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Amyloid β Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization.
- Published in:
- Journal of Neuroscience, 2008, v. 28, n. 16, p. 4231, doi. 10.1523/JNEUROSCI.5161-07.2008
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- Publication type:
- Article
Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway.
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- Journal of Neuroscience, 2007, v. 27, n. 11, p. 2866, doi. 10.1523/JNEUROSCI.4970-06.2007
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- Publication type:
- Article
Certain Inhibitors of Synthetic Amyloid β-Peptide (Aβ) Fibrillogenesis Block Oligomerization of Natural Aβ and Thereby Rescue Long-Term Potentiation.
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- Journal of Neuroscience, 2005, v. 25, n. 10, p. 2455, doi. 10.1523/JNEUROSCI.4391-04.2005
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- Publication type:
- Article
Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5.
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- Journal of Neuroscience, 2004, v. 24, n. 13, p. 3370, doi. 10.1523/JNEUROSCI.1633-03.2004
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- Publication type:
- Article
Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies.
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- Biochemical Journal, 2014, v. 461, n. 3, p. 413, doi. 10.1042/BJ20140219
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- Publication type:
- Article
Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease.
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- EMBO Journal, 2011, v. 30, n. 11, p. 2255, doi. 10.1038/emboj.2011.138
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- Publication type:
- Article
NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease Progression.
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- Cells (2073-4409), 2021, v. 10, n. 12, p. 3514, doi. 10.3390/cells10123514
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- Publication type:
- Article
Natural oligomers of the amyloid-ßprotein specifically disrupt cognitive function.
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- Nature Neuroscience, 2005, v. 8, n. 1, p. 79, doi. 10.1038/nn1372
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- Publication type:
- Article
A highly sensitive novel immunoassay specifically detects low levels of soluble Aß oligomers in human cerebrospinal fluid.
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- Alzheimer's Research & Therapy, 2015, v. 7, n. 1, p. 1, doi. 10.1186/s13195-015-0100-y
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- Publication type:
- Article
Plasma NT1 Tau is a Specific and Early Marker of Alzheimer's Disease.
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- Annals of Neurology, 2020, v. 88, n. 5, p. 878, doi. 10.1002/ana.25885
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- Publication type:
- Article
Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid.
- Published in:
- 2019
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- Publication type:
- journal article
MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways.
- Published in:
- Acta Neuropathologica, 2018, v. 136, n. 4, p. 537, doi. 10.1007/s00401-018-1880-5
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- Publication type:
- Article
Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain.
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- Acta Neuropathologica, 2018, v. 136, n. 1, p. 19, doi. 10.1007/s00401-018-1846-7
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- Publication type:
- Article
mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo.
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- Nature Communications, 2014, v. 5, n. 3, p. 3374, doi. 10.1038/ncomms4374
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- Publication type:
- Article
Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity.
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- Nature Communications, 2013, v. 4, n. 9, p. 2416, doi. 10.1038/ncomms3416
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- Publication type:
- Article
Exosomes neutralize synaptic-plasticity-disrupting activity of Abeta assemblies in vivo.
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- Molecular Brain, 2013, v. 6, n. 1, p. 1, doi. 10.1186/1756-6606-6-47
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- Publication type:
- Article
A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils.
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- Nature Structural Biology, 2000, v. 7, n. 12, p. 1095, doi. 10.1038/81937
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- Publication type:
- Article
Aggregation and Metal-Binding Properties of Mutant Forms of the Amyloid Aβ Peptide of Alzheimer's Disease.
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- Journal of Neurochemistry, 1996, v. 66, n. 2, p. 740, doi. 10.1046/j.1471-4159.1996.66020740.x
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- Publication type:
- Article
Small-molecule conversion of toxic oligomers to nontoxic ?-sheet-rich amyloid fibrils.
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- Nature Chemical Biology, 2012, v. 8, n. 1, p. 93, doi. 10.1038/nchembio.719
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- Publication type:
- Article
PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins.
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- Acta Neuropathologica, 2020, v. 139, n. 3, p. 503, doi. 10.1007/s00401-019-02114-9
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- Publication type:
- Article
Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid-β Aggregates.
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- Advanced Healthcare Materials, 2015, v. 4, n. 14, p. 2100, doi. 10.1002/adhm.201500487
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- Publication type:
- Article
Alzheimer's Disease: Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid-β Aggregates (Adv. Healthcare Mater. 14/2015).
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- Advanced Healthcare Materials, 2015, v. 4, n. 14, p. 2049, doi. 10.1002/adhm.201570081
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- Publication type:
- Article
The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons.
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- Human Molecular Genetics, 2014, v. 23, n. 13, p. 3523, doi. 10.1093/hmg/ddu064
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- Publication type:
- Article
De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease.
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- Human Molecular Genetics, 2013, v. 22, n. 15, p. 3077, doi. 10.1093/hmg/ddt164
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- Publication type:
- Article
Human Anti-Aβ IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide.
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- PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0050317
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- Publication type:
- Article
Methods for the isolation and analysis of Aβ from postmortem brain.
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- Frontiers in Neuroscience, 2023, v. 17, p. 1, doi. 10.3389/fnins.2023.1108715
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- Publication type:
- Article
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.
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- Nature Medicine, 2008, v. 14, n. 8, p. 837, doi. 10.1038/nm1782
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- Publication type:
- Article
Amyloidßprotein immunotherapy neutralizes Aßoligomers that disrupt synaptic plasticity in vivo.
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- Nature Medicine, 2005, v. 11, n. 5, p. 556, doi. 10.1038/nm1234
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- Publication type:
- Article
C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death.
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- Journal of Neuroscience, 2015, v. 35, n. 30, p. 10851, doi. 10.1523/JNEUROSCI.0387-15.2015
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- Publication type:
- Article
A Human Monoclonal IgG That Binds Aβ Assemblies and Diverse Amyloids Exhibits Anti-Amyloid Activities In Vitro and In Vivo.
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- Journal of Neuroscience, 2015, p. 6265, doi. 10.1523/JNEUROSCI.5109-14.2015
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- Publication type:
- Article
Peripheral Administration of a Humanized Anti-PrP Antibody Blocks Alzheimer's Disease Aβ Synaptotoxicity.
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- Journal of Neuroscience, 2014, v. 34, n. 18, p. 6140, doi. 10.1523/JNEUROSCI.3526-13.2014
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- Publication type:
- Article
Alzheimer's Disease Brain-Derived Amyloid-β-Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein.
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- Journal of Neuroscience, 2011, v. 31, n. 20, p. 7259, doi. 10.1523/JNEUROSCI.6500-10.2011
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- Publication type:
- Article
Amyloid β-Protein Dimers Rapidly Form Stable Synaptotoxic Protofibrils.
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- Journal of Neuroscience, 2010, v. 30, n. 43, p. 14411, doi. 10.1523/JNEUROSCI.3537-10.2010
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- Publication type:
- Article
Baseline characteristics from TANGO: Phase 2 study to evaluate gosuranemab (BIIB092) in patients with early Alzheimer's disease: Human: Improving clinical trial methodology.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.044910
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- Publication type:
- Article
Transcriptomic correlates of neurite degeneration due to human brain‐derived Aβ and protection by clinical anti‐Aβ antibodies: Molecular and cell biology/APP/Abeta/amyloid.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.043057
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- Publication type:
- Article
Learnings about the complexity of extracellular tau aid development of a blood‐based screen for Alzheimer's disease.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, n. 3, p. 487, doi. 10.1016/j.jalz.2018.09.010
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- Publication type:
- Article
DT‐02‐03: TARGET ENGAGEMENT IN AN AD TRIAL: CRENEZUMAB LOWERS Aβ OLIGOMER LEVELS IN CSF.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1669, doi. 10.1016/j.jalz.2018.07.012
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- Publication type:
- Article
P1‐301: CERTAIN PLASMA N‐TERMINAL TAU FRAGMENTS ARE ELEVATED IN AD AND AD‐MCI COMPARED TO CONTROLS.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P405, doi. 10.1016/j.jalz.2018.06.308
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- Publication type:
- Article
P1‐106: A HEAD‐TO‐HEAD COMPARISON OF LEAD CLINICAL ANTI‐Aβ ANTIBODIES.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P312, doi. 10.1016/j.jalz.2018.06.109
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- Publication type:
- Article
MEDI1814, A HIGH-AFFINITY ANTIBODY DIRECTED TO THE C-TERMINUS OF AβX-42, ABROGATES SYNAPTIC PLASTICITY DISRUPTION CAUSED BY SYNTHETIC OR AD BRAIN-DERIVED Aβ SOLUBLE ASSEMBLIES IN VIVO.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P943, doi. 10.1016/j.jalz.2017.06.1849
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- Publication type:
- Article
A NOVEL PARADIGM FOR THE IDENTIFICATION AND TARGETING OF BIOACTIVE ABETA SPECIES FROM ALZHEIMER BRAIN.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P1037, doi. 10.1016/j.jalz.2016.06.2148
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- Publication type:
- Article
The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 11, p. 1286, doi. 10.1016/j.jalz.2015.01.005
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- Publication type:
- Article
Getting a handle on soluble aß in Alzheimer’s disease brains.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P304, doi. 10.1016/j.jalz.2015.07.427
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- Publication type:
- Article
New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2013, v. 9, n. 2, p. 99, doi. 10.1016/j.jalz.2012.11.005
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- Publication type:
- Article
Soluble Aβ from PSAPP mice is different to that extracted from Alzheimer patients
- Published in:
- 2010
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- Publication type:
- Abstract
P3-415: The presence of Abeta dimers in soluble brain extract is associated with dementia
- Published in:
- 2008
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- Publication type:
- Abstract
P2-461: Selective modulation of gamma-secretase cleavage of the amyloid precursor family of proteins
- Published in:
- 2008
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- Publication type:
- Abstract
P2-422: Co-polymeric nanoparticles inhibit Abeta fibrillogenesis
- Published in:
- 2008
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- Publication type:
- Abstract
P1-368: Monomeric and oligmeric Aβ assays on plasma of Alzheimer patients
- Published in:
- 2008
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- Publication type:
- Abstract
O2-02-02: Soluble amyloid β-protein dimers isolated directly from Alzheimer's disease patients potently impair synaptic plasticity and memory
- Published in:
- 2008
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- Publication type:
- Abstract