Works by Vijgen, Leen

Results: 13

Safety, tolerability, and pharmacokinetics of AL-335 in healthy volunteers and hepatitis C virus-infected subjects.

Published in:

PLoS ONE, 2018, v. 13, n. 10, p. 1, doi. 10.1371/journal.pone.0204974

By:

McClure, Matthew W.;
Berliba, Elina;
Tsertsvadze, Tengiz;
Streinu-Cercel, Adrian;
Vijgen, Leen;
Astruc, Béatrice;
Patat, Alain;
Westland, Christopher;
Chanda, Sushmita;
Zhang, Qingling;
Kakuda, Thomas N.;
Vuong, Jennifer;
Khorlin, Nick;
Beigelman, Leonid;
Blatt, Lawrence M.;
Fry, John

Publication type:

Article

Replication capacity of minority variants in viral populations can affect the assessment of resistance in HCV chimeric replicon phenotyping assays.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2012, v. 67, n. 10, p. 2327, doi. 10.1093/jac/dks234

By:

Verbinnen, Thierry;
Jacobs, Tom;
Vijgen, Leen;
Ceulemans, Hugo;
Neyts, Johan;
Fanning, Gregory;
Lenz, Oliver

Publication type:

Article

Pyridine N-oxide derivatives are inhibitory to the human SARS and feline infectious peritonitis coronavirus in cell culture.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2006, v. 57, n. 3, p. 472, doi. 10.1093/jac/dki481

By:

Jan Balzarini;
Els Keyaerts;
Leen Vijgen;
Frank Vandermeer;
Miguel Stevens;
Erik De Clercq;
Herman Egberink;
Marc Van Ranst

Publication type:

Article

Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties.

Published in:

Angewandte Chemie, 2012, v. 124, n. 19, p. 4715, doi. 10.1002/ange.201200110

By:

Cummings, Maxwell D.;
Lin, Tse-I;
Hu, Lili;
Tahri, Abdellah;
McGowan, David;
Amssoms, Katie;
Last, Stefaan;
Devogelaere, Benoit;
Rouan, Marie-Claude;
Vijgen, Leen;
Berke, Jan Martin;
Dehertogh, Pascale;
Fransen, Els;
Cleiren, Erna;
van der Helm, Liesbet;
Fanning, Gregory;
Van Emelen, Kristof;
Nyanguile, Origène;
Simmen, Kenny;
Raboisson, Pierre

Publication type:

Article

Dengue Infections Among Household Contacts of Symptomatic Index Cases: Implications for Community-Based Intervention Studies.

Published in:

Viruses (1999-4915), 2025, v. 17, n. 6, p. 859, doi. 10.3390/v17060859

By:

Koehne, Erik;
Van Wesenbeeck, Liesbeth;
Hibberd, Martin L.;
Buelens, Annemie;
Toizumi, Michiko;
Clerck, Kim De;
Vijgen, Leen;
Lagatie, Ole;
Masdin, Lucy;
Nguyen, Hien Anh Thi;
Le, Hoang Huy;
Dang, Duc Anh;
Huynh, Mai Kim;
Le, Lien Thuy;
Nguyên, Trieu Bao;
Hue, Stephane;
Do, Hung Thai;
Herrera-Taracena, Guillermo;
Rasschaert, Freya;
Yoshida, Lay-Myint

Publication type:

Article

Virology analysis in HCV genotype 1-infected patients treated with the combination of simeprevir and TMC647055/ritonavir, with and without ribavirin, and JNJ-56914845.

Published in:

Virology Journal, 2017, v. 14, p. 1, doi. 10.1186/s12985-017-0760-2

By:

Vijgen, Leen;
Thys, Kim;
Vandebosch, An;
Van Remoortere, Pieter;
Verloes, René;
De Meyer, Sandra

Publication type:

Article

A Prospective Cohort Study of Primary Dengue Virus Infection in Medellín, Colombia.

Published in:

Vaccines, 2025, v. 13, n. 7, p. 748, doi. 10.3390/vaccines13070748

By:

Trujillo, Andrea;
Van Wesenbeeck, Liesbeth;
Salazar, Lina;
López, Liliana;
Tambuyzer, Lotke;
Buelens, Annemie;
Clerck, Kim De;
Lenz, Oliver;
Vijgen, Leen;
Van Loock, Marnix;
Herrera-Taracena, Guillermo;
Vélez, Iván Darío;
Rasschaert, Freya

Publication type:

Article

Efficacy, safety and pharmacokinetics of simeprevir and TMC647055/ritonavir with or without ribavirin and JNJ-56914845 in HCV genotype 1 infection.

Published in:

2017

By:

Bourgeois, Stefan;
Van Vlierberghe, Hans;
Moreno, Christophe;
Orlent, Hans;
Nevens, Frederik;
Arastéh, Keikawus;
Horsmans, Yves;
Schattenberg, Jörn M.;
Buggisch, Peter;
Francque, Sven;
Vijgen, Leen;
Kakuda, Thomas N.;
Hoeben, Eva;
Luo, Donghan;
Vandebosch, An;
Jacquemyn, Bert;
Van Remoortere, Pieter;
Verloes, René

Publication type:

journal article

JNJ-4178 (adafosbuvir, odalasvir, and simeprevir) in Japanese patients with chronic hepatitis C virus genotype 1 or 2 infection with or without compensated cirrhosis: the Phase IIa OMEGA-3 study.

Published in:

2020

By:

Takehara, Tetsuo;
Chayama, Kazuaki;
Kurosaki, Masayuki;
Yatsuhashi, Hiroshi;
Tanaka, Yasuhito;
Hiramatsu, Naoki;
Sakamoto, Naoya;
Asahina, Yasuhiro;
Nozaki, Akito;
Nakano, Toshikazu;
Hagiwara, Yosuke;
Shimizu, Hiroko;
Yoshida, Hiroki;
Huang, Yuhan;
Biermer, Michael;
Vijgen, Leen;
Hayashi, Norio

Publication type:

journal article

CROCuS, a Phase II Study Evaluating the Antiviral Activity, Clinical Outcomes, and Safety of Rilematovir in Children Aged ≥ 28 Days and ≤ 3 Years with Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus.

Published in:

Pediatric Drugs, 2024, v. 26, n. 4, p. 411, doi. 10.1007/s40272-024-00625-x

By:

Ferrero, Fernando;
Lin, Chien-Yu;
Liese, Johannes;
Luz, Kleber;
Stoeva, Tatyana;
Nemeth, Agnes;
Gijón, Manuel;
Calvo, Cristina;
Natalini, Silvina;
Toh, Teck-Hock;
Deleu, Sofie;
Chen, Bohang;
Rusch, Sarah;
Sánchez, Beatriz López;
Leipoldt, Illse;
Vijgen, Leen;
Huntjens, Dymphy;
Baguet, Tristan;
Bertzos, Kristi;
Gamil, Mohamed

Publication type:

Article

Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties.

Published in:

Angewandte Chemie International Edition, 2012, v. 51, n. 19, p. 4637, doi. 10.1002/anie.201200110

By:

Cummings, Maxwell D.;
Lin, Tse-I;
Hu, Lili;
Tahri, Abdellah;
McGowan, David;
Amssoms, Katie;
Last, Stefaan;
Devogelaere, Benoit;
Rouan, Marie-Claude;
Vijgen, Leen;
Berke, Jan Martin;
Dehertogh, Pascale;
Fransen, Els;
Cleiren, Erna;
van der Helm, Liesbet;
Fanning, Gregory;
Van Emelen, Kristof;
Nyanguile, Origène;
Simmen, Kenny;
Raboisson, Pierre

Publication type:

Article

Simeprevir, daclatasvir, and sofosbuvir for hepatitis C virus-infected patients: Long-term follow-up results from the open-label, Phase II IMPACT study.

Published in:

Health Science Reports, 2020, v. 3, n. 2, p. 1, doi. 10.1002/hsr2.145

By:

Lawitz, Eric;
Poordad, Fred;
Gutierrez, Julio A.;
Beumont, Maria;
Beets, Greet;
Vandevoorde, Ann;
Van Remoortere, Pieter;
Luo, Donghan;
Vijgen, Leen;
Van Eygen, Veerle;
Gamil, Mohamed

Publication type:

Article

A novel pancoronavirus RT-PCR assay: frequent detection of human coronavirus NL63 in children hospitalized with respiratory tract infections in Belgium.

Published in:

BMC Infectious Diseases, 2005, v. 5, n. 1, p. 6, doi. 10.1186/1471-2334-5-6

By:

Moës, Elien;
Vijgen, Leen;
Keyaerts, Els;
Zlateva, Kalina;
Li, Sandra;
Maes, Piet;
Pyrc, Krzysztof;
Berkhout, Ben;
van der Hoek, Lia;
Van Ranst, Marc

Publication type:

Article