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Rationale, Development, and Validation of HdxSim, a Clinical Decision Support Tool for Model‐Informed Precision Dosing of Hydroxyurea for Children with Sickle Cell Anemia.
- Published in:
- Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 670, doi. 10.1002/cpt.3119
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- Article
A Population Pharmacokinetic Analysis of l-Glutamine Exposure in Patients with Sickle Cell Disease: Evaluation of Dose and Food Effects.
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- Clinical Pharmacokinetics, 2024, v. 63, n. 3, p. 357, doi. 10.1007/s40262-024-01349-4
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- Article
Forecasting Fetal Buprenorphine Exposure through Maternal–Fetal Physiologically Based Pharmacokinetic Modeling.
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- Pharmaceutics, 2024, v. 16, n. 3, p. 375, doi. 10.3390/pharmaceutics16030375
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- Article
Ceftriaxone Pharmacokinetics and Pharmacodynamic Target Attainment for Three Pediatric Patients Receiving Continuous Kidney Replacement Therapy.
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- Journal of Pediatric Pharmacology & Therapeutics, 2024, v. 29, n. 2, p. 180, doi. 10.5863/1551-6776-29.2.180
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- Article
Tutorial on model selection and validation of model input into precision dosing software for model‐informed precision dosing.
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- CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 12, p. 1827, doi. 10.1002/psp4.13056
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- Article
Novel Therapeutic Modalities: The Future is Now.
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- Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 3, p. 493, doi. 10.1002/cpt.2996
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- Article
Adopting Model‐Informed Precision‐Dosing for Eculizumab in Transplant Associated‐Thrombotic Microangiopathy to Gene Therapies.
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- Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 3, p. 511, doi. 10.1002/cpt.2966
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- Article
Cefepime pharmacokinetics in critically ill children and young adults undergoing continuous kidney replacement therapy.
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- Journal of Antimicrobial Chemotherapy (JAC), 2023, v. 78, n. 9, p. 2140, doi. 10.1093/jac/dkad192
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- Article
Model‐Informed Precision Dosing Guidance of Ethosuximide Developed from a Randomized Controlled Clinical Trial of Childhood Absence Epilepsy.
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- Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 2, p. 459, doi. 10.1002/cpt.2965
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- Article
Implementation of CYP2D6-guided opioid therapy at Cincinnati Children's Hospital Medical Center.
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- American Journal of Health-System Pharmacy, 2023, v. 80, n. 13, p. 852, doi. 10.1093/ajhp/zxad025
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- Article
Pharmacokinetic parameters over time during sepsis and the association of target attainment and outcomes in critically ill children and young adults receiving ceftriaxone.
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- Pharmacotherapy, 2023, v. 43, n. 7, p. 609, doi. 10.1002/phar.2774
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- Article
Hydroxyurea treatment for sickle cell anemia during pregnancy and lactation: Current evidence and knowledge gaps.
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- Pharmacotherapy, 2023, v. 43, n. 5, p. 419, doi. 10.1002/phar.2793
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- Article
Real world population pharmacokinetic study in children and young adults with inflammatory bowel disease discovers novel blood and stool microbial predictors of vedolizumab clearance.
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- Alimentary Pharmacology & Therapeutics, 2023, v. 57, n. 5, p. 524, doi. 10.1111/apt.17277
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- Article
Relationship between piperacillin concentrations, clinical factors and piperacillin/tazobactam-associated acute kidney injury.
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- Journal of Antimicrobial Chemotherapy (JAC), 2023, v. 78, n. 2, p. 478, doi. 10.1093/jac/dkac416
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- Article
β-lactam precision dosing in critically ill children: Current state and knowledge gaps.
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- Frontiers in Pharmacology, 2022, v. 13, p. 01, doi. 10.3389/fphar.2022.1044683
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- Article
Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines.
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- Cardiovascular Drugs & Therapy, 2022, v. 36, n. 4, p. 589, doi. 10.1007/s10557-021-07169-z
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- Article
Clinical implementation of pharmacogenetics and model‐informed precision dosing to improve patient care.
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- British Journal of Clinical Pharmacology, 2022, v. 88, n. 4, p. 1418, doi. 10.1111/bcp.14426
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- Article
Antibodies‐to‐infliximab accelerate clearance while dose intensification reverses immunogenicity and recaptures clinical response in paediatric Crohn's disease.
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- Alimentary Pharmacology & Therapeutics, 2022, v. 55, n. 5, p. 593, doi. 10.1111/apt.16733
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- Article
Physiologically‐Based Pharmacokinetic Modeling to Investigate the Effect of Maturation on Buprenorphine Pharmacokinetics in Newborns with Neonatal Opioid Withdrawal Syndrome.
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- Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 2, p. 496, doi. 10.1002/cpt.2458
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- Article
Test‐dose pharmacokinetics guided melphalan dose adjustment in reduced intensity conditioning allogeneic transplant for non‐malignant disorders.
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- British Journal of Clinical Pharmacology, 2022, v. 88, n. 1, p. 115, doi. 10.1111/bcp.14932
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- Article
Model‐informed precision dosing for alemtuzumab in paediatric and young adult patients undergoing allogeneic haematopoietic cell transplantation.
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- British Journal of Clinical Pharmacology, 2022, v. 88, n. 1, p. 248, doi. 10.1111/bcp.14955
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- Article
Toward pharmacogenetic SLCO1B1‐guided dosing of methotrexate in arthritis using a murine Slco1b2 knockout model.
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- CTS: Clinical & Translational Science, 2021, v. 14, n. 6, p. 2267, doi. 10.1111/cts.13086
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- Article
Pharmacokinetic modelling to predict risk of ototoxicity with intravenous tobramycin treatment in cystic fibrosis.
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- 2021
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- Publication type:
- journal article
Early initiation of hydroxyurea (hydroxycarbamide) using individualised, pharmacokinetics‐guided dosing can produce sustained and nearly pancellular expression of fetal haemoglobin in children with sickle cell anaemia.
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- British Journal of Haematology, 2021, v. 194, n. 3, p. 617, doi. 10.1111/bjh.17663
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- Article
Machine Learning as a Novel Method to Support Therapeutic Drug Management and Precision Dosing.
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- Clinical Pharmacology & Therapeutics, 2021, v. 110, n. 2, p. 273, doi. 10.1002/cpt.2326
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- Article
Opioid Treatment for Neonatal Opioid Withdrawal Syndrome: Current Challenges and Future Approaches.
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- Journal of Clinical Pharmacology, 2021, v. 61, n. 7, p. 857, doi. 10.1002/jcph.1811
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- Article
Status Toward the Implementation of Precision Dosing in Children.
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- Journal of Clinical Pharmacology, 2021, v. 61, p. S36, doi. 10.1002/jcph.1830
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- Article
Model‐Informed Pediatric Drug Development: Application of Pharmacometrics to Define the Right Dose for Children.
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- Journal of Clinical Pharmacology, 2021, v. 61, p. S52, doi. 10.1002/jcph.1841
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- Article
Real‐World Infliximab Pharmacokinetic Study Informs an Electronic Health Record‐Embedded Dashboard to Guide Precision Dosing in Children with Crohn's Disease.
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- Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 6, p. 1639, doi. 10.1002/cpt.2148
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- Article
Hydroyxurea improves cerebral oxygen saturation in children with sickle cell anemia.
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- American Journal of Hematology, 2021, v. 96, n. 5, p. 538, doi. 10.1002/ajh.26120
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- Article
Hydroxyurea Pharmacokinetics in Pediatric Patients After Total Pancreatectomy With Islet Autotransplantation.
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- Journal of Clinical Pharmacology, 2021, v. 61, n. 4, p. 547, doi. 10.1002/jcph.1759
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- Article
Demonstrating Feasibility of an Opportunistic Sampling Approach for Pharmacokinetic Studies of β‐Lactam Antibiotics in Critically Ill Children.
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- Journal of Clinical Pharmacology, 2021, v. 61, n. 4, p. 565, doi. 10.1002/jcph.1773
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- Article
A Pilot Randomized, Controlled, Double‐Blind Trial of Bumetanide to Treat Neonatal Seizures.
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- Annals of Neurology, 2021, v. 89, n. 2, p. 327, doi. 10.1002/ana.25959
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- Article
Physiologic Indirect Response Modeling to Describe Buprenorphine Pharmacodynamics in Newborns Treated for Neonatal Opioid Withdrawal Syndrome.
- Published in:
- Clinical Pharmacokinetics, 2021, v. 60, n. 2, p. 249, doi. 10.1007/s40262-020-00939-2
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- Article
Electrochemical Determination of Hydroxyurea in a Complex Biological Matrix Using MoS 2 -Modified Electrodes and Chemometrics.
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- Biomedicines, 2021, v. 9, n. 1, p. 6, doi. 10.3390/biomedicines9010006
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- Article
Precision Dosing: The Clinical Pharmacology of Goldilocks.
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- Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 1, p. 11, doi. 10.1002/cpt.2112
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- Article
Roger W. Jelliffe, MD, FCP, FAAPS: A World Leader in Population Pharmacokinetic and Pharmacodynamic Modeling and Model‐Based Target Controlled Individualized Dosing.
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- Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 1, p. 22, doi. 10.1002/cpt.2114
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- Article
PK/PD Study of Mycophenolate Mofetil in Children With Systemic Lupus Erythematosus to Inform Model-Based Precision Dosing.
- Published in:
- Frontiers in Pharmacology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.605060
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- Article
Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia.
- Published in:
- 2020
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- Publication type:
- journal article
A phase II study of continuous oral mTOR inhibitor everolimus for recurrent, radiographic-progressive neurofibromatosis type 1–associated pediatric low-grade glioma: a Neurofibromatosis Clinical Trials Consortium study.
- Published in:
- Neuro-Oncology, 2020, v. 22, n. 10, p. 1527, doi. 10.1093/neuonc/noaa071
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- Publication type:
- Article
Hydromorphone population pharmacokinetics in pediatric surgical patients.
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- Pediatric Anesthesia, 2020, v. 30, n. 10, p. 1091, doi. 10.1111/pan.13975
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- Article
Molecular Adsorbent Recirculating System Therapy with Continuous Renal Replacement Therapy Enhanced Clearance of Piperacillin in a Pediatric Patient and Led to Failure to Attain Pharmacodynamic Targets.
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- Pharmacotherapy, 2020, v. 40, n. 10, p. 1061, doi. 10.1002/phar.2462
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- Article
MTXPK.org: A Clinical Decision Support Tool Evaluating High‐Dose Methotrexate Pharmacokinetics to Inform Post‐Infusion Care and Use of Glucarpidase.
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- Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 3, p. 635, doi. 10.1002/cpt.1957
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- Article
Influence of MRP3 Genetics and Hepatic Expression Ontogeny for Morphine Disposition in Neonatal and Pediatric Patients.
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- Journal of Clinical Pharmacology, 2020, v. 60, n. 8, p. 992, doi. 10.1002/jcph.1592
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- Article
Population pharmacokinetic modelling of busulfan and the influence of body composition in paediatric Fanconi anaemia patients.
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- British Journal of Clinical Pharmacology, 2020, v. 86, n. 5, p. 933, doi. 10.1111/bcp.14202
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- Article
Utilizing Pediatric Physiologically Based Pharmacokinetic Models to Examine Factors That Contribute to Methadone Pharmacokinetic Variability in Neonatal Abstinence Syndrome Patients.
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- Journal of Clinical Pharmacology, 2020, v. 60, n. 4, p. 453, doi. 10.1002/jcph.1538
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- Article
Next Challenge From the Variance in Individual Physiologically‐Based Pharmacokinetic Model‐Predicted to Observed Morphine Concentration in Critically Ill Neonates.
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- Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 2, p. 319, doi. 10.1002/cpt.1607
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- Article
Development and Implementation of Electronic Health Record–Integrated Model‐Informed Clinical Decision Support Tools for the Precision Dosing of Drugs.
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- Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 1, p. 129, doi. 10.1002/cpt.1679
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- Article
Electronic Health Record–Embedded Decision Support Platform for Morphine Precision Dosing in Neonates.
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- Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 1, p. 186, doi. 10.1002/cpt.1684
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- Article
1543. Ceftaroline Model-based Dose Individualization in an Infant with Kidney Disease and Mediastinitis.
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- Open Forum Infectious Diseases, 2019, v. 6, p. S563, doi. 10.1093/ofid/ofz360.1407
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- Article