Found: 68
Select item for more details and to access through your institution.
Phosphorylation regulates interaction of 210-kDa myosin light chain kinase N-terminal domain with actin cytoskeleton.
- Published in:
- Biochemistry (00062979), 2015, v. 80, n. 10, p. 1288, doi. 10.1134/S0006297915100090
- By:
- Publication type:
- Article
Optimizing the use of CROs by academia and small companies.
- Published in:
- Nature Reviews Drug Discovery, 2013, v. 12, n. 7, p. 487, doi. 10.1038/nrd4057
- By:
- Publication type:
- Article
Targeting protein kinases in central nervous system disorders.
- Published in:
- 2009
- By:
- Publication type:
- journal article
First‐in‐Human Studies of MW01‐6‐189WH, a Brain‐Penetrant, Antineuroinflammatory Small‐Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers.
- Published in:
- Clinical Pharmacology in Drug Development, 2021, v. 10, n. 2, p. 131, doi. 10.1002/cpdd.795
- By:
- Publication type:
- Article
Riboflavin and ultraviolet light: impact on dengue virus infectivity.
- Published in:
- Vox Sanguinis, 2016, v. 111, n. 3, p. 235, doi. 10.1111/vox.12414
- By:
- Publication type:
- Article
Glial Activation Links Early-Life Seizures and Long-Term Neurologic Dysfunction: Evidence Using a Small Molecule Inhibitor of Proinflammatory Cytokine Upregulation.
- Published in:
- Epilepsia (Series 4), 2007, v. 48, n. 9, p. 1785, doi. 10.1111/j.1528-1167.2007.01135.x
- By:
- Publication type:
- Article
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo.
- Published in:
- 2005
- By:
- Publication type:
- journal article
Human amyloid β‐induced neuroinflammation is an early event in neurodegeneration.
- Published in:
- Glia, 2006, v. 53, n. 5, p. 484, doi. 10.1002/glia.20306
- By:
- Publication type:
- Article
Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human -amyloid.
- Published in:
- Glia, 2005, v. 51, n. 3, p. 209, doi. 10.1002/glia.20194
- By:
- Publication type:
- Article
Atomic force microscopic and encrustation studies of novel prospective polyisobutylene-based thermoplastic elastomeric biomaterials.
- Published in:
- Polymers for Advanced Technologies, 2003, v. 14, n. 11/12, p. 763
- By:
- Publication type:
- Article
PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29471-6
- By:
- Publication type:
- Article
A PLATFORM FOR NOVEL IN VIVO MOLECULAR PROBES FOR ATTENUATION OF SYNAPTIC DYSFUNCTION AND PROINFLAMMATORY CYTOKINE OVERPRODUCTION.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P951, doi. 10.1016/j.jalz.2017.06.1265
- By:
- Publication type:
- Article
A SMALL MOLECULE ANTI-NEUROINFLAMMATORY EXPERIMENTAL THERAPEUTIC INHIBITED IL-1BETA LEVELS AFTER TRAUMATIC BRAIN INJURY WITH NO EFFECT ON MICROGLIA PHYSIOLOGICAL RESPONSES.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P661, doi. 10.1016/j.jalz.2016.06.1499
- By:
- Publication type:
- Article
An optimized and isoform-selective p38aMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P473, doi. 10.1016/j.jalz.2015.06.519
- By:
- Publication type:
- Article
Targeting proinflammatory cytokine up-regulation with a novel anti-cytokine therapeutic, MW-151, attenuates pathology in an APP/PS1 knock-in mouse model
- Published in:
- 2012
- By:
- Publication type:
- Abstract
P3-304: Death associated protein kinase (DAPK): A calcium/calmodulin (CAM) regulator of neuronal apoptosis that is a drug discovery target for neurodegenerative disorders
- Published in:
- 2008
- By:
- Publication type:
- Abstract
P2-419: Development of novel protein kinase inhibitors as experimental therapeutics for neurodegenerative disorders
- Published in:
- 2008
- By:
- Publication type:
- Abstract
P4-428: Glia as a therapeutic target: Selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-428: Glia as a therapeutic target: Selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration
- Published in:
- 2006
- By:
- Publication type:
- Abstract
Development of a new class of orally bioavailable and safe experimental therapeutics that attenuate disease progression in an Alzheimer’s disease-related mouse model
- Published in:
- 2005
- By:
- Publication type:
- Abstract
Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human β-amyloid in a murine model of neuroinflammation.
- Published in:
- Journal of Molecular Neuroscience, 2004, v. 24, n. 1, p. 115, doi. 10.1385/JMN:24:1:115
- By:
- Publication type:
- Article
Discovery of a new class of synthetic protein kinase inhibitors that suppress selective aspects of glial activation and protect against β-amyloid induced injury.
- Published in:
- Journal of Molecular Neuroscience, 2003, v. 20, n. 3, p. 411, doi. 10.1385/JMN:20:3:411
- By:
- Publication type:
- Article
Discovery of new chemical classes of synthetic ligands that suppress neuroinflammatory responses.
- Published in:
- Journal of Molecular Neuroscience, 2002, v. 19, n. 1/2, p. 89, doi. 10.1007/s12031-002-0016-4
- By:
- Publication type:
- Article
Product release is rate-limiting for catalytic processing by the Dengue virus protease.
- Published in:
- Scientific Reports, 2016, p. 37539, doi. 10.1038/srep37539
- By:
- Publication type:
- Article
Generation and Behavior Characterization of CaMKIIβ Knockout Mice.
- Published in:
- PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0105191
- By:
- Publication type:
- Article
Development of Novel <i>In Vivo</i> Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction.
- Published in:
- PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0066226
- By:
- Publication type:
- Article
Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase.
- Published in:
- PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0065235
- By:
- Publication type:
- Article
Critical Role of Non-Muscle Myosin Light Chain Kinase in Thrombin-Induced Endothelial Cell Inflammation and Lung PMN Infiltration.
- Published in:
- PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0059965
- By:
- Publication type:
- Article
Homodimerization of the Death-Associated Protein Kinase Catalytic Domain: Development of a New Small Molecule Fluorescent Reporter.
- Published in:
- PLoS ONE, 2010, v. 5, n. 11, p. 1, doi. 10.1371/journal.pone.0014120
- By:
- Publication type:
- Article
Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: Organization, expression, alternative splicing, and polymorphic marker.
- Published in:
- Journal of Cellular Biochemistry, 1999, v. 75, n. 3, p. 481, doi. 10.1002/(SICI)1097-4644(19991201)75:3<481::AID-JCB12>3.0.CO;2-5
- By:
- Publication type:
- Article
Organization of the genetic locus for chicken myosin light chain kinase is complex: Multiple proteins are encoded and exhibit differential expression and localization.
- Published in:
- Journal of Cellular Biochemistry, 1998, v. 70, n. 3, p. 402, doi. 10.1002/(SICI)1097-4644(19980901)70:3<402::AID-JCB13>3.0.CO;2-M
- By:
- Publication type:
- Article
Glia as a Therapeutic Target: Selective Suppression of Human Amyloid-β-Induced Upregulation of Brain Proinflammatory Cytokine Production Attenuates Neurodegeneration.
- Published in:
- Journal of Neuroscience, 2006, v. 26, n. 2, p. 662, doi. 10.1523/JNEUROSCI.4652-05.2006
- By:
- Publication type:
- Article
Nonmuscle Myosin Light Chain Kinase Regulates Murine Asthmatic Inflammation.
- Published in:
- American Journal of Respiratory Cell & Molecular Biology, 2014, v. 50, n. 6, p. 1129, doi. 10.1165/rcmb.2013-0434OC
- By:
- Publication type:
- Article
Non-Muscle Myosin Light Chain Kinase Isoform Is a Viable Molecular Target in Acute Inflammatory Lung Injury.
- Published in:
- American Journal of Respiratory Cell & Molecular Biology, 2011, v. 44, n. 1, p. 40, doi. 10.1165/rcmb.2009-0197OC
- By:
- Publication type:
- Article
Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ).
- Published in:
- 2011
- By:
- Publication type:
- journal article
Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury.
- Published in:
- Journal of Neuroinflammation, 2008, v. 5, p. 1, doi. 10.1186/1742-2094-5-28
- By:
- Publication type:
- Article
A novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.
- Published in:
- Journal of Neuroinflammation, 2007, v. 4, p. 21, doi. 10.1186/1742-2094-4-21
- By:
- Publication type:
- Article
Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid.
- Published in:
- Journal of Neuroinflammation, 2005, v. 2, p. 15, doi. 10.1186/1742-2094-2-15
- By:
- Publication type:
- Article
The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target.
- Published in:
- 2008
- By:
- Publication type:
- journal article
The p38α mitogen-activated protein kinase as a central nervous system drug discovery target.
- Published in:
- BMC Neuroscience, 2008, v. 9, p. 1, doi. 10.1186/1471-2202-9-S2-S12
- By:
- Publication type:
- Article
REPRODUCIBLE PRODUCTION AND ANTISERA CHARACTERIZATION OF ANTI-CALMODULIN.
- Published in:
- Annals of the New York Academy of Sciences, 1980, v. 356, n. 1, p. 437, doi. 10.1111/j.1749-6632.1980.tb29663.x
- By:
- Publication type:
- Article
INTRODUCTORY REMARKS.
- Published in:
- Annals of the New York Academy of Sciences, 1980, v. 356, n. 1, p. xi, doi. 10.1111/j.1749-6632.1980.tb29592.x
- By:
- Publication type:
- Article
SEQUENCE ALIGNMENT OF CALMODULIN DOMAINS BY METRIC ANALYSIS.
- Published in:
- Annals of the New York Academy of Sciences, 1980, v. 356, n. 1, p. 378, doi. 10.1111/j.1749-6632.1980.tb29635.x
- By:
- Publication type:
- Article
ISOLATION OF A PROTEIN FROM BRAIN USING CALCIUM-DEPENDENT AFFINITY-BASED ADSORPTION CHROMATOGRAPHY ON PHENOTHIAZINE-SEPHAROSE CONJUGATES.
- Published in:
- Annals of the New York Academy of Sciences, 1980, v. 356, n. 1, p. 410, doi. 10.1111/j.1749-6632.1980.tb29651.x
- By:
- Publication type:
- Article
COMPARATIVE BIOCHEMISTRY OF CALMODULINS AND CALMODULIN-LIKE PROTEINS.
- Published in:
- Annals of the New York Academy of Sciences, 1980, v. 356, n. 1, p. 36, doi. 10.1111/j.1749-6632.1980.tb29597.x
- By:
- Publication type:
- Article
Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia.
- Published in:
- GeroScience, 2019, v. 41, n. 5, p. 671, doi. 10.1007/s11357-019-00072-4
- By:
- Publication type:
- Article
Computational and site-specific mutagenesis analyses of the asymmetric charge distribution on calmodulin.
- Published in:
- Proteins, 1989, v. 6, n. 1, p. 70, doi. 10.1002/prot.340060107
- By:
- Publication type:
- Article
A protein crystallography and small molecule informatics‐based discovery engine for the development of selective chemical probes for in vivo investigations of protein kinases (968.3).
- Published in:
- FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.968.3
- By:
- Publication type:
- Article
Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology.
- Published in:
- Alzheimer's Research & Therapy, 2016, v. 8, p. 1, doi. 10.1186/s13195-016-0221-y
- By:
- Publication type:
- Article
A new discovery platform for novel CNS therapeutics with potential to alter disease progression.
- Published in:
- FASEB Journal, 2007, v. 21, n. 6, p. A787, doi. 10.1096/fasebj.21.6.a787-d
- By:
- Publication type:
- Article