Works by Varki, Ajit

Results: 135

Multifarious roles of sialic acids in immunity.

Published in:

Annals of the New York Academy of Sciences, 2012, v. 1253, n. 1, p. 16, doi. 10.1111/j.1749-6632.2012.06517.x

By:

Varki, Ajit;
Gagneux, Pascal

Publication type:

Article

Biochemical, Cellular, Physiological, and Pathological Consequences of Human Loss of N-Glycolylneuraminic Acid.

Published in:

ChemBioChem, 2017, v. 18, n. 13, p. 1155, doi. 10.1002/cbic.201700077

By:

Okerblom, Jonathan;
Varki, Ajit

Publication type:

Article

Class Assignment of Sequence-Unrelated Members of Enzyme Superfamilies by Activity-Based Protein ProfilingThis research was supported by the NIH (CA087660 and GM32373) and the Skaggs Institute for Chemical Biology.

Published in:

Angewandte Chemie, 2005, v. 117, n. 16, p. 2452, doi. 10.1002/ange.200463098

By:

Nadim Jessani;
Jason A. Young;
Sandra L. Diaz;
Matthew P. Patricelli;
Ajit Varki;
Benjamin F. Cravatt

Publication type:

Article

Are sialic acids involved in COVID-19 pathogenesis?

Published in:

Glycobiology, 2021, v. 31, n. 9, p. 1068, doi. 10.1093/glycob/cwab063

By:

Dhar, Chirag;
Sasmal, Aniruddha;
Diaz, Sandra;
Verhagen, Andrea;
Yu, Hai;
Li, Wanqing;
Chen, Xi;
Varki, Ajit

Publication type:

Article

Human-specific microglial Siglec-11 transcript variant has the potential to affect polysialic acid-mediated brain functions at a distance.

Published in:

Glycobiology, 2021, v. 31, n. 3, p. 231, doi. 10.1093/glycob/cwaa082

By:

Hane, Masaya;
Chen, Dillon Y;
Varki, Ajit

Publication type:

Article

Roland Schauer (1936–2019): A tribute to "Mr. Sialic Acid".

Published in:

Glycobiology, 2020, v. 30, n. 3, p. 132, doi. 10.1093/glycob/cwaa007

By:

Varki, Ajit

Publication type:

Article

Updates to the Symbol Nomenclature for Glycans guidelines.

Published in:

Glycobiology, 2019, v. 29, n. 9, p. 620, doi. 10.1093/glycob/cwz045

By:

Neelamegham, Sriram;
Aoki-Kinoshita, Kiyoko;
Bolton, Evan;
Frank, Martin;
Lisacek, Frederique;
Lütteke, Thomas;
O'Boyle, Noel;
Packer, Nicolle H;
Stanley, Pamela;
Toukach, Philip;
Varki, Ajit;
Woods, Robert J;
Group, The SNFG Discussion

Publication type:

Article

New and updated glycoscience-related resources at NCBI.

Published in:

Glycobiology, 2017, v. 27, n. 11, p. 993, doi. 10.1093/glycob/cwx077

By:

Varki, Ajit

Publication type:

Article

Biological roles of glycans.

Published in:

Glycobiology, 2017, v. 27, n. 1, p. 3, doi. 10.1093/glycob/cww086

By:

Varki, Ajit

Publication type:

Article

Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins.

Published in:

Glycobiology, 2016, v. 26, n. 11, p. 1221, doi. 10.1093/glycob/cww042

By:

Bensing, Barbara A.;
Khedri, Zahra;
Lingquan Deng;
Hai Yu;
Prakobphol, Akraporn;
Fisher, Susan J.;
Xi Chen;
Iverson, Tina M.;
Varki, Ajit;
Sullam, Paul M.

Publication type:

Article

Symbol Nomenclature for Graphical Representations of Glycans.

Published in:

Glycobiology, 2015, v. 25, n. 12, p. 1323, doi. 10.1093/glycob/cwv091

By:

Varki, Ajit;
Cummings, Richard D.;
Aebi, Markus;
Packer, Nicole H.;
Seeberger, Peter H.;
Esko, Jeffrey D.;
Stanley, Pamela;
Hart, Gerald;
Darvill, Alan;
Kinoshita, Taroh;
Prestegard, James J.;
Schnaar, Ronald L.;
Freeze, Hudson H.;
Marth, Jamey D.;
Bertozzi, Carolyn R.;
Etzler, Marilynn E.;
Frank, Martin;
Vliegenthart, Johannes F. G.;
Lütteke, Thomas;
Perez, Serge

Publication type:

Article

N-Glycolylneuraminic acid deficiency worsens cardiac and skeletal muscle pathophysiology in α-sarcoglycan-deficient mice.

Published in:

Glycobiology, 2013, v. 23, n. 7, p. 833, doi. 10.1093/glycob/cwt020

By:

Martin, Paul T;
Camboni, Marybeth;
Xu, Rui;
Golden, Bethannie;
Chandrasekharan, Kumaran;
Wang, Chiou-Miin;
Varki, Ajit;
Janssen, Paul M L

Publication type:

Article

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan “self-associated molecular patterns” dampen innate immunity, but pathogens can mimic them.

Published in:

Glycobiology, 2011, v. 21, n. 9, p. 1121, doi. 10.1093/glycob/cwr087

By:

Varki, Ajit

Publication type:

Article

Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology.

Published in:

Glycobiology, 2011, v. 21, n. 8, p. 1038, doi. 10.1093/glycob/cwr039

By:

Wang, Xiaoxia;
Chow, Renee;
Deng, Liwen;
Anderson, Dan;
Weidner, Noel;
Godwin, Andrew K;
Bewtra, Chanda;
Zlotnik, Albert;
Bui, Jack;
Varki, Ajit;
Varki, Nissi

Publication type:

Article

Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: Phenotypic and functional impact.

Published in:

Glycobiology, 2009, v. 19, n. 11, p. 1204, doi. 10.1093/glycob/cwp111

By:

Weiman, Shannon;
Dahesh, Samira;
Carlin, Aaron F.;
Varki, Ajit;
Nizet, Victor;
Lewis, Amanda L.

Publication type:

Article

Working group report: the roles of glycans in hemostasis, inflammation and vascular biology.

Published in:

Glycobiology, 2008, v. 18, n. 10, p. 747, doi. 10.1093/glycob/cwn065

By:

Ajit P Varki;
Linda G Baum;
Susan L Bellis;
Richard D Cummings;
Jeffrey D Esko;
Gerald W Hart;
Robert J Linhardt;
John B Lowe;
Rodger P McEver;
Arun Srivastava;
Rita Sarkar

Publication type:

Article

Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: Potential implications for disease.

Published in:

Glycobiology, 2008, v. 18, n. 10, p. 818, doi. 10.1093/glycob/cwn072

By:

Vered Padler-Karavani;
Hai Yu;
Hongzhi Cao;
Harshal Chokhawala;
Felix Karp;
Nissi Varki;
Xi Chen;
Ajit Varki

Publication type:

Article

Human-specific expression of Siglec-6 in the placenta.

Published in:

Glycobiology, 2007, v. 17, n. 9, p. 922, doi. 10.1093/glycob/cwm065

By:

Els C M Brinkman-Van der Linden;
Nancy Hurtado-Ziola;
Toshiyuki Hayakawa;
Lisa Wiggleton;
Kurt Benirschke;
Ajit Varki;
Nissi Varki

Publication type:

Article

Siglecs—the major subfamily of I-type lectins.

Published in:

Glycobiology, 2006, v. 16, n. 1, p. 1, doi. 10.1093/glycob/cwj008

By:

Ajit Varki;
Takashi Angata

Publication type:

Article

Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis.

Published in:

Glycobiology, 2004, v. 14, n. 11, p. 939

By:

Ajit Varki

Publication type:

Article

A uniquely human consequence of domain-specific functional adaptation in a sialic acid–binding receptor.

Published in:

Glycobiology, 2004, v. 14, n. 4, p. 339, doi. 10.1093/glycob/cwh039

By:

Justin L. Sonnenburg;
Tasha K. Altheide;
Ajit Varki

Publication type:

Article

Enhanced 3-O-sulfation of galactosein Asn-linked glycans and Maackia amurenesis lectinbinding in a new Chinese hamster ovary cell line.

Published in:

Glycobiology, 2001, v. 11, n. 8, p. 621, doi. 10.1093/glycob/11.8.621

By:

Bai, Xiaomei;
Brown, JillianR.;
Varki, Ajit;
Esko, JeffreyD.

Publication type:

Article

Exploring the outcome of genetic modifications of glycosylation in cultured cell lines by concurrent isolation of the major classes of vertebrate glycans.

Published in:

Glycobiology, 2000, v. 10, n. 7, p. 691, doi. 10.1093/glycob/10.7.691

By:

Norgard-Sumnicht, Karin;
Bai, Xiaomei;
D.Esko, Jeffrey;
Varki, Ajit;
E.Manzi, Adriana

Publication type:

Article

Exploring the glycan repertoire of genetically modified mice by isolation and profiling of the major glycan classes and nano-NMR analysis of glycan mixtures.

Published in:

Glycobiology, 2000, v. 10, n. 7, p. 669, doi. 10.1093/glycob/10.7.669

By:

E.Manzi, Adriana;
Norgard-Sumnicht, Karin;
Argade, Sulabha;
D.Marth, Jamey;
Halbeek, Herman van;
Varki, Ajit

Publication type:

Article

Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.

Published in:

Glycobiology, 2000, v. 10, n. 4, p. 431, doi. 10.1093/glycob/10.4.431

By:

Angata, Takashi;
Varki, Ajit

Publication type:

Article

Trans-sialidase from Trypanosoma cruzicatalyzes sialoside hydrolysis with retention of configuration.

Published in:

Glycobiology, 2000, v. 10, n. 2, p. 213, doi. 10.1093/glycob/10.2.213

By:

R.Todeschini, Adriane;
Mendonça-Previato, Lucia;
O.Previato, José;
Varki, Ajit;
Halbeek, Herman van

Publication type:

Article

Cryptic sialic acid binding lectins on human blood leukocytes can be unmasked by sialidase treatment or cellular activation.

Published in:

Glycobiology, 1999, v. 9, n. 11, p. 1225, doi. 10.1093/glycob/9.11.1225

By:

Razi, Nahid;
Varki, Ajit

Publication type:

Article

Evolutionary considerations in relating oligosaccharide diversity to biological function.

Published in:

Glycobiology, 1999, v. 9, n. 8, p. 747, doi. 10.1093/glycob/9.8.747

By:

Gagneux, Pascal;
Varki, Ajit

Publication type:

Article

Inhibition of L‐ and P‐selectin by a rationally synthesized novel core 2‐like branched structure containing GalNAc‐Lewisx and Neu5Acα2–3Galβ1–3GalNAc sequences.

Published in:

Glycobiology, 1998, v. 8, n. 7, p. 707, doi. 10.1093/glycob/8.7.707

By:

Jain, Rakesh K.;
Piskorz, Conrad F.;
Huang, Bao‐Guo;
Locke, Robert D.;
Han, Hui‐Ling;
Koenig, Andrea;
Varki, Ajit;
Matta, Khushi L.

Publication type:

Article

Siglecs: a family of sialic-acid binding lectins.

Published in:

Glycobiology, 1998, v. 8, n. 2, p. v, doi. 10.1093/oxfordjournals.glycob.a018832

By:

Crocker, Paul R.;
Clark, Edward A.;
Filbin, Marie;
Gordon, Siamon;
Jones, Yvonne;
Kehrl, John H.;
Kelm, Soerge;
Le Douarin, Nicole;
Powell, Leland;
Roder, John;
Schnaar, Ronald L.;
Sgroi, Dennis C.;
Stamenkovic, Ivan;
Schauer, Roland;
Schachner, Melitta;
van den Berg, Timo K.;
Watt, Suzanne M.;
Varki, Ajit

Publication type:

Article

Induction of sialic acid 9‐O‐acetylation by diverse gene products: implications for the expression cloning of sialic acid O‐acetyltransferases.

Published in:

Glycobiology, 1998, v. 8, n. 2, p. 199, doi. 10.1093/glycob/8.2.199

By:

Shi, Wei‐Xing;
Chammas, Roger;
Varki, Ajit

Publication type:

Article

A Human-Specific Deletion in Mouse Cmah Increases Disease Severity in the mdx Model of Duchenne Muscular Dystrophy.

Published in:

Science Translational Medicine, 2010, v. 2, n. 42, p. 1, doi. 10.1126/scitranslmed.3000692

By:

Chandrasekharan, Kumaran;
Yoon, Jung Hae;
Xu, Ying;
de Vries, Sarah;
Camboni, Marybeth;
Janssen, Paulus M. L.;
Varki, Ajit;
Martin, Paul T.

Publication type:

Article

Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages.

Published in:

Journal of Innate Immunity, 2020, v. 12, n. 4, p. 333, doi. 10.1159/000504323

By:

Tsai, Chih-Ming;
Riestra, Angelica M.;
Ali, Syed Raza;
Fong, Jerry J.;
Liu, Janet Z.;
Hughes, Gillian;
Varki, Ajit;
Nizet, Victor

Publication type:

Article

PAMPs, DAMPs and SAMPs: Host Glycans are Self‐Associated Molecular Patterns, but subject to Microbial Molecular Mimicry.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.00015

By:

Varki, Ajit

Publication type:

Article

Symbol nomenclature for glycan representation.

Published in:

Proteomics, 2009, v. 9, n. 24, p. 5398, doi. 10.1002/pmic.200900708

By:

Varki, Ajit;
Cummings, Richard D.;
Esko, Jeffrey D.;
Freeze, Hudson H.;
Stanley, Pamela;
Marth, Jamey D.;
Bertozzi, Carolyn R.;
Hart, Gerald W.;
Etzler, Marilynn E.

Publication type:

Article

Chemoenzymatic Assembly of Mammalian O‐Mannose Glycans.

Published in:

Angewandte Chemie, 2018, v. 130, n. 29, p. 9141, doi. 10.1002/ange.201804373

By:

Meng, Caicai;
Sasmal, Aniruddha;
Zhang, Yan;
Gao, Tian;
Liu, Chang‐Cheng;
Khan, Naazneen;
Varki, Ajit;
Wang, Fengshan;
Cao, Hongzhi

Publication type:

Article

Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin.

Published in:

2008

By:

Byres, Emma;
Paton, Adrienne W.;
Paton, James C.;
Löfling, Jonas C.;
Smith, David F.;
Wilce, Matthew C. J.;
Talbot, Ursula M.;
Chong, Damien C.;
Yu, Hai;
Huang, Shengshu;
Chen, Xi;
Varki, Nissi M.;
Varki, Ajit;
Rossjohn, Jamie;
Beddoe, Travis

Publication type:

Letter

Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins.

Published in:

Nature, 2007, v. 446, n. 7139, p. 1023, doi. 10.1038/nature05816

By:

Varki, Ajit

Publication type:

Article

Physician–scientists are needed now more than ever.

Published in:

2006

By:

Varki, Ajit

Publication type:

Letter

The ethics of research on great apes.

Published in:

Nature, 2005, v. 437, n. 7055, p. 27, doi. 10.1038/437027a

By:

Gagneux, Pascal;
Moore, James J.;
Varki, Ajit

Publication type:

Article

Open access: the JCI has already shown it works.

Published in:

Nature, 2003, v. 426, n. 6965, p. 383, doi. 10.1038/426383b

By:

Varki, Ajit

Publication type:

Article

Display of the human mucinome with defined O-glycans by gene engineered cells.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24366-4

By:

Nason, Rebecca;
Büll, Christian;
Konstantinidi, Andriana;
Sun, Lingbo;
Ye, Zilu;
Halim, Adnan;
Du, Wenjuan;
Sørensen, Daniel M.;
Durbesson, Fabien;
Furukawa, Sanae;
Mandel, Ulla;
Joshi, Hiren J.;
Dworkin, Leo Alexander;
Hansen, Lars;
David, Leonor;
Iverson, Tina M.;
Bensing, Barbara A.;
Sullam, Paul M.;
Varki, Ajit;
Vries, Erik de

Publication type:

Article

Display of the human mucinome with defined O-glycans by gene engineered cells.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24366-4

By:

Nason, Rebecca;
Büll, Christian;
Konstantinidi, Andriana;
Sun, Lingbo;
Ye, Zilu;
Halim, Adnan;
Du, Wenjuan;
Sørensen, Daniel M.;
Durbesson, Fabien;
Furukawa, Sanae;
Mandel, Ulla;
Joshi, Hiren J.;
Dworkin, Leo Alexander;
Hansen, Lars;
David, Leonor;
Iverson, Tina M.;
Bensing, Barbara A.;
Sullam, Paul M.;
Varki, Ajit;
Vries, Erik de

Publication type:

Article

Gardnerella Vaginolysin Potentiates Glycan Molecular Mimicry by Neisseria gonorrhoeae.

Published in:

Journal of Infectious Diseases, 2023, v. 228, n. 11, p. 1610, doi. 10.1093/infdis/jiad391

By:

Morrill, Sydney R;
Saha, Sudeshna;
Varki, Ajit P;
Lewis, Warren G;
Ram, Sanjay;
Lewis, Amanda L

Publication type:

Article

How to make an ape brain.

Published in:

Nature Genetics, 2004, v. 36, n. 10, p. 1034, doi. 10.1038/ng1004-1034

By:

Varki, Ajit

Publication type:

Article

Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates.

Published in:

BMC Evolutionary Biology, 2017, v. 17, p. 1, doi. 10.1186/s12862-017-1075-z

By:

Toshiyuki Hayakawa;
Khedri, Zahra;
Schwarz, Flavio;
Landig, Corinna;
Suh-Yuen Liang;
Hai Yu;
Xi Chen;
Fujito, Naoko T.;
Yoko Satta;
Varki, Ajit;
Angata, Takashi

Publication type:

Article

Evolutionary conservation of human ketodeoxynonulosonic acid production is independent of sialoglycan biosynthesis.

Published in:

2021

By:

Kunio Kawanishi;
Saha, Sudeshna;
Diaz, Sandra;
Vaill, Michael;
Sasmal, Aniruddha;
Siddiqui, Shoib S.;
Choudhury, Biswa P.;
Sharma, Kumar;
Xi Chen;
Schoenhofen, Ian C.;
Chihiro Sato;
Ken Kitajima;
Freeze, Hudson H.;
Münster-Kühnel, Anja;
Varki, Ajit;
Kawanishi, Kunio;
Choudhury, Biswa;
Chen, Xi;
Sato, Chihiro;
Kitajima, Ken

Publication type:

journal article

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells.

Published in:

2018

By:

Stanczak, Michal A.;
Siddiqui, Shoib S.;
Trefny, Marcel P.;
Thommen, Daniela S.;
Boligan, Kayluz Frias;
von Gunten, Stephan;
Tzankov, Alexandar;
Tietze, Lothar;
Lardinois, Didier;
Heinzelmann-Schwarz, Viola;
von Bergwelt-Baildon, Michael;
Wu Zhang;
Lenz, Heinz-Josef;
Younghun Han;
Amos, Christopher I.;
Syedbasha, Mohammedyaseen;
Egli, Adrian;
Stenner, Frank;
Speiser, Daniel E.;
Varki, Ajit

Publication type:

journal article

Acidic pH increases airway surface liquid viscosity in cystic fibrosis.

Published in:

2016

By:

Xiao Xiao Tang;
Ostedgaard, Lynda S.;
Hoegger, Mark J.;
Moninger, Thomas O.;
Karp, Philip H.;
McMenimen, James D.;
Choudhury, Biswa;
Varki, Ajit;
Stoltz, David A.;
Welsh, Michael J.;
Tang, Xiao Xiao

Publication type:

journal article

Hyaluronan digestion controls DC migration from the skin.

Published in:

2014

By:

Muto, Jun;
Morioka, Yasuhide;
Yamasaki, Kenshi;
Kim, Margaret;
Garcia, Andrea;
Carlin, Aaron F;
Varki, Ajit;
Gallo, Richard L

Publication type:

journal article