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Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel Disease.
Published in:
Journal of Neuroscience, 2023, v. 43, n. 10, p. 1797, doi. 10.1523/JNEUROSCI.1333-22.2023
By:
- Sompol, Pradoldej;
- Gollihue, Jenna L.;
- Weiss, Blaine E.;
- Ruei-Lung Lin;
- Case, Sami L.;
- Kraner, Susan D.;
- Weekman, Erica M.;
- Gant, John C.;
- Rogers, Colin B.;
- Niedowicz, Dana M.;
- Sudduth, Tiffany L.;
- Powell, David K.;
- Ai-Ling Lin;
- Thibault, Olivier;
- Wilcock, Donna M.;
- Norris, Christopher M.
Publication type:
Article
Alzheimer's disease and inflammatory biomarkers positively correlate in plasma in the UK‐ADRC cohort.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 2, p. 1374, doi. 10.1002/alz.13485
By:
- Foley, Kate E.;
- Winder, Zachary;
- Sudduth, Tiffany L.;
- Martin, Barbara J.;
- Nelson, Peter T.;
- Jicha, Gregory A.;
- Harp, Jordan P.;
- Weekman, Erica M.;
- Wilcock, Donna M.
Publication type:
Article
TNFα‐mediated inflammation in mouse models of VCID.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080310
By:
- Krick, Katelynn E;
- Sudduth, Tiffany L;
- Johnson, Sherika;
- Rogers, Colin B;
- Weekman, Erica M;
- Wilcock, Donna M.
Publication type:
Article
Glial changes are associated with cerebrovascular integrity in hyperhomocysteinemia‐induced VCID in mouse and human brain.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.072536
By:
- Weekman, Erica M;
- Winder, Zachary;
- Rogers, Colin B;
- Abner, Erin L;
- Sudduth, Tiffany L;
- Price, Brittani R.;
- Woolums, Abigail;
- Hawthorne, Danielle;
- IV, Charles E Seaks;
- Patel, Ela;
- Dugan, Adam;
- Fister, Shuling X;
- Wasek, Brandi;
- Bottiglieri, Teodoro;
- Fardo, David W.;
- Wilcock, Donna M.
Publication type:
Article
Evaluation of pathologies associated with hyperhomocysteinemia in human autopsy brain tissue.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.068004
By:
- Weekman, Erica M;
- Winder, Zachary;
- Rogers, Colin B;
- Abner, Erin L;
- Patel, Ela;
- Dugan, Adam;
- Fister, Shuling X;
- Wasek, Brandi;
- Bottiglieri, Teodoro;
- Fardo, David W.;
- Wilcock, Donna M
Publication type:
Article
Contribution of astrocytic MMP9 toward progression of VCID pathology.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.065982
By:
- Early, Alexandria N;
- Weekman, Erica M;
- Lee, Tiffany;
- Wilcock, Donna M
Publication type:
Article
Elucidating the role of MMP9 in hyperhomocysteinemia induced degradation of the neurovascular unit.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.065886
By:
- Gearon, Mary D;
- Early, Alexandria N;
- Weekman, Erica M;
- Lee, Tiffany;
- Wilcock, Donna M
Publication type:
Article
Apolipoprotein E genotypes modulate neuroinflammatory and vascular pathology in hyperhomocysteinemia‐induced VCID.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.056151
By:
- Seaks, Charles E;
- Weekman, Erica M;
- Sudduth, Tiffany L;
- Bottiglieri, Teodoro;
- Johnson, Lance A.;
- Wilcock, Donna M
Publication type:
Article
APOE‐e4 alters the microglial phenotype in the presence of Alzheimer's disease pathology compared to APOE‐e3.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.055489
By:
- Kloske, Courtney M;
- Weekman, Erica M;
- Xie, Kevin;
- Patel, Ela;
- Anderson, Sonya;
- Bachstetter, Adam D;
- Morganti, Josh M.;
- Fardo, David W.;
- Nelson, Peter T;
- Wilcock, Donna M
Publication type:
Article
Elucidating the neurodegnerative sequelae leading to VCID pathology.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.053015
By:
- Early, Alexandria N;
- Weekman, Erica M;
- Sudduth, Tiffany L;
- Price, Brittani R;
- Woolums, Abigail E;
- Hawthorne, Danielle;
- Seaks, Charles E;
- Wilcock, Donna M
Publication type:
Article
Time course of neuropathologic changes in hyperhomocysteinemia‐induced VCID.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.051364
By:
- Weekman, Erica M;
- Lee, Tiffany;
- Price, Brittani R;
- Woolums, Abigail E;
- Hawthorne, Danielle;
- Seaks, Charles E;
- Wilcock, Donna M
Publication type:
Article
Hyperhomocysteinemia as a model of VCID: Development of new models and analysis methods/behavioral models.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.039888
By:
- Weekman, Erica M.;
- Lee, Tiffany;
- Price, Brittani R.;
- Woolums, Abigail E.;
- Hawthorne, Danielle;
- IV, Charles E. Seaks;
- Wilcock, Donna M.
Publication type:
Article
O1‐08‐01: THERAPEUTIC TARGETING OF TREM2 BY AN ACTIVATING ANTIBODY AMELIORATES AMYLOID‐BETA DEPOSITION AND IMPROVES COGNITION IN THE 5XFAD MODEL OF ALZHEIMER'S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P214, doi. 10.1016/j.jalz.2019.06.4559
By:
- Price, Brittani R.;
- Sudduth, Tiffany L.;
- Weekman, Erica M.;
- Woolums, Abigail;
- Hawthorne, Danielle;
- Rosenthal, Arnon;
- Wilcock, Donna M.
Publication type:
Article
ASTROCYTE RESPONSE TO HYPERHOMOCYSTEINEMIA (HHCY).
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P318, doi. 10.1016/j.jalz.2017.06.018
By:
- Price, Brittani R.;
- Sudduth, Tiffany L.;
- Weekman, Erica M.;
- Wilcock, Donna M.;
- Woolums, Abigail
Publication type:
Article
ASTROCYTE RESPONSE TO HYPERHOMOCYSTEINEMIA (HHCY).
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P232, doi. 10.1016/j.jalz.2017.06.071
By:
- Price, Brittani R.;
- Sudduth, Tiffany L.;
- Weekman, Erica M.;
- Wilcock, Donna M.;
- Woolums, Abigail
Publication type:
Article
NEUROVASCULAR ASTROCYTE DYSFUNCTION AS A KEY MEDIATOR OF VASCULAR COGNITIVE IMPAIRMENT.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P270, doi. 10.1016/j.jalz.2016.06.489
By:
- Wilcock, Donna M.;
- Sudduth, Tiffany L.;
- Weekman, Erica M.;
- Pleiss, Melanie M.;
- Woolums, Abigail;
- Norris, Chris M.
Publication type:
Article
Reduced efficacy of anti-Aβ immunotherapy in a mouse model of amyloid deposition and vascular cognitive impairment co-morbidity.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P137, doi. 10.1016/j.jalz.2015.07.481
By:
- Weekman, Erica M.;
- Kopper, Timothy J.;
- Sudduth, Tiffany L.;
- Wilcock, Donna M.
Publication type:
Article
Time course of neuropathological events in hyperhomocysteinemic amyloid depositing mice reveals early neuroinflammatory changes that precede amyloid changes and cerebrovascular events.
Published in:
2019
By:
- Weekman, Erica M.;
- Sudduth, Tiffany L.;
- Price, Brittani R.;
- Woolums, Abigail E.;
- Hawthorne, Danielle;
- Seaks, Charles E.;
- Wilcock, Donna M.
Publication type:
journal article
Soluble TNF mediates amyloid-independent, diet-induced alterations to immune and neuronal functions in an Alzheimer's disease mouse model.
Published in:
Frontiers in Cellular Neuroscience, 2023, v. 17, p. 1, doi. 10.3389/fncel.2023.895017
By:
- MacPherson, Kathryn P.;
- Eidson, Lori N.;
- Houser, Madelyn C.;
- Weiss, Blaine E.;
- Gollihue, Jenna L.;
- Herrick, Mary K.;
- de Sousa Rodrigues, Maria Elizabeth;
- Sniffen, Lindsey;
- Weekman, Erica M.;
- Hamilton, Adam M.;
- Kelly, Sean D.;
- Oliver, Danielle L.;
- Yuan Yang;
- Jianjun Chang;
- Sampson, Timothy R.;
- Norris, Christopher M.;
- Tansey, Malú Gámez
Publication type:
Article
Using digital pathology to analyze the murine cerebrovasculature.
Published in:
Journal of Cerebral Blood Flow & Metabolism, 2024, v. 44, n. 4, p. 595, doi. 10.1177/0271678X231216142
By:
- Niedowicz, Dana M;
- Gollihue, Jenna L;
- Weekman, Erica M;
- Phe, Panhavuth;
- Wilcock, Donna M;
- Norris, Christopher M;
- Nelson, Peter T
Publication type:
Article
Apolipoprotein E ε4/4 genotype limits response to dietary induction of hyperhomocysteinemia and resulting inflammatory signaling.
Published in:
Journal of Cerebral Blood Flow & Metabolism, 2022, v. 42, n. 5, p. 771, doi. 10.1177/0271678X211069006
By:
- Seaks, Charles E;
- Weekman, Erica M;
- Sudduth, Tiffany L;
- Xie, Kevin;
- Wasek, Brandi;
- Fardo, David W;
- Johnson, Lance A;
- Bottiglieri, Teodoro;
- Wilcock, Donna M
Publication type:
Article
Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes.
Published in:
Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-023-02883-x
By:
- Weekman, Erica M.;
- Johnson, Sherika N.;
- Rogers, Colin B.;
- Sudduth, Tiffany L.;
- Xie, Kevin;
- Qiao, Qi;
- Fardo, David W.;
- Bottiglieri, Teodoro;
- Wilcock, Donna M.
Publication type:
Article
Hyperhomocysteinemia-Induced Gene Expression Changes in the Cell Types of the Brain.
Published in:
ASN Neuro (Sage Publications, Ltd.), 2017, v. 9, n. 6, p. 1, doi. 10.1177/1759091417742296
By:
- Weekman, Erica M.;
- Woolums, Abigail E.;
- Sudduth, Tiffany L.;
- Wilcock, Donna M.
Publication type:
Article
Beta-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice.
Published in:
Alzheimer's Research & Therapy, 2014, v. 6, n. 3, p. 1, doi. 10.1186/alzrt262
By:
- Sudduth, Tiffany L.;
- Weekman, Erica M.;
- Brothers, Holly M.;
- Braun, Kaitlyn;
- Wilcock, Donna M.
Publication type:
Article
Genetic expression changes and pathologic findings associated with hyperhomocysteinemia in human autopsy brain tissue.
Published in:
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2022, v. 8, n. 1, p. 1, doi. 10.1002/trc2.12368
By:
- Weekman, Erica M.;
- Winder, Zach;
- Rogers, Colin B.;
- Abner, Erin L.;
- Sudduth, Tiffany L.;
- Patel, Ela;
- Dugan, Adam J.;
- Fister, Shuling X.;
- Wasek, Brandi;
- Nelson, Peter T.;
- Jicha, Gregory A.;
- Bottiglieri, Teodoro;
- Fardo, David W.;
- Wilcock, Donna M.
Publication type:
Article
Reduced Efficacy of Anti-Aβ Immunotherapy in a Mouse Model of Amyloid Deposition and Vascular Cognitive Impairment Comorbidity.
Published in:
Journal of Neuroscience, 2016, v. 36, n. 38, p. 9896, doi. 10.1523/JNEUROSCI.1762-16.2016
By:
- Weekman, Erica M.;
- Sudduth, Tiffany L.;
- Caverly, Carly N.;
- Kopper, Timothy J.;
- Phillips, Oliver W.;
- Powell, Dave K.;
- Wilcock, Donna M.
Publication type:
Article
Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice.
Published in:
Journal of Neuroinflammation, 2015, v. 12, n. 1, p. 1, doi. 10.1186/s12974-015-0243-6
By:
- Latta, Clare H.;
- Sudduth, Tiffany L.;
- Weekman, Erica M.;
- Brothers, Holly M.;
- Abner, Erin L.;
- Popa, Gabriel J.;
- Mendenhall, Michael D.;
- Gonzalez-Oregon, Floracita;
- Braun, Kaitlyn;
- Wilcock, Donna M.
Publication type:
Article
Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice.
Published in:
2014
By:
- Weekman, Erica M;
- Sudduth, Tiffany L;
- Abner, Erin L;
- Popa, Gabriel J;
- Mendenhall, Michael D;
- Brothers, Holly M;
- Braun, Kaitlyn;
- Greenstein, Abigail;
- Wilcock, Donna M
Publication type:
journal article
Mechanisms of ARIA: is it time to focus on the unique immune environment of the neurovascular unit?
Published in:
2023
By:
- Foley, Kate E.;
- Weekman, Erica M.;
- Wilcock, Donna M.
Publication type:
Editorial
Editorial: Modulation of neuroimmune systems to preserve brain function in aging and dementia.
Published in:
Frontiers in Neuroscience, 2022, v. 16, p. 1, doi. 10.3389/fnins.2022.995409
By:
- Braun, David J.;
- Weekman, Erica M.;
- Gordon, Marcia N.;
- Späni, Claudia B.
Publication type:
Article

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