Works matching AU Weedon, Michael N.

Results: 133

Analysis of large-scale sequencing cohorts does not support the role of variants in UCP2 as a cause of hyperinsulinaemic hypoglycaemia.
Published in:
Human Mutation, 2017, v. 38, n. 10, p. 1442, doi. 10.1002/humu.23289
By:
- Laver, Thomas W;
- Weedon, Michael N;
- Caswell, Richard;
- Hussain, Khalid;
- Ellard, Sian;
- Flanagan, Sarah E
Publication type:
Article
Genome-wide association analysis of composite sleep health scores in 413,904 individuals.
Published in:
Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-07514-0
By:
- Goodman, Matthew O.;
- Faquih, Tariq;
- Paz, Valentina;
- Nagarajan, Pavithra;
- Lane, Jacqueline M.;
- Spitzer, Brian;
- Maher, Matthew;
- Chung, Joon;
- Cade, Brian E.;
- Purcell, Shaun M.;
- Zhu, Xiaofeng;
- Noordam, Raymond;
- Phillips, Andrew J. K.;
- Kyle, Simon D.;
- Spiegelhalder, Kai;
- Weedon, Michael N.;
- Lawlor, Deborah A.;
- Rotter, Jerome I.;
- Taylor, Kent D.;
- Isasi, Carmen R.
Publication type:
Article
Type 1 diabetes genetic risk score variation across ancestries using whole genome sequencing and array-based approaches.
Published in:
Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-82278-x
By:
- Arni, Ankit M.;
- Fraser, Diane P.;
- Sharp, Seth A.;
- Oram, Richard A.;
- Johnson, Matthew B.;
- Weedon, Michael N.;
- Patel, Kashyap A.
Publication type:
Article
PLIN1 Haploinsufficiency Is Not Associated With Lipodystrophy.
Published in:
2018
By:
- Laver, Thomas W;
- Patel, Kashyap A;
- Colclough, Kevin;
- Curran, Jacqueline;
- Dale, Jane;
- Davis, Nikki;
- Savage, David B;
- Flanagan, Sarah E;
- Ellard, Sian;
- Hattersley, Andrew T;
- Weedon, Michael N
Publication type:
journal article
Type 1 Diabetes Genetic Risk Score Differentiates Subgroups of Ketosis-Prone Diabetes.
Published in:
Diabetes Care, 2023, v. 46, n. 10, p. 1778, doi. 10.2337/dc23-0622
By:
- Osafehinti, Deborah;
- Mulukutla, Surya N.;
- Hampe, Christiane S.;
- Gaba, Ruchi;
- Ram, Nalini;
- Weedon, Michael N.;
- Oram, Richard A.;
- Balasubramanyam, Ashok
Publication type:
Article
Utility of Diabetes Type-Specific Genetic Risk Scores for the Classification of Diabetes Type Among Multiethnic Youth.
Published in:
2022
By:
- Oram, Richard A.;
- Sharp, Seth A.;
- Pihoker, Catherine;
- Ferrat, Lauric;
- Imperatore, Giuseppina;
- Williams, Adrienne;
- Redondo, Maria J.;
- Wagenknecht, Lynne;
- Dolan, Lawrence M.;
- Lawrence, Jean M.;
- Weedon, Michael N.;
- D'Agostino Jr., Ralph;
- Hagopian, William A.;
- Divers, Jasmin;
- Dabelea, Dana;
- D'Agostino, Ralph
Publication type:
journal article
Assessing the Causal Role of Sleep Traits on Glycated Hemoglobin: A Mendelian Randomization Study.
Published in:
2022
By:
- Junxi Liu;
- Richmond, Rebecca C.;
- Bowden, Jack;
- Barry, Ciarrah;
- Dashti, Hassan S.;
- Daghlas, Iyas;
- Lane, Jacqueline M.;
- Jones, Samuel E.;
- Wood, Andrew R.;
- Frayling, Timothy M.;
- Wright, Alison K.;
- Carr, Matthew J.;
- Anderson, Simon G.;
- Emsley, Richard A.;
- Ray, David W.;
- Weedon, Michael N.;
- Saxena, Richa;
- Lawlor, Deborah A.;
- Rutter, Martin K.;
- Liu, Junxi
Publication type:
journal article
Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis.
Published in:
2019
By:
- Sharp, Seth A.;
- Rich, Stephen S.;
- Wood, Andrew R.;
- Jones, Samuel E.;
- Beaumont, Robin N.;
- Harrison, James W.;
- Schneider, Darius A.;
- Locke, Jonathan M.;
- Tyrrell, Jess;
- Weedon, Michael N.;
- Hagopian, William A.;
- Oram, Richard A.
Publication type:
journal article
Zinc Transporter 8 Autoantibodies (ZnT8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes.
Published in:
2019
By:
- Patel, Kashyap A.;
- Weedon, Michael N.;
- Shields, Beverley M.;
- Pearson, Ewan R.;
- Hattersley, Andrew T.;
- McDonald, Timothy J.;
- UNITED study team
Publication type:
Letter
Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data.
Published in:
2018
By:
- Dennis, John M.;
- Henley, William E.;
- Weedon, Michael N.;
- Lonergan, Mike;
- Rodgers, Lauren R.;
- Jones, Angus G.;
- Hamilton, William T.;
- Sattar, Naveed;
- Janmohamed, Salim;
- Holman, Rury R.;
- Pearson, Ewan R.;
- Shields, Beverley M.;
- Hattersley, Andrew T.;
- MASTERMIND Consortium
Publication type:
journal article
A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.
Published in:
2018
By:
- Redondo, Maria J.;
- Geyer, Susan;
- Steck, Andrea K.;
- Sharp, Seth;
- Wentworth, John M.;
- Weedon, Michael N.;
- Antinozzi, Peter;
- Sosenko, Jay;
- Atkinson, Mark;
- Pugliese, Alberto;
- Oram, Richard A.;
- Type 1 Diabetes TrialNet Study Group
Publication type:
journal article
Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-term Glycemic Response to DPP-4 Inhibitor Therapy.
Published in:
2018
By:
- Dennis, John M.;
- Shields, Beverley M.;
- Hill, Anita V.;
- Knight, Bridget A.;
- McDonald, Timothy J.;
- Rodgers, Lauren R.;
- Weedon, Michael N.;
- Henley, William E.;
- Sattar, Naveed;
- Holman, Rury R.;
- Pearson, Ewan R.;
- Hattersley, Andrew T.;
- Jones, Angus G.;
- MASTERMIND Consortium
Publication type:
journal article
A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults.
Published in:
2016
By:
- Oram, Richard A.;
- Patel, Kashyap;
- Hill, Anita;
- Shields, Beverley;
- McDonald, Timothy J.;
- Jones, Angus;
- Hattersley, Andrew T.;
- Weedon, Michael N.
Publication type:
journal article
Adherence to Oral Glucose-Lowering Therapies and Associations With 1-Year HbA1c: A Retrospective Cohort Analysis in a Large Primary Care Database.
Published in:
2016
By:
- Farmer, Andrew J.;
- Rodgers, Lauren R.;
- Lonergan, Mike;
- Shields, Beverley;
- Weedon, Michael N.;
- Donnelly, Louise;
- Holman, Rury R.;
- Pearson, Ewan R.;
- Hattersley, Andrew T.;
- MASTERMIND Consortium
Publication type:
journal article
Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children.
Published in:
2018
By:
- Bonifacio, Ezio;
- Beyerlein, Andreas;
- Hippich, Markus;
- Winkler, Christiane;
- Vehik, Kendra;
- Weedon, Michael N.;
- Laimighofer, Michael;
- Hattersley, Andrew T.;
- Krumsiek, Jan;
- Frohnert, Brigitte I.;
- Steck, Andrea K.;
- Hagopian, William A.;
- Krischer, Jeffrey P.;
- Lernmark, Åke;
- Rewers, Marian J.;
- She, Jin-Xiong;
- Toppari, Jorma;
- Akolkar, Beena;
- Oram, Richard A.;
- Rich, Stephen S.
Publication type:
journal article
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Published in:
Nature, 2010, v. 467, n. 7317, p. 832, doi. 10.1038/nature09410
By:
- Lango Allen, Hana;
- Estrada, Karol;
- Lettre, Guillaume;
- Berndt, Sonja I.;
- Weedon, Michael N.;
- Rivadeneira, Fernando;
- Willer, Cristen J.;
- Jackson, Anne U.;
- Vedantam, Sailaja;
- Raychaudhuri, Soumya;
- Ferreira, Teresa;
- Wood, Andrew R.;
- Weyant, Robert J.;
- Segrè, Ayellet V.;
- Speliotes, Elizabeth K.;
- Wheeler, Eleanor;
- Soranzo, Nicole;
- Ju-Hyun Park;
- Jian Yang;
- Gudbjartsson, Daniel
Publication type:
Article
Response to: Genetic risk scores may compound rather than solve the issue of prostate cancer overdiagnosis (BJC-LT3342090).
Published in:
2023
By:
- Green, Harry D.;
- Merriel, Samuel W. D.;
- Oram, Richard A.;
- Ruth, Katherine S.;
- Tyrrell, Jessica;
- Jones, Samuel E.;
- Thirlwell, Chrissie;
- Weedon, Michael N.;
- Bailey, Sarah E. R.
Publication type:
Letter
Applying a genetic risk score for prostate cancer to men with lower urinary tract symptoms in primary care to predict prostate cancer diagnosis: a cohort study in the UK Biobank.
Published in:
2022
By:
- Green, Harry D.;
- Merriel, Samuel W. D.;
- Oram, Richard A.;
- Ruth, Katherine S.;
- Tyrrell, Jessica;
- Jones, Samuel E.;
- Thirlwell, Chrissie;
- Weedon, Michael N.;
- Bailey, Sarah E. R.
Publication type:
journal article
Phosphodiesterase 8B Gene Polymorphism Is Associated with Subclinical Hypothyroidism in Pregnancy.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2009, v. 94, n. 11, p. 4608, doi. 10.1210/jc.2009-1298
By:
- Shields, Beverley M.;
- Freathy, Rachel M.;
- Knight, Bridget A.;
- Hill, Anita;
- Weedon, Michael N.;
- Frayling, Timothy M.;
- Hattersley, Andrew T.;
- Vaidya, Bijay
Publication type:
Article
A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine.
Published in:
2008
By:
- Panicker, Vijay;
- Cluett, Christie;
- Shields, Beverley;
- Murray, Anna;
- Parnell, Kirstie S;
- Perry, John R B;
- Weedon, Michael N;
- Singleton, Andrew;
- Hernandez, Dena;
- Evans, Jonathan;
- Durant, Claire;
- Ferrucci, Luigi;
- Melzer, David;
- Saravanan, Ponnusamy;
- Visser, Theo J;
- Ceresini, Graziano;
- Hattersley, Andrew T;
- Vaidya, Bijay;
- Dayan, Colin M;
- Frayling, Timothy M
Publication type:
journal article
Another explanation for apparent epistasis.
Published in:
Nature, 2014, v. 514, n. 7520, p. E3, doi. 10.1038/nature13691
By:
- Wood, Andrew R.;
- Tuke, Marcus A.;
- Melzer, David;
- Frayling, Timothy M.;
- Weedon, Michael N.;
- Nalls, Mike A.;
- Singleton, Andrew B.;
- Hernandez, Dena G.;
- Bandinelli, Stefania;
- Ferrucci, Luigi
Publication type:
Article
A genome-wide association study of early menopause and the combined impact of identified variants.
Published in:
Human Molecular Genetics, 2013, v. 22, n. 7, p. 1465, doi. 10.1093/hmg/dds551
By:
- Perry, John R. B.;
- Corre, Tanguy;
- Esko, Tõnu;
- Chasman, Daniel I.;
- Fischer, Krista;
- Franceschini, Nora;
- He, Chunyan;
- Kutalik, Zoltan;
- Mangino, Massimo;
- Rose, Lynda M.;
- Vernon Smith, Albert;
- Stolk, Lisette;
- Sulem, Patrick;
- Weedon, Michael N.;
- Zhuang, Wei V.;
- Arnold, Alice;
- Ashworth, Alan;
- Bergmann, Sven;
- Buring, Julie E.;
- Burri, Andrea
Publication type:
Article
Adult height variants affect birth length and growth rate in children.
Published in:
Human Molecular Genetics, 2011, v. 20, n. 20, p. 4069, doi. 10.1093/hmg/ddr309
By:
- Paternoster, Lavinia;
- Howe, Laura D.;
- Tilling, Kate;
- Weedon, Michael N.;
- Freathy, Rachel M.;
- Frayling, Timothy M.;
- Kemp, John P.;
- Smith, George Davey;
- Timpson, Nicholas J.;
- Ring, Susan M.;
- Evans, David M.;
- Lawlor, Debbie A.
Publication type:
Article
Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association.
Published in:
Human Molecular Genetics, 2011, v. 20, n. 20, p. 4082, doi. 10.1093/hmg/ddr328
By:
- Wood, Andrew R.;
- Hernandez, Dena G.;
- Nalls, Michael A.;
- Yaghootkar, Hanieh;
- Gibbs, J. Raphael;
- Harries, Lorna W.;
- Chong, Sean;
- Moore, Matthew;
- Weedon, Michael N.;
- Guralnik, Jack M.;
- Bandinelli, Stefania;
- Murray, Anna;
- Ferrucci, Luigi;
- Singleton, Andrew B;
- Melzer, David;
- Frayling, Timothy M.
Publication type:
Article
Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study.
Published in:
Human Molecular Genetics, 2011, v. 20, n. 1, p. 186, doi. 10.1093/hmg/ddq417
By:
- Murray, Anna;
- Bennett, Claire E.;
- Perry, John R.B.;
- Weedon, Michael N.;
- Consortium, ReproGen;
- Jacobs, Patricia A.;
- Morris, Danielle H.;
- Orr, Nicholas;
- Schoemaker, Minouk J.;
- Jones, Michael;
- Ashworth, Alan;
- Swerdlow, Anthony J.
Publication type:
Article
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes.
Published in:
Human Molecular Genetics, 2010, v. 19, n. 3, p. 535, doi. 10.1093/hmg/ddp522
By:
- Perry, John R.B.;
- Weedon, Michael N.;
- Langenberg, Claudia;
- Jackson, Anne U.;
- Lyssenko, Valeriya;
- Sparsø, Thomas;
- Thorleifsson, Gudmar;
- Grallert, Harald;
- Ferrucci, Luigi;
- Maggio, Marcello;
- Paolisso, Giuseppe;
- Walker, Mark;
- Palmer, Colin N.A.;
- Payne, Felicity;
- Young, Elizabeth;
- Herder, Christian;
- Narisu, Narisu;
- Morken, Mario A.;
- Bonnycastle, Lori L.;
- Owen, Katharine R.
Publication type:
Article
A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5–CHRNA3–CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.
Published in:
Human Molecular Genetics, 2009, v. 18, n. 15, p. 2922, doi. 10.1093/hmg/ddp216
By:
- Freathy, Rachel M.;
- Ring, Susan M.;
- Shields, Beverley;
- Galobardes, Bruna;
- Knight, Beatrice;
- Weedon, Michael N.;
- Smith, George Davey;
- Frayling, Timothy M.;
- Hattersley, Andrew T.
Publication type:
Article
Estimating disease prevalence in large datasets using genetic risk scores.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26501-7
By:
- Evans, Benjamin D.;
- Słowiński, Piotr;
- Hattersley, Andrew T.;
- Jones, Samuel E.;
- Sharp, Seth;
- Kimmitt, Robert A.;
- Weedon, Michael N.;
- Oram, Richard A.;
- Tsaneva-Atanasova, Krasimira;
- Thomas, Nicholas J.
Publication type:
Article
Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes.
Published in:
Diabetes, 2010, v. 59, n. 1, p. 266, doi. 10.2337/db09-0555
By:
- Allen, Hana Lango;
- Johansson, Stefan;
- Ellard, Sian;
- Shields, Beverley;
- Hertel, Jens K.;
- Ræder, Helge;
- Colclough, Kevin;
- Molven, Anders;
- Frayling, Timothy M.;
- Njølstad, Pål R.;
- Hattersley, Andrew T.;
- Weedon, Michael N.
Publication type:
Article
Interrogating Type 2 Diabetes Genome-Wide Association Data Using a Biological Pathway-Based Approach.
Published in:
Diabetes, 2009, v. 58, n. 6, p. 1463, doi. 10.2337/db08-1378
By:
- Perry, John R. B.;
- McCarthy, Mark I.;
- Hattersley, Andrew T.;
- Zeggini, Eleftheria;
- Weedon, Michael N.;
- Frayling, Timothy M.
Publication type:
Article
Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth.
Published in:
Diabetes, 2009, v. 58, n. 6, p. 1428, doi. 10.2337/db08-1739
By:
- Freathy, Rachel M.;
- Bennett, Amanda J.;
- Ring, Susan M.;
- Shields, Beverley;
- Groves, Christopher J.;
- Timpson, Nicholas J.;
- Weedon, Michael N.;
- Zeggini, Eleftheria;
- Lindgren, Cecilia M.;
- Lango, Hana;
- Perry, John R. B.;
- Pouta, Anneli;
- Ruokonen, Aimo;
- Hyppönen, Elina;
- Power, Chris;
- Elliott, Paul;
- Strachan, David P.;
- Järvelin, Marjo-Riitta;
- Smith, George Davey;
- McCarthy, Mark I.
Publication type:
Article
Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data.
Published in:
Diabetes, 2009, v. 58, n. 2, p. 505, doi. 10.2337/db08-0906
By:
- Timpson, Nicholas J.;
- Lindgren, Cecilia M.;
- Weedon, Michael N.;
- Randall, Joshua;
- Ouwehand, Willem H.;
- Strachan, David P.;
- Rayner, N. William;
- Walker, Mark;
- Hitman, Graham A.;
- Doney, Alex S. F.;
- Palmer, Colin N. A.;
- Morris, Andrew D.;
- Hattersley, Andrew T.;
- Zeggini, Eleftheria;
- Frayling, Timothy M.;
- McCarthy, Mark I.
Publication type:
Article
Population-Specific Risk of Type 2 Diabetes Conferred by HNF4A P2 Promoter Variants.
Published in:
Diabetes, 2008, v. 57, n. 11, p. 3161, doi. 10.2337/db08-0719
By:
- Barroso, Inês;
- Luan, Jian'an;
- Wheeler, Eleanor;
- Whittaker, Pamela;
- Wasson, Jon;
- Zeggini, Eleftheria;
- Weedon, Michael N.;
- Hunt, Sarah;
- Venkatesh, Ranganath;
- Frayling, Timothy M.;
- Delgado, Marcos;
- Neuman, Rosalind J.;
- Zhao, Jinghua;
- Sherva, Richard;
- Glaser, Benjamin;
- Walker, Mark;
- Hitman, Graham;
- McCarthy, Mark I.;
- Hattersley, Andrew T.;
- Permutt, M. Alan
Publication type:
Article
Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk.
Published in:
Diabetes, 2008, v. 57, n. 11, p. 3129, doi. 10.2337/db08-0504
By:
- Lango, Hana;
- Palmer, Colin N. A.;
- Morris, Andrew D.;
- Zeggini, Eleftheria;
- Hattersley, Andrew T.;
- McCarthy, Mark I.;
- Frayling, Timothy M.;
- Weedon, Michael N.
Publication type:
Article
Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI.
Published in:
Diabetes, 2008, v. 57, n. 5, p. 1419, doi. 10.2337/db07-1466
By:
- Freathy, Rachel M.;
- Timpson, Nicholas J.;
- Lawlor, Debbie A.;
- Pouta, Anneli;
- Ben-Shlomo, Yoav;
- Ruokonen, Aimo;
- Ebrahim, Shah;
- Shields, Beverley;
- Zeggini, Eleftheria;
- Weedon, Michael N.;
- Lindgren, Cecilia M.;
- Lango, Hana;
- Melzer, David;
- Ferrucci, Luigi;
- Paolisso, Giuseppe;
- Neville, Matthew J.;
- Karpe, Fredrik;
- Palmer, Colin N. A.;
- Morris, Andrew D.;
- Elliott, Paul
Publication type:
Article
Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.
Published in:
2007
By:
- Pascoe L;
- Tura A;
- Patel SK;
- Ibrahim IM;
- Ferrannini E;
- Zeggini E;
- Weedon MN;
- Mari A;
- Hattersley AT;
- McCarthy MI;
- Frayling TM;
- Walker M;
- RISC Consortium;
- Pascoe, Laura;
- Tura, Andrea;
- Patel, Sheila K;
- Ibrahim, Ibrahim M;
- Ferrannini, Ele;
- Zeggini, Eleftheria;
- Weedon, Michael N
Publication type:
journal article
Common Variants of the Novel Type 2 Diabetes Genes CDK4L1 and HHEX/IDE Are Associated With Decreased Pancreatic β-Cell Function.
Published in:
Diabetes, 2007, v. 56, n. 12, p. 3101, doi. 10.2337/db07-0634
By:
- Pascoe, Laura;
- Tura, Andrea;
- Patel, Sheila K.;
- Ibrahim, Ibrahim M.;
- Ferrannini, Ele;
- Zeggini, Eleftheria;
- Weedon, Michael N.;
- Mari, Andrea;
- Hattersley, Andrew T.;
- McCarthy, Mark I.;
- Frayling, Timothy M.;
- Walker, Mark
Publication type:
Article
Genome-Wide Association Analysis in UK Subjects Provides Evidence for a Novel Type 2 Diabetes Susceptibility Gene in the CDKAL1 Region of Chromosome 6.
Published in:
Diabetes, 2007, v. 56, p. A302
By:
- Zeggini, Eleftheria;
- Weedon, Michael N.;
- Lindgren, Cecilia M.;
- Lango, Hana;
- Timpson, Nicholas J.;
- Rayner, Nigel W.;
- Elliott, Kate;
- Groves, Christopher J.;
- Perry, John;
- Hitman, Graham A.;
- Walker, Mark;
- Barrett, Jeffrey C.;
- Donnelly, Peter;
- Clayton, David G.;
- Morris, Andrew P.;
- Cardon, Lon R.;
- Palmer, Colin N.;
- Morris, Andrew;
- Frayling, Timothy M.;
- Hattersley, Andrew T.
Publication type:
Article
Analysis of Insulin Gene Variants in 5663 UK Subjects Provides Evidence of a Modest Effect on T2D Risk.
Published in:
Diabetes, 2007, v. 56, p. A292
By:
- Rayner, William;
- Groves, Chris J.;
- Powell, Brenda;
- Hitman, Graham A.;
- Walker, Mark;
- Elliott, Kate;
- Weedon, Michael N.;
- Frayling, Timothy M.;
- Hattersley, Andrew T.;
- Lindgren, Cecilia M.;
- Zeggini, Eleftheria;
- McCarthy, Mark I.
Publication type:
Article
WFS1 Is a Type 2 Diabetes Susceptibility Gene.
Published in:
Diabetes, 2007, v. 56, p. A20
By:
- Sandhu, Manjinder S.;
- Weedon, Michael N.;
- Fawcett, Katherine A.;
- Wasson, Jon;
- Debenham, Sally L.;
- Daly, Allan;
- Lango, Hana;
- Frayling, Timothy M.;
- Neumann, Roz;
- Blech, Ilana;
- Pharoah, Paul D.;
- Palmer, Colin N.;
- Kimber, Charlotte;
- Tavendale, Roger;
- Morris, Andrew D.;
- Mccarthy, Mark I.;
- Walker, Mark;
- Hitman, Graham A.;
- Glaser, Benjamin;
- Permutt, M. A.
Publication type:
Article
Evaluation of Common Variants in the Six Known Maturity-Onset Diabetes of the Young (MODY) Genes for Association With Type 2 Diabetes.
Published in:
Diabetes, 2007, v. 56, n. 3, p. 685, doi. 10.2337/db06-0202
By:
- Winckler, Wendy;
- Weedon, Michael N.;
- Graham, Robert R.;
- McCarroll, Steven A.;
- Purcell, Shaun;
- Almgren, Peter;
- Tuomi, Tiinamaija;
- Gaudet, Daniel;
- Boström, Kristina Bengtsson;
- Walker, Mark;
- Hitman, Graham;
- Hattersley, Andrew T.;
- McCarthy, Mark I.;
- Ardlie, Kristin G.;
- Hirschhorn, Joel N.;
- Daly, Mark J.;
- Frayling, Timothy M.;
- Groop, Leif;
- Altshuler, David
Publication type:
Article
No Evidence of Association of ENPP1 Variants With Type 2 Diabetes or Obesity in a Study of 8,089 U.K. Caucasians.
Published in:
Diabetes, 2006, v. 55, n. 11, p. 3175, doi. 10.2337/db06-0410
By:
- Weedon, Michael N.;
- Shields, Beverley;
- Hitman, Graham;
- Walker, Mark;
- McCarthy, Mark I.;
- Hattersley, Andrew T.;
- Frayling, Timothy M.
Publication type:
Article
Association Analysis of 6,736 U.K. Subjects Provides Replication and Confirms TCF7L2 as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk.
Published in:
Diabetes, 2006, v. 55, n. 9, p. 2640, doi. 10.2337/db06-0355
By:
- Groves, Christopher J.;
- Zeggini, Eleftheria;
- Minton, Jayne;
- Frayling, Timothy M.;
- Weedon, Michael N.;
- Rayner, Nigel W.;
- Hitman, Graham A.;
- Walker, Mark;
- Wiltshire, Steven;
- Hattersley, Andrew T.;
- McCarthy, Mark I.
Publication type:
Article
Assessment of the Role of Common Genetic Variation in the Transient Neonatal Diabetes Mellitus (TNDM) Region in Type 2 Diabetes.
Published in:
Diabetes, 2006, v. 55, n. 8, p. 2272, doi. 10.2337/db06-0216
By:
- Gloyn, Anna L.;
- Mackay, Deborah J. G.;
- Weedon, Michael N.;
- McCarthy, Mark I.;
- Walker, Mark;
- Hitman, Graham;
- Knight, Bridget A.;
- Owen, Katharine R.;
- Hattersley, Andrew T.;
- Frayling, Timothy M.
Publication type:
Article
A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.
Published in:
2005
By:
- Weedon MN;
- Owen KR;
- Shields B;
- Hitman G;
- Walker M;
- McCarthy MI;
- Hattersley AT;
- Frayling TM;
- Weedon, Michael N;
- Owen, Katharine R;
- Shields, Beverley;
- Hitman, Graham;
- Walker, Mark;
- McCarthy, Mark I;
- Hattersley, Andrew T;
- Frayling, Timothy M
Publication type:
journal article
A Large-Scale Association Analysis of Common Variation of the HNF1α Gene With Type 2 Diabetes in the U.K. Caucasian Population.
Published in:
Diabetes, 2005, v. 54, n. 8, p. 2487, doi. 10.2337/diabetes.54.8.2487
By:
- Weedon, Michael N.;
- Owen, Katharine R.;
- Shields, Beverley;
- Hitman, Graham;
- Walker, Mark;
- McCarthy, Mark I.;
- Hattersley, Andrew T.;
- Frayling, Timothy M.
Publication type:
Article
Genetic Regulation of Birth Weight and Fasting Glucose by a Common Polymorphism in the Islet Cell Promoter of the Glucokinase Gene.
Published in:
Diabetes, 2005, v. 54, n. 2, p. 576
By:
- Weedon, Michael N.;
- Frayling, Timothy M.;
- Shields, Beverley;
- Knight, Beatrice;
- Turner, Tina;
- Metcalf, Bradley S.;
- Voss, Linda;
- Wilkin, Terence J.;
- McCarthy, Anne;
- Ben-Shlomo, Yoav;
- Smith, George Davey;
- Ring, Sue;
- Jones, Richard;
- Golding, Jean;
- Byberg, Liisa;
- Mann, Vera;
- Axelsson, Tomas;
- Syvänen, Ann-Christine;
- Leon, David;
- Hattersley, Andrew T.
Publication type:
Article
Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.
Published in:
2004
By:
- Weedon, Michael N.;
- Owen, Katharine R.;
- Shields, Beverley;
- Hitman, Graham;
- Walker, Mark;
- McCarthy, Mark I.;
- Love-Gregory, Latisha D.;
- Permutt, M. Alan;
- Hattersley, Andrew T.;
- Frayling, Timothy M.
Publication type:
journal article
Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.
Published in:
2003
By:
- Mitchell, Simon M.S.;
- Weedon, Michael N.;
- Owen, Katharine R.;
- Shields, Beverley;
- Wilkins-Wall, Beverley;
- Walker, Mark;
- McCarthy, Mark I.;
- Frayling, Timothy M.;
- Hattersley, Andrew T.
Publication type:
journal article
Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
Published in:
2003
By:
- Gloyn, Anna L.;
- Weedon, Michael N.;
- Owen, Katharine R.;
- Turner, Martina J.;
- Knight, Bridget A.;
- Hitman, Graham;
- Walker, Mark;
- Levy, Jonathan C.;
- Sampson, Mike;
- Halford, Stephanie;
- McCarthy, Mark I.;
- Hattersley, Andrew T.;
- Frayling, Timothy M.
Publication type:
journal article