year follow-up study
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2011, v. 7, n. 4, p. 418, doi. 10.1016/j.jalz.2010.07.003
By:
- Wessels, Alette M.;
- Lane, Kathleen A.;
- Gao, Sujuan;
- Hall, Kathleen S.;
- Unverzagt, Frederick W.;
- Hendrie, Hugh C.
Publication type:
Article
P2-077: Comparison of manual and automated determination of hippocampal volumes in MCI and older adults with cognitive complaints
Published in:
2008
By:
- Shen, Li;
- Saykin, Andrew J.;
- Firpi, Hiram;
- West, John D.;
- McHugh, Tara L.;
- Wishart, Heather A.;
- Flashman, Laura A.;
- Wessels, Alette M.;
- McDonald, Brenna C.;
- Cannon, Aaron
Publication type:
Abstract
IC-P1-054: Comparison of manual and automated determination of hippocampal volumes in MCI and older adults with cognitive complaints
Published in:
2008
By:
- Shen, Li;
- Saykin, Andrew J.;
- Firpi, Hiram;
- West, John D.;
- McHugh, Tara L.;
- Wishart, Heather A.;
- Flashman, Laura A.;
- Wessels, Alette M.;
- McDonald, Brenna C.;
- Cannon, Aaron
Publication type:
Abstract
Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.
Published in:
JAMA: Journal of the American Medical Association, 2023, v. 330, n. 6, p. 512, doi. 10.1001/jama.2023.13239
By:
- Sims, John R.;
- Zimmer, Jennifer A.;
- Evans, Cynthia D.;
- Lu, Ming;
- Ardayfio, Paul;
- Sparks, JonDavid;
- Wessels, Alette M.;
- Shcherbinin, Sergey;
- Wang, Hong;
- Monkul Nery, Emel Serap;
- Collins, Emily C.;
- Solomon, Paul;
- Salloway, Stephen;
- Apostolova, Liana G.;
- Hansson, Oskar;
- Ritchie, Craig;
- Brooks, Dawn A.;
- Mintun, Mark;
- Skovronsky, Daniel M.
Publication type:
Article
Differential impact of subclinical carotid artery disease on cerebral structure and functioning in type 1 diabetes patients with versus those without proliferative retinopathy.
Published in:
Cardiovascular Diabetology, 2014, v. 13, n. 1, p. 1, doi. 10.1186/1475-2840-13-58
By:
- Duinkerken, Eelco van;
- IJzerman, Richard G.;
- van der Zijl, Nynke J.;
- Barkhof, Frederik;
- Pouwels, Petra J. W.;
- Schoonheim, Menno M.;
- Moll, Annette C.;
- Boerop, Jeannette;
- Wessels, Alette M.;
- Klein, Martin;
- Snoek, Frank J.;
- Diamant, Michaela
Publication type:
Article
Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease: The AMARANTH and DAYBREAK-ALZ Randomized Clinical Trials.
Published in:
JAMA Neurology, 2020, v. 77, n. 2, p. 199, doi. 10.1001/jamaneurol.2019.3988
By:
- Wessels, Alette M.;
- Tariot, Pierre N.;
- Zimmer, Jennifer A.;
- Selzler, Katherine J.;
- Bragg, Sonja M.;
- Andersen, Scott W.;
- Landry, John;
- Krull, James H.;
- Downing, AnnCatherine M.;
- Willis, Brian A.;
- Shcherbinin, Sergey;
- Mullen, Jamie;
- Barker, Peter;
- Schumi, Jennifer;
- Shering, Craig;
- Matthews, Brandy R.;
- Stern, Robert A.;
- Vellas, Bruno;
- Cohen, Sharon;
- MacSweeney, Emer
Publication type:
Article
Population Pharmacokinetic Modeling of Ziprasidone in Patients With Schizophrenia From the CATIE Study.
Published in:
2011
By:
- Wessels, Alette M.;
- Bies, Robert R.;
- Pollock, Bruce G.;
- Schneider, Lon S.;
- Lieberman, Jeffrey A.;
- Stroup, Scott;
- Li, Claire H.;
- Coley, Kim;
- Kirshner, Margaret M.;
- Marder, Stephen R.
Publication type:
Case Study
Cognitive Performance in Type 1 Diabetes Patients Is Associated with Cerebral White Matter Volume.
Published in:
Diabetes, 2007, v. 56, p. A1
By:
- Wessels, Alette M.;
- Rombouts, Serge A.;
- Remijnse, Peter L.;
- Boom, Yvette;
- Scheltens, Philip;
- Barkhof, Frederik;
- Heine, Robert J.;
- Snoek, Frank J.
Publication type:
Article
Microvascular disease in type 1 diabetes alters brain activation: a functional magnetic resonance imaging study.
Published in:
2006
By:
- Wessels AM;
- Rombouts SAR;
- Simsek S;
- Kuijer JPA;
- Kostense PJ;
- Barkhof F;
- Scheltens P;
- Snoek FJ;
- Heine RJ;
- Wessels, Alette M;
- Rombouts, Serge A R B;
- Simsek, Suat;
- Kuijer, Joost P A;
- Kostense, Piet J;
- Barkhof, Frederik;
- Scheltens, Philip;
- Snoek, Frank J;
- Heine, Robert J
Publication type:
journal article
Microvascular Disease in Type 1 Diabetes Alters Brain Activation.
Published in:
Diabetes, 2006, v. 55, n. 2, p. 334, doi. 10.2337/diabetes.55.02.06.db05-0680
By:
- Wessels, Alette M.;
- Rombouts, Serge A. R. B.;
- Simsek, Suat;
- Kuijer, Joost P. A.;
- Kostense, Piet J.;
- Barkhof, Frederik;
- Scheltens, Philip;
- Snoek, Frank J.;
- Heine, Robert J.
Publication type:
Article
Integrated Alzheimer's Disease Rating Scale: Clinically meaningful change estimates.
Published in:
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2022, v. 8, n. 1, p. 1, doi. 10.1002/trc2.12312
By:
- Wessels, Alette M.;
- Rentz, Dorene M.;
- Case, Michael;
- Lauzon, Steve;
- Sims, John R.
Publication type:
Article
Building clinically relevant outcomes across the Alzheimer’s disease spectrum.
Published in:
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2021, v. 7, n. 1, p. 1, doi. 10.1002/trc2.12181
By:
- Rentz, Dorene M.;
- Wessels, Alette M.;
- Annapragada, Ananth V.;
- Berger, Anna-Karin;
- Edgar, Chris J.;
- Gold, Michael;
- Miller, David S.;
- Randolph, Christopher;
- Ryan, J. Michael;
- Wunderlich, Glen;
- Zoschg, Megan Canniere;
- Trépel, Dominic;
- Knopman, David S.;
- Staffaroni, Adam M.;
- Bain, Lisa J.;
- Carrillo, Maria C.;
- Weber, Christopher J.
Publication type:
Article
Lanabecestat: Neuroimaging results in early symptomatic Alzheimer’s disease.
Published in:
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2021, v. 7, n. 1, p. 1, doi. 10.1002/trc2.12123
By:
- Zimmer, Jennifer A.;
- Shcherbinin, Sergey;
- Devous Sr., Michael D.;
- Bragg, Sonja M.;
- Selzler, Katherine J.;
- Wessels, Alette M.;
- Shering, Craig;
- Mullen, Jamie;
- Landry, John;
- Andersen, Scott W.;
- Downing, AnnCatherine M.;
- Fleisher, Adam S.;
- Otero Svaldi, Diana;
- Sims, John R.
Publication type:
Article
Cytochrome P450 Polymorphisms and their Relationship with Premature Ovarian Failure in Premenopausal Women with Breast Cancer Receiving Doxorubicin and Cyclophosphamide.
Published in:
Breast Journal, 2011, v. 17, n. 5, p. 536, doi. 10.1111/j.1524-4741.2011.01144.x
By:
- Wessels, Alette M.;
- Flockhart, David A.;
- Carpenter, Janet S.;
- Radovich, Milan;
- Li, Lang;
- Miller, Kathy D.;
- Sledge, George W.;
- Storniolo, Anna M.;
- Otte, Julie L.;
- Lemler, Suzanne M.;
- Schneider, Bryan P.
Publication type:
Article

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