Works by Vlodavsky, Israel

Results: 145

Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase.

Published in:

Nature, 1984, v. 310, n. 5974, p. 241, doi. 10.1038/310241a0

By:

Naparstek, Yaakov;
Cohen, Irun R.;
Fuks, Zvi;
Vlodavsky, Israel

Publication type:

Article

Production of heparanase by normal and neoplastic murine B-lymphocytes.

Published in:

International Journal of Cancer, 1991, v. 47, n. 1, p. 92, doi. 10.1002/ijc.2910470117

By:

Laskov, Reuven;
Michaeli, Rivka-Ishai;
Sharir, Hava;
Yefenof, Eitan;
Vlodavsky, Israel

Publication type:

Article

Maintenance on extracellular matrix and expression of heparanase activity by human ovarian carcinoma cells from biopsy specimens.

Published in:

International Journal of Cancer, 1990, v. 45, n. 6, p. 1054, doi. 10.1002/ijc.2910450613

By:

Peretz, Tamar;
Antebi, Shaul U.;
Beller, Uziel;
Horowitz, Aviva T.;
Fuks, Zvi;
Vlodavsky, Israel

Publication type:

Article

Defibrotide: potential for treating endothelial dysfunction related to viral and post-infectious syndromes.

Published in:

Expert Opinion on Therapeutic Targets, 2021, v. 25, n. 6, p. 423, doi. 10.1080/14728222.2021.1944101

By:

Richardson, Edward;
García-Bernal, David;
Calabretta, Eleonora;
Jara, Rubén;
Palomo, Marta;
Baron, Rebecca M.;
Yanik, Gregory;
Fareed, Jawed;
Vlodavsky, Israel;
Iacobelli, Massimo;
Díaz-Ricart, Maribel;
Richardson, Paul G.;
Carlo-Stella, Carmelo;
Moraleda, Jose M.

Publication type:

Article

Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis.

Published in:

Nature Medicine, 1999, v. 5, n. 7, p. 793, doi. 10.1038/10518

By:

Vlodavsky, Israel;
Friedmann, Yael;
Elkin, Michael;
Aingorn, Helena;
Atzmon, Ruth;
Ishai-Michaeli, Rivka;
Bitan, Menachem;
Pappo, Orit;
Peretz, Tuvia;
Michal, Israel;
Spector, Larissa;
Pecker, Iris

Publication type:

Article

Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence.

Published in:

Modern Pathology, 2006, v. 19, n. 6, p. 878, doi. 10.1038/modpathol.3800603

By:

Doviner, Victoria;
Maly, Bella;
Kaplan, Victoria;
Gingis-Velitski, Svetlana;
Ilan, Neta;
Vlodavsky, Israel;
Sherman, Yoav

Publication type:

Article

Mammary Branching Morphogenesis Requires Reciprocal Signaling by Heparanase and MMP-14.

Published in:

Journal of Cellular Biochemistry, 2015, v. 116, n. 8, p. 1668, doi. 10.1002/jcb.25127

By:

Gomes, Angélica Maciel;
Bhat, Ramray;
Correia, Ana Luísa;
Mott, Joni D.;
Ilan, Neta;
Vlodavsky, Israel;
Pavão, Mauro S.G.;
Bissell, Mina

Publication type:

Article

Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain.

Published in:

Acta Neuropathologica, 2012, v. 124, n. 4, p. 465, doi. 10.1007/s00401-012-0997-1

By:

Zhang, Xiao;
Wang, Bo;
O'Callaghan, Paul;
Hjertström, Elina;
Jia, Juan;
Gong, Feng;
Zcharia, Eyal;
Nilsson, Lars;
Lannfelt, Lars;
Vlodavsky, Israel;
Lindahl, Ulf;
Li, Jin-Ping

Publication type:

Article

Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer's disease.

Published in:

Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01182-x

By:

Zhang, Xiao;
O'Callaghan, Paul;
Li, Honglian;
Tan, Yingxia;
Zhang, Ganlin;
Barash, Uri;
Wang, Xiaomin;
Lannfelt, Lars;
Vlodavsky, Israel;
Lindahl, Ulf;
Li, Jin-Ping

Publication type:

Article

Correction: Tumor- and host-derived heparanase-2 (Hpa2) attenuates tumorigenicity: role of Hpa2 in macrophage polarization and BRD7 nuclear localization.

Published in:

2025

By:

Soboh, Soaad;
Vorontsova, Avital;
Farhoud, Malik;
Barash, Uri;
Naroditsky, Inna;
Gross-Cohen, Miriam;
Weissmann, Marina;
Nishioka, Yasuhiko;
Woolf, Adrian S.;
Roberts, Neil A.;
Shaked, Yuval;
Ilan, Neta;
Vlodavsky, Israel

Publication type:

Correction Notice

Tumor- and host-derived heparanase-2 (Hpa2) attenuates tumorigenicity: role of Hpa2 in macrophage polarization and BRD7 nuclear localization.

Published in:

Cell Death & Disease, 2024, v. 15, n. 12, p. 1, doi. 10.1038/s41419-024-07262-9

By:

Soboh, Soaad;
Vorontsova, Avital;
Farhoud, Malik;
Barash, Uri;
Naroditsky, Inna;
Gross-Cohen, Miriam;
Weissmann, Marina;
Yasuhiko, Nishioka;
Woolf, Adrian S.;
Roberts, Neil A.;
Shaked, Yuval;
Ilan, Neta;
Vlodavsky, Israel

Publication type:

Article

Nuclear localization of heparanase 2 (Hpa2) attenuates breast carcinoma growth and metastasis.

Published in:

Cell Death & Disease, 2024, v. 15, n. 3, p. 1, doi. 10.1038/s41419-024-06596-8

By:

Hilwi, Maram;
Shulman, Katherina;
Naroditsky, Inna;
Feld, Sari;
Gross-Cohen, Miriam;
Boyango, Ilanit;
Soboh, Soaad;
Vornicova, Olga;
Farhoud, Malik;
Singh, Preeti;
Bar-Sela, Gil;
Goldberg, Hadassah;
Götte, Martin;
Sharrocks, Andrew D.;
Li, Yaoyong;
Sanderson, Ralph D.;
Ilan, Neta;
Vlodavsky, Israel

Publication type:

Article

miR-184 represses β-catenin and behaves as a skin tumor suppressor.

Published in:

Cell Death & Disease, 2024, v. 15, n. 2, p. 1, doi. 10.1038/s41419-024-06554-4

By:

Turovsky, Lubov;
Kheshaiboun, Ghazal;
Yassen, Gharam;
Nagosa, Sara;
Boyango, Ilanit;
Amitai-Lange, Aya;
Bhattacharya, Swarnabh;
Ilan, Neta;
Vlodavsky, Israel;
Aberdam, Daniel;
Shalom-Feuerstein, Ruby;
Avitan-Hersh, Emily

Publication type:

Article

Heparanase 2 (Hpa2)- a new player essential for pancreatic acinar cell differentiation.

Published in:

Cell Death & Disease, 2023, v. 14, n. 7, p. 1, doi. 10.1038/s41419-023-05990-y

By:

Kayal, Yasmin;
Barash, Uri;
Naroditsky, Inna;
Ilan, Neta;
Vlodavsky, Israel

Publication type:

Article

Nephroprotective Effect of Heparanase in Experimental Nephrotic Syndrome.

Published in:

PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0119610

By:

Assady, Suheir;
Alter, Joel;
Axelman, Elena;
Zohar, Yaniv;
Sabo, Edmond;
Litvak, Michael;
Kaplan, Marielle;
Ilan, Neta;
Vlodavsky, Israel;
Abassi, Zaid

Publication type:

Article

Heparanase Interacts with Resistin and Augments Its Activity.

Published in:

PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0085944

By:

Novick, Daniela;
Barak, Sara;
Ilan, Neta;
Vlodavsky, Israel

Publication type:

Article

Clinical Significance of Heparanase Splice Variant (T5) in Renal Cell Carcinoma: Evaluation by a Novel T5-Specific Monoclonal Antibody.

Published in:

PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0051494

By:

Barash, Uri;
Arvatz, Gil;
Farfara, Roy;
Naroditsky, Inna;
Doweck, Ilana;
Feld, Sari;
Ben-Izhak, Ofer;
Ilan, Neta;
Nativ, Ofer;
Vlodavsky, Israel

Publication type:

Article

Elevated Urine Heparanase Levels Are Associated with Proteinuria and Decreased Renal Allograft Function.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0044076

By:

Shafat, Itay;
Agbaria, Amir;
Boaz, Mona;
Schwartz, Doron;
Baruch, Ronny;
Nakash, Richard;
Ilan, Neta;
Vlodavsky, Israel;
Weinstein, Talia;
Câmara, Niels Olsen Saraiva

Publication type:

Article

Accelerated Resolution of AA Amyloid in Heparanase Knockout Mice Is Associated with Matrix Metalloproteases.

Published in:

PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0039899

By:

Bo Wang;
Ying-xia Tan;
Juan Jia;
Digre, Andreas;
Xiao Zhang;
Vlodavsky, Israel;
Jin-ping Li

Publication type:

Article

Dissociation between Mature Phenotype and Impaired Transmigration in Dendritic Cells from Heparanase-Deficient Mice.

Published in:

PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0035602

By:

Benhamron, Sandrine;
Reiner, Inna;
Zcharia, Eyal;
Atallah, Mizhir;
Grau, Amir;
Vlodavsky, Israel;
Mevorach, Dror

Publication type:

Article

Heparanase Affects Food Intake and Regulates Energy Balance in Mice.

Published in:

PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0034313

By:

Karlsson-Lindahl, Linda;
Schmidt, Linnéa;
Haage, David;
Hansson, Caroline;
Taube, Magdalena;
Egeciouglu, Emil;
Ying-xia Tan;
Admyre, Therese;
Jansson, John-Olov;
Vlodavsky, Israel;
Jin-Ping Li;
Lindahl, Ulf;
Dickson, Suzanne L.

Publication type:

Article

Role of Heparanase on Hepatic Uptake of Intestinal Derived Lipoprotein and Fatty Streak Formation in Mice.

Published in:

PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0018370

By:

Planer, David;
Metzger, Shulamit;
Zcharia, Eyal;
Wexler, Isaiah D.;
Vlodavsky, Israel;
Chajek-Shaul, Tova

Publication type:

Article

Heparanase Levels Are Elevated in the Urine and Plasma of Type 2 Diabetes Patients and Associate with Blood Glucose Levels.

Published in:

PLoS ONE, 2011, v. 6, n. 2, p. 1, doi. 10.1371/journal.pone.0017312

By:

Shafat, Itay;
Ilan, Neta;
Zoabi, Samih;
Vlodavsky, Israel;
Nakhoul, Farid

Publication type:

Article

Heparanase Promotes Engraftment and Prevents Graft versus Host Disease in Stem Cell Transplantation.

Published in:

PLoS ONE, 2010, v. 5, n. 4, p. 1, doi. 10.1371/journal.pone.0010135

By:

Bitan, Menachem;
Weiss, Lola;
Zeira, Michael;
Zcharia, Eyal;
Slavin, Shimon;
Nagler, Arnon;
Vlodavsky, Israel

Publication type:

Article

Newly Generated Heparanase Knock-Out Mice Unravel Co-Regulation of Heparanase and Matrix etalloproteinases.

Published in:

PLoS ONE, 2009, v. 4, n. 4, p. 1, doi. 10.1371/journal.pone.0005181

By:

Zcharia, Eyal;
Juan Jia;
Xiao Zhang;
Baraz, Lea;
Lindahl, Ulf;
Peretz, Tamar;
Vlodavsky, Israel;
Jin-Ping Li

Publication type:

Article

Heparanase Facilitates Cell Adhesion and Spreading by Clustering of Cell Surface Heparan Sulfate Proteoglycans.

Published in:

PLoS ONE, 2008, v. 3, n. 6, p. 1, doi. 10.1371/journal.pone.0002319

By:

Levy-Adam, Flonia;
Feld, Sari;
Suss-Toby, Edith;
Vlodavsky, Israel;
Ilan, Neta

Publication type:

Article

Heparanase is overexpressed in lung cancer and correlates inversely with patient survival.

Published in:

2008

By:

Cohen, Esti;
Doweck, Ilana;
Naroditsky, Inna;
Ben-Izhak, Ofer;
Kremer, Ran;
Best, Lael A.;
Vlodavsky, Israel;
Ilan, Neta

Publication type:

journal article

COVID‐19‐induced endotheliitis: emerging evidence and possible therapeutic strategies.

Published in:

British Journal of Haematology, 2021, v. 193, n. 1, p. 43, doi. 10.1111/bjh.17240

By:

Calabretta, Eleonora;
Moraleda, Jose M.;
Iacobelli, Massimo;
Jara, Ruben;
Vlodavsky, Israel;
O'Gorman, Peter;
Pagliuca, Antonio;
Mo, Clifton;
Baron, Rebecca M.;
Aghemo, Alessio;
Soiffer, Robert;
Fareed, Jawed;
Carlo‐Stella, Carmelo;
Richardson, Paul

Publication type:

Article

Heparanase expression in Langerhans cell histiocytosis.

Published in:

Pediatric Blood & Cancer, 2014, v. 61, n. 10, p. 1883, doi. 10.1002/pbc.25046

By:

Dvir, Rina;
Vlodavsky, Israel;
Ilan, Neta;
Bitan, Menachem;
Issacov, Josephine;
Elhasid, Ronit

Publication type:

Article

Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs.

Published in:

FASEB Journal, 2016, v. 30, n. 5, p. 1767, doi. 10.1096/fj.201500046

By:

Petrovich, Ekaterina;
Feigelson, Sara W.;
Stoler-Barak, Liat;
Hatzav, Miki;
Solomon, Adam;
Bar-Shai, Amir;
Ilan, Neta;
Jin-Ping Li;
Engelhardt, Britta;
Vlodavsky, Israel;
Alon, Ronen

Publication type:

Article

Heparanase of murine effector lymphocytes and neutrophils is not required for their diapedesis into sites of inflammation.

Published in:

FASEB Journal, 2015, v. 29, n. 5, p. 2010, doi. 10.1096/fj.14-265447

By:

Stoler-Barak, Liat;
Petrovich, Ekaterina;
Aychek, Tegest;
Gurevich, Irina;
Tal, Orna;
Hatzav, Miki;
Ilan, Neta;
Feigelson, Sara W.;
Shakhar, Guy;
Vlodavsky, Israel;
Alon, Ronen

Publication type:

Article

Post‐transcriptional regulation of heparanase gene expression by a 3’ AU‐rich element.

Published in:

FASEB Journal, 2010, v. 24, n. 12, p. 4969, doi. 10.1096/fj.10.156372

By:

Arvatz, Gil;
Barash, Uri;
Nativ, Ofer;
Ilan, Neta;
Vlodavsky, Israel

Publication type:

Article

Post-transcriptional regulation of heparanase gene expression by a 3' AU-rich element.

Published in:

FASEB Journal, 2010, v. 24, n. 12, p. 4969, doi. 10.1096/fj.10-156372

By:

Arvatz, Gil;
Barash, Uri;
Nativ, Ofer;
Ilan, Neta;
Vlodavsky, Israel

Publication type:

Article

A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics.

Published in:

FASEB Journal, 2010, v. 24, n. 4, p. 1239, doi. 10.1096/fj.09-147074

By:

Barash, Uri;
Cohen-Kaplan, Victoria;
Arvatz, Gil;
Gingis-Velitski, Svetlana;
Levy-Adam, Flonia;
Nativ, Ofer;
Shemesh, Ronen;
Ayalon-Sofer, Michal;
Ilan, Neta;
Vlodavsky, Israel

Publication type:

Article

Anti-heparanase monoclonal antibody enhances heparanase enzymatic activity and facilitates wound healing.

Published in:

FASEB Journal, 2007, v. 21, n. 14, p. 3986, doi. 10.1096/fj.07-8866com

By:

Gingis-Velitski, Svetlana;
Ishai-Michaeli, Rivka;
Vlodavsky, Israel;
Ilan, Neta

Publication type:

Article

P-selectin- and heparanase-dependent antimetastatic activity of non-anticoagulant heparins.

Published in:

FASEB Journal, 2007, v. 21, n. 13, p. 3562, doi. 10.1096/fj.07-8450com

By:

Hostettler, Nina;
Naggi, Annamaria;
Torri, Giangiacomo;
Ishai-Michaeli, Riva;
Casu, Benito;
Vlodavsky, Israel;
Borsig, Lubor

Publication type:

Article

Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models.

Published in:

FASEB Journal, 2005, v. 19, n. 2, p. 211, doi. 10.1096/fj.04-1970com

By:

Zcharia, Eyal;
Zilka, Rachel;
Yaar, Alon;
Yacoby-Zeevi, Oron;
Zetser, Anna;
Metzger, Shula;
Sarid, Ronit;
Naggi, Annamaria;
Casu, Benito;
Ilant, Neta;
Vlodavsky, Israel;
Abramovitch, Rinat

Publication type:

Article

Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior.

Published in:

FASEB Journal, 2004, v. 18, n. 2, p. 252, doi. 10.1096/fj.03-0572com

By:

Zcharia, Eyal;
Metzger, Shula;
Chajek-Shaul, Tova;
Aingorn, Helena;
Friedmann, Yael;
Weinstein, Talia;
Jin-Ping Li;
Lindahl, Ulf;
Vlodavsky, Israel;
Elkin, Michael

Publication type:

Article

Heparanase mediates cell adhesion independent of its enzymatic activity.

Published in:

FASEB Journal, 2003, v. 17, n. 9, p. 1015, doi. 10.1096/fj.02-0773com

By:

GOLDSHMIDT, ORIT;
ZCHARIA, EYAL;
COHEN, MIRIAM;
AINGORN, HELENA;
COHEN, IRIT;
NADAV, LIAT;
KATZ, BEN-ZION;
GEIGER, BENJAMIN;
VLODAVSKY, ISRAEL

Publication type:

Article

Aortic endothelial cells synthesize basic fibroblast growth factor which remains cell associated and platelet-derived growth factor-like protein which is secreted.

Published in:

Journal of Cellular Physiology, 1987, v. 131, n. 3, p. 402, doi. 10.1002/jcp.1041310312

By:

Vlodavsky, Israel;
Fridman, Rafael;
Sullivan, Robert;
Sasse, Joachim;
Klagsbrun, Michael

Publication type:

Article

Soluble antigen induces T lymphocytes to secrete an endoglycosidase that degrades the heparan sulfate moiety of subendothelial extracellular matrix.

Published in:

Journal of Cellular Physiology, 1987, v. 130, n. 1, p. 85, doi. 10.1002/jcp.1041300113

By:

Fridman, Rafael;
Lider, Ofer;
Naparstek, Yaakov;
Fuks, Zvi;
Vlodavsky, Israel;
Cohen, Irun R.

Publication type:

Article

Involvement of both heparanase and plasminogen activator in lymphoma cell-mediated degradation of heparan sulfate in the subendothelial extracellular matrix.

Published in:

Journal of Cellular Physiology, 1986, v. 128, n. 2, p. 299, doi. 10.1002/jcp.1041280223

By:

Bar-Ner, Matia;
Mayer, Michael;
Schirrmacher, Volker;
Vlodavsky, Israel

Publication type:

Article

Production and characterization of interferon from endothelial cells.

Published in:

Journal of Cellular Physiology, 1985, v. 122, n. 2, p. 200, doi. 10.1002/jcp.1041220206

By:

Einhorn, Stefan;
Vlodavsky, Israel;
Fuks, Zvi;
Eldor, Amiram;
Panet, Amos

Publication type:

Article

Cultured endothelial cells increase their capacity to synthesize prostacyclin following the formation of a contact inhibited cell monolayer.

Published in:

Journal of Cellular Physiology, 1983, v. 114, n. 2, p. 179, doi. 10.1002/jcp.1041140206

By:

Eldor, Amiram;
Vlodavsky, Israel;
Hy-Am, Esther;
Atzmon, Ruth;
Weksler, Babette B.;
Raz, Amiram;
Fuks, Zvi

Publication type:

Article

Epidermal growth factor induced membrane changes in 3T3 cells.

Published in:

Journal of Cellular Physiology, 1978, v. 95, n. 2, p. 195, doi. 10.1002/jcp.1040950209

By:

Aharonov, Aharon;
Vlodavsky, Israel;
Pruss, Rebecca M.;
Fox, C. Fred;
Herschman, Harvey R.

Publication type:

Article

Control of normal differentiation of myeloid leukemic cells. X. Glucose utilization, cellular ATP and associated membrane changes in D<sup>+</sup> and D<sup>−</sup> cells.

Published in:

Journal of Cellular Physiology, 1976, v. 87, n. 2, p. 167, doi. 10.1002/jcp.1040870205

By:

Vlodavsky, Israel;
Fibach, Eitan;
Sachs, Leo

Publication type:

Article

Halofuginone: From veterinary use to human therapy.

Published in:

Drug Development Research, 2000, v. 50, n. 3/4, p. 371, doi. 10.1002/1098-2299(200007/08)50:3/4<371::AID-DDR19>3.0.CO;2-R

By:

Pines, Mark;
Vlodavsky, Israel;
Nagler, Arnon

Publication type:

Article

Heparanase prevents the development of type 1 diabetes in non-obese diabetic mice by regulating T-cell activation and cytokines production.

Published in:

Diabetes/Metabolism Research & Reviews, 2008, v. 24, n. 5, p. 413, doi. 10.1002/dmrr.868

By:

Bitan, Menachem;
Weiss, Lola;
Zeira, Michael;
Reich, Shoshana;
Pappo, Orit;
Vlodavsky, Israel;
Slavin, Shimon

Publication type:

Article

Endothelial dysfunction and its critical role in COVID‐19‐associated coagulopathy: Defibrotide as an endothelium‐protective, targeted therapy.

Published in:

EJHaem, 2021, v. 2, n. 3, p. 680, doi. 10.1002/jha2.198

By:

García‐Bernal, David;
Richardson, Edward;
Vlodavsky, Israel;
Carlo‐Stella, Carmelo;
Iacobelli, Massimo;
Jara, Rubén;
Richardson, Paul G.;
Moraleda, Jose M.

Publication type:

Article

Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications.

Published in:

2018

By:

Barash, Uri;
Feld, Sari;
Ilan, Neta;
Vlodavsky, Israel;
Lapidot, Moshe;
Zohar, Yaniv;
Loomis, Cynthia;
Moreira, Andre;
Goparaju, Chandra;
Pass, Harvey I;
Yang, Haining;
Hammond, Edward;
Zhang, Ganlin;
Li, Jin-Ping;
Nagler, Arnon

Publication type:

journal article