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Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure.
Published in:
Cardiovascular Diabetology, 2019, v. 18, n. 1, p. N.PAG, doi. 10.1186/s12933-019-0892-3
By:
- Uddin, Golam M.;
- Zhang, Liyan;
- Shah, Saumya;
- Fukushima, Arata;
- Wagg, Cory S.;
- Gopal, Keshav;
- Al Batran, Rami;
- Pherwani, Simran;
- Ho, Kim L.;
- Boisvenue, Jamie;
- Karwi, Qutuba G.;
- Altamimi, Tariq;
- Wishart, David S.;
- Dyck, Jason R. B.;
- Ussher, John R.;
- Oudit, Gavin Y.;
- Lopaschuk, Gary D.
Publication type:
Article
Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction.
Published in:
Cardiovascular Diabetology, 2019, v. 18, n. 1, p. 1, doi. 10.1186/s12933-019-0806-4
By:
- Karwi, Qutuba G.;
- Zhang, Liyan;
- Wagg, Cory S.;
- Wang, Wang;
- Ghandi, Manoj;
- Thai, Dung;
- Yan, Hai;
- Ussher, John R.;
- Oudit, Gavin Y.;
- Lopaschuk, Gary D.
Publication type:
Article
Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation.
Published in:
Cardiovascular Diabetology, 2023, v. 22, n. 1, p. 1, doi. 10.1186/s12933-023-01811-w
By:
- Gopal, Keshav;
- Karwi, Qutuba G.;
- Tabatabaei Dakhili, Seyed Amirhossein;
- Wagg, Cory S.;
- Zhang, Liyan;
- Sun, Qiuyu;
- Saed, Christina T.;
- Panidarapu, Sai;
- Perfetti, Riccardo;
- Ramasamy, Ravichandran;
- Ussher, John R.;
- Lopaschuk, Gary D.
Publication type:
Article
Weight loss enhances cardiac energy metabolism and function in heart failure associated with obesity.
Published in:
Diabetes, Obesity & Metabolism, 2019, v. 21, n. 8, p. 1944, doi. 10.1111/dom.13762
By:
- Karwi, Qutuba G.;
- Zhang, Liyan;
- Altamimi, Tariq R.;
- Wagg, Cory S.;
- Patel, Vaibhav;
- Uddin, Golam M.;
- Joerg, Alice R.;
- Padwal, Raj S.;
- Johnstone, David E.;
- Sharma, Arya;
- Oudit, Gavin Y.;
- Lopaschuk, Gary D.
Publication type:
Article
Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling.
Published in:
Cardiovascular Research, 2014, v. 103, n. 4, p. 485, doi. 10.1093/cvr/cvu156
By:
- Alrob, Osama Abo;
- Sankaralingam, Sowndramalingam;
- Ma, Cary;
- Wagg, Cory S.;
- Fillmore, Natasha;
- Jaswal, Jagdip S.;
- Sack, Michael N.;
- Lehner, Richard;
- Gupta, Mahesh P.;
- Michelakis, Evangelos D.;
- Padwal, Raj S.;
- Johnstone, David E.;
- Sharma, Arya M.;
- Lopaschuk, Gary D.
Publication type:
Article
Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation.
Published in:
Cardiovascular Research, 2014, v. 101, n. 1, p. 30, doi. 10.1093/cvr/cvt216
By:
- Masoud, Waleed G.T.;
- Ussher, John R.;
- Wang, Wei;
- Jaswal, Jagdip S.;
- Wagg, Cory S.;
- Dyck, Jason R.;
- Lygate, Craig A.;
- Neubauer, Stefan;
- Clanachan, Alexander S.;
- Lopaschuk, Gary D.
Publication type:
Article
Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury.
Published in:
Cardiovascular Research, 2012, v. 94, n. 2, p. 359, doi. 10.1093/cvr/cvs129
By:
- Ussher, John R.;
- Wang, Wei;
- Gandhi, Manoj;
- Keung, Wendy;
- Samokhvalov, Victor;
- Oka, Tatsujiro;
- Wagg, Cory S.;
- Jaswal, Jagdip S.;
- Harris, Robert A.;
- Clanachan, Alexander S.;
- Dyck, Jason R.B.;
- Lopaschuk, Gary D.
Publication type:
Article
Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice.
Published in:
Cardiovascular Research, 2009, v. 82, n. 1, p. 84, doi. 10.1093/cvr/cvp016
By:
- Theodore P. Abraham;
- Michelle Jones;
- Katarzyna Kazmierczak;
- Hsin-Yueh Liang;
- Aurelio C. Pinheiro;
- Cory S. Wagg;
- Gary D. Lopaschuk;
- Danuta Szczesna-Cordary
Publication type:
Article
Mitochondrial fatty acid oxidation is the major source of cardiac adenosine triphosphate production in heart failure with preserved ejection fraction.
Published in:
Cardiovascular Research, 2024, v. 120, n. 4, p. 360, doi. 10.1093/cvr/cvae006
By:
- Sun, Qiuyu;
- Güven, Berna;
- Wagg, Cory S;
- Oliveira, Amanda Almeida de;
- Silver, Heidi;
- Zhang, Liyan;
- Chen, Brandon;
- Wei, Kaleigh;
- Ketema, Ezra B;
- Karwi, Qutuba G;
- Persad, Kaya L;
- Vu, Jennie;
- Wang, Faqi;
- Dyck, Jason R B;
- Oudit, Gavin Y;
- Lopaschuk, Gary D
Publication type:
Article
Insulin directly stimulates mitochondrial glucose oxidation in the heart.
Published in:
Cardiovascular Diabetology, 2020, v. 19, n. 1, p. 1, doi. 10.1186/s12933-020-01177-3
By:
- Karwi, Qutuba G.;
- Wagg, Cory S.;
- Altamimi, Tariq R.;
- Uddin, Golam M.;
- Ho, Kim L.;
- Darwesh, Ahmed M.;
- Seubert, John M.;
- Lopaschuk, Gary D.
Publication type:
Article
Pharmacological Inhibition of Succinyl Coenzyme A:3-Ketoacid Coenzyme A Transferase Alleviates the Progression of Diabetic Cardiomyopathy.
Published in:
Journal of the American Heart Association, 2024, v. 13, n. 7, p. 1, doi. 10.1161/JAHA.123.032697
By:
- Greenwell, Amanda A.;
- Dakhili, Seyed Amirhossein Tabatabaei;
- Wagg, Cory S.;
- Saed, Christina T.;
- Chan, Jordan S. F.;
- Kunyan Yang;
- Mangra-Bala, Indiresh A.;
- Stenlund, Magnus J.;
- Eaton, Farah;
- Gopal, Keshav;
- Dyck, Jason R. B.;
- Lopaschuk, Gary D.;
- Ussher, John R.
Publication type:
Article
p53-Mediated Repression of the PGC1A (PPARG Coactivator 1α) and APLNR (Apelin Receptor) Signaling Pathways Limits Fatty Acid Oxidation Energetics: Implications for Cardio-oncology.
Published in:
2020
By:
- Saleme, Bruno;
- Das, Subhash K.;
- Yongneng Zhang;
- Boukouris, Aristeidis E.;
- Lorenzana Carrillo, Maria Areli;
- Jovel, Juan;
- Wagg, Cory S.;
- Lopaschuk, Gary D.;
- Michelakis, Evangelos D.;
- Sutendra, Gopinath;
- Zhang, Yongneng
Publication type:
Letter
Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction.
Published in:
Molecular Medicine, 2018, v. 24, n. 1, p. 1, doi. 10.1186/s10020-018-0005-x
By:
- Fillmore, Natasha;
- Levasseur, Jody L.;
- Fukushima, Arata;
- Wagg, Cory S.;
- Wei Wang;
- Dyck, Jason R. B.;
- Lopaschuk, Gary D.
Publication type:
Article
Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction.
Published in:
Frontiers in Physiology, 2022, v. 13, p. 1, doi. 10.3389/fphys.2022.892979
By:
- Mahmud, Zabed;
- Tikunova, Svetlana;
- Belevych, Natalya;
- Wagg, Cory S.;
- Zhabyeyev, Pavel;
- Liu, Philip B.;
- Rasicci, David V.;
- Yengo, Christopher M.;
- Oudit, Gavin Y.;
- Lopaschuk, Gary D.;
- Reiser, Peter J.;
- Davis, Jonathan P.;
- Hwang, Peter M.
Publication type:
Article
379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates.
Published in:
Diabetes, 2021, v. 70, p. N.PAG, doi. 10.2337/db21-379-P
By:
- GOPAL, KESHAV;
- KARWI, QUTUBA G.;
- DAKHILI, SEYED AMIRHOSSEIN TABATABAEI;
- WAGG, CORY S.;
- PERFETTI, RICCARDO;
- RAMASAMY, RAVICHANDRAN;
- USSHER, JOHN R.;
- LOPASCHUK, GARY
Publication type:
Article
Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice.
Published in:
2016
By:
- Ussher, John R.;
- Fillmore, Natasha;
- Keung, Wendy;
- Liyan Zhang;
- Mori, Jun;
- Sidhu, Vaninder K.;
- Fukushima, Arata;
- Gopal, Keshav;
- Lopaschuk, David G.;
- Wagg, Cory S.;
- Jaswal, Jagdip S.;
- Dyck, Jason R. B.;
- Lopaschuk, Gary D.;
- Zhang, Liyan
Publication type:
journal article
Lowering Body Weight in Obese Mice With Diastolic Heart Failure Improves Cardiac Insulin Sensitivity and Function: Implications for the Obesity Paradox.
Published in:
Diabetes, 2015, v. 64, n. 5, p. 1643, doi. 10.2337/db14-1050
By:
- Sankaralingam, Sowndramalingam;
- Alrob, Osama Abo;
- Liyan Zhang;
- Jaswal, Jagdip S.;
- Wagg, Cory S.;
- Fukushima, Arata;
- Padwal, Raj S.;
- Johnstone, David E.;
- Sharma, Arya M.;
- Lopaschuk, Gary D.
Publication type:
Article
Inhibition of Carnitine Palmitoyltransferase-1 Activity Alleviates Insulin Resistance in Diet-Induced Obese Mice.
Published in:
Diabetes, 2013, v. 62, n. 3, p. 711, doi. 10.2337/db12-0259
By:
- Keung, Wendy;
- Ussher, John R.;
- Jaswal, Jagdip S.;
- Raubenheimer, Monique;
- Lam, Victoria H. M.;
- Wagg, Cory S.;
- Lopaschuk, Gary D.
Publication type:
Article

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