Works matching AU Watkins, Paul B.

Results: 109

How to Diagnose and Exclude Drug-Induced Liver Injury.

Published in:

Digestive Diseases, 2015, v. 33, n. 4, p. 472, doi. 10.1159/000374091

By:

Watkins, Paul B.

Publication type:

Article

THE HUMAN CYP3A SUBFAMILY: PRACTICAL CONSIDERATIONS*.

Published in:

Drug Metabolism Reviews, 2000, v. 32, n. 3/4, p. 339, doi. 10.1081/DMR-100102338

By:

WRIGHTON, STEVEN A.;
SCHUETZ, ERIN G.;
THUMMEL, KENNETH E.;
SHEN, DANNY D.;
KORZEKWA, KENNETH R.;
WATKINS, PAUL B.

Publication type:

Article

Precision Dosing Priority Criteria: Drug, Disease, and Patient Population Variables.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. 1, doi. 10.3389/fphar.2020.00420

By:

Tyson, Rachel J.;
Park, Christine C.;
Powell, J. Robert;
Patterson, J. Herbert;
Weiner, Daniel;
Watkins, Paul B.;
Gonzalez, Daniel

Publication type:

Article

Correction: Cytokine profiles in acute liver injury—Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group.

Published in:

2019

By:

Bonkovsky, Herbert L.;
Barnhart, Huiman X.;
Foureau, David M.;
Steuerwald, Nury;
Lee, William M.;
Gu, Jiezhun;
Fontana, Robert J.;
Hayashi, Paul H.;
Chalasani, Naga;
Navarro, Victor M.;
Odin, Joseph;
Stolz, Andrew;
Watkins, Paul B.;
Serrano, Jose

Publication type:

Correction Notice

Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis.

Published in:

PLoS ONE, 2019, v. 14, n. 01, p. 1, doi. 10.1371/journal.pone.0208958

By:

Norona, Leah M.;
Nguyen, Deborah G.;
Gerber, David A.;
Presnell, Sharon C.;
Mosedale, Merrie;
Watkins, Paul B.

Publication type:

Article

Cytokine profiles in acute liver injury—Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group.

Published in:

PLoS ONE, 2018, v. 13, n. 10, p. 1, doi. 10.1371/journal.pone.0206389

By:

Bonkovsky, Herbert L.;
Barnhart, Huiman X.;
Foureau, David M.;
Steuerwald, Nury;
Lee, William M.;
Gu, Jiezhun;
Fontana, Robert J.;
Hayashi, Paul J.;
Chalasani, Naga;
Navarro, Victor M.;
Odin, Joseph;
Stolz, Andrew;
Watkins, Paul B.;
Serrano, Jose;
null, null

Publication type:

Article

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.

Published in:

Nature Genetics, 2001, v. 27, n. 4, p. 383, doi. 10.1038/86882

By:

Kuehl, Peter;
Zhang, Jiong;
Lin, Yvonne;
Lamba, Jatinder;
Assem, Mahfoud;
Schuetz, John;
Watkins, Paul B.;
Daly, Ann;
Wrighton, Steven A.;
Hall, Stephen D.;
Maurel, Patrick;
Relling, Mary;
Brimer, Cynthia;
Yasuda, Kazuto;
Venkataramanan, Raman;
Strom, Stephen;
Thummel, Kenneth;
Boguski, Mark S.;
Schuetz, Erin

Publication type:

Article

Improving Interpretation of New and Old Serum Biomarkers of Drug‐Induced Liver Injury Through Mechanistic Modeling.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 6, p. 357, doi. 10.1002/psp4.12303

By:

Watkins, Paul B.

Publication type:

Article

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury.

Published in:

Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00240

By:

Woodhead, Jeffrey L.;
Kyunghee Yang;
Siler, Scott Q.;
Watkins, Paul B.;
Brouwer, Kim L. R.;
Barton, Hugh A.;
Howel, Brett A.;
Maggi, Adriana;
Lohman, Rink-Jan

Publication type:

Article

Profiles of Serum Cytokines in Acute Drug-Induced Liver Injury and Their Prognostic Significance.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0081974

By:

Steuerwald, Nury M.;
Foureau, David M.;
Norton, H. James;
Zhou, Jie;
Parsons, Judith C.;
Chalasani, Naga;
Fontana, Robert J.;
Watkins, Paul B.;
Lee, William M.;
Reddy, K. Rajender;
Stolz, Andrew;
Talwalkar, Jayant;
Davern, Timothy;
Saha, Dhanonjoy;
Bell, Lauren N.;
Barnhart, Huiman;
Gu, Jiezhun;
Serrano, Jose;
Bonkovsky, Herbert L.

Publication type:

Article

Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses.

Published in:

Gene Regulation & Systems Biology, 2017, n. 11, p. 1, doi. 10.1177/1177625017696074

By:

Shoda, Lisl K. M.;
Battista, Christina;
Siler, Scott Q.;
Pisetsky, David S.;
Watkins, Paul B.;
Howell, Brett A.

Publication type:

Article

Descending paralysis resulting from occult wound botulism.

Published in:

Annals of Neurology, 1984, v. 16, n. 3, p. 359, doi. 10.1002/ana.410160314

By:

Rapoport, Samuel;
Watkins, Paul B.

Publication type:

Article

Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia.

Published in:

Journal of Clinical Investigation, 2006, v. 116, n. 6, p. 1703, doi. 10.1172/JCI27793

By:

Changcheng Zhou;
Assem, Mahfoud;
Tay, Jessica C.;
Watkins, Paul B.;
Blumberg, Bruce;
Schuetz, Erin G.;
Thummel, Kenneth E.

Publication type:

Article

Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges.

Published in:

2008

By:

Wilke, Russell A.;
Lin, Debbie W.;
Roden, Dan M.;
Watkins, Paul B.;
Flockhart, David;
Zineh, Issam;
Giacomini, Kathleen M.;
Krauss, Ronald M.

Publication type:

Correction Notice

Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges.

Published in:

2007

By:

Wilke, Russell A.;
Lin, Debbie W.;
Roden, Dan M.;
Watkins, Paul B.;
Flockhart, David;
Zineh, Issam;
Giacomini, Kathleen M.;
Krauss, Ronald M.

Publication type:

journal article

The Environmental Polymorphisms Registry: a DNA resource to study genetic susceptibility loci.

Published in:

Human Genetics, 2008, v. 123, n. 2, p. 207, doi. 10.1007/s00439-007-0457-5

By:

Chulada, Patricia C.;
Vahdat, Heather L.;
Sharp, Richard R.;
DeLozier, Tracy C.;
Watkins, Paul B.;
Pusek, Susan N.;
Blackshear, Perry J.

Publication type:

Article

Benign elevations in serum aminotransferases and biomarkers of hepatotoxicity in healthy volunteers treated with cholestyramine.

Published in:

BMC Pharmacology & Toxicology, 2014, v. 15, n. 1, p. 42, doi. 10.1186/2050-6511-15-42

By:

Rohit Singhal, Rohit Singhal;
Harrill, Alison H.;
Menguy-Vacheron, Francoise;
Jayyosi, Zaid;
Benzerdjeb, Hadj;
Watkins, Paul B.

Publication type:

Article

Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease.

Published in:

JAMA: Journal of the American Medical Association, 1994, v. 271, n. 13, p. 992, doi. 10.1001/jama.1994.03510370044030

By:

Watkins, Paul B.;
Zimmerman, Hyman J.

Publication type:

Article

Serum biomarkers of drug‐induced liver injury: Current status and future directions.

Published in:

Journal of Digestive Diseases, 2019, v. 20, n. 1, p. 2, doi. 10.1111/1751-2980.12684

By:

Church, Rachel J.;
Watkins, Paul B.

Publication type:

Article

Understanding hepatotoxicity - from patients to mice to computer.

Published in:

2012

By:

Watkins, Paul B.

Publication type:

Abstract

The new revolution in toxicology: The good, the bad, and the ugly.

Published in:

Annals of the New York Academy of Sciences, 2013, v. 1278, n. 1, p. 11, doi. 10.1111/nyas.12086

By:

Davis, Myrtle;
Boekelheide, Kim;
Boverhof, Darrell R.;
Eichenbaum, Gary;
Hartung, Thomas;
Holsapple, Michael P.;
Jones, Thomas W.;
Richard, Ann M.;
Watkins, Paul B.

Publication type:

Article

The transformation in biomarker detection and management of drug-induced liver injury.

Published in:

Liver International, 2017, v. 37, n. 11, p. 1582, doi. 10.1111/liv.13441

By:

Church, Rachel J.;
Watkins, Paul B.

Publication type:

Article

Profiles of mi RNAs in serum in severe acute drug induced liver injury and their prognostic significance.

Published in:

Liver International, 2017, v. 37, n. 5, p. 757, doi. 10.1111/liv.13312

By:

Russo, Mark W.;
Steuerwald, Nury;
Norton, Harry J.;
Anderson, William E.;
Foureau, David;
Chalasani, Naga;
Fontana, Robert J.;
Watkins, Paul B.;
Serrano, Jose;
Bonkovsky, Herbert L.

Publication type:

Article

Keratin-18 and micro RNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts.

Published in:

Liver International, 2014, v. 34, n. 3, p. 367, doi. 10.1111/liv.12322

By:

Thulin, Petra;
Nordahl, Gunnar;
Gry, Marcus;
Yimer, Getnet;
Aklillu, Eleni;
Makonnen, Eyasu;
Aderaye, Getachew;
Lindquist, Lars;
Mattsson, C. Mikael;
Ekblom, Björn;
Antoine, Daniel J.;
Park, B. Kevin;
Linder, Stig;
Harrill, Alison H.;
Watkins, Paul B.;
Glinghammar, Björn;
Schuppe‐Koistinen, Ina

Publication type:

Article

Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition.

Published in:

Frontiers in Pharmacology, 2023, v. 14, p. 1, doi. 10.3389/fphar.2022.1085621

By:

Beaudoin, James J.;
Yang, Kyunghee;
Adiwidjaja, Jeffry;
Taneja, Guncha;
Watkins, Paul B.;
Siler, Scott Q.;
Howell, Brett A.;
Woodhead, Jeffrey L.

Publication type:

Article

Cannabidiol and Abnormal Liver Chemistries in Healthy Adults: Results of a Phase I Clinical Trial.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 5, p. 1224, doi. 10.1002/cpt.2071

By:

Watkins, Paul B.;
Church, Rachel J.;
Li, Jie;
Knappertz, Volker

Publication type:

Article

Genetic Risk Factors in Drug‐Induced Liver Injury Due to Isoniazid‐Containing Antituberculosis Drug Regimens.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 4, p. 1125, doi. 10.1002/cpt.2100

By:

Nicoletti, Paola;
Devarbhavi, Harshad;
Goel, Ashish;
Venkatesan, Radha;
Eapen, Chundamannil E.;
Grove, Jane I.;
Zafer, Samreen;
Bjornsson, Einar;
Lucena, M. Isabel;
Andrade, Raul J.;
Pirmohamed, Munir;
Wadelius, Mia;
Larrey, Dominique;
Maitland‐van der Zee, Anke‐Hilse;
Ibanez, Luisa;
Watkins, Paul B;
Daly, Ann K.;
Aithal, Guruprasad P.

Publication type:

Article

Quantitative Systems Toxicology Modeling Predicts that Reduced Biliary Efflux Contributes to Tolvaptan Hepatotoxicity.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 2, p. 433, doi. 10.1002/cpt.2007

By:

Beaudoin, James J.;
Brock, William J.;
Watkins, Paul B.;
Brouwer, Kim L. R.

Publication type:

Article

Next‐Generation DILI Biomarkers: Prioritization of Biomarkers for Qualification and Best Practices for Biospecimen Collection in Drug Development.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 2, p. 333, doi. 10.1002/cpt.1571

By:

Roth, Sharin E.;
Avigan, Mark I.;
Bourdet, David;
Brott, David;
Church, Rachel;
Dash, Ajit;
Keller, Douglas;
Sherratt, Philip;
Watkins, Paul B.;
Westcott‐Baker, Lucas;
Lentini, Silvia;
Merz, Michael;
Ramaiah, Lila;
Ramaiah, Shashi K.;
Stanley, Ann Marie;
Marcinak, John

Publication type:

Article

A Rapid Method to Estimate Hepatocyte Loss Due to Drug‐Induced Liver Injury.

Published in:

Clinical Pharmacology & Therapeutics, 2019, v. 105, n. 3, p. 746, doi. 10.1002/cpt.1254

By:

Chung, Jae‐Yong;
Longo, Diane M.;
Watkins, Paul B.

Publication type:

Article

Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective.

Published in:

Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 5, p. 916, doi. 10.1002/cpt.1222

By:

Kenna, J. Gerry;
Lai, Yurong;
Maher, Jonathan;
Pak, Y. Anne;
Pedersen, Jenny M.;
Polli, Joseph W.;
Rodrigues, A. David;
Watkins, Paul B.;
Yucha, Robert W.;
Taskar, Kunal S.;
Battista, Christina;
Yang, Kyunghee;
Bourdet, David L.;
Brouwer, Kim L.R.;
Brouwer, Kenneth R.;
Dai, David;
Funk, Christoph;
Hafey, Michael J.

Publication type:

Article

MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype*.

Published in:

Clinical Pharmacology & Therapeutics, 2006, v. 79, n. 4, p. 325, doi. 10.1016/j.clpt.2005.11.013

By:

Lamba, Jatinder;
Strom, Stephen;
Venkataramanan, Raman;
Thummel, Kenneth E.;
Lin, Yvonne S.;
Wei Liu;
Cheng Cheng;
Lamba, Vishal;
Watkins, Paul B.;
Schuetz, Erin

Publication type:

Article

Variation in oral clearance of saquinavir is predicted by CYP3A5*1 genotype but not by enterocyte content of cytochrome P450 3A5

Published in:

Clinical Pharmacology & Therapeutics, 2005, v. 78, n. 6, p. 605, doi. 10.1016/j.clpt.2005.08.014

By:

Mouly, Stéphane J.;
Matheny, Chris;
Paine, Mary F.;
Smith, Glenn;
Lamba, Jatinder;
Lamba, Vishal;
Pusek, Susan N.;
Schuetz, Erin G.;
Stewart, Paul W.;
Watkins, Paul B.

Publication type:

Article

6′7′-Dihydroxybergamottin Contributes to the Grapefruit Juice Effect*.

Published in:

Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 6, p. 569, doi. 10.1016/j.clpt.2004.02.007

By:

Kakar, Shefali M.;
Paine, Mary F.;
Stewart, Paul W.;
Watkins, Paul B.

Publication type:

Article

Cytochrome P450 3A4 and P-glycoprotein mediate the interaction between an oral erythromycin breath test and rifampin*.

Published in:

Clinical Pharmacology & Therapeutics, 2002, v. 72, n. 5, p. 524, doi. 10.1067/mcp.2002.128387

By:

Paine, Mary F.;
Wagner, David A.;
Hoffmaster, Keith A.;
Watkins, Paul B.

Publication type:

Article

Hepatic but not intestinal CYP3A4 displays dose-dependent induction by efavirenz in humans*.

Published in:

Clinical Pharmacology & Therapeutics, 2002, v. 72, n. 1, p. 1, doi. 10.1067/mcp.2002.124519

By:

Mouly, Stéphane;
Lown, Kenneth S.;
Kornhauser, David;
Joseph, Jeffrey L.;
Fiske, William D.;
Benedek, Irma H.;
Watkins, Paul B.

Publication type:

Article

Erythromycin breath test.

Published in:

Clinical Pharmacology & Therapeutics, 2001, v. 70, n. 4, p. 395, doi. 10.1016/S0009-9236(01)90132-8

By:

Rivory, Laurent P.;
Watkins, Paul B.

Publication type:

Article

Seville orange juice-felodipine interaction: Comparison with dilute grapefruit juice and involvement of furocoumarins*.

Published in:

Clinical Pharmacology & Therapeutics, 2001, v. 69, n. 1, p. 14, doi. 10.1067/mcp.2001.113185

By:

Malhotra, Shefali;
Bailey, David G.;
Paine, Mary F.;
Watkins, Paul B.

Publication type:

Article

Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults*.

Published in:

Clinical Pharmacology & Therapeutics, 2000, v. 67, n. 6, p. 591, doi. 10.1067/mcp.2000.106574

By:

Thummel, Kenneth E.;
Slattery, John T.;
Ro, Howard;
Chien, Jenny Y.;
Nelson, Sidney D.;
Lown, Kenneth E.;
Watkins, Paul B.

Publication type:

Article

Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity.

Published in:

Pharmacology Research & Perspectives, 2019, v. 7, n. 6, p. 1, doi. 10.1002/prp2.523

By:

Generaux, Grant;
Lakhani, Vinal V.;
Yuching Yang;
Nadanaciva, Sashi;
Luping Qiu;
Riccardi, Keith;
Li Di;
Howell, Brett A.;
Siler, Scott Q.;
Watkins, Paul B.;
Barton, Hugh A.;
Aleo, Michael D.;
Shoda, Lisl K. M.

Publication type:

Article

Pilot study of rosiglitazone as an in vivo probe of paclitaxel exposure.

Published in:

British Journal of Clinical Pharmacology, 2012, v. 74, n. 1, p. 197, doi. 10.1111/j.1365-2125.2012.04165.x

By:

Hertz, Daniel L.;
Walko, Christine M.;
Bridges, Arlene S.;
Hull, J. Heyward;
Herendeen, Jill;
Rollins, Kristan;
Watkins, Paul B.;
Dees, E. Claire

Publication type:

Article

Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?

Published in:

British Journal of Clinical Pharmacology, 2002, v. 54, n. 6, p. 643, doi. 10.1046/j.1365-2125.2002.01687.x

By:

Wanwimolruk, Sompon;
Paine, Mary F.;
Pusek, Susan N.;
Watkins, Paul B.

Publication type:

Article

Correction to: Liver Safety of Fasiglifam (TAK-875) in Patients with Type 2 Diabetes: Review of the Global Clinical Trial Experience.

Published in:

2018

By:

Marcinak, John F.;
Munsaka, Melvin S.;
Watkins, Paul B.;
Ohira, Takashi;
Smith, Neila

Publication type:

journal article

Liver Safety of Fasiglifam (TAK-875) in Patients with Type 2 Diabetes: Review of the Global Clinical Trial Experience.

Published in:

2018

By:

Marcinak, John F.;
Munsaka, Melvin S.;
Watkins, Paul B.;
Ohira, Takashi;
Smith, Neila

Publication type:

journal article

Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database.

Published in:

2015

By:

Watkins, Paul;
Lewis, James;
Kaplowitz, Neil;
Alpers, David;
Blais, Jaime;
Smotzer, Dan;
Krasa, Holly;
Ouyang, John;
Torres, Vicente;
Czerwiec, Frank;
Zimmer, Christopher;
Watkins, Paul B;
Lewis, James H;
Alpers, David H;
Blais, Jaime D;
Smotzer, Dan M;
Torres, Vicente E;
Czerwiec, Frank S;
Zimmer, Christopher A

Publication type:

journal article

Liver safety assessment in special populations (hepatitis B, C, and oncology trials).

Published in:

2014

By:

Kullak-Ublick, Gerd A;
Merz, Michael;
Griffel, Louis;
Kaplowitz, Neil;
Watkins, Paul B

Publication type:

journal article

Causality assessment for suspected DILI during clinical phases of drug development.

Published in:

2014

By:

Regev, Arie;
Seeff, Leonard B;
Merz, Michael;
Ormarsdottir, Sif;
Aithal, Guruprasad P;
Gallivan, Jim;
Watkins, Paul B

Publication type:

journal article

Methodology to assess clinical liver safety data.

Published in:

2014

By:

Merz, Michael;
Lee, Kwan R;
Kullak-Ublick, Gerd A;
Brueckner, Andreas;
Watkins, Paul B

Publication type:

journal article

Liver safety assessment: required data elements and best practices for data collection and standardization in clinical trials.

Published in:

2014

By:

Avigan, Mark I;
Bjornsson, Einar S;
Pasanen, Markku;
Cooper, Charles;
Andrade, Raul J;
Watkins, Paul B;
Lewis, James H;
Merz, Michael

Publication type:

journal article

The clinical liver safety assessment best practices workshop: rationale, goals, accomplishments and the future.

Published in:

2014

By:

Watkins, Paul B;
Merz, Michael;
Avigan, Mark I;
Kaplowitz, Neil;
Regev, Arie;
Senior, John R

Publication type:

journal article