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The GBA1 K198E Variant Is Associated with Suppression of Glucocerebrosidase Activity, Autophagy Impairment, Oxidative Stress, Mitochondrial Damage, and Apoptosis in Skin Fibroblasts.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 17, p. 9220, doi. 10.3390/ijms25179220
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- Publication type:
- Article
TPEN exerts selective anti-leukemic efficacy in ex vivo drug-resistant childhood acute leukemia.
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- BioMetals, 2021, v. 34, n. 1, p. 49, doi. 10.1007/s10534-020-00262-0
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- Publication type:
- Article
Metal chelator TPEN selectively induces apoptosis in K562 cells through reactive oxygen species signaling mechanism: implications for chronic myeloid leukemia.
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- BioMetals, 2017, v. 30, n. 3, p. 405, doi. 10.1007/s10534-017-0015-0
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- Publication type:
- Article
Acute and chronic metal exposure impairs locomotion activity in Drosophila melanogaster: a model to study Parkinsonism.
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- BioMetals, 2011, v. 24, n. 6, p. 1045, doi. 10.1007/s10534-011-9463-0
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- Publication type:
- Article
Autosomal recessive juvenile parkinsonism Cys212Tyr mutation in parkin renders lymphocytes susceptible to dopamine- and iron-mediated apoptosis.
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- Movement Disorders, 2004, v. 19, n. 3, p. 324, doi. 10.1002/mds.10670
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- Publication type:
- Article
Erratum: Variable frequency of LRRK2 variants in the Latin American research consortium on the genetics of Parkinson's disease (LARGE-PD), a case of ancestry.
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- 2018
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- Publication type:
- Correction Notice
Variable frequency of LRRK2 variants in the Latin American research consortium on the genetics of Parkinson's disease (LARGE-PD), a case of ancestry.
- Published in:
- NPJ Parkinson's Disease, 2017, v. 3, n. 1, p. N.PAG, doi. 10.1038/s41531-017-0020-6
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- Publication type:
- Article
Phenolic‐rich extract of avocado Persea americana (var. Colinred) peel blunts paraquat/maneb‐induced apoptosis through blocking phosphorylation of LRRK2 kinase in human nerve‐like cells.
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- Environmental Toxicology, 2022, v. 37, n. 3, p. 660, doi. 10.1002/tox.23433
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- Publication type:
- Article
Effects of Insulin-Like Growth Factor-1 on Rotenone-Induced Apoptosis in Human Lymphocyte Cells.
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- Basic & Clinical Pharmacology & Toxicology, 2010, v. 106, n. 1, p. 53, doi. 10.1111/j.1742-7843.2009.00472.x
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- Publication type:
- Article
High Yield of Functional Dopamine-like Neurons Obtained in NeuroForsk 2.0 Medium to Study Acute and Chronic Rotenone Effects on Oxidative Stress, Autophagy, and Apoptosis.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 21, p. 15744, doi. 10.3390/ijms242115744
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- Publication type:
- Article
Rotenone Blocks the Glucocerebrosidase Enzyme and Induces the Accumulation of Lysosomes and Autophagolysosomes Independently of LRRK2 Kinase in HEK-293 Cells.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 13, p. 10589, doi. 10.3390/ijms241310589
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- Publication type:
- Article
LRRK2 Knockout Confers Resistance in HEK-293 Cells to Rotenone-Induced Oxidative Stress, Mitochondrial Damage, and Apoptosis.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 13, p. 10474, doi. 10.3390/ijms241310474
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- Publication type:
- Article
PSEN1 E280A Cholinergic-like Neurons and Cerebral Spheroids Derived from Mesenchymal Stromal Cells and from Induced Pluripotent Stem Cells Are Neuropathologically Equivalent.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 10, p. 8957, doi. 10.3390/ijms24108957
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- Publication type:
- Article
Latent Tri-lineage Potential of Human Menstrual Blood–Derived Mesenchymal Stromal Cells Revealed by Specific In Vitro Culture Conditions.
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- Molecular Neurobiology, 2021, v. 58, n. 10, p. 5194, doi. 10.1007/s12035-021-02442-6
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- Publication type:
- Article
Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function.
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- Journal of Pineal Research, 2017, v. 63, n. 2, p. n/a, doi. 10.1111/jpi.12415
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- Publication type:
- Article
Combination of Tramiprosate, Curcumin, and SP600125 Reduces the Neuropathological Phenotype in Familial Alzheimer Disease PSEN1 I416T Cholinergic-like Neurons.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 9, p. 4925, doi. 10.3390/ijms25094925
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- Publication type:
- Article
Using Paraquat to Generate Anion Free Radicals and Hydrogen Peroxide in In Vitro: Antioxidant Effect of Vitamin E.
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- Biochemistry & Molecular Biology Education, 2010, v. 38, n. 2, p. 104, doi. 10.1002/bmb.20349
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- Publication type:
- Article
Neuroprotective Effects of Methanolic Extract of Avocado Persea americana (var. Colinred) Peel on Paraquat-Induced Locomotor Impairment, Lipid Peroxidation and Shortage of Life Span in Transgenic knockdown Parkin Drosophila melanogaster.
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- Neurochemical Research, 2019, v. 44, n. 8, p. 1986, doi. 10.1007/s11064-019-02835-z
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- Publication type:
- Article
Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson's Disease.
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- Neurochemical Research, 2016, v. 41, n. 10, p. 2675, doi. 10.1007/s11064-016-1982-1
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- Publication type:
- Article
Life Span and Locomotor Activity Modification by Glucose and Polyphenols in Drosophila melanogaster Chronically Exposed to Oxidative Stress-stimuli: Implications in Parkinson's Disease.
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- Neurochemical Research, 2011, v. 36, n. 6, p. 1073, doi. 10.1007/s11064-011-0451-0
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- Publication type:
- Article
Protective Effects of the Synthetic Cannabinoids CP55,940 and JWH-015 on Rat Brain Mitochondria upon Paraquat Exposure.
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- Neurochemical Research, 2010, v. 35, n. 9, p. 1323, doi. 10.1007/s11064-010-0188-1
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- Publication type:
- Article
Elevated cerebrospinal fluid amyloid-Beta42 levels in young adults at genetic risk for early-onset alzheimer's disease
- Published in:
- 2011
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- Publication type:
- Abstract
Fructose sensitizes Jurkat cells oxidative stress-induced apoptosis via caspase-dependent and caspase-independent mechanisms.
- Published in:
- Cell Biology International, 2016, v. 40, n. 11, p. 1162, doi. 10.1002/cbin.10653
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- Publication type:
- Article
Rotenone Induces a Neuropathological Phenotype in Cholinergic-like Neurons Resembling Parkinson’s Disease Dementia (PDD)
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- Neurotoxicity Research, 2024, v. 42, n. 3, p. 1, doi. 10.1007/s12640-024-00705-3
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- Publication type:
- Article
(−)-Epigallocatechin-3-Gallate Diminishes Intra-and Extracellular Amyloid-Induced Cytotoxic Effects on Cholinergic-like Neurons from Familial Alzheimer's Disease PSEN1 E280A.
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- Biomolecules (2218-273X), 2021, v. 11, n. 12, p. 1845, doi. 10.3390/biom11121845
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- Publication type:
- Article
Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer's disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca<sup>2+</sup> dysregulation: Therapeutic implications
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- PLoS ONE, 2020, p. 1, doi. 10.1371/journal.pone.0221669
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- Publication type:
- Article
CA1 Hippocampal Neuronal Loss in Familial Alzheimer's Disease Presenilin-1 E280A Mutation Is Related to Epilepsy.
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- Epilepsia (Series 4), 2004, v. 45, n. 7, p. 751, doi. 10.1111/j.0013-9580.2004.55403.x
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- Publication type:
- Article
TPEN/TPGS (T2) combo dramatically reduces Philadelphia chromosome-positive pro-lymphoblastic B leukemia in BALB/c mice.
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- 2023
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- Publication type:
- journal article
Combinational treatment of TPEN and TPGS induces apoptosis in acute lymphoblastic and chronic myeloid leukemia cells in vitro and ex vivo.
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- 2022
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- Publication type:
- journal article
Cholinergic-like neurons and cerebral spheroids bearing the PSEN1 p.Ile416Thr variant mirror Alzheimer's disease neuropathology.
- Published in:
- Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-39630-4
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- Publication type:
- Article
Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism.
- Published in:
- Cancer Cell International, 2011, v. 11, n. 1, p. 19, doi. 10.1186/1475-2867-11-19
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- Publication type:
- Article
Ultrastructure evidence of necrotic neural cell death in familial Alzheimer's disease brains bearing presenilin-1 E280A mutation.
- Published in:
- Journal of Alzheimer's Disease, 2001, v. 3, n. 4, doi. 10.3233/JAD-2001-3408
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- Publication type:
- Article
Vitamin E TPGS 1000 Induces Apoptosis in the K562 Cell Line: Implications for Chronic Myeloid Leukemia.
- Published in:
- Oxidative Medicine & Cellular Longevity, 2021, p. 1, doi. 10.1155/2021/5580288
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- Publication type:
- Article
Response to Rotenone Is Glucose-Sensitive in a Model of Human Acute Lymphoblastic Leukemia: Involvement of Oxidative Stress Mechanism, DJ-1, Parkin, and PINK-1 Proteins.
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- Oxidative Medicine & Cellular Longevity, 2014, v. 2014, p. 1, doi. 10.1155/2014/457154
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- Publication type:
- Article
TPEN Induces Apoptosis Independently of Zinc Chelator Activity in a Model of Acute Lymphoblastic Leukemia and Ex Vivo Acute Leukemia Cells through Oxidative Stress and Mitochondria Caspase-3- and AIF-Dependent Pathways.
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- Oxidative Medicine & Cellular Longevity, 2012, v. 2012, p. 1, doi. 10.1155/2012/313275
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- Publication type:
- Article
The Bad, the Good, and the Ugly about Oxidative Stress.
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- Oxidative Medicine & Cellular Longevity, 2012, v. 2012, p. 1, doi. 10.1155/2012/163913
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- Publication type:
- Article
Glucose promotes resistance in lymphocytes against oxidative stress-induced apoptosis through signaling and metabolic pathways. Implications for Parkinson's disease.
- Published in:
- Iatreia, 2017, v. 30, n. 2, p. 117, doi. 10.17533/udea.iatreia.v30n2a02
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- Publication type:
- Article
LRRK2 Kinase Inhibitor PF-06447475 Protects Drosophila melanogaster against Paraquat-Induced Locomotor Impairment, Life Span Reduction, and Oxidative Stress.
- Published in:
- Neurochemical Research, 2024, v. 49, n. 9, p. 2440, doi. 10.1007/s11064-024-04141-9
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- Publication type:
- Article
Vitamin E synthetic derivate-TPGS-selectively induces apoptosis in jurkat t cells via oxidative stress signaling pathways: implications for acute lymphoblastic leukemia.
- Published in:
- Apoptosis, 2016, v. 21, n. 9, p. 1019, doi. 10.1007/s10495-016-1266-x
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- Publication type:
- Article
Melatonin Increases Life Span, Restores the Locomotor Activity, and Reduces Lipid Peroxidation (LPO) in Transgenic Knockdown Parkin Drosophila melanogaster Exposed to Paraquat or Paraquat/Iron.
- Published in:
- Neurotoxicity Research, 2021, v. 39, n. 5, p. 1551, doi. 10.1007/s12640-021-00397-z
- By:
- Publication type:
- Article
Correction to: Epigallocatechin-3-Gallate Protects and Prevents Paraquat-Induced Oxidative Stress and Neurodegeneration in Knockdown dj-1-β Drosophila melanogaster.
- Published in:
- Neurotoxicity Research, 2018, v. 34, n. 3, p. 417, doi. 10.1007/s12640-018-9919-x
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- Publication type:
- Article
Epigallocatechin-3-Gallate Protects and Prevents Paraquat-Induced Oxidative Stress and Neurodegeneration in Knockdown dj-1-β Drosophila melanogaster.
- Published in:
- Neurotoxicity Research, 2018, v. 34, n. 3, p. 401, doi. 10.1007/s12640-018-9899-x
- By:
- Publication type:
- Article
Cholinergic-like neurons and cerebral spheroids bearing the PSEN1 p.Ile416Thr variant mirror Alzheimer's disease neuropathology.
- Published in:
- Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-39630-4
- By:
- Publication type:
- Article