Works by Weber, Irene

Results: 53

Verstärkung der Bindung an das Proteinrückgrat - ein fruchtbares Konzept gegen die Arzneimittelresistenz von HIV.

Published in:

Angewandte Chemie, 2012, v. 124, n. 8, p. 1812, doi. 10.1002/ange.201102762

By:

Ghosh, Arun K.;
Anderson, David D.;
Weber, Irene T.;
Mitsuya, Hiroaki

Publication type:

Article

HIV Protease: Historical Perspective and Current Research.

Published in:

Viruses (1999-4915), 2021, v. 13, n. 5, p. 839, doi. 10.3390/v13050839

By:

Weber, Irene T.;
Wang, Yuan-Fang;
Harrison, Robert W.;
Rein, Alan

Publication type:

Article

In vitro heme biotransformation by the HupZ enzyme from Group A streptococcus.

Published in:

BioMetals, 2016, v. 29, n. 4, p. 593, doi. 10.1007/s10534-016-9937-1

By:

Sachla, Ankita;
Ouattara, Mahamoudou;
Romero, Elvira;
Agniswamy, Johnson;
Weber, Irene;
Gadda, Giovanni;
Eichenbaum, Zehava

Publication type:

Article

Antimicrobial susceptibility of Gram-negative organisms from intra abdominal infections and evolution of isolates with extended spectrum ß-lactamases in the SMART study in Spain (2002-2010).

Published in:

Revista Española de Quimioterapia, 2011, v. 24, n. 4, p. 223

By:

Cantón, Rafael;
Loza, Elena;
Aznar, Javier;
Calvo, Jorge;
Cercenado, Emilia;
Cisterna, Ramón;
Romo, Fernando González;
Hontangas, José Luis López;
Calvo, Carmen Rubio;
Barrenechea, Ana Isabel Suárez;
Tubau, Fe;
Weber, Irene;
Yuste, Patricia;
Cavanillas, Rafael

Publication type:

Article

Combining mutations in HIV-1 protease to understand mechanisms of resistance.

Published in:

Proteins, 2002, v. 48, n. 1, p. 107, doi. 10.1002/prot.10140

By:

Mahalingam, Bhuvaneshwari;
Boross, Peter;
Wang, Yuan-Fang;
Louis, John M.;
Fischer, Christopher C.;
Tozser, Jozsef;
Harrison, Robert W.;
Weber, Irene T.

Publication type:

Article

Structural implications of drug-resistant mutants of HIV-1 protease: High-resolution crystal structures of the mutant protease/substrate analogue complexes.

Published in:

Proteins, 2001, v. 43, n. 4, p. 455, doi. 10.1002/prot.1057

By:

Mahalingam, Bhuvaneshwari;
Louis, John M.;
Hung, Jason;
Harrison, Robert W.;
Weber, Irene T.

Publication type:

Article

Analysis of comparative modeling predictions for CASP2 targets 1, 3, 9, and 17.

Published in:

Proteins, 1997, v. 29, n. S1, p. 68, doi. 10.1002/(SICI)1097-0134(1997)1+<68::AID-PROT10>3.0.CO;2-P

By:

Harrison, Robert W.;
Reed, Charles C.;
Weber, Irene T.

Publication type:

Article

Analysis of six protein structures predicted by comparative modeling techniques.

Published in:

Proteins, 1995, v. 23, n. 4, p. 463, doi. 10.1002/prot.340230402

By:

Harrison, Robert W.;
Chatterjee, Devjani;
Weber, Irene T.

Publication type:

Article

Comparative analysis of the sequences and structures of HIV-1 and HIV-2 proteases.

Published in:

Proteins, 1991, v. 10, n. 4, p. 325, doi. 10.1002/prot.340100406

By:

Gustchina, Alla;
Weber, Irene T.

Publication type:

Article

Evaluation of homology modeling of HIV Protease.

Published in:

Proteins, 1990, v. 7, n. 2, p. 172, doi. 10.1002/prot.340070206

By:

Weber, Irene T.

Publication type:

Article

Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters.

Published in:

FEBS Journal, 2010, v. 277, n. 18, p. 3699, doi. 10.1111/j.1742-4658.2010.07771.x

By:

Chen-Hsiang Shen;
Yuan-Fang Wang;
Kovalevsky, Andrey Y.;
Harrison, Robert W.;
Weber, Irene T.

Publication type:

Article

Plasticity of S2–S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis.

Published in:

FEBS Journal, 2007, v. 274, n. 18, p. 4752, doi. 10.1111/j.1742-4658.2007.05994.x

By:

Agniswamy, Johnson;
Bin Fang;
Weber, Irene T.

Publication type:

Article

Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 Å resolution crystal structures of HIV-1 protease mutants with substrate analogs.

Published in:

FEBS Journal, 2005, v. 272, n. 20, p. 5265, doi. 10.1111/j.1742-4658.2005.04923.x

By:

Yunfeng Tie;
Boross, Peter I.;
Yuan-Fang Wang;
Gaddis, Laquasha;
Fengling Liu;
Xianfeng Chen;
Tozser, Jozsef;
Harrison, Robert W.;
Weber, Irene T.

Publication type:

Article

Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics.

Published in:

PLoS ONE, 2016, v. 11, n. 12, p. 1, doi. 10.1371/journal.pone.0168616

By:

Agniswamy, Johnson;
Louis, John M.;
Roche, Julien;
Harrison, Robert W.;
Weber, Irene T.

Publication type:

Article

Enhancing Protein Backbone Binding-A Fruitful Concept for Combating Drug-Resistant HIV.

Published in:

Angewandte Chemie International Edition, 2012, v. 51, n. 8, p. 1778, doi. 10.1002/anie.201102762

By:

Ghosh, Arun K.;
Anderson, David D.;
Weber, Irene T.;
Mitsuya, Hiroaki

Publication type:

Article

Analysis of drug resistance in HIV protease.

Published in:

BMC Bioinformatics, 2018, v. 19, n. 1, p. 1, doi. 10.1186/s12859-018-2331-y

By:

Pawar, Shrikant D.;
Freas, Christopher;
Weber, Irene T.;
Harrison, Robert W.

Publication type:

Article

Close pairs of carboxylates: a possibility of multicenter hydrogen bonds in proteins.

Published in:

Protein Engineering, 2003, v. 16, n. 3, p. 201, doi. 10.1093/proeng/gzg027

By:

Torshin, Ivan Y.;
Harrison, Robert W.;
Weber, Irene T.

Publication type:

Article

Geometric criteria of hydrogen bonds in proteins and identification of `bifurcated' hydrogen bonds.

Published in:

Protein Engineering, 2002, v. 15, n. 5, p. 359, doi. 10.1093/protein/15.5.359

By:

Torshin, Ivan Y.;
Weber, Irene T.;
Harrison, Robert W.

Publication type:

Article

Antiviral agent based on the non-structural protein targeting the maturation process of HIV-1: expression and susceptibility of chimeric Vpr as a substrate for cleavage by HIV-1 protease.

Published in:

Protein Engineering, 2000, v. 13, n. 6, p. 431, doi. 10.1093/protein/13.6.431

By:

Serio, Dawn;
Singh, Satya P.;
Cartas, Maria A.;
Weber, Irene T.;
Harrison, Robert W.;
Louis, John M.;
Srinivasan, Alagarsamy

Publication type:

Article

Molecular mechanics analysis of drug-resistant mutants of HIV protease.

Published in:

Protein Engineering, 1999, v. 12, n. 6, p. 469, doi. 10.1093/protein/12.6.469

By:

Weber, Irene T.;
Harrison, Robert W.

Publication type:

Article

Molecular mechanics calculations on HIV-1 protease with peptide substrates correlate with experimental data.

Published in:

Protein Engineering, 1996, v. 9, n. 8, p. 679, doi. 10.1093/protein/9.8.679

By:

Weber, Irene T.;
Harrison, Robert W.

Publication type:

Article

Predicted ligand interactions for 3′,5′-cyclic nucleotide-gated channel binding sites: comparison of retina and olfactory binding site models.

Published in:

Protein Engineering, 1996, v. 9, n. 4, p. 333, doi. 10.1093/protein/9.4.333

By:

Scott, Sean-Patrick;
Harrison, Robert W.;
Weber, Irene T.;
Tanaka, Jacqueline C.

Publication type:

Article

Steric hindrance controls pyridine nucleotide specificity of a flavin‐dependent NADH:quinone oxidoreductase.

Published in:

Protein Science: A Publication of the Protein Society, 2019, v. 28, n. 1, p. 167, doi. 10.1002/pro.3514

By:

Ball, Jacob;
Reis, Renata A. G.;
Agniswamy, Johnson;
Weber, Irene T.;
Gadda, Giovanni

Publication type:

Article

Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.

Published in:

Protein Science: A Publication of the Protein Society, 2012, v. 21, n. 3, p. 339, doi. 10.1002/pro.2019

By:

Tie, Yunfeng;
Wang, Yuan-Fang;
Boross, Peter I.;
Chiu, Ting-Yi;
Ghosh, Arun K.;
Tozser, Jozsef;
Louis, John M.;
Harrison, Robert W.;
Weber, Irene T.

Publication type:

Article

Autocatalytic maturation, physical/chemical properties, and crystal structure of group N HIV-1 protease: Relevance to drug resistance.

Published in:

Protein Science: A Publication of the Protein Society, 2010, v. 19, n. 11, p. 2055, doi. 10.1002/pro.486

By:

Sayer, Jane M.;
Agniswamy, Johnson;
Weber, Irene T.;
Louis, John M.

Publication type:

Article

Molecular mechanics calculations on rous sarcoma virus protease with peptide substrates.

Published in:

Protein Science: A Publication of the Protein Society, 1997, v. 6, n. 11, p. 2365, doi. 10.1002/pro.5560061110

By:

Weber, Irene T.;
Harrison, Robert W.

Publication type:

Article

Molecular mechanics calculations on Rous sarcoma virus protease with peptide substrates

Published in:

Protein Science: A Publication of the Protein Society, 1997, p. 2365

By:

Weber, Irene T.;
Harrison, Robert W.

Publication type:

Article

Crystal structure of yeast nitronate monooxygenase from <italic>Cyberlindnera saturnus</italic>.

Published in:

Proteins, 2018, v. 86, n. 5, p. 599, doi. 10.1002/prot.25470

By:

Agniswamy, Johnson;
Reis, Renata A. G.;
Wang, Yuan‐Fang;
Smitherman, Crystal;
Su, Dan;
Weber, Irene;
Gadda, Giovanni

Publication type:

Article

Highly conserved glycine 86 and arginine 87 residues contribute differently to the structure and activity of the mature HIV-1 protease.

Published in:

Proteins, 2010, v. 78, n. 4, p. 1015, doi. 10.1002/prot.22625

By:

Ishima, Rieko;
Gong, Qingguo;
Tie, Yunfeng;
Weber, Irene T.;
Louis, John M.

Publication type:

Article

Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir.

Published in:

Proteins, 2007, v. 67, n. 1, p. 232, doi. 10.1002/prot.21304

By:

Tie, Yunfeng;
Kovalevsky, Andrey Y.;
Boross, Peter;
Wang, Yuan-Fang;
Ghosh, Arun K.;
Tozser, Jozsef;
Harrison, Robert W.;
Weber, Irene T.

Publication type:

Article

Prediction of HIV drug resistance from genotype with encoded three-dimensional protein structure.

Published in:

BMC Genomics, 2014, v. 15, p. 1, doi. 10.1186/1471-2164-15-S5-S1

By:

Xiaxia Yu;
Weber, Irene T.;
Harrison, Robert W.

Publication type:

Article

Automated prediction of HIV drug resistance from genotype data.

Published in:

BMC Bioinformatics, 2016, v. 17, p. 563, doi. 10.1186/s12859-016-1114-6

By:

ChenHsiang Shen;
Xiaxia Yu;
Harrison, Robert W.;
Weber, Irene T.

Publication type:

Article

Identifying representative drug resistant mutants of HIV.

Published in:

BMC Bioinformatics, 2015, v. 16, p. 1, doi. 10.1186/1471-2105-16-S17-S1

By:

Xiaxia Yu;
Weber, Irene T.;
Harrison, Robert W.

Publication type:

Article

Potent HIV‐1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein‐Ligand X‐ray Structural Studies.

Published in:

ChemMedChem, 2019, v. 14, n. 21, p. 1863, doi. 10.1002/cmdc.201900508

By:

Ghosh, Arun K.;
Xia, Zilei;
Kovela, Satish;
Robinson, William L.;
Johnson, Megan E.;
Kneller, Daniel W.;
Wang, Yuan‐Fang;
Aoki, Manabu;
Takamatsu, Yuki;
Weber, Irene T.;
Mitsuya, Hiroaki

Publication type:

Article

Front Cover: Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants (ChemMedChem 8/2018).

Published in:

ChemMedChem, 2018, v. 13, n. 8, p. 762, doi. 10.1002/cmdc.201800226

By:

Ghosh, Arun K.;
Rao, Kalapala Venkateswara;
Nyalapatla, Prasanth R.;
Kovela, Satish;
Brindisi, Margherita;
Osswald, Heather L.;
Sekhara Reddy, Bhavanam;
Agniswamy, Johnson;
Wang, Yuan‐Fang;
Aoki, Manabu;
Hattori, Shin‐ichiro;
Weber, Irene T.;
Mitsuya, Hiroaki

Publication type:

Article

Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants.

Published in:

ChemMedChem, 2018, v. 13, n. 8, p. 803, doi. 10.1002/cmdc.201700824

By:

Ghosh, Arun K.;
Rao, Kalapala Venkateswara;
Nyalapatla, Prasanth R.;
Kovela, Satish;
Brindisi, Margherita;
Osswald, Heather L.;
Sekhara Reddy, Bhavanam;
Agniswamy, Johnson;
Wang, Yuan‐Fang;
Aoki, Manabu;
Hattori, Shin‐ichiro;
Weber, Irene T.;
Mitsuya, Hiroaki

Publication type:

Article

Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2′ Ligands of Darunavir.

Published in:

ChemMedChem, 2017, v. 12, n. 23, p. 1942, doi. 10.1002/cmdc.201700614

By:

Ghosh, Arun K.;
Fyvie, W. Sean;
Brindisi, Margherita;
Steffey, Melinda;
Agniswamy, Johnson;
Wang, Yuan‐Fang;
Aoki, Manabu;
Amano, Masayuki;
Weber, Irene T.;
Mitsuya, Hiroaki

Publication type:

Article

Design of gem-Difluoro- bis-Tetrahydrofuran as P2 Ligand for HIV-1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X-ray Studies, and Biological Evaluation.

Published in:

ChemMedChem, 2015, v. 10, n. 1, p. 107, doi. 10.1002/cmdc.201402358

By:

Ghosh, Arun K.;
Yashchuk, Sofiya;
Mizuno, Akira;
Chakraborty, Nilanjana;
Agniswamy, Johnson;
Wang, Yuan‐Fang;
Aoki, Manabu;
Gomez, Pedro Miguel Salcedo;
Amano, Masayuki;
Weber, Irene T.;
Mitsuya, Hiroaki

Publication type:

Article

Cover Picture: Probing Multidrug-Resistance and Protein-Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors (ChemMedChem 11/2010).

Published in:

ChemMedChem, 2010, v. 5, n. 11, p. 1797, doi. 10.1002/cmdc.201090049

By:

Ghosh, Arun K.;
Xu, Chun-Xiao;
Rao, Kalapala Venkateswara;
Baldridge, Abigail;
Agniswamy, Johnson;
Wang, Yuan-Fang;
Weber, Irene T.;
Aoki, Manabu;
Miguel, Salcedo Gomez Pedro;
Amano, Masayuki;
Mitsuya, Hiroaki

Publication type:

Article

Probing Multidrug-Resistance and Protein-Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors.

Published in:

ChemMedChem, 2010, v. 5, n. 11, p. 1850, doi. 10.1002/cmdc.201000318

By:

Ghosh, Arun K.;
Xu, Chun-Xiao;
Rao, Kalapala Venkateswara;
Baldridge, Abigail;
Agniswamy, Johnson;
Wang, Yuan-Fang;
Weber, Irene T.;
Aoki, Manabu;
Miguel, Salcedo Gomez Pedro;
Amano, Masayuki;
Mitsuya, Hiroaki

Publication type:

Article

Bis-Tetrahydrofuran: a Privileged Ligand for Darunavir and a New Generation of HIV Protease Inhibitors That Combat Drug Resistance.

Published in:

ChemMedChem, 2006, v. 1, n. 9, p. 939, doi. 10.1002/cmdc.200600103

By:

Ghosh, Arun K.;
Ramu Sridhar, Perali;
Kumaragurubaran, Nagaswamy;
Koh, Yasuhiro;
Weber, Irene T.;
Mitsuya, Hiroaki

Publication type:

Article

Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site.

Published in:

Angewandte Chemie, 2016, v. 128, n. 16, p. 5008, doi. 10.1002/ange.201509989

By:

Gerlits, Oksana;
Wymore, Troy;
Das, Amit;
Shen, Chen ‐ Hsiang;
Parks, Jerry M.;
Smith, Jeremy C.;
Weiss, Kevin L.;
Keen, David A.;
Blakeley, Matthew P.;
Louis, John M.;
Langan, Paul;
Weber, Irene T.;
Kovalevsky, Andrey

Publication type:

Article

Conformational similarity in the activation of caspase-3 and -7 revealed by the unliganded and inhibited structures of caspase-7.

Published in:

Apoptosis, 2009, v. 14, n. 10, p. 1135, doi. 10.1007/s10495-009-0388-9

By:

Agniswamy, Johnson;
Fang, Bin;
Weber, Irene

Publication type:

Article

Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling.

Published in:

Apoptosis, 2009, v. 14, n. 5, p. 741, doi. 10.1007/s10495-009-0333-y

By:

Fang, Bin;
Fu, Guoxing;
Agniswamy, Johnson;
Harrison, Robert;
Weber, Irene

Publication type:

Article

Structural basis for executioner caspase recognition of P5 position in substrates.

Published in:

Apoptosis, 2008, v. 13, n. 11, p. 1291, doi. 10.1007/s10495-008-0259-9

By:

Fu, Guoxing;
Chumanevich, Alexander;
Agniswamy, Johnson;
Fang, Bin;
Harrison, Robert;
Weber, Irene

Publication type:

Article

Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia.

Published in:

1999

By:

Mahalingam, Bhuvaneshwari;
Cuesta-Munoz, Antonio;
Davis, Elizabeth A.;
Matschinsky, Franz M.;
Harrison, Robert W.;
Weber, Irene T.;
Mahalingam, B;
Cuesta-Munoz, A;
Davis, E A;
Matschinsky, F M;
Harrison, R W;
Weber, I T

Publication type:

journal article

Mutations affecting cleavage at the p10-capsid protease cleavage site block Rous sarcoma virus replication.

Published in:

Retrovirology, 2005, v. 2, p. 58, doi. 10.1186/1742-4690-2-58

By:

Vana, Marcy L.;
Aiping Chen;
Boross, Peter;
Weber, Irene;
Colman, Dalbinder;
Barklis, Eric;
Leis, Jonathan

Publication type:

Article

HIV-1 Protease: Structural Perspectives on Drug Resistance.

Published in:

Viruses (1999-4915), 2009, v. 1, n. 3, p. 1110, doi. 10.3390/v1031110

By:

Weber, Irene T.;
Agniswamy, Johnson

Publication type:

Article

Design, Synthesis and X‐Ray Structural Studies of Potent HIV‐1 Protease Inhibitors Containing C‐4 Substituted Tricyclic Hexahydro‐Furofuran Derivatives as P2 Ligands.

Published in:

ChemMedChem, 2022, v. 17, n. 9, p. 1, doi. 10.1002/cmdc.202200058

By:

Ghosh, Arun K.;
Kovela, Satish;
Sharma, Ashish;
Shahabi, Dana;
Ghosh, Ajay K.;
Hopkins, Denver R.;
Yadav, Monika;
Johnson, Megan E.;
Agniswamy, Johnson;
Wang, Yuan‐Fang;
Hattori, Shin‐Ichiro;
Higashi‐Kuwata, Nobuyo;
Aoki, Manabu;
Amano, Masayuki;
Weber, Irene T.;
Mitsuya, Hiroaki

Publication type:

Article

Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site.

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 16, p. 4924, doi. 10.1002/anie.201509989

By:

Gerlits, Oksana;
Wymore, Troy;
Das, Amit;
Shen, Chen-Hsiang;
Parks, Jerry M.;
Smith, Jeremy C.;
Weiss, Kevin L.;
Keen, David A.;
Blakeley, Matthew P.;
Louis, John M.;
Langan, Paul;
Weber, Irene T.;
Kovalevsky, Andrey

Publication type:

Article