Works by Weetall, Marla

Results: 34

Discovery and SAR Studies of Potent Modulators of BMI‐1 Expression.

Published in:

Helvetica Chimica Acta, 2023, v. 106, n. 9, p. 1, doi. 10.1002/hlca.202300076

By:

Baiazitov, Ramil Y.;
Sydorenko, Nadiya;
Du, Wu;
Ren, Hongyu;
Cao, Liang;
Davis, Thomas;
Cintron‐Lue, Katherine;
Kim, Min‐Jung;
Zhuo, Jin;
Mody, Shreshtha;
Weetall, Marla;
Sheedy, Josephine;
Risher, Nicole;
Almstead, Neil;
Moon, Young‐Choon

Publication type:

Article

Pharmacokinetics and Safety of PTC596, a Novel Tubulin‐Binding Agent, in Subjects With Advanced Solid Tumors.

Published in:

Clinical Pharmacology in Drug Development, 2021, v. 10, n. 8, p. 940, doi. 10.1002/cpdd.904

By:

Shapiro, Geoffrey I.;
O'Mara, Edward;
Laskin, Oscar L.;
Gao, Lan;
Baird, John D.;
Spiegel, Robert J.;
Kaushik, Diksha;
Weetall, Marla;
Colacino, Joseph;
O'Keefe, Kylie;
Branstrom, Arthur;
Goodwin, Elizabeth;
Infante, Jeffrey;
Bedard, Philippe L.;
Kong, Ronald

Publication type:

Article

Phase 1 Study of Safety, Tolerability, and Pharmacokinetics of PTC299, an Inhibitor of Stress-Regulated Protein Translation.

Published in:

Clinical Pharmacology in Drug Development, 2016, v. 5, n. 4, p. 296, doi. 10.1002/cpdd.240

By:

Weetall, Marla;
Davis, Thomas;
Elfring, Gary;
Northcutt, Valerie;
Cao, Liangxian;
Moon, Young‐Choon;
Riebling, Peter;
Dali, Mandar;
Hirawat, Samit;
Babiak, John;
Colacino, Joseph;
Almstead, Neil;
Spiegel, Robert;
Peltz, Stuart W.

Publication type:

Article

Efficacy of the novel tubulin polymerization inhibitor PTC‐028 for myelodysplastic syndrome.

Published in:

Cancer Science, 2020, v. 111, n. 12, p. 4336, doi. 10.1111/cas.14684

By:

Zhong, Cheng;
Kayamori, Kensuke;
Koide, Shuhei;
Shinoda, Daisuke;
Oshima, Motohiko;
Nakajima‐Takagi, Yaeko;
Nagai, Yurie;
Mimura, Naoya;
Sakaida, Emiko;
Yamazaki, Satoshi;
Iwano, Satoshi;
Miyawaki, Atsushi;
Ito, Ryoji;
Tohyama, Kaoru;
Yamaguchi, Kiyoshi;
Furukawa, Yoichi;
Lennox, William;
Sheedy, Josephine;
Weetall, Marla;
Iwama, Atsushi

Publication type:

Article

Small molecule splicing modifiers with systemic HTT-lowering activity.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27157-z

By:

Bhattacharyya, Anuradha;
Trotta, Christopher R.;
Narasimhan, Jana;
Wiedinger, Kari J.;
Li, Wencheng;
Effenberger, Kerstin A.;
Woll, Matthew G.;
Jani, Minakshi B.;
Risher, Nicole;
Yeh, Shirley;
Cheng, Yaofeng;
Sydorenko, Nadiya;
Moon, Young-Choon;
Karp, Gary M.;
Weetall, Marla;
Dakka, Amal;
Gabbeta, Vijayalakshmi;
Naryshkin, Nikolai A.;
Graci, Jason D.;
Tripodi Jr., Thomas

Publication type:

Article

In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor.

Published in:

Xenobiotica, 2022, v. 52, n. 2, p. 152, doi. 10.1080/00498254.2021.2010287

By:

Ma, Jiyuan;
Kaushik, Diksha;
Yeh, Shirley;
Northcutt, Valerie;
Babiak, John;
Risher, Nicole;
Weetall, Marla;
Moon, Young-Choon;
Welch, Ellen M.;
Molony, Lachlan;
O'Keefe, Kylie;
Kong, Ronald

Publication type:

Article

In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren.

Published in:

Pharmacology Research & Perspectives, 2020, v. 8, n. 2, p. 1, doi. 10.1002/prp2.576

By:

Ronald Kong;
Jiyuan Ma;
Seongwoo Hwang;
Young-Choon Moon;
Welch, Ellen M.;
Weetall, Marla;
Colacino, Joseph M.;
Almstead, Neil;
Babiak, John;
Goodwin, Elizabeth

Publication type:

Article

Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs.

Published in:

Pharmacology Research & Perspectives, 2018, v. 6, n. 6, p. 1, doi. 10.1002/prp2.447

By:

Poirier, Agnès;
Weetall, Marla;
Heinig, Katja;
Bucheli, Franz;
Schoenlein, Kerstin;
Alsenz, Jochem;
Bassett, Simon;
Ullah, Mohammed;
Senn, Claudia;
Ratni, Hasane;
Naryshkin, Nikolai;
Paushkin, Sergey;
Mueller, Lutz

Publication type:

Article

SMN protein is required throughout life to prevent spinal muscular atrophy disease progression.

Published in:

Human Molecular Genetics, 2022, v. 31, n. 1, p. 82, doi. 10.1093/hmg/ddab220

By:

Zhao, Xin;
Feng, Zhihua;
Risher, Nicole;
Mollin, Anna;
Sheedy, Josephine;
Ling, Karen K Y;
Narasimhan, Jana;
Dakka, Amal;
Baird, John D;
Ratni, Hasane;
Lutz, Catherine;
Chen, Karen S;
Naryshkin, Nikolai A;
Ko, Chien-Ping;
Welch, Ellen;
Metzger, Friedrich;
Weetall, Marla

Publication type:

Article

Corrigendum to: Pharmacologically-induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset.

Published in:

Human Molecular Genetics, 2021, v. 30, n. 9, p. 843, doi. 10.1093/hmg/ddaa247

By:

Feng, Zhihua;
Ling, Karen K Y;
Zhao, Xin;
Zhou, Chunyi;
Karp, Gary;
Welch, Ellen M;
Naryshkin, Nikolai;
Ratni, Hasane;
Chen, Karen S;
Metzger, Friedrich;
Paushkin, Sergey;
Weetall, Marla;
Ko, Chien-Ping

Publication type:

Article

Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform.

Published in:

PLoS ONE, 2016, v. 11, n. 12, p. 1, doi. 10.1371/journal.pone.0168366

By:

Cao, Liangxian;
Weetall, Marla;
Bombard, Jenelle;
Qi, Hongyan;
Arasu, Tamil;
Lennox, William;
Hedrick, Jean;
Sheedy, Josephine;
Risher, Nicole;
Brooks, Peter C.;
Trifillis, Panayiota;
Trotta, Christopher;
Moon, Young-Choon;
Babiak, John;
Almstead, Neil G.;
Colacino, Joseph M.;
Davis, Thomas W.;
Peltz, Stuart W.

Publication type:

Article

SMN Protein Can Be Reliably Measured in Whole Blood with an Electrochemiluminescence (ECL) Immunoassay: Implications for Clinical Trials.

Published in:

PLoS ONE, 2016, v. 11, n. 3, p. 1, doi. 10.1371/journal.pone.0150640

By:

Zaworski, Phillip;
von Herrmann, Katharine M.;
Taylor, Shannon;
Sunshine, Sara S.;
McCarthy, Kathleen;
Risher, Nicole;
Newcomb, Tara;
Weetall, Marla;
Prior, Thomas W.;
Swoboda, Kathryn J.;
Chen, Karen S.;
Paushkin, Sergey

Publication type:

Article

Improved binding of a bivalent single-chain immunotoxin results in increased efficacy for in vivo T-cell depletion.

Published in:

Protein Engineering, 2001, v. 14, n. 12, p. 1035, doi. 10.1093/protein/14.12.1035

By:

Thompson, Jerry;
Stavrou, Scott;
Weetall, Marla;
Hexham, J.Mark;
Digan, Mary Ellen;
Wang, Zhuri;
Woo, Jung Hee;
Yu, Yongjun;
Mathias, Askale;
Liu, Yuan Yi;
Ma, Shenglin;
Gordienko, Irina;
Lake, Philip;
Neville, David M.

Publication type:

Article

Identification of benzazole compounds that induce HIV-1 transcription.

Published in:

PLoS ONE, 2017, v. 12, n. 6, p. 1, doi. 10.1371/journal.pone.0179100

By:

Graci, Jason D.;
Michaels, Daniel;
Chen, Guangming;
Schiralli Lester, Gillian M.;
Nodder, Sarah;
Weetall, Marla;
Karp, Gary M.;
Gu, Zhengxian;
Colacino, Joseph M.;
Henderson, Andrew J.

Publication type:

Article

Absorption and disposition of a tripeptoid and a tetrapeptide in the rat.

Published in:

Biopharmaceutics & Drug Disposition, 1999, v. 20, n. 2, p. 69, doi. 10.1002/(SICI)1099-081X(199903)20:2<69::AID-BDD153>3.0.CO;2-B

By:

Wang, Yanfeng;
Lin, Hanford;
Tullman, Robert;
Jewell, Charles F.;
Weetall, Marla L.;
Tse, Francis L.S.

Publication type:

Article

Targeting ferroptosis with the lipoxygenase inhibitor PTC-041 as a therapeutic strategy for the treatment of Parkinson's disease.

Published in:

PLoS ONE, 2024, v. 19, n. 9, p. 1, doi. 10.1371/journal.pone.0309893

By:

Minnella, Angela;
McCusker, Kevin P.;
Amagata, Akiko;
Trias, Beatrice;
Weetall, Marla;
Latham, Joey C.;
O'Neill, Sloane;
Wyse, Richard K.;
Klein, Matthew B.;
Trimmer, Jeffrey K.

Publication type:

Article

BMI1 as a novel target for drug discovery in cancer.

Published in:

Journal of Cellular Biochemistry, 2011, v. 112, n. 10, p. 2729, doi. 10.1002/jcb.23234

By:

Cao, Liangxian;
Bombard, Jenelle;
Cintron, Katherine;
Sheedy, Josephine;
Weetall, Marla L.;
Davis, Thomas W.

Publication type:

Article

Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia.

Published in:

Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.832816

By:

Branstrom, Arthur;
Cao, Liangxian;
Furia, Bansri;
Trotta, Christopher;
Santaguida, Marianne;
Graci, Jason D.;
Colacino, Joseph M.;
Ray, Balmiki;
Li, Wencheng;
Sheedy, Josephine;
Mollin, Anna;
Yeh, Shirley;
Kong, Ronald;
Sheridan, Richard;
Baird, John D.;
O'Keefe, Kylie;
Spiegel, Robert;
Goodwin, Elizabeth;
Keating, Suzanne;
Weetall, Marla

Publication type:

Article

The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential.

Published in:

PLoS ONE, 2018, v. 13, n. 10, p. 1, doi. 10.1371/journal.pone.0206158

By:

Friesen, Westley J.;
Johnson, Briana;
Sierra, Jairo;
Zhuo, Jin;
Vazirani, Priya;
Xue, Xiaojiao;
Tomizawa, Yuki;
Baiazitov, Ramil;
Morrill, Christie;
Ren, Hongyu;
Babu, Suresh;
Moon, Young-Choon;
Branstrom, Art;
Mollin, Anna;
Hedrick, Jean;
Sheedy, Josephine;
Elfring, Gary;
Weetall, Marla;
Colacino, Joseph M.;
Welch, Ellen M.

Publication type:

Article

Ataluren suppresses a premature termination codon in an MPS I-H mouse.

Published in:

Journal of Molecular Medicine, 2022, v. 100, n. 8, p. 1223, doi. 10.1007/s00109-022-02232-0

By:

Wang, Dan;
Xue, Xiaojiao;
Gunn, Gwen;
Du, Ming;
Siddiqui, Amna;
Weetall, Marla;
Keeling, Kim M.

Publication type:

Article

Reduction of retinal ganglion cell death in mouse models of familial dysautonomia using AAV-mediated gene therapy and splicing modulators.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-45376-w

By:

Schultz, Anastasia;
Cheng, Shun-Yun;
Kirchner, Emily;
Costello, Stephanann;
Miettinen, Heini;
Chaverra, Marta;
King, Colin;
George, Lynn;
Zhao, Xin;
Narasimhan, Jana;
Weetall, Marla;
Slaugenhaupt, Susan;
Morini, Elisabetta;
Punzo, Claudio;
Lefcort, Frances

Publication type:

Article

The anti‐mitotic agents PTC‐028 and PTC596 display potent activity in pre‐clinical models of multiple myeloma but challenge the role of BMI‐1 as an essential tumour gene.

Published in:

British Journal of Haematology, 2020, v. 190, n. 6, p. 877, doi. 10.1111/bjh.16595

By:

Bolomsky, Arnold;
Muller, Joséphine;
Stangelberger, Kathrin;
Lejeune, Margaux;
Duray, Elodie;
Breid, Helene;
Vrancken, Louise;
Pfeiffer, Christina;
Hübl, Wolfgang;
Willheim, Martin;
Weetall, Marla;
Branstrom, Art;
Zojer, Niklas;
Caers, Jo;
Ludwig, Heinz

Publication type:

Article

Divergent pathways of gene expression are activated by the RAGE ligands S100b and AGE-BSA.

Published in:

2004

By:

Valencia, Jessica V.;
Mone, Manisha;
Zhang, Jin;
Weetall, Maria;
Buxton, Frank P.;
Hughes, Thomas E.;
Weetall, Marla

Publication type:

journal article

Combinatorial approaches to inhibitors of VLA-4: Piperazine-peptoid-bisarylureas.

Published in:

Molecular Diversity, 2000, v. 5, n. 2, p. 61, doi. 10.1023/A:1013990624215

By:

Lewis, Ian;
Rohde, Bernhard;
Mengus, Marc;
Weetall, Marla;
Maida, Susan;
Hugo, Ron;
Lake, Philip

Publication type:

Article

THER-14. SMALL MOLECULE INHIBITOR TARGETING SELF-RENEWAL AS A THERAPEUTIC OPTION FOR RECURRENT MEDULLOBLASTOMA.

Published in:

Neuro-Oncology, 2019, v. 21, p. ii117, doi. 10.1093/neuonc/noz036.221

By:

Adile, Ashley;
Bakhshinyan, David;
Venugopal, Chitra;
Subapanditha, Minomi;
Weetall, Marla;
Davis, Thomas;
Singh, Sheila

Publication type:

Article

THER-11. BMI-1 MODULATION IMPAIRS DNA DAMAGE RESPONSE AND SENSITIZES DIPG CELLS TO IONIZING RADIATION.

Published in:

Neuro-Oncology, 2019, v. 21, p. ii116, doi. 10.1093/neuonc/noz036.218

By:

Kumar, Shiva Senthil;
Sengupta, Satarupa;
Weetall, Marla;
Baird, John;
Drissi, Rachid

Publication type:

Article

ATRT-05. PRC1 IS AN ESSENTIAL DEPENDENCY AND THERAPEUTIC TARGET IN SMARCB1 DEFICIENT ATYPICAL TERATOID RHABDOID TUMORS.

Published in:

Neuro-Oncology, 2019, v. 21, p. ii63, doi. 10.1093/neuonc/noz036.004

By:

Alimova, Irina;
Danis, Ettiene;
Weetall, Marla;
Pierce, Angelela M;
Balakrishnan, Ilango;
Wang, Dong;
Foreman, Nicholas K;
Baird, John;
Hoffman, Lindsey;
Venkataraman, Sujatha;
Vibhakar, Rajeev

Publication type:

Article

Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA.

Published in:

Science Translational Medicine, 2021, v. 13, n. 578, p. 1, doi. 10.1126/scitranslmed.abb6871

By:

Kong, Lingling;
Valdivia, David O.;
Simon, Christian M.;
Hassinan, Cera W.;
Delestrée, Nicolas;
Ramos, Daniel M.;
Park, Jae Hong;
Pilato, Celeste M.;
Xu, Xixi;
Crowder, Melissa;
Grzyb, Chloe C.;
King, Zachary A.;
Petrillo, Marco;
Swoboda, Kathryn J.;
Davis, Crystal;
Lutz, Cathleen M.;
Stephan, Alexander H.;
Zhao, Xin;
Weetall, Marla;
Naryshkin, Nikolai A.

Publication type:

Article

AML-284: Emvododstat (PTC299) Targets De Novo Pyrimidine Synthesis in Acute Myeloid Leukemia.

Published in:

Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S300, doi. 10.1016/S2152-2650(21)01714-6

By:

Piya, Sujan;
Weetall, Marla;
Sheedy, Josephine;
Ray, Balmiki;
Huaxian Ma;
Kojima, Kensuke;
Ruvolo, Vivian;
Basyal, Mahesh;
Konopleva, Marina;
Andreeff, Michael;
Borthakur, Gautam

Publication type:

Article

Poster: AML-284: Emvododstat (PTC299) Targets De Novo Pyrimidine Synthesis in Acute Myeloid Leukemia.

Published in:

Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S215, doi. 10.1016/S2152-2650(21)01356-2

By:

Sujan Piya;
Weetall, Marla;
Sheedy, Josephine;
Ray, Balmiki;
Ma, Huaxian;
Kojima, Kensuke;
Ruvolo, Vivian;
Basyal, Mahesh;
Konopleva, Marina;
Andreeff, Michael;
Borthakur, Gautam

Publication type:

Article

Targeting of BMI-1 in Mantle Cell Lymphoma.

Published in:

Clinical Lymphoma, Myeloma & Leukemia, 2018, v. 18, p. S275, doi. 10.1016/j.clml.2018.07.202

By:

Kojima, Kensuke;
Aya, Maeda;
Nishida, Yuki;
Weetall, Marla;
Cao, Liangxian;
Branstrom, Arthur;
Yoshimura, Mariko;
Kimura, Shinya

Publication type:

Article

Editorial: New therapeutics for soft tissue sarcomas.

Published in:

Frontiers in Oncology, 2023, p. 1, doi. 10.3389/fonc.2023.1297215

By:

Weetall, Marla;
Rance, Mark;
Ingham, Matthew;
Van Tine, Brian A.

Publication type:

Article

Functional rescue of REP1 following treatment with PTC124 and novel derivative PTC-414 in human choroideremia fibroblasts and the nonsense-mediated zebrafish model.

Published in:

Human Molecular Genetics, 2016, v. 25, n. 16, p. 3416, doi. 10.1093/hmg/ddw184

By:

Moosajee, Mariya;
Tracey-White, Dhani;
Smart, Matthew;
Weetall, Marla;
Torriano, Simona;
Kalatzis, Vasiliki;
da Cruz, Lyndon;
Coffey, Peter;
Webster, Andrew R.;
Welch, Ellen

Publication type:

Article

Pharmacologically induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset.

Published in:

Human Molecular Genetics, 2016, v. 25, n. 5, p. 964, doi. 10.1093/hmg/ddv629

By:

Zhihua Feng;
Ling, Karen K. Y.;
Xin Zhao;
Chunyi Zhou;
Karp, Gary;
Welch, Ellen M.;
Naryshkin, Nikolai;
Ratni, Hasane;
Chen, Karen S.;
Metzger, Friedrich;
Paushkin, Sergey;
Weetall, Marla;
Chien-Ping Ko

Publication type:

Article