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Abeta deposition is essential to AD neuropathology.
- Published in:
- 2002
- By:
- Publication type:
- journal article
A promising, novel, and unique BACE1 inhibitor emerges in the quest to prevent Alzheimer's disease.
- Published in:
- EMBO Molecular Medicine, 2018, v. 10, n. 11, p. N.PAG, doi. 10.15252/emmm.201809717
- By:
- Publication type:
- Article
Proteomic Substrate Identification for Membrane Proteases in the Brain.
- Published in:
- Frontiers in Molecular Neuroscience, 2016, v. 9, p. 1, doi. 10.3389/fnmol.2016.00096
- By:
- Publication type:
- Article
The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease.
- Published in:
- 2022
- By:
- Publication type:
- journal article
Anti-Inflammatory Drug Therapy Alters Β-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease.
- Published in:
- Journal of Neuroscience, 2003, v. 23, n. 20, p. 7504, doi. 10.1523/JNEUROSCI.23-20-07504.2003
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- Publication type:
- Article
The case for low‐dose BACE inhibition.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082782
- By:
- Publication type:
- Article
Behavioral, biochemical, and neuropathological outcomes in amyloid‐bearing mice treated long‐term with a range of doses of BACE inhibitor.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.077596
- By:
- Publication type:
- Article
A new biochemical method for ultra‐purification of amyloids from Alzheimer's disease brain tissues.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.054185
- By:
- Publication type:
- Article
O5‐06‐02: AXONAL ORGANIZATION DEFECTS IN THE HIPPOCAMPUS OF ADULT CONDITIONAL BACE1 KNOCKOUT MICE: IMPLICATIONS FOR BACE1 INHIBITOR CLINICAL TRIALS IN HUMANS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1629, doi. 10.1016/j.jalz.2019.06.4865
- By:
- Publication type:
- Article
FTS3‐01‐01: UMIBECESTAT (CNP520) IS NOT ASSOCIATED WITH CHANGES IN HIPPOCAMPAL MORPHOLOGY IN RATS OR CHANGES IN CSF AD BIOMARKERS IN HUMANS TREATED FOR 3 MONTHS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P872, doi. 10.1016/j.jalz.2019.06.4618
- By:
- Publication type:
- Article
P2‐057: 3K3A‐ACTIVATED PROTEIN C BLOCKS AMYLOIDOGENIC BACE1 PATHWAY AND IMPROVES FUNCTIONAL OUTCOME IN MICE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P593, doi. 10.1016/j.jalz.2019.06.2464
- By:
- Publication type:
- Article
P2‐167: EXPRESSION OF THE DUAL LEUCINE ZIPPER KINASE IN DYSTROPHIC NEURITES AND AXONAL BEADING DURING PATHOLOGY PROGRESSION IN ALZHEIMER'S DISEASE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P732, doi. 10.1016/j.jalz.2018.06.854
- By:
- Publication type:
- Article
P1‐163: MOLECULAR MECHANISMS OF THE ALZHEIMER'S RISK GENE UNC5C IN NEURONAL DEATH.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P340, doi. 10.1016/j.jalz.2018.06.167
- By:
- Publication type:
- Article
P1‐027: KINETIC BEHAVIOR OF NEWLY GENERATED BACE1‐CLEAVED APP IN THE HUMAN CENTRAL NERVOUS SYSTEM IN ALZHEIMER'S DISEASE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P276, doi. 10.1016/j.jalz.2018.06.028
- By:
- Publication type:
- Article
Aberrant glial activation and synaptic defects in CaMKIIα-iCre and nestin-Cre transgenic mouse models.
- Published in:
- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-26671-4
- By:
- Publication type:
- Article
The metabolism of human soluble amyloid precursor protein isoforms is quantifiable by a stable isotope labeling-tandem mass spectrometry method.
- Published in:
- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-18869-3
- By:
- Publication type:
- Article
BACE1, THE BETA-SECRETASE ENZYME: A LEADING THERAPEUTIC TARGET FOR ALZHEIMER'S DISEASE.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P162, doi. 10.1016/j.jalz.2016.06.289
- By:
- Publication type:
- Article
Quantitative comparison of dense-core amyloid plaque burdens in Alzheimer’s disease patients and amyloid precursor protein transgenic mice.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P353, doi. 10.1016/j.jalz.2015.06.236
- By:
- Publication type:
- Article
The Alzheimer's beta-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
- Published in:
- 2012
- By:
- Publication type:
- Abstract
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis
- Published in:
- 2009
- By:
- Publication type:
- Abstract
P3-337: S-palmitoylation targets BACE-1 to lipid rafts
- Published in:
- 2008
- By:
- Publication type:
- Abstract
S3-03-01: BACE1 levels are elevated in a rapid amyloid pathology transgenic mouse model of Alzheimer's disease
- Published in:
- 2008
- By:
- Publication type:
- Abstract
O2-03-01: Exploring β-secretase activity in lipid raft microdomains
- Published in:
- 2008
- By:
- Publication type:
- Abstract
P4-047: Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: Possible early events in Alzheimer’s disease pathogenesis
- Published in:
- 2006
- By:
- Publication type:
- Abstract
O4-06-04: Intraneuronal Abeta42 aggregates seed amyloid plaques and cause neuronal loss in transgenic mice with five familial Alzheimer’s disease mutations
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-047: Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: Possible early events in Alzheimer’s disease pathogenesis
- Published in:
- 2006
- By:
- Publication type:
- Abstract
O4-06-04: Intraneuronal Abeta42 aggregates seed amyloid plaques and cause neuronal loss in transgenic mice with five familial Alzheimer’s disease mutations
- Published in:
- 2006
- By:
- Publication type:
- Abstract
A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.
- Published in:
- PLoS Genetics, 2017, v. 13, n. 8, p. 1, doi. 10.1371/journal.pgen.1006962
- By:
- Publication type:
- Article
Low-Level Laser Therapy Ameliorates Disease Progression in a Mouse Model of Alzheimer's Disease.
- Published in:
- Journal of Molecular Neuroscience, 2015, v. 55, n. 2, p. 430, doi. 10.1007/s12031-014-0354-z
- By:
- Publication type:
- Article
Bace 1.
- Published in:
- Journal of Molecular Neuroscience, 2004, v. 23, n. 1/2, p. 105, doi. 10.1385/JMN:23:1-2:105
- By:
- Publication type:
- Article
The β-secretase, BACE.
- Published in:
- Journal of Molecular Neuroscience, 2001, v. 17, n. 2, p. 157, doi. 10.1385/JMN:17:2:157
- By:
- Publication type:
- Article
Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models.
- Published in:
- Acta Neuropathologica Communications, 2015, v. 3, p. 1, doi. 10.1186/s40478-015-0250-y
- By:
- Publication type:
- Article
Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer’s disease and aging.
- Published in:
- Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-023-44465-8
- By:
- Publication type:
- Article
Genetic Inhibition of Phosphorylation of the Translation Initiation Factor eIF2α Does Not Block Aβ-Dependent Elevation of BACE1 and APP Levels or Reduce Amyloid Pathology in a Mouse Model of Alzheimer’s Disease.
- Published in:
- PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0101643
- By:
- Publication type:
- Article
Orally Administrated Cinnamon Extract Reduces β- Amyloid Oligomerization and Corrects Cognitive Impairment in Alzheimer's Disease Animal Models.
- Published in:
- PLoS ONE, 2011, v. 6, n. 1, p. 1, doi. 10.1371/journal.pone.0016564
- By:
- Publication type:
- Article
Molecular Differences and Similarities Between Alzheimer's Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis.
- Published in:
- Biochemistry Insights, 2013, n. 6, p. 1, doi. 10.4137/BCI.S13025
- By:
- Publication type:
- Article
The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential.
- Published in:
- Journal of Neuroscience, 2009, v. 29, n. 41, p. 12787, doi. 10.1523/JNEUROSCI.3657-09.2009
- By:
- Publication type:
- Article
β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Levels Become Elevated in Neurons around Amyloid Plaques: Implications for Alzheimer's Disease Pathogenesis.
- Published in:
- Journal of Neuroscience, 2007, v. 27, n. 14, p. 3639, doi. 10.1523/JNEUROSCI.4396-06.2007
- By:
- Publication type:
- Article
Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation.
- Published in:
- Journal of Neuroscience, 2006, v. 26, n. 40, p. 10129, doi. 10.1523/JNEUROSCI.1202-06.2006
- By:
- Publication type:
- Article
Energy Inhibition Elevates ß-Secretase Levels and Activity and Is Potentially Amyloidogenic in APP Transgenic Mice: Possible Early Events in Alzheimer's Disease Pathogenesis.
- Published in:
- Journal of Neuroscience, 2005, v. 25, n. 47, p. 10874, doi. 10.1523/JNEUROSCI.2350-05.2005
- By:
- Publication type:
- Article
APP mouse models for Alzheimer's disease preclinical studies.
- Published in:
- EMBO Journal, 2017, v. 36, n. 17, p. 2473, doi. 10.15252/embj.201797397
- By:
- Publication type:
- Article
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.
- Published in:
- PLoS Biology, 2024, v. 22, n. 7, p. 1, doi. 10.1371/journal.pbio.3002727
- By:
- Publication type:
- Article
The γ -secretase complex: from structure to function.
- Published in:
- Frontiers in Cellular Neuroscience, 2014, v. 8, p. 1, doi. 10.3389/fncel.2014.00427
- By:
- Publication type:
- Article
BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.
- Published in:
- Alzheimer's Research & Therapy, 2014, v. 6, n. 9, p. 1, doi. 10.1186/s13195-014-0089-7
- By:
- Publication type:
- Article
The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease.
- Published in:
- Alzheimer's Research & Therapy, 2011, v. 3, n. 3, p. 1, doi. 10.1186/alzrt82
- By:
- Publication type:
- Article
Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice.
- Published in:
- Science Translational Medicine, 2018, v. 10, n. 459, p. 1, doi. 10.1126/scitranslmed.aao5620
- By:
- Publication type:
- Article
Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.
- Published in:
- Journal of Neurochemistry, 2014, v. 130, n. 1, p. 4, doi. 10.1111/jnc.12715
- By:
- Publication type:
- Article
Identification and biology of β-secretase.
- Published in:
- Journal of Neurochemistry, 2012, v. 120, p. 55, doi. 10.1111/j.1471-4159.2011.07512.x
- By:
- Publication type:
- Article
Genetic Bases of Epidermolysis Bullosa Simplex and Epidermolytic Hyperkeratosis.
- Published in:
- Journal of Investigative Dermatology, 1994, v. 103, p. 25S, doi. 10.1038/jid.1994.6
- By:
- Publication type:
- Article
Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease.
- Published in:
- Acta Neuropathologica, 2016, v. 132, n. 2, p. 235, doi. 10.1007/s00401-016-1558-9
- By:
- Publication type:
- Article