Works by Watkins, Paul B.

Results: 109

The new revolution in toxicology: The good, the bad, and the ugly.

Published in:

Annals of the New York Academy of Sciences, 2013, v. 1278, n. 1, p. 11, doi. 10.1111/nyas.12086

By:

Davis, Myrtle;
Boekelheide, Kim;
Boverhof, Darrell R.;
Eichenbaum, Gary;
Hartung, Thomas;
Holsapple, Michael P.;
Jones, Thomas W.;
Richard, Ann M.;
Watkins, Paul B.

Publication type:

Article

How to Diagnose and Exclude Drug-Induced Liver Injury.

Published in:

Digestive Diseases, 2015, v. 33, n. 4, p. 472, doi. 10.1159/000374091

By:

Watkins, Paul B.

Publication type:

Article

Acetaminophen and Aminotransferase Elevations.

Published in:

2006

By:

Watkins, Paul B.;
Kaplowitz, Neil;
Colucci, Salvatore V.;
Stewart, Paul W.;
Harris, Stephen C.

Publication type:

Letter

Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial.

Published in:

2006

By:

Watkins PB;
Kaplowitz N;
Slattery JT;
Colonese CR;
Colucci SV;
Stewart PW;
Harris SC;
Watkins, Paul B;
Kaplowitz, Neil;
Slattery, John T;
Colonese, Connie R;
Colucci, Salvatore V;
Stewart, Paul W;
Harris, Stephen C

Publication type:

journal article

Aminotransferase Elevations in Healthy Adults Receiving 4 Grams of Acetaminophen Daily.

Published in:

JAMA: Journal of the American Medical Association, 2006, v. 296, n. 1, p. 87, doi. 10.1001/jama.296.1.87

By:

Watkins, Paul B.;
Kaplowitz, Neil;
Slattery, John T.;
Colonese, Connie R.;
Colucci, Salvatore V.;
Stewart, Paul W.;
Harris, Stephen C.

Publication type:

Article

Serum biomarkers of drug‐induced liver injury: Current status and future directions.

Published in:

Journal of Digestive Diseases, 2019, v. 20, n. 1, p. 2, doi. 10.1111/1751-2980.12684

By:

Church, Rachel J.;
Watkins, Paul B.

Publication type:

Article

Understanding hepatotoxicity - from patients to mice to computer.

Published in:

2012

By:

Watkins, Paul B.

Publication type:

Abstract

Management of Select Adverse Events Following Delandistrogene Moxeparvovec Gene Therapy for Patients With Duchenne Muscular Dystrophy.

Published in:

Journal of Neuromuscular Diseases, 2024, v. 11, n. 3, p. 687, doi. 10.3233/JND-230185

By:

Zaidman, Craig M.;
Goedeker, Natalie L.;
Aqul, Amal A.;
Butterfield, Russell J.;
Connolly, Anne M.;
Crystal, Ronald G.;
Godwin, Kara E.;
Hor, Kan N.;
Mathews, Katherine D.;
Proud, Crystal M.;
Kula Smyth, Elizabeth;
Veerapandiyan, Aravindhan;
Watkins, Paul B.;
Mendell, Jerry R.

Publication type:

Article

Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease.

Published in:

JAMA: Journal of the American Medical Association, 1994, v. 271, n. 13, p. 992, doi. 10.1001/jama.1994.03510370044030

By:

Watkins, Paul B.;
Zimmerman, Hyman J.

Publication type:

Article

Did this drug cause my patient's hepatitis?

Published in:

2003

By:

Kaplowitz, Neil;
Lewis, James H;
Watkins, Paul B

Publication type:

Letter

The Environmental Polymorphisms Registry: a DNA resource to study genetic susceptibility loci.

Published in:

Human Genetics, 2008, v. 123, n. 2, p. 207, doi. 10.1007/s00439-007-0457-5

By:

Chulada, Patricia C.;
Vahdat, Heather L.;
Sharp, Richard R.;
DeLozier, Tracy C.;
Watkins, Paul B.;
Pusek, Susan N.;
Blackshear, Perry J.

Publication type:

Article

Idiosyncratic Liver Injury: Challenges and Approaches.

Published in:

Toxicologic Pathology, 2005, v. 33, n. 1, p. 1, doi. 10.1080/01926230590888306

By:

Watkins, Paul B.

Publication type:

Article

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.

Published in:

Nature Genetics, 2001, v. 27, n. 4, p. 383, doi. 10.1038/86882

By:

Kuehl, Peter;
Zhang, Jiong;
Lin, Yvonne;
Lamba, Jatinder;
Assem, Mahfoud;
Schuetz, John;
Watkins, Paul B.;
Daly, Ann;
Wrighton, Steven A.;
Hall, Stephen D.;
Maurel, Patrick;
Relling, Mary;
Brimer, Cynthia;
Yasuda, Kazuto;
Venkataramanan, Raman;
Strom, Stephen;
Thummel, Kenneth;
Boguski, Mark S.;
Schuetz, Erin

Publication type:

Article

The transformation in biomarker detection and management of drug-induced liver injury.

Published in:

Liver International, 2017, v. 37, n. 11, p. 1582, doi. 10.1111/liv.13441

By:

Church, Rachel J.;
Watkins, Paul B.

Publication type:

Article

Profiles of mi RNAs in serum in severe acute drug induced liver injury and their prognostic significance.

Published in:

Liver International, 2017, v. 37, n. 5, p. 757, doi. 10.1111/liv.13312

By:

Russo, Mark W.;
Steuerwald, Nury;
Norton, Harry J.;
Anderson, William E.;
Foureau, David;
Chalasani, Naga;
Fontana, Robert J.;
Watkins, Paul B.;
Serrano, Jose;
Bonkovsky, Herbert L.

Publication type:

Article

Keratin-18 and micro RNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts.

Published in:

Liver International, 2014, v. 34, n. 3, p. 367, doi. 10.1111/liv.12322

By:

Thulin, Petra;
Nordahl, Gunnar;
Gry, Marcus;
Yimer, Getnet;
Aklillu, Eleni;
Makonnen, Eyasu;
Aderaye, Getachew;
Lindquist, Lars;
Mattsson, C. Mikael;
Ekblom, Björn;
Antoine, Daniel J.;
Park, B. Kevin;
Linder, Stig;
Harrill, Alison H.;
Watkins, Paul B.;
Glinghammar, Björn;
Schuppe‐Koistinen, Ina

Publication type:

Article

Benign elevations in serum aminotransferases and biomarkers of hepatotoxicity in healthy volunteers treated with cholestyramine.

Published in:

BMC Pharmacology & Toxicology, 2014, v. 15, n. 1, p. 42, doi. 10.1186/2050-6511-15-42

By:

Rohit Singhal, Rohit Singhal;
Harrill, Alison H.;
Menguy-Vacheron, Francoise;
Jayyosi, Zaid;
Benzerdjeb, Hadj;
Watkins, Paul B.

Publication type:

Article

Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition.

Published in:

Frontiers in Pharmacology, 2023, v. 14, p. 1, doi. 10.3389/fphar.2022.1085621

By:

Beaudoin, James J.;
Yang, Kyunghee;
Adiwidjaja, Jeffry;
Taneja, Guncha;
Watkins, Paul B.;
Siler, Scott Q.;
Howell, Brett A.;
Woodhead, Jeffrey L.

Publication type:

Article

Correction: Cytokine profiles in acute liver injury—Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group.

Published in:

2019

By:

Bonkovsky, Herbert L.;
Barnhart, Huiman X.;
Foureau, David M.;
Steuerwald, Nury;
Lee, William M.;
Gu, Jiezhun;
Fontana, Robert J.;
Hayashi, Paul H.;
Chalasani, Naga;
Navarro, Victor M.;
Odin, Joseph;
Stolz, Andrew;
Watkins, Paul B.;
Serrano, Jose

Publication type:

Correction Notice

Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis.

Published in:

PLoS ONE, 2019, v. 14, n. 01, p. 1, doi. 10.1371/journal.pone.0208958

By:

Norona, Leah M.;
Nguyen, Deborah G.;
Gerber, David A.;
Presnell, Sharon C.;
Mosedale, Merrie;
Watkins, Paul B.

Publication type:

Article

Cytokine profiles in acute liver injury—Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group.

Published in:

PLoS ONE, 2018, v. 13, n. 10, p. 1, doi. 10.1371/journal.pone.0206389

By:

Bonkovsky, Herbert L.;
Barnhart, Huiman X.;
Foureau, David M.;
Steuerwald, Nury;
Lee, William M.;
Gu, Jiezhun;
Fontana, Robert J.;
Hayashi, Paul J.;
Chalasani, Naga;
Navarro, Victor M.;
Odin, Joseph;
Stolz, Andrew;
Watkins, Paul B.;
Serrano, Jose;
null, null

Publication type:

Article

Progress toward a universal biomedical data translator.

Published in:

CTS: Clinical & Translational Science, 2022, v. 15, n. 8, p. 1838, doi. 10.1111/cts.13301

By:

Fecho, Karamarie;
Thessen, Anne E.;
Baranzini, Sergio E.;
Bizon, Chris;
Hadlock, Jennifer J.;
Huang, Sui;
Roper, Ryan T.;
Southall, Noel;
Ta, Casey;
Watkins, Paul B.;
Williams, Mark D.;
Xu, Hao;
Byrd, William;
Dančík, Vlado;
Duby, Marc P.;
Dumontier, Michel;
Glusman, Gustavo;
Harris, Nomi L.;
Hinderer, Eugene W.;
Hyde, Greg

Publication type:

Article

The Challenge of Interpreting Alanine Aminotransferase Elevations in Clinical Trials of New Drug Candidates.

Published in:

CTS: Clinical & Translational Science, 2021, v. 14, n. 2, p. 434, doi. 10.1111/cts.12900

By:

Church, Rachel J.;
Watkins, Paul B.

Publication type:

Article

The DILI‐sim Initiative: Insights into Hepatotoxicity Mechanisms and Biomarker Interpretation.

Published in:

CTS: Clinical & Translational Science, 2019, v. 12, n. 2, p. 122, doi. 10.1111/cts.12629

By:

Watkins, Paul B.

Publication type:

Article

Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling.

Published in:

CTS: Clinical & Translational Science, 2018, v. 11, n. 5, p. 498, doi. 10.1111/cts.12560

By:

Woodhead, Jeffrey L.;
Paech, Franziska;
Maurer, Martina;
Engelhardt, Marc;
Schmitt‐Hoffmann, Anne H.;
Spickermann, Jochen;
Messner, Simon;
Wind, Mathias;
Witschi, Anne‐Therese;
Krähenbühl, Stephan;
Siler, Scott Q.;
Watkins, Paul B.;
Howell, Brett A.

Publication type:

Article

MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype*.

Published in:

Clinical Pharmacology & Therapeutics, 2006, v. 79, n. 4, p. 325, doi. 10.1016/j.clpt.2005.11.013

By:

Lamba, Jatinder;
Strom, Stephen;
Venkataramanan, Raman;
Thummel, Kenneth E.;
Lin, Yvonne S.;
Wei Liu;
Cheng Cheng;
Lamba, Vishal;
Watkins, Paul B.;
Schuetz, Erin

Publication type:

Article

Variation in oral clearance of saquinavir is predicted by CYP3A5*1 genotype but not by enterocyte content of cytochrome P450 3A5

Published in:

Clinical Pharmacology & Therapeutics, 2005, v. 78, n. 6, p. 605, doi. 10.1016/j.clpt.2005.08.014

By:

Mouly, Stéphane J.;
Matheny, Chris;
Paine, Mary F.;
Smith, Glenn;
Lamba, Jatinder;
Lamba, Vishal;
Pusek, Susan N.;
Schuetz, Erin G.;
Stewart, Paul W.;
Watkins, Paul B.

Publication type:

Article

6′7′-Dihydroxybergamottin Contributes to the Grapefruit Juice Effect*.

Published in:

Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 6, p. 569, doi. 10.1016/j.clpt.2004.02.007

By:

Kakar, Shefali M.;
Paine, Mary F.;
Stewart, Paul W.;
Watkins, Paul B.

Publication type:

Article

Cytochrome P450 3A4 and P-glycoprotein mediate the interaction between an oral erythromycin breath test and rifampin*.

Published in:

Clinical Pharmacology & Therapeutics, 2002, v. 72, n. 5, p. 524, doi. 10.1067/mcp.2002.128387

By:

Paine, Mary F.;
Wagner, David A.;
Hoffmaster, Keith A.;
Watkins, Paul B.

Publication type:

Article

Hepatic but not intestinal CYP3A4 displays dose-dependent induction by efavirenz in humans*.

Published in:

Clinical Pharmacology & Therapeutics, 2002, v. 72, n. 1, p. 1, doi. 10.1067/mcp.2002.124519

By:

Mouly, Stéphane;
Lown, Kenneth S.;
Kornhauser, David;
Joseph, Jeffrey L.;
Fiske, William D.;
Benedek, Irma H.;
Watkins, Paul B.

Publication type:

Article

Erythromycin breath test.

Published in:

Clinical Pharmacology & Therapeutics, 2001, v. 70, n. 4, p. 395, doi. 10.1016/S0009-9236(01)90132-8

By:

Rivory, Laurent P.;
Watkins, Paul B.

Publication type:

Article

Seville orange juice-felodipine interaction: Comparison with dilute grapefruit juice and involvement of furocoumarins*.

Published in:

Clinical Pharmacology & Therapeutics, 2001, v. 69, n. 1, p. 14, doi. 10.1067/mcp.2001.113185

By:

Malhotra, Shefali;
Bailey, David G.;
Paine, Mary F.;
Watkins, Paul B.

Publication type:

Article

Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults*.

Published in:

Clinical Pharmacology & Therapeutics, 2000, v. 67, n. 6, p. 591, doi. 10.1067/mcp.2000.106574

By:

Thummel, Kenneth E.;
Slattery, John T.;
Ro, Howard;
Chien, Jenny Y.;
Nelson, Sidney D.;
Lown, Kenneth E.;
Watkins, Paul B.

Publication type:

Article

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*.

Published in:

Clinical Pharmacology & Therapeutics, 1997, v. 62, n. 3, p. 248, doi. 10.1016/S0009-9236(97)90027-8

By:

Lown, Kenneth S.;
Mayo, Robert R.;
Leichtman, Alan B.;
Hsiao, Hsiu-ling;
Turgeon, D. Kim;
Schmiedlin-Ren, Phyllissa;
Brown, Morton B.;
Guo, Wensheng;
Rossi, Stephen J.;
Benet, Leslie Z.;
Watkins, Paul B.

Publication type:

Article

Steady-state pharmacokinetics of delavirdine in HIV-positive patients: Effect on erythromycin breath test *.

Published in:

Clinical Pharmacology & Therapeutics, 1997, v. 61, n. 5, p. 531, doi. 10.1016/S0009-9236(97)90133-8

By:

Cheng, Ching-Ling;
Smith, David E.;
Carver, Peggy L.;
Cox, Steven R.;
Watkins, Paul B.;
Blake, Debbie S.;
Kauffman, Carol A.;
Meyer, Katherine M.;
Amidon, Gordon L.;
Stetson, Philip L.

Publication type:

Article

The erythromycin breath test predicts the clearance of midazolam*.

Published in:

Clinical Pharmacology & Therapeutics, 1995, v. 57, n. 1, p. 16, doi. 10.1016/0009-9236(95)90261-9

By:

Lown, Kenneth S.;
Thummel, Kenneth E.;
Benedict, Patrick E.;
Shen, Danny D.;
Turgeon, Danielle K.;
Berent, Stanley;
Watkins, Paul B.

Publication type:

Article

Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges.

Published in:

2008

By:

Wilke, Russell A.;
Lin, Debbie W.;
Roden, Dan M.;
Watkins, Paul B.;
Flockhart, David;
Zineh, Issam;
Giacomini, Kathleen M.;
Krauss, Ronald M.

Publication type:

Correction Notice

Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges.

Published in:

2007

By:

Wilke, Russell A.;
Lin, Debbie W.;
Roden, Dan M.;
Watkins, Paul B.;
Flockhart, David;
Zineh, Issam;
Giacomini, Kathleen M.;
Krauss, Ronald M.

Publication type:

journal article

Blood toxicogenomics reveals potential biomarkers for management of idiosyncratic drug-induced liver injury.

Published in:

Frontiers in Genetics, 2025, p. 1, doi. 10.3389/fgene.2025.1524433

By:

Church, Rachel J.;
Anchang, Benedict;
Bennett, Brian D.;
Bushel, Pierre R.;
Watkins, Paul B.

Publication type:

Article

Correction to: Liver Safety of Fasiglifam (TAK-875) in Patients with Type 2 Diabetes: Review of the Global Clinical Trial Experience.

Published in:

2018

By:

Marcinak, John F.;
Munsaka, Melvin S.;
Watkins, Paul B.;
Ohira, Takashi;
Smith, Neila

Publication type:

journal article

Liver Safety of Fasiglifam (TAK-875) in Patients with Type 2 Diabetes: Review of the Global Clinical Trial Experience.

Published in:

2018

By:

Marcinak, John F.;
Munsaka, Melvin S.;
Watkins, Paul B.;
Ohira, Takashi;
Smith, Neila

Publication type:

journal article

Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database.

Published in:

2015

By:

Watkins, Paul;
Lewis, James;
Kaplowitz, Neil;
Alpers, David;
Blais, Jaime;
Smotzer, Dan;
Krasa, Holly;
Ouyang, John;
Torres, Vicente;
Czerwiec, Frank;
Zimmer, Christopher;
Watkins, Paul B;
Lewis, James H;
Alpers, David H;
Blais, Jaime D;
Smotzer, Dan M;
Torres, Vicente E;
Czerwiec, Frank S;
Zimmer, Christopher A

Publication type:

journal article

Methodology to assess clinical liver safety data.

Published in:

2014

By:

Merz, Michael;
Lee, Kwan R;
Kullak-Ublick, Gerd A;
Brueckner, Andreas;
Watkins, Paul B

Publication type:

journal article

Liver safety assessment in special populations (hepatitis B, C, and oncology trials).

Published in:

2014

By:

Kullak-Ublick, Gerd A;
Merz, Michael;
Griffel, Louis;
Kaplowitz, Neil;
Watkins, Paul B

Publication type:

journal article

Causality assessment for suspected DILI during clinical phases of drug development.

Published in:

2014

By:

Regev, Arie;
Seeff, Leonard B;
Merz, Michael;
Ormarsdottir, Sif;
Aithal, Guruprasad P;
Gallivan, Jim;
Watkins, Paul B

Publication type:

journal article

Liver safety assessment: required data elements and best practices for data collection and standardization in clinical trials.

Published in:

2014

By:

Avigan, Mark I;
Bjornsson, Einar S;
Pasanen, Markku;
Cooper, Charles;
Andrade, Raul J;
Watkins, Paul B;
Lewis, James H;
Merz, Michael

Publication type:

journal article

The clinical liver safety assessment best practices workshop: rationale, goals, accomplishments and the future.

Published in:

2014

By:

Watkins, Paul B;
Merz, Michael;
Avigan, Mark I;
Kaplowitz, Neil;
Regev, Arie;
Senior, John R

Publication type:

journal article

Current Challenges and Controversies in Drug-Induced Liver Injury.

Published in:

Drug Safety, 2012, v. 35, n. 12, p. 1099, doi. 10.2165/11632970-000000000-00000

By:

Corsini, Alberto;
Ganey, Patricia;
Ju, Cynthia;
Kaplowitz, Neil;
Pessayre, Dominique;
Roth, Robert;
Watkins, Paul B.;
Albassam, Mudher;
Liu, Baolian;
Stancic, Saray;
Suter, Laura;
Bortolini, Michele

Publication type:

Article

Evaluation of drug-induced serious hepatotoxicity (eDISH): application of this data organization approach to phase III clinical trials of rivaroxaban after total hip or knee replacement surgery.

Published in:

2011

By:

Watkins PB;
Desai M;
Berkowitz SD;
Peters G;
Horsmans Y;
Larrey D;
Maddrey W;
Watkins, Paul B;
Desai, Mehul;
Berkowitz, Scott D;
Peters, Gary;
Horsmans, Yves;
Larrey, Dominique;
Maddrey, Willis

Publication type:

journal article

Drug-Induced Liver Injury Network (DILIN) prospective study: rationale, design and conduct.

Published in:

2009

By:

Fontana RJ;
Watkins PB;
Bonkovsky HL;
Chalasani N;
Davern T;
Serrano J;
Rochon J;
DILIN Study Group;
Fontana, Robert J;
Watkins, Paul B;
Bonkovsky, Herbert L;
Chalasani, Naga;
Davern, Timothy;
Serrano, Jose;
Rochon, James

Publication type:

journal article