Works by Walsh, Christopher A.

Results: 316

High-resolution detection of copy number alterations in single cells with HiScanner.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60446-5

By:

Zhao, Yifan;
Luquette, Lovelace J.;
Veit, Alexander D.;
Wang, Xiaochen;
Xi, Ruibin;
Viswanadham, Vinayak V.;
Zhang, Yuwei;
Shao, Diane D.;
Walsh, Christopher A.;
Yang, Hong Wei;
Johnson, Mark D.;
Park, Peter J.

Publication type:

Article

Quantifying the success of stormwater control measure networks using effective imperviousness.

Published in:

PLoS Water, 2025, v. 4, n. 6, p. 1, doi. 10.1371/journal.pwat.0000335

By:

Bhaskar, Aditi S.;
Stillwell, Charles C.;
Burns, Matthew J.;
Hopkins, Kristina G.;
Walsh, Christopher J.

Publication type:

Article

Accelerated Evolution of the ASPM Gene Controlling Brain Size Begins Prior to Human Brain Expansion.

Published in:

PLoS Biology, 2004, v. 2, n. 5, p. 653, doi. 10.1371/journal.pbio.0020126

By:

Kouprina, Natalay;
Pavlicek, Adam;
Mochida, Ganeshwaran H.;
Solomon, Gregory;
Gersch, William;
Young-Ho Yoon;
Collura, Randall;
Ruvolo, Maryellen;
Barrett, J. Carl;
Woods, C. Geoffrey;
Walsh, Christopher A.;
Jurka, Jerzy;
Larionov, Vladimir

Publication type:

Article

Accelerated Evolution of the ASPM Gene Controlling Brain Size Begins Prior to Human Brain Expansion.

Published in:

PLoS Biology, 2004, v. 2, n. 3, p. 1, doi. 10.1371/journal.pbio.0020126

By:

Kouprina, Natalay;
Pavlicek, Adam;
Mochida, Ganeshwaran H;
Solomon, Gregory;
Gersch, William;
Yoon, Young-Ho;
Collura, Randall;
Ruvolo, Maryellen;
Barrett, J. Carl;
Woods, C. Geoffrey;
Walsh, Christopher A;
Jurka, Jerzy;
Larionov, Vladimir

Publication type:

Article

Posttranslationale Proteinmodifikation: die Chemie der Proteomdiversifizierung.

Published in:

Angewandte Chemie, 2005, v. 117, n. 45, p. 7508, doi. 10.1002/ange.200501023

By:

Christopher T. Walsh;
Sylvie Garneau-Tsodikova;
Gregory J. Gatto

Publication type:

Article

Peptidyl Thiophenols as Substrates for Nonribosomal Peptide Cyclases (We gratefully acknowledge the Studienstiftung des deutschen Volkes (S.A.S.), Deutsche Forschungsgemeinschaft (M.A.M.), and National Institutes of Health (grant no. GM20011; C.T.W.). We thank Dirk Schwarzer for helpful comments, Uwe Linne for MS/MS sequencing, Christina Dauth for her help with the synthesis, and Antje Schäfer for technical assistance. J.T. thanks Kim Albizati, Van Martin, and Shanghui Hu for their generous support of his Pfizer secondment.)

Published in:

Angewandte Chemie, 2004, v. 116, n. 4, p. 499, doi. 10.1002/ange.200352787

By:

Stephan A. Sieber;
Junhua Tao;
Christopher T. Walsh;
Mohamed A. Marahiel

Publication type:

Article

Characterization of NovP and NovN: Completion of Novobiocin Biosynthesis by Sequential Tailoring of the Noviosyl Ring ( We gratefully acknowledge the National Institutes of Health Grants 49338 (to C.T.W.), 66174 (to D.K.), and AI054007-01 (to C.L.F.M.). The contribution of X.H. and L.H. was supported by a grant from the Deutsche Forschungsgemeinschaft. )

Published in:

Angewandte Chemie, 2004, v. 116, n. 1, p. 69, doi. 10.1002/ange.200352626

By:

Caren L. Freel Meyers;
Markus Oberthür;
Hui Xu;
Lutz Heide;
Daniel Kahne;
Christopher T. Walsh

Publication type:

Article

Analysis of denitrifying communities in streams from an urban and non-urban catchment.

Published in:

Aquatic Ecology, 2008, v. 42, n. 1, p. 95

By:

Gavin Rees;
Christopher Walsh

Publication type:

Article

The Influence of Urban Density and Drainage Infrastructure on the Concentrations and Loads of Pollutants in Small Streams Stream Pollutants and Urbanization.

Published in:

Environmental Management, 2004, v. 34, n. 1, p. 112, doi. 10.1007/s00267-004-0221-8

By:

Hatt, Belinda E.;
Fletcher, Tim D.;
Walsh, Christopher J.;
Taylor, Sally L.

Publication type:

Article

Chemical Biology: Here to Stay?

Published in:

Israel Journal of Chemistry, 2019, v. 59, n. 1/2, p. 7, doi. 10.1002/ijch.201800004

By:

Walsh, Christopher T

Publication type:

Article

Understanding and managing the interactive impacts of growth in urban land use and climate change on freshwater biota: A case study using the platypus (Ornithorhynchus anatinus).

Published in:

Global Change Biology, 2022, v. 28, n. 4, p. 1287, doi. 10.1111/gcb.16015

By:

Coleman, Rhys A.;
Chee, Yung En;
Bond, Nick R.;
Weeks, Andrew;
Griffiths, Josh;
Serena, Melody;
Williams, Geoff A.;
Walsh, Christopher J.

Publication type:

Article

Efficacy of EHL N9-GP for on-demand treatment of bleeding episodes in hemophilia B: analysis of pivotal trial data.

Published in:

Journal of Blood Medicine, 2019, v. 10, p. 243, doi. 10.2147/JBM.S212690

By:

Escobar, Miguel A;
Walsh, Christopher E;
Cooper, David L;
Young, Guy

Publication type:

Article

Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52443-x

By:

Barão, Soraia;
Xu, Yijun;
Llongueras, José P.;
Vistein, Rachel;
Goff, Loyal;
Nielsen, Kristina J.;
Bae, Byoung-Il;
Smith, Richard S.;
Walsh, Christopher A.;
Stein-O'Brien, Genevieve;
Müller, Ulrich

Publication type:

Article

Insights into the gyrification of developing ferret brain by magnetic resonance imaging.

Published in:

Journal of Anatomy, 2007, v. 210, n. 1, p. 66, doi. 10.1111/j.1469-7580.2006.00674.x

By:

Neal, Jason;
Takahashi, Masaya;
Silva, Matthew;
Tiao, Grace;
Walsh, Christopher A.;
Sheen, Volney L.

Publication type:

Article

Clonal mixing, clonal restriction, and specification of cell types in the developing rat olfactory bulb.

Published in:

Journal of Comparative Neurology, 1999, v. 403, n. 1, p. 106, doi. 10.1002/(SICI)1096-9861(19990105)403:1<106::AID-CNE8>3.0.CO;2-S

By:

Reid,†, Christopher B.;
Liang,†, Ivan;
Walsh, Christopher A.

Publication type:

Article

New antibiotics from bacterial natural products.

Published in:

Nature Biotechnology, 2006, v. 24, n. 12, p. 1541, doi. 10.1038/nbt1266

By:

Clardy, Jon;
Fischbach, Michael A.;
Walsh, Christopher T.

Publication type:

Article

Predictability of European winter 2022/23.

Published in:

Atmospheric Science Letters (John Wiley & Sons, Inc. ), 2024, v. 25, n. 12, p. 1, doi. 10.1002/asl.1275

By:

Stringer, Nicky;
Scaife, Adam A.;
Bulmer, Chris;
Davies, Paul;
Dunstone, Nick;
Gordon, Margaret;
Ineson, Sarah;
Knight, Jeff;
Mancell, Joseph;
McLean, Peter;
Smith, Doug;
Walker, Brent;
Walsh, Christopher

Publication type:

Article

Diverse genomic alterations in single neurons after chronic brain trauma.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.091891

By:

Miller, Michael B;
Ma, Chanthia;
Dong, Guanlan;
Naik, Samuel;
McDonough, Gannon;
Mao, Shulin;
McKee, Ann C.;
Huang, August Yue;
Lee, Eunjung Alice;
Walsh, Christopher A

Publication type:

Article

The ILAE consensus classification of focal cortical dysplasia: An update proposed by an ad hoc task force of the ILAE diagnostic methods commission.

Published in:

Epilepsia (Series 4), 2022, v. 63, n. 8, p. 1899, doi. 10.1111/epi.17301

By:

Najm, Imad;
Lal, Dennis;
Alonso Vanegas, Mario;
Cendes, Fernando;
Lopes‐Cendes, Iscia;
Palmini, Andre;
Paglioli, Eliseu;
Sarnat, Harvey B.;
Walsh, Christopher A.;
Wiebe, Samuel;
Aronica, Eleonora;
Baulac, Stéphanie;
Coras, Roland;
Kobow, Katja;
Cross, J. Helen;
Garbelli, Rita;
Holthausen, Hans;
Rössler, Karl;
Thom, Maria;
El‐Osta, Assam

Publication type:

Article

Toward a better definition of focal cortical dysplasia: An iterative histopathological and genetic agreement trial.

Published in:

Epilepsia (Series 4), 2021, v. 62, n. 6, p. 1416, doi. 10.1111/epi.16899

By:

Blümcke, Ingmar;
Coras, Roland;
Busch, Robyn M.;
Morita‐Sherman, Marcia;
Lal, Dennis;
Prayson, Richard;
Cendes, Fernando;
Lopes‐Cendes, Iscia;
Rogerio, Fabio;
Almeida, Vanessa S.;
Rocha, Cristiane S.;
Sim, Nam Suk;
Lee, Jeong Ho;
Kim, Se Hoon;
Baulac, Stephanie;
Baldassari, Sara;
Adle‐Biassette, Homa;
Walsh, Christopher A.;
Bizzotto, Sara;
Doan, Ryan N.

Publication type:

Article

Homozygous PLCB1 deletion associated with malignant migrating partial seizures in infancy.

Published in:

Epilepsia (Series 4), 2012, v. 53, n. 8, p. e146, doi. 10.1111/j.1528-1167.2012.03538.x

By:

Poduri, Annapurna;
Chopra, Sameer S.;
Neilan, Edward G.;
Christina Elhosary, P.;
Kurian, Manju A.;
Meyer, Esther;
Barry, Brenda J.;
Khwaja, Omar S.;
Salih, Mustafa A. M.;
Stödberg, Tommy;
Scheffer, Ingrid E.;
Maher, Eamonn R.;
Sahin, Mustafa;
Wu, Bai-Lin;
Berry, Gerard T.;
Walsh, Christopher A.;
Picker, Jonathan;
Kothare, Sanjeev V.

Publication type:

Article

Rare genetic causes of lissencephaly may implicate microtubule-based transport in the pathogenesis of cortical dysplasias.

Published in:

Epilepsia (Series 4), 2010, v. 51, p. 67, doi. 10.1111/j.1528-1167.2010.02853.x

By:

Liu, Judy S.;
Walsh, Christopher A.

Publication type:

Article

Genetic malformations of the human frontal lobe.

Published in:

Epilepsia (Series 4), 2010, v. 51, p. 13, doi. 10.1111/j.1528-1167.2009.02435.x

By:

Amrom, Dina;
Walsh, Christopher A.

Publication type:

Article

Bilateral frontoparietal polymicrogyria, Lennox-Gastaut syndrome, and GPR56 gene mutations.

Published in:

Epilepsia (Series 4), 2009, v. 50, n. 6, p. 1344, doi. 10.1111/j.1528-1167.2008.01787.x

By:

Parrini, Elena;
Ferrari, Anna Rita;
Dorn, Thomas;
Walsh, Christopher A.;
Guerrini, Renzo

Publication type:

Article

Periventricular Heterotopia: New Insights into Ehlers-Danlos Syndrome.

Published in:

Clinical Medicine & Research, 2005, v. 3, n. 4, p. 229, doi. 10.3121/cmr.3.4.229

By:

Sheen, Volney L.;
Walsh, Christopher A.

Publication type:

Article

Toward efficient analysis of <70 kDa proteins with 100% sequence coverage.

Published in:

Proteomics, 2001, v. 1, n. 8, p. 927, doi. 10.1002/1615-9861(200108)1:8<927::AID-PROT927>3.0.CO;2-T

By:

Forbes, Andrew J.;
Mazur, Matthew T.;
Patel, Hiten M.;
Walsh, Christopher T.;
Kelleher, Neil L.

Publication type:

Article

Enzymkaskadenreaktionen in der Biosynthese.

Published in:

Angewandte Chemie, 2019, v. 131, n. 21, p. 6918, doi. 10.1002/ange.201807844

By:

Walsh, Christopher T.;
Moore, Bradley S.

Publication type:

Article

Time-shared HSQC-NOESY for accurate distance constraints measured at high-field in 15N-13C-ILV methyl labeled proteins.

Published in:

Journal of Biomolecular NMR, 2009, v. 45, n. 3, p. 311, doi. 10.1007/s10858-009-9372-5

By:

Frueh, Dominique;
Leed, Alison;
Arthanari, Haribabu;
Koglin, Alexander;
Walsh, Christopher;
Wagner, Gerhard

Publication type:

Article

Impediments and Solutions to Sustainable, Watershed-Scale Urban Stormwater Management: Lessons from Australia and the United States.

Published in:

Environmental Management, 2008, v. 42, n. 2, p. 344, doi. 10.1007/s00267-008-9119-1

By:

Roy, Allison;
Wenger, Seth;
Fletcher, Tim;
Walsh, Christopher;
Ladson, Anthony;
Shuster, William;
Thurston, Hale;
Brown, Rebekah

Publication type:

Article

Impact of inhibitors on hemophilia a mortality in the United States.

Published in:

American Journal of Hematology, 2015, v. 90, n. 5, p. 400, doi. 10.1002/ajh.23957

By:

Walsh, Christopher E.;
Soucie, J. Michael;
Miller, Connie H.

Publication type:

Article

Eradication of factor viii inhibitors in patients with mild and moderate hemophilia A.

Published in:

American Journal of Hematology, 2012, v. 87, n. 9, p. 933, doi. 10.1002/ajh.23269

By:

Kempton, Christine L.;
Allen, Geoff;
Hord, Jeffrey;
Kruse-Jarres, Rebecca;
Pruthi, Rajiv K.;
Walsh, Christopher;
Young, Guy;
Soucie, J. Michael

Publication type:

Article

Structural basis for the selectivity of the external thioesterase of the surfactin synthetase.

Published in:

Nature, 2008, v. 454, n. 7206, p. 907, doi. 10.1038/nature07161

By:

Koglin, Alexander;
Löhr, Frank;
Bernhard, Frank;
Rogov, Vladimir V.;
Frueh, Dominique P.;
Strieter, Eric R.;
Mofid, Mohammad R.;
Güntert, Peter;
Wagner, Gerhard;
Walsh, Christopher T.;
Marahiel, Mohamed A.;
Dötsch, Volker

Publication type:

Article

Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase.

Published in:

Nature, 2008, v. 454, n. 7206, p. 903, doi. 10.1038/nature07162

By:

Frueh, Dominique P.;
Arthanari, Haribabu;
Koglin, Alexander;
Vosburg, David A.;
Bennett, Andrew E.;
Walsh, Christopher T.;
Wagner, Gerhard

Publication type:

Article

A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines.

Published in:

Nature, 2007, v. 448, n. 7155, p. 824, doi. 10.1038/nature06068

By:

Fortin, Pascal D.;
Walsh, Christopher T.;
Magarvey, Nathan A.

Publication type:

Article

BluB cannibalizes flavin to form the lower ligand of vitamin B12.

Published in:

2007

By:

Taga, Michiko E.;
Larsen, Nicholas A.;
Howard-Jones, Annaleise R.;
Walsh, Christopher T.;
Walker, Graham C.

Publication type:

Letter

Chemical biology: A sweet exchange.

Published in:

Nature, 2006, v. 443, n. 7109, p. 285, doi. 10.1038/443285a

By:

Walsh, Christopher T.

Publication type:

Article

Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis.

Published in:

Nature, 2006, v. 440, n. 7082, p. 368, doi. 10.1038/nature04544

By:

Blasiak, Leah C.;
Vaillancourt, Frédéric H.;
Walsh, Christopher T.;
Drennan, Catherine L.

Publication type:

Article

Molecular insights into human brain evolution.

Published in:

Nature, 2005, v. 437, n. 7055, p. 64, doi. 10.1038/nature04103

By:

Hill, Robert Sean;
Walsh, Christopher A.

Publication type:

Article

Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis.

Published in:

Nature, 2005, v. 436, n. 7054, p. 1191, doi. 10.1038/nature03797

By:

Vaillancourt, Frédéric H.;
Yeh, Ellen;
Vosburg, David A.;
O'Connor, Sarah E.;
Walsh, Christopher T.

Publication type:

Article

Lessons from natural molecules.

Published in:

Nature, 2004, v. 432, n. 7019, p. 829, doi. 10.1038/nature03194

By:

Clardy, Jon;
Walsh, Christopher

Publication type:

Article

The leader peptide is essential for the post-translational modification of the DNA-gyrase inhibitor microcin B17.

Published in:

Molecular Microbiology, 1997, v. 23, n. 1, p. 161, doi. 10.1046/j.1365-2958.1997.2041565.x

By:

Madison, Lara L.;
Vivas, Eugenio I.;
Yue-Ming Li;
Walsh, Christopher T.;
Kolter, Roberto

Publication type:

Article

Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 14, p. 6608, doi. 10.1093/nar/gks318

By:

Reynolds, John J.;
Walker, Alexandra K.;
Gilmore, Edward C.;
Walsh, Christopher A.;
Caldecott, Keith W.

Publication type:

Article

oPOSSUM: identification of over-represented transcription factor binding sites in co-expressed genes.

Published in:

Nucleic Acids Research, 2005, v. 33, n. 10, p. 3154, doi. 10.1093/nar/gki624

By:

Ho Sui, Shannan J.;
Mortimer, James R.;
Arenillas, David J.;
Brumm, Jochen;
Walsh, Christopher J.;
Kennedy, Brian P.;
Wasserman, Wyeth W.

Publication type:

Article

Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30968-3

By:

Lim, Elaine T.;
Chan, Yingleong;
Dawes, Pepper;
Guo, Xiaoge;
Erdin, Serkan;
Tai, Derek J. C.;
Liu, Songlei;
Reichert, Julia M.;
Burns, Mannix J.;
Chan, Ying Kai;
Chiang, Jessica J.;
Meyer, Katharina;
Zhang, Xiaochang;
Walsh, Christopher A.;
Yankner, Bruce A.;
Raychaudhuri, Soumya;
Hirschhorn, Joel N.;
Gusella, James F.;
Talkowski, Michael E.;
Church, George M.

Publication type:

Article

16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23113-z

By:

Sundberg, Maria;
Pinson, Hannah;
Smith, Richard S.;
Winden, Kellen D.;
Venugopal, Pooja;
Tai, Derek J. C.;
Gusella, James F.;
Talkowski, Michael E.;
Walsh, Christopher A.;
Tegmark, Max;
Sahin, Mustafa

Publication type:

Article

Genetic causes of microcephaly and lessons for neuronal development.

Published in:

WIREs: Developmental Biology, 2013, v. 2, n. 4, p. 461, doi. 10.1002/wdev.89

By:

Gilmore, Edward C.;
Walsh, Christopher A.

Publication type:

Article

Whole-genome analysis reveals the contribution of non-coding de novo transposon insertions to autism spectrum disorder.

Published in:

Mobile DNA, 2021, v. 12, n. 1, p. 1, doi. 10.1186/s13100-021-00256-w

By:

Borges-Monroy, Rebeca;
Chu, Chong;
Dias, Caroline;
Choi, Jaejoon;
Lee, Soohyun;
Gao, Yue;
Shin, Taehwan;
Park, Peter J.;
Walsh, Christopher A.;
Lee, Eunjung Alice

Publication type:

Article

A recurrent de novo variant in NUSAP1 escapes nonsense‐mediated decay and leads to microcephaly, epilepsy, and developmental delay.

Published in:

Clinical Genetics, 2023, v. 104, n. 1, p. 73, doi. 10.1111/cge.14335

By:

Mo, Alisa;
Paz‐Ebstein, Emuna;
Yanovsky‐Dagan, Shira;
Lai, Abbe;
Mor‐Shaked, Hagar;
Gilboa, Tal;
Yang, Edward;
Shao, Diane D.;
Walsh, Christopher A.;
Harel, Tamar

Publication type:

Article

PDCD6IP, encoding a regulator of the ESCRT complex, is mutated in microcephaly.

Published in:

Clinical Genetics, 2020, v. 98, n. 1, p. 80, doi. 10.1111/cge.13756

By:

Khan, Amjad;
Alaamery, Manal;
Massadeh, Salam;
Obaid, Abdulrahman;
Kashgari, Amna A.;
Walsh, Christopher A.;
Eyaid, Wafaa

Publication type:

Article

Estimating nonlinear additive models with nonstationarities and correlated errors.

Published in:

Scandinavian Journal of Statistics, 2019, v. 46, n. 1, p. 160, doi. 10.1111/sjos.12342

By:

Vogt, Michael;
Walsh, Christopher

Publication type:

Article