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A Direct Fluorescent Activity Assay for Glycosyltransferases Enables Convenient High‐Throughput Screening: Application to O‐GlcNAc Transferase.
- Published in:
- Angewandte Chemie, 2020, v. 132, n. 24, p. 9688, doi. 10.1002/ange.202000621
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- Publication type:
- Article
Metabolic Inhibitors of O‐GlcNAc Transferase That Act In Vivo Implicate Decreased O‐GlcNAc Levels in Leptin‐Mediated Nutrient Sensing.
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- Angewandte Chemie, 2018, v. 130, n. 26, p. 7770, doi. 10.1002/ange.201803254
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- Publication type:
- Article
Cura Annonae - chemische Erhöhung des Getreideertrags durch metabolisches Verfüttern einer pflanzlichen Signalmolekülvorstufe.
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- Angewandte Chemie, 2017, v. 129, n. 22, p. 6074, doi. 10.1002/ange.201701474
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- Article
Characterization and downstream mannose phosphorylation of human recombinant α- L-iduronidase produced in Arabidopsis complex glycan-deficient ( cgl) seeds.
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- Plant Biotechnology Journal, 2013, v. 11, n. 9, p. 1034, doi. 10.1111/pbi.12096
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- Publication type:
- Article
O-GLcNAc post-translational modifications regulate the entry of neurons into an axon branching program.
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- Developmental Neurobiology (19328451), 2009, v. 69, n. 2/3, p. 162, doi. 10.1002/dneu.20695
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- Publication type:
- Article
Metabolic Inhibitors of O‐GlcNAc Transferase That Act In Vivo Implicate Decreased O‐GlcNAc Levels in Leptin‐Mediated Nutrient Sensing.
- Published in:
- Angewandte Chemie International Edition, 2018, v. 57, n. 26, p. 7644, doi. 10.1002/anie.201803254
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- Publication type:
- Article
Cura Annonae-Chemically Boosting Crop Yields Through Metabolic Feeding of a Plant Signaling Precursor.
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- Angewandte Chemie International Edition, 2017, v. 56, n. 22, p. 5980, doi. 10.1002/anie.201701474
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- Publication type:
- Article
A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors.
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- Angewandte Chemie International Edition, 2015, v. 54, n. 51, p. 15429, doi. 10.1002/anie.201507985
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- Publication type:
- Article
Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N-Acetylgalactosaminyltransferase 2.
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- Angewandte Chemie International Edition, 2014, v. 53, n. 31, p. 8206, doi. 10.1002/anie.201402781
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- Publication type:
- Article
P2‐168: IMMUNOHISTOCHEMISTRY OF O‐LINKED N‐ACETYLGLUCOSAMINE TRANSFERASE (OGT) AND AUTOPHAGY MARKER LC3B IN ALZHEIMER'S DISEASE.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P640, doi. 10.1016/j.jalz.2019.06.2575
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- Article
Altered Tau Kinase Activity in rTg4510 Mice after a Single Interfaced CHIMERA Traumatic Brain Injury.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9439, doi. 10.3390/ijms24119439
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- Article
Cryo-EM structure provides insights into the dimer arrangement of the O-linked β-N-acetylglucosamine transferase OGT.
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- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26796-6
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- Article
PHARMACOKINETICS AND PHARMACODYNAMICS TO SUPPORT CLINICAL STUDIES OF MK-8719: AN O-GLCNACASE INHIBITOR FOR PROGRESSIVE SUPRANUCLEAR PALSY.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P1028, doi. 10.1016/j.jalz.2016.06.2125
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- Publication type:
- Article
EARLY CLINICAL RESULTS AND PRECLINICAL VALIDATION OF THE O-GLCNACASE (OGA) INHIBITOR MK-8719 AS A NOVEL THERAPEUTIC FOR THE TREATMENT OF TAUOPATHIES.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P261, doi. 10.1016/j.jalz.2016.06.469
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- Article
O-GlcNAc regulation of hippocampal synaptic plasticity in wild type and 3xTg-AD mice
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- 2009
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- Publication type:
- Abstract
Characterization of a β- N-acetylhexosaminidase and a β- N-acetylglucosaminidase/β-glucosidase from Cellulomonas fimi.
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- FEBS Journal, 2006, v. 273, n. 13, p. 2929, doi. 10.1111/j.1742-4658.2006.05308.x
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- Publication type:
- Article
Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation.
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- Nature Structural & Molecular Biology, 2008, v. 15, n. 7, p. 764, doi. 10.1038/nsmb.1443
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- Article
Structure and mechanism of a bacterial β-glucosaminidase having O-GlcNAcase activity.
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- Nature Structural & Molecular Biology, 2006, v. 13, n. 4, p. 365, doi. 10.1038/nsmb1079
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- Publication type:
- Article
A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors.
- Published in:
- Angewandte Chemie, 2015, v. 127, n. 51, p. 15649, doi. 10.1002/ange.201507985
- By:
- Publication type:
- Article
Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N-Acetylgalactosaminyltransferase 2.
- Published in:
- Angewandte Chemie, 2014, v. 126, n. 31, p. 8345, doi. 10.1002/ange.201402781
- By:
- Publication type:
- Article
Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter.
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- Journal of Molecular Cell Biology, 2016, v. 8, n. 1, p. 2, doi. 10.1093/jmcb/mjv033
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- Publication type:
- Article
Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation.
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- PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0035277
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- Publication type:
- Article
Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody.
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- Amino Acids, 2011, v. 40, n. 3, p. 857, doi. 10.1007/s00726-010-0705-1
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- Publication type:
- Article
In Situ Imaging of O-Linked β-N-Acetylglucosamine Using On-Tissue Hydrolysis and MALDI Mass Spectrometry.
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- Cancers, 2023, v. 15, n. 4, p. 1224, doi. 10.3390/cancers15041224
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- Publication type:
- Article
A divergent synthesis to generate targeted libraries of inhibitors for endo- N-acetylglucosaminidases.
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- Canadian Journal of Chemistry, 2018, v. 96, n. 2, p. 248, doi. 10.1139/cjc-2017-0461
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- Publication type:
- Article
Pharmacological inhibition and knockdown of O‐GlcNAcase reduces cellular internalization of α‐synuclein preformed fibrils.
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- FEBS Journal, 2021, v. 288, n. 2, p. 452, doi. 10.1111/febs.15349
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- Publication type:
- Article
Synthesis of Uronic Acid 1‐Azasugars as Putative Inhibitors of α‐Iduronidase, β‐Glucuronidase and Heparanase**.
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- ChemBioChem, 2023, v. 24, n. 4, p. 1, doi. 10.1002/cbic.202200619
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- Publication type:
- Article
The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to β-Lactams.
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- ChemBioChem, 2013, v. 14, n. 15, p. 1973, doi. 10.1002/cbic.201300395
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- Article
Discovery of a New Drug-like Series of OGT Inhibitors by Virtual Screening.
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- Molecules, 2022, v. 27, n. 6, p. 1996, doi. 10.3390/molecules27061996
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- Publication type:
- Article
Protective Roles of O‐GlcNAc in Neurodegenerative Diseases.
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- FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.00054
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- Article
Modulation of O‐GlcNAc levels as a disease modifying approach for Alzheimer disease (223.3).
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- FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.223.3
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- Article
Multivalency To Inhibit and Discriminate Hexosaminidases.
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- Chemistry - A European Journal, 2017, v. 23, n. 38, p. 9022, doi. 10.1002/chem.201701756
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- Publication type:
- Article
A Fixable Fluorescence‐Quenched Substrate for Quantitation of Lysosomal Glucocerebrosidase Activity in Both Live and Fixed Cells.
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- Angewandte Chemie, 2023, v. 135, n. 40, p. 1, doi. 10.1002/ange.202309306
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- Publication type:
- Article
Potent De Novo Macrocyclic Peptides That Inhibit O‐GlcNAc Transferase through an Allosteric Mechanism.
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- Angewandte Chemie, 2023, v. 135, n. 5, p. 1, doi. 10.1002/ange.202215671
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- Publication type:
- Article
Pharmacological Chaperones for GCase that Switch Conformation with pH Enhance Enzyme Levels in Gaucher Animal Models.
- Published in:
- Angewandte Chemie, 2022, v. 134, n. 38, p. 1, doi. 10.1002/ange.202207974
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- Publication type:
- Article
A mechanism-based inactivator of glycoside hydrolases involving formation of a transient non-classical carbocation.
- Published in:
- Nature Communications, 2014, v. 5, n. 12, p. 5590, doi. 10.1038/ncomms6590
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- Publication type:
- Article
A Fixable Fluorescence‐Quenched Substrate for Quantitation of Lysosomal Glucocerebrosidase Activity in Both Live and Fixed Cells.
- Published in:
- Angewandte Chemie International Edition, 2023, v. 62, n. 40, p. 1, doi. 10.1002/anie.202309306
- By:
- Publication type:
- Article
Potent De Novo Macrocyclic Peptides That Inhibit O‐GlcNAc Transferase through an Allosteric Mechanism.
- Published in:
- Angewandte Chemie International Edition, 2023, v. 62, n. 5, p. 1, doi. 10.1002/anie.202215671
- By:
- Publication type:
- Article
Pharmacological Chaperones for GCase that Switch Conformation with pH Enhance Enzyme Levels in Gaucher Animal Models.
- Published in:
- Angewandte Chemie International Edition, 2022, v. 61, n. 38, p. 1, doi. 10.1002/anie.202207974
- By:
- Publication type:
- Article
A Direct Fluorescent Activity Assay for Glycosyltransferases Enables Convenient High‐Throughput Screening: Application to O‐GlcNAc Transferase.
- Published in:
- Angewandte Chemie International Edition, 2020, v. 59, n. 24, p. 9601, doi. 10.1002/anie.202000621
- By:
- Publication type:
- Article
The primary familial brain calcification-associated protein MYORG is an α-galactosidase with restricted substrate specificity.
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- PLoS Biology, 2022, v. 20, n. 9, p. 1, doi. 10.1371/journal.pbio.3001764
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- Publication type:
- Article
A Selective Inhibitor Gal-PUGNAc of Human Lysosomal β-Hexosaminidases Modulates Levels of the Ganglioside GM2 in Neuroblastoma Cells.
- Published in:
- Angewandte Chemie, 2009, v. 121, n. 7, p. 1326, doi. 10.1002/ange.200804583
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- Publication type:
- Article
A Strategy for Functional Proteomic Analysis of Glycosidase Activity from Cell LysatesThe authors thank S. G. Withers for samples of recombinant Agrobacterium sp. ?-glucosidase and Xanthomonas manihotis ?-galactosidase, and H. C. Hang for useful discussions. D.J.V. thanks the Canadian Institutes of Health Research for a fellowship. The authors thank A. Debowski for technical assistance. This research was supported by a grant to C.R.B. from the National Institutes of Health (Grant no. GM066047), a President's Research Grant from Simon Fraser University, and a grant to D.J.V from the Natural Sciences and Engineering Research Council of Canada. The center for New Directions in Organic Synthesis is funded by Bristol–Myers Squibb as a supporting member and Novartis as a sponsoring member.
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- Angewandte Chemie, 2004, v. 116, n. 40, p. 5452, doi. 10.1002/ange.200454235
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- Article
Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate.
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- Nature, 2001, v. 412, n. 6849, p. 835, doi. 10.1038/35090602
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- Publication type:
- Article
O-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains.
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- Nature Chemical Biology, 2015, v. 11, n. 5, p. 319, doi. 10.1038/nchembio.1774
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- Publication type:
- Article
A Strategy for Functional Proteomic Analysis of Glycosidase Activity from Cell Lysates.
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- Angewandte Chemie International Edition, 2004, v. 43, n. 40, p. 5338, doi. 10.1002/anie.200454235
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- Publication type:
- Article
Software for rapid time dependent ChIP-sequencing analysis (TDCA).
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- BMC Bioinformatics, 2017, v. 18, p. 1, doi. 10.1186/s12859-017-1936-x
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- Publication type:
- Article
Potent and Selective Cell‐Active Iminosugar Inhibitors of Human α‐N‐Acetylgalactosaminidase (α‐NAGAL).
- Published in:
- Chemistry - A European Journal, 2023, v. 29, n. 44, p. 1, doi. 10.1002/chem.202300982
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- Publication type:
- Article
Mammalian Notch is modified by d-Xyl-α1-3-d-Xyl-α1-3-d-Glc-β1-O-Ser: Implementation of a method to study O-glucosylation.
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- Glycobiology, 2010, v. 20, n. 3, p. 287, doi. 10.1093/glycob/cwp173
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- Publication type:
- Article
Insight into a strategy for attenuating AmpC‐mediated β‐lactam resistance: Structural basis for selective inhibition of the glycoside hydrolase NagZ.
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- Protein Science: A Publication of the Protein Society, 2009, v. 18, n. 7, p. 1541, doi. 10.1002/pro.137
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- Publication type:
- Article