Works matching AU Wagner, Kay‐Uwe

Results: 53

Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy.

Published in:

Journal of Hematology & Oncology, 2012, v. 5, n. 1, p. 68, doi. 10.1186/1756-8722-5-68

By:

Rachagani, Satyanarayana;
Torres, María P.;
Kumar, Sushil;
Haridas, Dhanya;
Baine, Michael;
Macha, Muzafar A.;
Kaur, Sukhwinder;
Ponnusamy, Moorthy P.;
Dey, Parama;
Seshacharyulu, Parthasarathy;
Johansson, Sonny L.;
Jain, Maneesh;
Wagner, Kay-Uwe;
Batra, Surinder K.

Publication type:

Article

AKT3 drives adenoid cystic carcinoma development in salivary glands.

Published in:

Cancer Medicine, 2018, v. 7, n. 2, p. 445, doi. 10.1002/cam4.1293

By:

Zboray, Katalin;
Mohrherr, Julian;
Stiedl, Patricia;
Pranz, Klemens;
Wandruszka, Laura;
Grabner, Beatrice;
Eferl, Robert;
Moriggl, Richard;
Stoiber, Dagmar;
Sakamoto, Kazuhito;
Wagner, Kay‐Uwe;
Popper, Helmut;
Casanova, Emilio;
Moll, Herwig P.

Publication type:

Article

Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23957-5

By:

Rädler, Patrick D.;
Wehde, Barbara L.;
Triplett, Aleata A.;
Shrestha, Hridaya;
Shepherd, Jonathan H.;
Pfefferle, Adam D.;
Rui, Hallgeir;
Cardiff, Robert D.;
Perou, Charles M.;
Wagner, Kay-Uwe

Publication type:

Article

Critical Role of Jak2 in the Maintenance and Function of Adult Hematopoietic Stem Cells.

Published in:

Stem Cells, 2014, v. 32, n. 7, p. 1878, doi. 10.1002/stem.1711

By:

Akada, Hajime;
Akada, Saeko;
Hutchison, Robert E.;
Sakamoto, Kazuhito;
Wagner, Kay-Uwe;
Mohi, Golam

Publication type:

Article

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

Published in:

Nature Genetics, 1999, v. 22, n. 1, p. 37, doi. 10.1038/8743

By:

Xu, Xiaoling;
Wagner, Kay-Uwe;
Larson, Denise;
Weaver, Zoë;
Li, Cuiling;
Ried, Thomas;
Hennighausen, Lothar;
Wynshaw-Boris, Anthony;
Deng, Chu-Xia

Publication type:

Article

Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 163, doi. 10.1172/JCI57292

By:

Hlady, Ryan A.;
Novakova, Slavomira;
Opavska, Jana;
Klinkebiel, David;
Peters, Staci L.;
Bies, Juraj;
Hannah, Jay;
Iqbal, Javeed;
Anderson, Kristi M.;
Siebler, Hollie M.;
Smith, Lynette M.;
Greiner, Timothy C.;
Bastola, Dhundy;
Joshi, Shantaram;
Lockridge, Oksana;
Simpson, Melanie A.;
Felsher, Dean W.;
Wagner, Kay-Uwe;
Chan, Wing C.;
Christman, Judith K.

Publication type:

Article

Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2.

Published in:

2011

By:

Sos, Brandon C.;
Charles Harris;
Nordstrom, Sarah M.;
Tran, Jennifer L.;
Balázs, Mercedesz;
Caplazi, Patrick;
Febbraio, Maria;
Applegate, Milana A. B.;
Wagner, Kay-Uwe;
Weiss, Ethan J.;
Harris, Charles;
Balázs, Mercedesz

Publication type:

journal article

Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species.

Published in:

Cardiovascular Research, 2011, v. 91, n. 1, p. 171, doi. 10.1093/cvr/cvr059

By:

Kirabo, Annet;
Kearns, Patrick N.;
Jarajapu, Yagna P.;
Sasser, Jennifer M.;
Oh, Suk Paul;
Grant, Maria B.;
Kasahara, Hideko;
Cardounel, Arturo J.;
Baylis, Chris;
Wagner, Kay-Uwe;
Sayeski, Peter P.

Publication type:

Article

Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03078-5

By:

Dotan, Idit;
Yang, Jiaqi;
Ikeda, Jiro;
Roth, Ziv;
Pollock-Tahiri, Evan;
Desai, Harsh;
Sivasubramaniyam, Tharini;
Rehal, Sonia;
Rapps, Josh;
Li, Yu Zhe;
Le, Helen;
Farber, Gedaliah;
Alchami, Edouard;
Xiao, Changting;
Karim, Saraf;
Gronda, Marcela;
Saikali, Michael F.;
Tirosh, Amit;
Wagner, Kay-Uwe;
Genest, Jacques

Publication type:

Article

Signal transducer and activator of transcription (Stat) 5 controls the proliferation and...

Published in:

Journal of Cell Biology, 2001, v. 155, n. 4, p. 531, doi. 10.1083/jcb.200107065

By:

Miyoshi, Keiko;
Shillingford, Jonathan M.;
Smith, Gilbert H.;
Grimm, Sandra L.;
Wagner, Kay-Uwe;
Oka, Takami;
Rosen, Jeffrey M.;
Robinson, Gertraud W.;
Hennighausen, Lothar

Publication type:

Article

Jak2 Is Necessary for Neuroendocrine Control of Female Reproduction.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 1, p. 184, doi. 10.1523/JNEUROSCI.2974-10.2011

By:

Sheng Wu;
Divall, Sara;
Hoffman, Gloria E.;
Wei Wei Le;
Wagner, Kay-Uwe;
Wolfe, Andrew

Publication type:

Article

Peripubertal requirement of Tsg101 in maintaining the integrity of membranous structures in mouse oocytes.

Published in:

Cell Proliferation, 2022, v. 55, n. 10, p. 1, doi. 10.1111/cpr.13288

By:

Shin, Hyejin;
Park, Dayoung;
Kim, Jiyeon;
Nam, Min‐Yeong;
Kwon, Sojung;
Um, Da‐Eun;
Oh, Ji‐Eun;
Youn, Esther;
Shim, Yhong‐Hee;
Wagner, Kay‐Uwe;
Jun, Jin Hyun;
Kim, Hye‐Ryun;
Song, Haengseok;
Lim, Hyunjung Jade

Publication type:

Article

Cre-mediated gene deletion in the mammary gland.

Published in:

Nucleic Acids Research, 1997, v. 25, n. Supplement, p. 4323, doi. 10.1093/nar/25.21.4323

By:

Wagner, Kay-Uwe;
Wall, Robert J.;
St-Onge, Luc;
Gruss, Peter;
Wynshaw-Boris, Anthony;
Garrett, Lisa;
Li, Minglin;
Furth, Priscilla A.;
Hennighausen, Lothar

Publication type:

Article

The Japanese Wild-Derived Inbred Mouse Strain, MSM/Ms in Cancer Research.

Published in:

Cancers, 2021, v. 13, n. 5, p. 1026, doi. 10.3390/cancers13051026

By:

Okumura, Kazuhiro;
Saito, Megumi;
Isogai, Eriko;
Wakabayashi, Yuichi;
Wagner, Kay-Uwe

Publication type:

Article

The Multifaceted Roles of the Tumor Susceptibility Gene 101 (TSG101) in Normal Development and Disease.

Published in:

Cancers, 2020, v. 12, n. 2, p. 450, doi. 10.3390/cancers12020450

By:

Ferraiuolo, Rosa-Maria;
Manthey, Karoline C.;
Stanton, Marissa J.;
Triplett, Aleata A.;
Wagner, Kay-Uwe

Publication type:

Article

Brca1-Deficient Murine Mammary Epithelial Cells Have Increased Sensitivity to CDDP and MMS.

Published in:

Cell Cycle, 2004, v. 3, n. 11, p. 1451, doi. 10.4161/cc.3.11.1211

By:

Sgagias, Magdalene K.;
Wagner, Kay-Uwe;
Hamik, Brad;
Stoeger, Scott;
Spieker, Rebecca;
Huber, L. Julie;
Chodosh, Lewis A.;
Cowan, Kenneth H.

Publication type:

Article

Tumor susceptibility gene 101 is required for the maintenance of uterine epithelial cells during embryo implantation.

Published in:

Reproductive Biology & Endocrinology, 2021, v. 19, n. 1, p. 1, doi. 10.1186/s12958-021-00788-z

By:

Byun, Hyunji;
Kwon, Sojung;
Wagner, Kay-Uwe;
Shin, Hyejin;
Lim, Hyunjung Jade

Publication type:

Article

Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.

Published in:

Molecular & Cellular Biology, 2016, v. 36, n. 11, p. 1673, doi. 10.1128/MCB.00999-15

By:

Sakamoto, Kazuhito;
Wehde, Barbara L.;
Kyung Hyun Yoo;
Taemook Kim;
Rajbhandari, Nirakar;
Ha Youn Shin;
Triplett, Aleata A.;
Rädler, Patrick D.;
Schuler, Fabian;
Villunger, Andreas;
Keunsoo Kang;
Hennighausen, Lothar;
Wagner, Kay-Uwe

Publication type:

Article

Stat5 Regulates the Phosphatidylinositol 3-Kinase/Akt1 Pathway during Mammary Gland Development and Tumorigenesis.

Published in:

Molecular & Cellular Biology, 2014, v. 34, n. 7, p. 1363, doi. 10.1128/MCB.01220-13

By:

Schmidt, Jeffrey W.;
Wehde, Barbara L.;
Kazuhito Sakamoto;
Triplett, Aleata A.;
Anderson, Steven M.;
Tsichlis, Philip N.;
Leone, Gustavo;
Wagner, Kay-Uwe

Publication type:

Article

Stat5 Promotes Survival of Mammary Epithelial Cells through Transcriptional Activation of a Distinct Promoter in Akt1.

Published in:

Molecular & Cellular Biology, 2010, v. 30, n. 12, p. 10, doi. 10.1128/MCB.00851-09

By:

Creamer, Bradley A.;
Sakamoto, Kazuhito;
Schmidt, Jeffrey W.;
Triplett, Aleata A.;
Moriggl, Richard;
Wagner, Kay-Uwe

Publication type:

Article

Corrigendum: The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.

Published in:

Nature Immunology, 2014, v. 15, n. 3, p. 305, doi. 10.1038/ni0314-305a

By:

Bell, Bryan D;
Kitajima, Masayuki;
Larson, Ryan P;
Stoklasek, Thomas A;
Dang, Kristen;
Sakamoto, Kazuhito;
Wagner, Kay-Uwe;
Reizis, Boris;
Hennighausen, Lothar;
Ziegler, Steven F

Publication type:

Article

The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.

Published in:

Nature Immunology, 2013, v. 14, n. 4, p. 364, doi. 10.1038/ni.2541

By:

Bell, Bryan D;
Kitajima, Masayuki;
Larson, Ryan P;
Stoklasek, Thomas A;
Dang, Kristen;
Sakamoto, Kazuhito;
Wagner, Kay-Uwe;
Reizis, Boris;
Hennighausen, Lothar;
Ziegler, Steven F

Publication type:

Article

Neuronal Deletion of Tumor Susceptibility Gene 101 (Tsg101) Causes Rapid Apoptotic Loss of Hippocampal CA3 Neurons.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 6, p. 786, doi. 10.3390/biom15060786

By:

Walker, Will P.;
Ratz-Mitchem, Megan Lea;
Wagner, Kay-Uwe;
Gunn, Teresa M.

Publication type:

Article

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets.

Published in:

Nature Communications, 2015, v. 6, n. 4, p. 6744, doi. 10.1038/ncomms7744

By:

Witkiewicz, Agnieszka K.;
McMillan, Elizabeth A.;
Balaji, Uthra;
Baek, GuemHee;
Lin, Wan-Chi;
Mansour, John;
Mollaee, Mehri;
Wagner, Kay-Uwe;
Koduru, Prasad;
Yopp, Adam;
Choti, Michael A.;
Yeo, Charles J.;
McCue, Peter;
White, Michael A.;
Knudsen, Erik S.

Publication type:

Article

Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy.

Published in:

Biology of the Cell (Wiley-Blackwell), 2016, v. 108, n. 11, p. 324, doi. 10.1111/boc.201600014

By:

Walker, Will P.;
Oehler, Abby;
Edinger, Aimee L.;
Wagner, Kay-Uwe;
Gunn, Teresa M.

Publication type:

Article

Activation of b-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation.

Published in:

Oncogene, 2003, v. 22, n. 25, p. 3875, doi. 10.1038/sj.onc.1206426

By:

Bierie, Brian;
Nozawa, Masahiro;
Renou, Jean-Pierre;
Shillingford, Jonathan M;
Morgan, Fanta;
Oka, Takami;
Taketo, Makoto M;
Cardiff, Robert D;
Miyoshi, Keiko;
Wagner, Kay-Uwe;
Robinson, Gertraud W;
Hennighausen, Lothar

Publication type:

Article

Functional mammary gland development and oncogene-induced tumor formation are not affected by the absence of the retinoblastoma gene.

Published in:

Oncogene, 2001, v. 20, n. 48, p. 7115, doi. 10.1038/sj.onc.1204888

By:

Robinson, Gertraud W;
Wagner, Kay-Uwe;
Hennighausen, Lothar

Publication type:

Article

Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: Common types of shorter transcripts are true alternative splice variants.

Published in:

Oncogene, 1998, v. 17, n. 21, p. 2761, doi. 10.1038/sj.onc.1202529

By:

Wagner, Kay-Uwe;
Dierisseau, Patricia;
B Rucker, Edmund;
Robinson, Gertraud W;
Hennighausen, Lothar

Publication type:

Article

Cellular Plasticity in Mammary Gland Development and Breast Cancer.

Published in:

Cancers, 2023, v. 15, n. 23, p. 5605, doi. 10.3390/cancers15235605

By:

Wicker, Madison N.;
Wagner, Kay-Uwe

Publication type:

Article

Exosomal microRNA in Pancreatic Cancer Diagnosis, Prognosis, and Treatment: From Bench to Bedside.

Published in:

Cancers, 2021, v. 13, n. 11, p. 2777, doi. 10.3390/cancers13112777

By:

Uddin, Md. Hafiz;
Al-Hallak, Mohammed Najeeb;
Philip, Philip A.;
Mohammad, Ramzi M.;
Viola, Nerissa;
Wagner, Kay-Uwe;
Azmi, Asfar S.

Publication type:

Article

Ectoderm specific deletion of Jak2 results in developmental and neuronal abnormalities (1121.4).

Published in:

FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.1121.4

By:

Park, Sung;
Wagner, Kay‐Uwe;
Sayeski, Peter

Publication type:

Article

Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cells.

Published in:

BMC Cancer, 2014, v. 14, n. 1, p. 1, doi. 10.1186/1471-2407-14-195

By:

Schmidt, Jeffrey W.;
Wehde, Barbara L.;
Kazuhito Sakamoto;
Triplett, Aleata A.;
West, William W.;
Wagner, Kay-Uwe

Publication type:

Article

Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cells.

Published in:

BMC Cancer, 2014, v. 14, p. 1, doi. 10.1186/1471-2407-14-195

By:

Schmidt, Jeffrey W.;
Wehde, Barbara L.;
Kazuhito Sakamoto;
Triplett, Aleata A.;
West, William W.;
Wagner, Kay-Uwe

Publication type:

Article

Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cells.

Published in:

2014

By:

Schmidt, Jeffrey W;
Wehde, Barbara L;
Sakamoto, Kazuhito;
Triplett, Aleata A;
West, William W;
Wagner, Kay-Uwe

Publication type:

journal article

Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax.

Published in:

Genesis: The Journal of Genetics & Development, 2011, v. 49, n. 1, p. 24, doi. 10.1002/dvg.20691

By:

Rucker, Edmund B.;
Hale, Amber N.;
Durtschi, David C.;
Sakamoto, Kazuhito;
Wagner, Kay-Uwe

Publication type:

Article

Temporally and spatially controlled expression of transgenes in embryonic and adult tissues.

Published in:

Transgenic Research, 2010, v. 19, n. 3, p. 499, doi. 10.1007/s11248-009-9329-1

By:

Zhang, Qian;
Triplett, Aleata A.;
Harms, Don W.;
Wan-Chi Lin;
Creamer, Bradley A.;
Rizzino, Angie;
Wagner, Kay-Uwe

Publication type:

Article

The transcription factor Sox10 is an essential determinant of branching morphogenesis and involution in the mouse mammary gland.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-74664-y

By:

Mertelmeyer, Svenja;
Weider, Matthias;
Baroti, Tina;
Reiprich, Simone;
Fröb, Franziska;
Stolt, C. Claus;
Wagner, Kay-Uwe;
Wegner, Michael

Publication type:

Article

Gain-of-Function of Stat5 Leads to Excessive Granulopoiesis and Lethal Extravasation of Granulocytes to the Lung.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0060902

By:

Lin, Wan-chi;
Schmidt, Jeffrey W.;
Creamer, Bradley A.;
Triplett, Aleata A.;
Wagner, Kay-Uwe

Publication type:

Article

Conditional Deletion of Jak2 Reveals an Essential Role in Hematopoiesis throughout Mouse Ontogeny: Implications for Jak2 Inhibition in Humans.

Published in:

PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0059675

By:

Park, Sung O.;
Wamsley, Heather L.;
Bae, Kyungmi;
Hu, Zhongbo;
Li, Xiaomiao;
Choe, Se-woon;
Slayton, William B.;
Oh, S. Paul;
Wagner, Kay-Uwe;
Sayeski, Peter P.

Publication type:

Article

Generation of a Novel MMTV-tTA Transgenic Mouse Strain for the Targeted Expression of Genes in the Embryonic and Postnatal Mammary Gland.

Published in:

PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0043778

By:

Sakamoto, Kazuhito;
Schmidt, Jeffrey W.;
Wagner, Kay-Uwe;
Xiuhcun Tian

Publication type:

Article

A Knockout of the Tsg101 Gene Leads to Decreased Expression of ErbB Receptor Tyrosine Kinases and Induction of Autophagy Prior to Cell Death.

Published in:

PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0034308

By:

Morris, Chantey R.;
Stanton, Marissa J.;
Manthey, Karoline C.;
Oh, Keon Bong;
Wagner, Kay-Uwe

Publication type:

Article

IRF4 Is a Suppressor of c-Myc Induced B Cell Leukemia.

Published in:

PLoS ONE, 2011, v. 6, n. 7, p. 1, doi. 10.1371/journal.pone.0022628

By:

Pathak, Simanta;
Ma, Shibin;
Trinh, Long;
Eudy, James;
Wagner, Kay-Uwe;
Joshi, Shantaram S.;
Lu, Runqing

Publication type:

Article

Models of pancreatic ductal adenocarcinoma.

Published in:

Cancer & Metastasis Reviews, 2021, v. 40, n. 3, p. 803, doi. 10.1007/s10555-021-09989-9

By:

Dennaoui, Rayane;
Shrestha, Hridaya;
Wagner, Kay-Uwe

Publication type:

Article

Genetically engineered mucin mouse models for inflammation and cancer.

Published in:

Cancer & Metastasis Reviews, 2015, v. 34, n. 4, p. 593, doi. 10.1007/s10555-015-9549-1

By:

Joshi, Suhasini;
Kumar, Sushil;
Bafna, Sangeeta;
Rachagani, Satyanarayana;
Wagner, Kay-Uwe;
Jain, Maneesh;
Batra, Surinder

Publication type:

Article

Dual recombinase action in the normal and neoplastic mammary gland epithelium.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-00231-8

By:

Rädler, Patrick D.;
Vistisen, Kerry;
Triplett, Aleata A.;
Dennaoui, Rayane;
Li, Yong;
Shrestha, Hridaya;
Ferraiuolo, Rosa-Maria;
Thangasamy, Amalraj;
Saur, Dieter;
Wagner, Kay-Uwe

Publication type:

Article

Deficiency in Mouse Oxytocin Prevents Milk Ejection,but not Fertility or Parturition.

Published in:

Journal of Neuroendocrinology, 1996, v. 8, n. 11, p. 847, doi. 10.1046/j.1365-2826.1996.05266.x

By:

Young III, W. Scott;
Shepard, Emily;
Amico, Janet;
Hennighausen, Lothar;
Wagner, Kay-Uwe;
LaMarca, Mary E.;
McKinney, Cindy;
Ginns, Edward I.

Publication type:

Article

Know thy cells: commonly used triple-negative human breast cancer cell lines carry mutations in RAS and effectors.

Published in:

2022

By:

Wagner, Kay-Uwe

Publication type:

Letter

BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia.

Published in:

Nature Chemical Biology, 2012, v. 8, n. 3, p. 285, doi. 10.1038/nchembio.775

By:

Hantschel, Oliver;
Warsch, Wolfgang;
Eckelhart, Eva;
Kaupe, Ines;
Grebien, Florian;
Wagner, Kay-Uwe;
Superti-Furga, Giulio;
Sexl, Veronika

Publication type:

Article

Tsg101 Is Essential for Cell Growth, Proliferation, and cell Survival of Embryonic and Adult Tissues.

Published in:

Molecular & Cellular Biology, 2003, v. 23, n. 1, p. 150, doi. 10.1128/MCB.23.1.150-162.2003

By:

Wagner, Kay-Uwe;
Krempler, Andrea;
Youngyue Qi;
KyungRan Park;
Henry, MaLinda D.;
Triplett, Aleata A.;
Riedlinger, Gregory;
Rucker III, Edmund B.;
Hennighausen, Lothar

Publication type:

Article

Generation of Janus kinase 1 (JAK1) conditional knockout mice.

Published in:

Genesis: The Journal of Genetics & Development, 2016, v. 54, n. 11, p. 582, doi. 10.1002/dvg.22982

By:

Sakamoto, Kazuhito;
Wehde, Barbara L.;
Rädler, Patrick D.;
Triplett, Aleata A.;
Wagner, Kay‐Uwe

Publication type:

Article