Works by Wanrooij, Sjoerd

Results: 27

Activating AMPK improves pathological phenotypes due to mtDNA depletion.

Published in:

FEBS Journal, 2025, v. 292, n. 9, p. 2359, doi. 10.1111/febs.70006

By:

Carvalho, Gustavo;
Nguyen, Tran V. H.;
Repolês, Bruno;
Forslund, Josefin M. E.;
Wijethunga, W. M. Ruchitha Rukmal;
Ranjbarian, Farahnaz;
Mendes, Isabela C.;
Gorospe, Choco Michael;
Chaudhari, Namrata;
Falabella, Micol;
Doimo, Mara;
Wanrooij, Sjoerd;
Pitceathly, Robert D. S.;
Hofer, Anders;
Wanrooij, Paulina H.

Publication type:

Article

TEFM facilitates transition from RNA synthesis to DNA synthesis at H-strand replication origin of mtDNA.

Published in:

Communications Biology, 2025, p. 1, doi. 10.1038/s42003-025-07645-4

By:

Matsuda, Shigeru;
Nakayama, Masunari;
Do, Yura;
Ishiuchi, Takashi;
Yagi, Mikako;
Wanrooij, Sjoerd;
Nakada, Kazuto;
Wei, Fan-Yan;
Ichiyanagi, Kenji;
Sasaki, Hiroyuki;
Kang, Dongchon;
Yasukawa, Takehiro

Publication type:

Article

Photoactivated Colibactin Probes Induce Cellular DNA Damage.

Published in:

Angewandte Chemie, 2019, v. 131, n. 5, p. 1431, doi. 10.1002/ange.201812326

By:

Moodie, Lindon W. K.;
Hubert, Madlen;
Zhou, Xin;
Albers, Michael F.;
Lundmark, Richard;
Wanrooij, Sjoerd;
Hedberg, Christian

Publication type:

Article

The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 19, p. 6458, doi. 10.1093/nar/gkm676

By:

Hyvärinen, Anne K.;
Pohjoismäki, Jaakko L. O.;
Reyes, Aurelio;
Wanrooij, Sjoerd;
Yasukawa, Takehiro;
Karhunen, Pekka J.;
Spelbrink, Johannes N.;
Holt, Ian J.;
Jacobs, Howard T.

Publication type:

Article

Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 10, p. 3238, doi. 10.1093/nar/gkm215

By:

Wanrooij, Sjoerd;
Goffart, Steffi;
Pohjoismäki, Jaakko L.O.;
Yasukawa, Takehiro;
Spelbrink, Johannes N.

Publication type:

Article

Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells.

Published in:

Nucleic Acids Research, 2006, v. 34, n. 20, p. 5815

By:

Pohjoismäki, Jaakko L. O.;
Wanrooij, Sjoerd;
Hyvärinen, Anne K.;
Goffart, Steffi;
Holt, Ian J.;
Spelbrink, Johannes N.;
Jacobs, Howard T.

Publication type:

Article

Twinkle and POLG defects enhance age‐dependent accumulation of mutations in the control region of mtDNA.

Published in:

Nucleic Acids Research, 2004, v. 32, n. 10, p. 3053, doi. 10.1093/nar/gkh634

By:

Wanrooij, Sjoerd;
Luoma, Petri;
van Goethem, Gert;
van Broeckhoven, Christine;
Suomalainen, Anu;
Spelbrink, Johannes N.

Publication type:

Article

What causes mitochondrial DNA deletions in human cells?

Published in:

Nature Genetics, 2008, v. 40, n. 3, p. 275, doi. 10.1038/ng.f.94

By:

Krishnan, Kim J.;
Reeve, Amy K.;
Samuels, David C.;
Chinnery, Patrick F.;
Blackwood, John K.;
Taylor, Robert W.;
Wanrooij, Sjoerd;
Spelbrink, Johannes N.;
Lightowlers, Robert N.;
Turnbull, Doug M.

Publication type:

Article

Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria.

Published in:

Nature Genetics, 2001, v. 28, n. 3, p. 223, doi. 10.1038/90058

By:

Spelbrink, Johannes N.;
Li, Fang-Yuan;
Tiranti, Valeria;
Nikali, Kaisu;
Yuan, Qiu-Ping;
Tariq, Muhammed;
Wanrooij, Sjoerd;
Garrido, Nuria;
Comi, Giacomo;
Morandi, Lucia;
Santoro, Lucio;
Toscano, Antonio;
Fabrizi, Gian-Maria;
Somer, Hannu;
Croxen, Rebecca;
Beeson, David;
Poulton, Joanna;
Suomalainen, Anu;
Jacobs, Howard T

Publication type:

Article

In Vivo Occupancy of Mitochondrial Single-Stranded DNA Binding Protein Supports the Strand Displacement Mode of DNA Replication.

Published in:

PLoS Genetics, 2014, v. 10, n. 12, p. 1, doi. 10.1371/journal.pgen.1004832

By:

Miralles Fusté, Javier;
Shi, Yonghong;
Wanrooij, Sjoerd;
Zhu, Xuefeng;
Jemt, Elisabeth;
Persson, Örjan;
Sabouri, Nasim;
Gustafsson, Claes M.;
Falkenberg, Maria

Publication type:

Article

Unravelling the Therapeutic Potential of Antibiotics in Hypoxia in a Breast Cancer MCF-7 Cell Line Model.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 14, p. 11540, doi. 10.3390/ijms241411540

By:

Akhunzianov, Almaz A.;
Nesterova, Alfiya I.;
Wanrooij, Sjoerd;
Filina, Yulia V.;
Rizvanov, Albert A.;
Miftakhova, Regina R.

Publication type:

Article

Human Polymerase δ-Interacting Protein 2 (PolDIP2) Inhibits the Formation of Human Tau Oligomers and Fibrils.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 11, p. 5768, doi. 10.3390/ijms22115768

By:

Kasho, Kazutoshi;
Krasauskas, Lukas;
Smirnovas, Vytautas;
Stojkovič, Gorazd;
Morozova-Roche, Ludmilla A.;
Wanrooij, Sjoerd

Publication type:

Article

DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol.

Published in:

International Journal of Molecular Sciences, 2017, v. 18, n. 7, p. 1584, doi. 10.3390/ijms18071584

By:

Boldinova, Elizaveta O.;
Wanrooij, Paulina H.;
Shilkin, Evgeniy S.;
Wanrooij, Sjoerd;
Makarova, Alena V.

Publication type:

Article

Optimization of the expression, purification and polymerase activity reaction conditions of recombinant human PrimPol.

Published in:

PLoS ONE, 2017, v. 12, n. 9, p. 1, doi. 10.1371/journal.pone.0184489

By:

Boldinova, Elizaveta O.;
Stojkovič, Gorazd;
Khairullin, Rafil;
Wanrooij, Sjoerd;
Makarova, Alena V.

Publication type:

Article

Photoactivated Colibactin Probes Induce Cellular DNA Damage.

Published in:

Angewandte Chemie International Edition, 2019, v. 58, n. 5, p. 1417, doi. 10.1002/anie.201812326

By:

Moodie, Lindon W. K.;
Hubert, Madlen;
Zhou, Xin;
Albers, Michael F.;
Lundmark, Richard;
Wanrooij, Sjoerd;
Hedberg, Christian

Publication type:

Article

Preferential binding of ADP‐bound mitochondrial HSP70 to the nucleotide exchange factor GRPEL1 over GRPEL2.

Published in:

Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 11, p. 1, doi. 10.1002/pro.5190

By:

Manjunath, Pooja;
Stojkovič, Gorazd;
Euro, Liliya;
Konovalova, Svetlana;
Wanrooij, Sjoerd;
Koski, Kristian;
Tyynismaa, Henna

Publication type:

Article

Known Unknowns of Mammalian Mitochondrial DNA Maintenance.

Published in:

BioEssays, 2018, v. 40, n. 9, p. 1, doi. 10.1002/bies.201800102

By:

Pohjoismäki, Jaakko L. O.;
Forslund, Josefin M. E.;
Goffart, Steffi;
Torregrosa‐Muñumer, Rubén;
Wanrooij, Sjoerd

Publication type:

Article

Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells.

Published in:

Nucleic Acids Research, 2023, v. 51, n. 14, p. 7392, doi. 10.1093/nar/gkad535

By:

Doimo, Mara;
Chaudhari, Namrata;
Abrahamsson, Sanna;
L'Hôte, Valentin;
Nguyen, Tran V H;
Berner, Andreas;
Ndi, Mama;
Abrahamsson, Alva;
Das, Rabindra Nath;
Aasumets, Koit;
Goffart, Steffi;
Pohjoismäki, Jaakko L O;
López, Marcela Dávila;
Chorell, Erik;
Wanrooij, Sjoerd

Publication type:

Article

Motif WFYY of human PrimPol is crucial to stabilize the incoming 3′-nucleotide during replication fork restart.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 14, p. 8199, doi. 10.1093/nar/gkab634

By:

Calvo, Patricia A;
Martínez-Jiménez, María I;
Díaz, Marcos;
Stojkovic, Gorazd;
Kasho, Kazutoshi;
Guerra, Susana;
Wanrooij, Sjoerd;
Méndez, Juan;
Blanco, Luis

Publication type:

Article

A unique arginine cluster in PolDIP2 enhances nucleotide binding and DNA synthesis by PrimPol.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 4, p. 2179, doi. 10.1093/nar/gkab049

By:

Kasho, Kazutoshi;
Stojkovič, Gorazd;
Velázquez-Ruiz, Cristina;
Martínez-Jiménez, Maria Isabel;
Doimo, Mara;
Laurent, Timothée;
Berner, Andreas;
Pérez-Rivera, Aldo E;
Jenninger, Louise;
Blanco, Luis;
Wanrooij, Sjoerd

Publication type:

Article

A two-nuclease pathway involving RNase H1 is required for primer removal at human mitochondrial OriL.

Published in:

Nucleic Acids Research, 2018, v. 46, n. 18, p. 9471, doi. 10.1093/nar/gky708

By:

Al-Behadili, Ali;
Uhler, Jay P;
Berglund, Anna-Karin;
Peter, Bradley;
Doimo, Mara;
Reyes, Aurelio;
Wanrooij, Sjoerd;
Zeviani, Massimo;
Falkenberg, Maria

Publication type:

Article

The presence of rNTPs decreases the speed of mitochondrial DNA replication.

Published in:

PLoS Genetics, 2018, v. 14, n. 3, p. 1, doi. 10.1371/journal.pgen.1007315

By:

Forslund, Josefin M. E.;
Pfeiffer, Annika;
Stojkovič, Gorazd;
Wanrooij, Paulina H.;
Wanrooij, Sjoerd

Publication type:

Article

In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication.

Published in:

EMBO Reports, 2012, v. 13, n. 12, p. 1130, doi. 10.1038/embor.2012.161

By:

Wanrooij, Sjoerd;
Miralles Fusté, Javier;
Stewart, James B;
Wanrooij, Paulina H;
Samuelsson, Tore;
Larsson, Nils-Göran;
Gustafsson, Claes M;
Falkenberg, Maria

Publication type:

Article

Oxidative DNA damage stalls the human mitochondrial replisome.

Published in:

Scientific Reports, 2016, p. 28942, doi. 10.1038/srep28942

By:

Stojkovič, Gorazd;
Makarova, Alena V.;
Wanrooij, Paulina H.;
Forslund, Josefin;
Burgers, Peter M.;
Wanrooij, Sjoerd

Publication type:

Article

ATPase-deficient mitochondrial inner membrane protein ATAD3A disturbs mitochondrial dynamics in dominant hereditary spastic paraplegia.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 8, p. 1432, doi. 10.1093/hmg/ddx042

By:

Cooper, Helen M.;
Yang Yang;
Ylikallio, Emil;
Khairullin, Rafil;
Woldegebriel, Rosa;
Kai-Lan Lin;
Euro, Liliya;
Palin, Eino;
Wolf, Alexander;
Trokovic, Ras;
Isohanni, Pirjo;
Kaakkola, Seppo;
Auranen, Mari;
Lönnqvist, Tuula;
Wanrooij, Sjoerd;
Tyynismaa, Henna

Publication type:

Article

Sequence-specific stalling of DNA polymerase γ and the effects of mutations causing progressive ophthalmoplegia†.

Published in:

Human Molecular Genetics, 2011, v. 20, n. 6, p. 1212, doi. 10.1093/hmg/ddq565

By:

Atanassova, Neli;
Fusté, Javier Miralles;
Wanrooij, Sjoerd;
Macao, Bertil;
Goffart, Steffi;
Bäckström, Stefan;
Farge, Geraldine;
Khvorostov, Ivan;
Larsson, Nils-Göran;
Spelbrink, Johannes N.;
Falkenberg, Maria

Publication type:

Article

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling.

Published in:

Human Molecular Genetics, 2009, v. 18, n. 2, p. 328, doi. 10.1093/hmg/ddn359

By:

Goffart, Steffi;
Cooper, Helen M.;
Tyynismaa, Henna;
Wanrooij, Sjoerd;
Suomalainen, Anu;
Spelbrink, Johannes N.

Publication type:

Article