Works by Waagepetersen, Helle S.

Results: 69

Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.

Published in:

Frontiers in Neuroscience, 2021, p. 1, doi. 10.3389/fnins.2021.646291

By:

Voss, Caroline M.;
Arildsen, Lene;
Nissen, Jakob D.;
Waagepetersen, Helle S.;
Schousboe, Arne;
Maechler, Pierre;
Ott, Peter;
Vilstrup, Hendrik;
Walls, Anne B.

Publication type:

Article

Deletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function.

Published in:

Journal of Neuroscience, 2019, v. 39, n. 25, p. 4847, doi. 10.1523/jneurosci.0894-18.2019

By:

McNair, Laura F.;
Andersen, Jens V.;
Aldana, Blanca I.;
Hohnholt, Michaela C.;
Nissen, Jakob D.;
Yan Sun;
Fischer, Kathryn D.;
Sonnewald, Ursula;
Nyberg, Nils;
Webster, Sophie C.;
Kapur, Kush;
Rimmele, Theresa S.;
Barone, Ilaria;
Hawks-Mayer, Hannah;
Lipton, Jonathan O.;
Hodgson, Nathaniel W.;
Hensch, Takao K.;
Aoki, Chiye J.;
Rosenberg, Paul A.;
Waagepetersen, Helle S.

Publication type:

Article

Fluidic system for long-term in vitro culturing and monitoring of organotypic brain slices.

Published in:

Biomedical Microdevices, 2015, v. 17, n. 4, p. 1, doi. 10.1007/s10544-015-9973-6

By:

Bakmand, Tanya;
Troels-Smith, Ane R.;
Dimaki, Maria;
Nissen, Jakob D.;
Andersen, Karsten B.;
Sasso, Luigi;
Waagepetersen, Helle S.;
Gramsbergen, Jan B.;
Svendsen, Winnie E.

Publication type:

Article

The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 45, p. 12255, doi. 10.1523/JNEUROSCI.3404-07.2007

By:

Lovatt, Ditte;
Sonnewald, Ursula;
Waagepetersen, Helle S.;
Schousboe, Arne;
Wei He;
Lin, Jane H.-C.;
Xiaoning Han;
Takano, Takahiro;
Su Wang;
Sim, Fraser J.;
Goldman, Steven A.;
Nedergaard, Maiken

Publication type:

Article

Rates of pyruvate carboxylase, glutamate and GABA neurotransmitter cycling, and glucose oxidation in multiple brain regions of the awake rat using a combination of [2- 13 C]/[1- 13 C]glucose infusion and 1 H-[ 13 C]NMR ex vivo.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2022, v. 42, n. 8, p. 1507, doi. 10.1177/0271678X221074211

By:

McNair, Laura M;
Mason, Graeme F;
Chowdhury, Golam MI;
Jiang, Lihong;
Ma, Xiaoxian;
Rothman, Douglas L;
Waagepetersen, Helle S;
Behar, Kevin L

Publication type:

Article

Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2018, v. 38, n. 10, p. 1754, doi. 10.1177/0271678X17714680

By:

Hohnholt, Michaela C.;
Andersen, Vibe H.;
Andersen, Jens V.;
Christensen, Sofie K.;
Karaca, Melis;
Maechler, Pierre;
Waagepetersen, Helle S.

Publication type:

Article

Characterization of the L-glutamate clearance pathways across the blood–brain barrier and the effect of astrocytes in an in vitro blood–brain barrier model.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2017, v. 37, n. 12, p. 3744, doi. 10.1177/0271678X17690760

By:

Helms, Hans C. C.;
Aldana, Blanca I.;
Groth, Simon;
Jensen, Morten M.;
Waagepetersen, Helle S.;
Nielsen, Carsten U.;
Brodin, Birger

Publication type:

Article

Improved cerebral energetics and ketone body metabolism in db/db mice.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2017, v. 37, n. 3, p. 1137, doi. 10.1177/0271678X16684154

By:

Andersen, Jens V.;
Christensen, Sofie K.;
Nissen, Jakob D.;
Waagepetersen, Helle S.

Publication type:

Article

A subconvulsive dose of kainate selectively compromises astrocytic metabolism in the mouse brain in vivo.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2014, v. 34, n. 8, p. 1340, doi. 10.1038/jcbfm.2014.88

By:

Walls, Anne B;
Eyjolfsson, Elvar M;
Schousboe, Arne;
Sonnewald, Ursula;
Waagepetersen, Helle S

Publication type:

Article

Effect of glutamine synthetase inhibition on brain and interorgan ammonia metabolism in bile duct ligated rats.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2014, v. 34, n. 3, p. 460, doi. 10.1038/jcbfm.2013.218

By:

Fries, Andreas W;
Dadsetan, Sherry;
Keiding, Susanne;
Bak, Lasse K;
Schousboe, Arne;
Waagepetersen, Helle S;
Simonsen, Mette;
Ott, Peter;
Vilstrup, Hendrik;
Sørensen, Michael

Publication type:

Article

Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2013, v. 33, n. 8, p. 1235, doi. 10.1038/jcbfm.2013.73

By:

Dadsetan, Sherry;
Kukolj, Eva;
Bak, Lasse K;
Sørensen, Michael;
Ott, Peter;
Vilstrup, Hendrik;
Schousboe, Arne;
Keiding, Susanne;
Waagepetersen, Helle S

Publication type:

Article

Quantitative importance of the pentose phosphate pathway determined by incorporation of 13C from [2-13C]- and [3-13C]glucose into TCA cycle intermediates and neurotransmitter amino acids in functionally intact neurons.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2012, v. 32, n. 9, p. 1788, doi. 10.1038/jcbfm.2012.85

By:

Brekke, Eva M F;
Walls, Anne B;
Schousboe, Arne;
Waagepetersen, Helle S;
Sonnewald, Ursula

Publication type:

Article

Trafficking between glia and neurons of TCA cycle intermediates and related metabolites.

Published in:

Glia (0894-1491), 1997, v. 21, n. 1, p. 99, doi. 10.1002/(SICI)1098-1136(199709)21:1<99::AID-GLIA11>3.0.CO;2-W

By:

Schousboe, Arne;
Westergaard, Niels;
Waagepetersen, Helle S.;
Larsson, Orla M.;
Bakken, Inger J.;
Sonnewald, Ursula

Publication type:

Article

Functional Importance of the Astrocytic Glycogen-Shunt and Glycolysis for Maintenance of an Intact Intra/Extracellular Glutamate Gradient.

Published in:

Neurotoxicity Research, 2010, v. 18, n. 1, p. 94, doi. 10.1007/s12640-010-9171-5

By:

Schousboe, Arne;
Sickmann, Helle M.;
Walls, Anne B.;
Bak, Lasse K.;
Waagepetersen, Helle S.

Publication type:

Article

Energy Substrates to Support Glutamatergic and GABAergic Synaptic Function: Role of Glycogen, Glucose and Lactate.

Published in:

Neurotoxicity Research, 2007, v. 12, n. 4, p. 263, doi. 10.1007/BF03033909

By:

Schousboe, Arne;
Bak, Lasse k.;
Sickmann, Helle M.;
Sonnewald, Ursula;
Waagepetersen, Helle s.

Publication type:

Article

Astrocytic control of biosynthesis and turnover of the neurotransmitters glutamate and GABA.

Published in:

Frontiers in Endocrinology, 2013, v. 4, p. 1, doi. 10.3389/fendo.2013.00102

By:

Schousboe, Arne;
Bak, Lasse K.;
Waagepetersen, Helle S.

Publication type:

Article

Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease.

Published in:

Frontiers in Aging Neuroscience, 2021, v. 13, p. 1, doi. 10.3389/fnagi.2021.736580

By:

Salcedo, Claudia;
Andersen, Jens V.;
Vinten, Kasper Tore;
Pinborg, Lars H.;
Waagepetersen, Helle S.;
Freude, Kristine K.;
Aldana, Blanca I.

Publication type:

Article

Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia.

Published in:

Molecular Brain, 2020, v. 13, n. 1, p. N.PAG, doi. 10.1186/s13041-020-00658-6

By:

Aldana, Blanca I.;
Zhang, Yu;
Jensen, Pia;
Chandrasekaran, Abinaya;
Christensen, Sofie K.;
Nielsen, Troels T.;
Nielsen, Jørgen E.;
Hyttel, Poul;
Larsen, Martin R.;
Waagepetersen, Helle S.;
Freude, Kristine K.

Publication type:

Article

Expression of the human isoform of glutamate dehydrogenase, hGDH2, augments TCA cycle capacity and oxidative metabolism of glutamate during glucose deprivation in astrocytes.

Published in:

Glia (0894-1491), 2017, v. 65, n. 3, p. 474, doi. 10.1002/glia.23105

By:

Nissen, Jakob D.;
Lykke, Kasper;
Bryk, Jaroslaw;
Stridh, Malin H.;
Zaganas, Ioannis;
Skytt, Dorte M.;
Schousboe, Arne;
Bak, Lasse K.;
Enard, Wolfgang;
Pääbo, Svante;
Waagepetersen, Helle S.

Publication type:

Article

Dysfunctional TCA-Cycle Metabolism in Glutamate Dehydrogenase Deficient Astrocytes.

Published in:

Glia (0894-1491), 2015, v. 63, n. 12, p. 2313, doi. 10.1002/glia.22895

By:

Nissen, Jakob D.;
Pajęcka, Kamilla;
Stridh, Malin H.;
Skytt, Dorte M.;
Waagepetersen, Helle S.

Publication type:

Article

Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes.

Published in:

Glia (0894-1491), 2015, v. 63, n. 1, p. 154, doi. 10.1002/glia.22741

By:

Müller, Margit S.;
Pedersen, Sofie E.;
Walls, Anne B.;
Waagepetersen, Helle S.;
Bak, Lasse K.

Publication type:

Article

Astrocyte glycogenolysis is triggered by store-operated calcium entry and provides metabolic energy for cellular calcium homeostasis.

Published in:

Glia (0894-1491), 2014, v. 62, n. 4, p. 526, doi. 10.1002/glia.22623

By:

Müller, Margit S.;
Fox, Rebecca;
Schousboe, Arne;
Waagepetersen, Helle S.;
Bak, Lasse K.

Publication type:

Article

Direct measurement of backflux between oxaloacetate and fumarate following pyruvate carboxylation.

Published in:

Glia (0894-1491), 2012, v. 60, n. 1, p. 147, doi. 10.1002/glia.21265

By:

Brekke, Eva;
Walls, Anne B.;
Nørfeldt, Lasse;
Schousboe, Arne;
Waagepetersen, Helle S.;
Sonnewald, Ursula

Publication type:

Article

Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of α‐ketoglutarate dehydrogenase.

Published in:

Glia (0894-1491), 2006, v. 53, n. 2, p. 225, doi. 10.1002/glia.20276

By:

Helle S. Waagepetersen;
Gert H. Hansen;
Kirsten Fenger;
J. Gordon Lindsay;
Gary Gibson;
Arne Schousboe

Publication type:

Article

Multiple compartments with different metabolic characteristics are involved in biosynthesis of intracellular and released glutamine and citrate in astrocytes.

Published in:

Glia (0894-1491), 2001, v. 35, n. 3, p. 246, doi. 10.1002/glia.1089

By:

Waagepetersen, Helle S.;
Sonnewald, Ursula;
Larsson, Orla M.;
Schousboe, Arne

Publication type:

Article

Glycogen metabolism is impaired in the brain of male type 2 diabetic Goto‐Kakizaki rats.

Published in:

Journal of Neuroscience Research, 2019, v. 97, n. 8, p. 1004, doi. 10.1002/jnr.24437

By:

Soares, Ana Francisca;
Nissen, Jakob D.;
Garcia‐Serrano, Alba M.;
Nussbaum, Sakura S.;
Waagepetersen, Helle S.;
Duarte, João M. N.

Publication type:

Article

Astrocytic pyruvate carboxylation: Status after 35 years.

Published in:

Journal of Neuroscience Research, 2019, v. 97, n. 8, p. 890, doi. 10.1002/jnr.24402

By:

Schousboe, Arne;
Waagepetersen, Helle S.;
Sonnewald, Ursula

Publication type:

Article

Distinct differences in rates of oxygen consumption and ATP synthesis of regionally isolated non‐synaptic mouse brain mitochondria.

Published in:

Journal of Neuroscience Research, 2019, v. 97, n. 8, p. 961, doi. 10.1002/jnr.24371

By:

Andersen, Jens V.;
Jakobsen, Emil;
Waagepetersen, Helle S.;
Aldana, Blanca I.

Publication type:

Article

The antidiabetic drug metformin decreases mitochondrial respiration and tricarboxylic acid cycle activity in cultured primary rat astrocytes.

Published in:

Journal of Neuroscience Research, 2017, v. 95, n. 11, p. 2307, doi. 10.1002/jnr.24050

By:

Hohnholt, Michaela C.;
Blumrich*, Eva‐Maria;
Waagepetersen, Helle S.;
Dringen, Ralf

Publication type:

Article

The novel anticonvulsant neuropeptide and galanin analogue, NAX-5055, does not alter energy and amino acid metabolism in cultured brain cells.

Published in:

Journal of Neuroscience Research, 2017, v. 95, n. 11, p. 2286, doi. 10.1002/jnr.24057

By:

Aldana, Blanca I.;
Waagepetersen, Helle S.;
Schousboe, Arne;
White, H. Steve;
Bulaj, Grzegorz;
Walls, Anne B.

Publication type:

Article

Glutamate oxidation in astrocytes: Roles of glutamate dehydrogenase and aminotransferases.

Published in:

Journal of Neuroscience Research, 2016, v. 94, n. 12, p. 1561, doi. 10.1002/jnr.23908

By:

McKenna, Mary C.;
Stridh, Malin H.;
McNair, Laura F.;
Sonnewald, Ursula;
Waagepetersen, Helle S.;
Schousboe, Arne

Publication type:

Article

Glucose replaces glutamate as energy substrate to fuel glutamate uptake in glutamate dehydrogenase-deficient astrocytes.

Published in:

Journal of Neuroscience Research, 2015, v. 93, n. 7, p. 1093, doi. 10.1002/jnr.23568

By:

Pajęcka, Kamilla;
Nissen, Jakob D.;
Stridh, Malin H.;
Skytt, Dorte M.;
Schousboe, Arne;
Waagepetersen, Helle S.

Publication type:

Article

Valine but not leucine or isoleucine supports neurotransmitter glutamate synthesis during synaptic activity in cultured cerebellar neurons.

Published in:

Journal of Neuroscience Research, 2012, v. 90, n. 9, p. 1768, doi. 10.1002/jnr.23072

By:

Bak, Lasse K.;
Johansen, Maja L.;
Schousboe, Arne;
Waagepetersen, Helle S.

Publication type:

Article

Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy.

Published in:

Frontiers in Molecular Neuroscience, 2019, p. N.PAG, doi. 10.3389/fnmol.2019.00120

By:

Huyghe, Deborah;
Denninger, Andrew R.;
Voss, Caroline M.;
Frank, Pernille;
Gao, Ning;
Brandon, Nicholas;
Waagepetersen, Helle S.;
Ferguson, Andrew D.;
Pangalos, Menelas;
Doig, Peter;
Moss, Stephen J.

Publication type:

Article

Two Metabolic Fuels, Glucose and Lactate, Differentially Modulate Exocytotic Glutamate Release from Cultured Astrocytes.

Published in:

Neurochemical Research, 2021, v. 46, n. 10, p. 2551, doi. 10.1007/s11064-021-03340-y

By:

Montana, Vedrana;
Flint, Daniel;
Waagepetersen, Helle S.;
Schousboe, Arne;
Parpura, Vladimir

Publication type:

Article

Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease.

Published in:

Neurochemical Research, 2021, v. 46, n. 10, p. 2676, doi. 10.1007/s11064-021-03276-3

By:

Salcedo, Claudia;
Wagner, Antonie;
Andersen, Jens V.;
Vinten, Kasper Tore;
Waagepetersen, Helle S.;
Schousboe, Arne;
Freude, Kristine K.;
Aldana, Blanca I.

Publication type:

Article

Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus.

Published in:

Neurochemical Research, 2020, v. 45, n. 6, p. 1420, doi. 10.1007/s11064-020-03000-7

By:

McNair, Laura F.;
Andersen, Jens V.;
Nissen, Jakob D.;
Sun, Yan;
Fischer, Kathryn D.;
Hodgson, Nathaniel W.;
Du, Muzi;
Aoki, Chiye J.;
Waagepetersen, Helle S.;
Rosenberg, Paul A.;
Aldana, Blanca I.

Publication type:

Article

Fueling Brain Inhibition: Integrating GABAergic Neurotransmission and Energy Metabolism.

Published in:

Neurochemical Research, 2025, v. 50, n. 2, p. 1, doi. 10.1007/s11064-025-04384-0

By:

Walls, Anne B.;
Andersen, Jens V.;
Waagepetersen, Helle S.;
Bak, Lasse K.

Publication type:

Article

Increased glucose metabolism and impaired glutamate transport in human astrocytes are potential early triggers of abnormal extracellular glutamate accumulation in hiPSC-derived models of Alzheimer's disease.

Published in:

Journal of Neurochemistry, 2024, v. 168, n. 5, p. 822, doi. 10.1111/jnc.16014

By:

Salcedo, Claudia;
Garcia, Victoria Pozo;
García-Adán, Bernat;
Ameen, Aishat O.;
Gegelashvili, Georgi;
Waagepetersen, Helle S.;
Freude, Kristine K.;
Aldana, Blanca I.

Publication type:

Article

Effects of ketone bodies in Alzheimer's disease in relation to neural hypometabolism, β-amyloid toxicity, and astrocyte function.

Published in:

Journal of Neurochemistry, 2015, v. 134, n. 1, p. 7, doi. 10.1111/jnc.13107

By:

Hertz, Leif;
Chen, Ye;
Waagepetersen, Helle S.

Publication type:

Article

Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter.

Published in:

Journal of Neuroscience Research, 2005, v. 79, n. 1/2, p. 74, doi. 10.1002/jnr.20335

By:

Angus M. Brown;
Helle M. Sickmann;
Keld Fosgerau;
Trine M. Lund;
Arne Schousboe;
Helle S. Waagepetersen;
Bruce R. Ransom

Publication type:

Article

Activity of the lactate–alanine shuttle is independent of glutamate–glutamine cycle activity in cerebellar neuronal–astrocytic cultures.

Published in:

Journal of Neuroscience Research, 2005, v. 79, n. 1/2, p. 88, doi. 10.1002/jnr.20319

By:

Lasse K. Bak;
Helle M. Sickmann;
Arne Schousboe;
Helle S. Waagepetersen

Publication type:

Article

Synthesis of vesicular GABA from glutamine involves TCA cycle metabolism in neocortical neurons.

Published in:

Journal of Neuroscience Research, 1999, v. 57, n. 3, p. 342, doi. 10.1002/(SICI)1097-4547(19990801)57:3<342::AID-JNR6>3.0.CO;2-X

By:

Waagepetersen, Helle S.;
Sonnewald, Ursula;
Larsson, Orla M.;
Schousboe, Arne

Publication type:

Article

Oxidative metabolism of astrocytes is not reduced in hepatic encephalopathy: a PET study with [11C]acetate in humans.

Published in:

Frontiers in Neuroscience, 2014, v. 8, p. 1, doi. 10.3389/fnins.2014.00353

By:

Iversen, Peter;
Mouridsen, Kim;
Hansen, Mikkel B.;
Jensen, Svend B.;
Sørensen, Michael;
Bak, Lasse K.;
Waagepetersen, Helle S.;
Schousboe, Arne;
Ott, Peter;
Vilstrup, Hendrik;
Keiding, Susanne;
GjeddeWaagepetersen, Albert

Publication type:

Article

A Possible Role of Alanine for Ammonia Transfer Between Astrocytes and Glutamatergic Neurons.

Published in:

Journal of Neurochemistry, 2000, v. 75, n. 2, p. 471, doi. 10.1046/j.1471-4159.2000.0750471.x

By:

Waagepetersen, Helle S;
Sonnewald, Ursula;
Larsson, Orla M;
Schousboe, Arne

Publication type:

Article

The GABA Paradox.

Published in:

Journal of Neurochemistry, 1999, v. 73, n. 4, p. 1335, doi. 10.1046/j.1471-4159.1999.0731335.x

By:

Waagepetersen, Helle S.;
Sonnewald, Ursula;
Schousboe, Arne

Publication type:

Article

In Memoriam: Arne Schousboe 1944–2024.

Published in:

Glia (0894-1491), 2024, v. 72, n. 12, p. 2357, doi. 10.1002/glia.24608

By:

Andersen, Jens V.;
Waagepetersen, Helle S.;
Bak, Lasse K.

Publication type:

Article

Pharmacological inhibition of mitochondrial soluble adenylyl cyclase in astrocytes causes activation of AMP‐activated protein kinase and induces breakdown of glycogen.

Published in:

Glia (0894-1491), 2021, v. 69, n. 12, p. 2828, doi. 10.1002/glia.24072

By:

Jakobsen, Emil;
Andersen, Jens V.;
Christensen, Sofie K.;
Siamka, Olga;
Larsen, Martin R.;
Waagepetersen, Helle S.;
Aldana, Blanca I.;
Bak, Lasse K.

Publication type:

Article

Clearance of activity‐evoked K+ transients and associated glia cell swelling occur independently of AQP4: A study with an isoform‐selective AQP4 inhibitor.

Published in:

Glia (0894-1491), 2021, v. 69, n. 1, p. 28, doi. 10.1002/glia.23851

By:

Toft‐Bertelsen, Trine Lisberg;
Larsen, Brian Roland;
Christensen, Sofie Kjellerup;
Khandelia, Himanshu;
Waagepetersen, Helle S.;
MacAulay, Nanna

Publication type:

Article

Extensive astrocyte metabolism of γ‐aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex.

Published in:

Glia (0894-1491), 2020, v. 68, n. 12, p. 2601, doi. 10.1002/glia.23872

By:

Andersen, Jens V.;
Jakobsen, Emil;
Westi, Emil W.;
Lie, Maria E. K.;
Voss, Caroline M.;
Aldana, Blanca I.;
Schousboe, Arne;
Wellendorph, Petrine;
Bak, Lasse K.;
Pinborg, Lars H.;
Waagepetersen, Helle S.

Publication type:

Article